#CB1 Receptors

[ashokan-kannaarth]

Marijuana's Influence on Brain Health: Unraveling Complex Cognitive and Psychiatric Effects

Marijuana is a category of drug, it has many medical uses abut abuse causes many complications and leads to many unpredictable life issues.

Marijuana, particularly its psychoactive component Δ9-tetrahydrocannabinol (THC), has significant effects on the brain, primarily through its interaction with the endocannabinoid system. This system includes cannabinoid receptors, mainly CB1 and CB2, distributed throughout the brain and body https://www.webmd.com/mental-health/addiction/marijuana-use-and-its-effects Mechanisms of Action CB1…

[time4hemp]

What Is Tetrahydrocannabinol?

(THC) naturally occurs in the brain.

Delta-9-Tetrahydrocannabinol: A Short Summary About THC.

Tetrahydrocannabinol (THC) is the primary psychoactive component of the cannabis plant. This cannabinoid was first isolated in 1964 by an Israeli Professor Dr. Raphael Mechoulam and Dr. Yechiel Gaoni. THC is currently a schedule I drug in the United States, meaning that it is deemed by the federal government to have no medicinal value whatsoever. One of the best ways to highlight this absurd notion is through the the double-standard of synthesizing of THC, a synthetic chemical that has been developed and legally sold in the United States under the name Marinol, which is available as a schedule III drug requiring a prescription.

THC is also a naturally occurring chemical with the human brain; this is where the psychoactive properties of THC come from. When you inhale or otherwise consume THC you flood your brain as well as the rest of your body with more THC than your body would naturally create on its own.

Tetrahydrocannabinol (THC) has a wide range of pain relief effects.

 THC has a wide range from mild to moderate analgesic or pain relieving effect, and has been used to treat pain by alerting the release of signals from various bodily components such as the spinal cord. There are often a number of other effects, including relaxation and a modification of the senses such as sight and auditory response, in addition to an increase in appetite.

It is well known that cannabis consumption increases appetite and food intake in humans, which is believed to be a result of THC effects on the CB1 receptors in the hypothalamus of the human brain. A study with mice suggests that cannabis stimulates taste as well as the pleasure experienced in the consumption of food. These studies are showing that increased pleasure may not be the only cause for an increase in appetite under the influence of THC.

Cancer patients benefit from the use of THC. 

Cancer patients often experience nausea from their chemotherapy as well as a loss in appetite. One of the hardest things cancer patients often deal with is a lack of nutrition as their appetite is either very low or nonexistent. Many of those suffering from cancer are finding marijuana and the THC within it to be a lifesaving appetite-stimulant which increases their appetite so they can eat, helping them take in the nutrition they desperately need. These same patients have also noticed a decrease in nausea, pain and other debilitating symptoms that other drugs have been unable to resolve without major addictions or side effects.

HIV/AIDS patients have also found relief from their conditions with THC, which reduces symptoms such as neuropathic pain induced by their therapy as well as an increase in weight gain. Because Marinol does not contain many of the other therapeutic components within real marijuana, like CBD, terpenoids, and flavonoids. AIDS/HIV sufferers who use this product may not achieve maximum benefit. Furthermore, some patients report that a single Marinol tablet frequently causes the patient to sleep or experience an all-day high that inhibits their cognitive ability throughout the day. Natural THC does not have the same effects, however, as the patient is able to carefully control their dose as well as take in the many other components of the natural drug.

Please share this with your friends.

[stonedcoast]

Artificial Intelligence

It's been a week, again! Here's my first Ramble since starting the blog. It's a little off topic, but it should lead to some interesting writing in the future. I hope you enjoy!

I could see myself doing an insane deep dive into Artificial Intelligence: there’s no lack of writing on the topic, it’s constantly improving, and we’re gaining access to it casually more and more every day. But this is a cannabis blog, and this was meant to be a filler post this week, as I am (as is noted in the AI chat I’m linking below) in between anniversary bookends, with my own having been…

[brightlotusmoon]

(9) Question

Cannabis is probably the least toxic therapeutically active substance known to man. Its Therapeutic Ratio (TR) is so high as to be virtually impossible to calculate but is believed to be between 1:20000 and 1:40000. Thus if 100mg of cannabis would produce an effect, between two to four kilos (taken at once) would be fatal. This amount is, of course, impossible to consume.

Therapeutic Ratio (TR) is the ratio of effective dose for 50% of users (ED50) to lethal dose for 50% of users (LD50). The TR of alcohol is 1:20. TR of heroin is 1:5.

Also, cannabis works on our body because it modulates the endocannabinoid system which consists of a network of CB1 and CB2 receptors throughout the body and endocannabinoids which are the body’s natural chemicals equivalent to the chemicals in the cannabis plant. The CB1 receptor is now believed to be the most prevalent receptor in the brain but does not exist in the brain stem which controls the cardiovascular and pulmonary systems. This is why, unlike opiates, alcohol or other drugs, cannabis cannot depress basic life functions to the point of death.

Many doctors are unaware of the endcocannabinoid system because it was only discovered in 1988 and so has only recently been documented in medical education. It is now believed to be the most important physiological system in our body, regulating the central nervous system, immune, cardiovascular, gastrointestinal and reproductive systems. This is why mankind has found cannabis such a safe and effective medicine for at least 5,000 years for such a wide variety of conditions.

_

INTERESTING.

[kratomcapsules12]

THC vs THCA- What are the Differences and Benefits

Cannabinoids, which are the amassed substances that are found in marijuana plants, have sparked interest because of the potential benefits they could bring to clinical treatment. Two such combinations, tetrahydrocannabinolic destructive (THCA) and tetrahydrocannabinol (THC), are discussed occasionally. Knowing the qualifications between THCA, and THC, is fundamental, particularly when you are looking for ordinary arrangements like CBD chewy dessert tablets for stress help and a brief look at joy. This article will examine these substances' definitions, contrasts, and purposes.

The marijuana plant is a mind-boggling animal overflowing with different mixes, which adds to its properties and benefits. Among these combinations, THC (tetrahydrocannabinol) and THCA (tetrahydrocannabinolic destructive) are habitually discussed for their primary positions. Even though they have a comparative name and are synthetically related, their purposes and properties might be very particular. This article centres on the specific qualities of THC and THCA, their benefits and weaknesses, and an investigation of THCA Best Price which is more established.

What is Mellow Fellow Disposable Vapes?

Mellow fellow disposable vapes are pre-filled, single-use devices that contain many cannabinoids. They're made to offer an easy and discrete method of experiencing the benefits of CBD with no hassles of maintaining or refilling. They are prepared to use right out of the package and are suitable for novices and experienced users. In the ever-changing marketplace of products containing cannabinoids, Mellow Fellow has carved its niche by offering high-end, lab-tested products. Mellow Fellow disposable vapes are well-known for their ease of use, portability and efficiency in their wide range of products. If you want to try these new products, Smokegem is the top online shop for selling Mellow Fellow Disposable Vapes in the Florida, United States with best price and doorstep shipping, we'll explore the factors that make Mellow Fellow disposable vapes worth a try, their characteristics and applications, and why Smokegem will be your desirable option to purchase the products online. 

The main differences between THC and THCA

Psych activity the most striking difference is the way that THC has psychoactive properties, while THCA doesn't. This implies that THCA is the ideal choice for people who need to stay away from a high connection with THC.

Compound Development: THCA has an extra carboxyl social event in contrast with THC that keeps it from getting into the CB1 receptors in the frontal cortex, in this manner keeping away from psychoactive impacts.

Usage Procedures: THC is usually disposed of by smoking, vaping, or biting. Yet, THCA is frequently consumed through straightforward weed crushes, tones, or even cases in which individuals have been warmed.

Legitimate Status: In numerous areas, THC is totally coordinated because of its psychoactive and endless impacts. At the same time, THCA is non-psychoactive and constantly under less severe rules.

The benefits of THC

Help with uneasiness THC is famous for its properties to ease torment and is a decent decision in facilitating the enduring of a leader.

Hunger Excitation is frequently used to help patients with ailments, for example, HIV and infections, to support their craving.

Decreased nervousness is particularly advantageous for chemotherapy patients who experience the ill effects of outrageous sickness.

Mental health might help facilitate burdensome and apprehensive feelings. Still, it could also cause more unfriendly, pessimistic impacts on specific individuals.

Benefits of THCA

Quieting THCA is known for its mitigating solid properties, which are advantageous for conditions like joint agony and lupus.

Neuroprotective Expected benefits for neurodegenerative infections like Parkinson's illness and Alzheimer's.

Antiemetic decreases queasiness and produces a heaved like THC, yet without the psychoactive impacts.

Threatening to proliferate early examinations recommend THCA could support the development of specific illness cells.

Which is more grounded? THC or THCA

The strength of a substance most frequently alludes to its psychoactive capability. In this occurrence, THC is unequivocally more grounded than THCA because of its capacity to give a lift. In any case, on the likelihood that we consider the strength of THCA regarding unwinding potential, without psychoactive impacts, THCA might be viewed as more helpful to specific clients; especially the people who are hoping to unwind or have neuroprotective benefits, without an adjustment of mental state.

Legitimate and Prosperity Thoughts

The lawful Status of THCA, when contrasted with THC Online Shop, varies given the ward. THC is named as a controlled substance in various areas, while THCA might be lawful because of its essential design. In any case, it's necessary to know the way that warming or taking care of THCA can adjust it into THC and create legitimate issues.

Where to Buy THC and THCA Items

If you're keen on purchasing combinations, numerous web-based stores provide a range of items. Here are a few techniques to find reasonable choices

THCA Online Shop: Quest for organizations that are given to crude cannabis items to ensure you are purchasing THCA without decarboxylation. Our Smokegem stores ordinarily offer the most minimal costs and the best items.

THC Online Supplier: Search out reliable suppliers offering an immense determination of THC items, going from blossoms to edibles. You should rest assured that they will give outside research facility tests to check the quality and strength.

The best THC Online Store: Look at the most recent internet-based stores, explore clients' reviews, and determine and assess to chase the top THC items for your necessities.

Every one of THC and THCA enjoys unmistakable benefits, and the decision between them depends on individual inclinations and requirements for prosperity. Whether you're looking for the psychoactive impacts that come from THC or the positive benefits of THCA, the developing business market of maryjane-related items guarantees you'll track down something for everybody. Continuously talk with a certified clinical expert before starting any new treatment given cannabis, and just buy from respectable providers to guarantee security and quality.

[dafitness4shawn]

Hey y’all! Went for a run today. It was meh but what should I expect from the first run back. I’ll blame it on not being at sea level anymore. That’s not what I wanted to talk about though!

After smoking weed almost daily for 10 years, tonight marks 28 days of not smoking or ingesting THC. The significance of the number came from this video (https://youtu.be/7u_cm5b1s7Y). According to the video that’s when your “affected endocannabinoid system and CB1 receptors return to baseline.” I take that info with a grain of salt because we are not all built the same but it’s still nice to say I made it to that number, it’s the longest I’ve ever gone. I actually took a home-drug test at Day 14 (brand was Equate) and passed, which I was very surprised about and didn’t want to believe. I feel one reason people never touch the stuff is because you hear things like “it’s detectable for months!” However my lab tech girlfriend who deals with test very similar says it’s accurate and that the time it stays detectable is going to differ from person to person.

Anyway, if you’ve followed for a while you know that I’ve struggled in the past with taking breaks so of course I wanted to share this milestone. Definitely couldn’t do it without support. @emilweeb suggested supplements (specifically the Ashwagandha) and I heard the Magnesium Glycinate helps with sleep so I gave that a try as well. They definitely helped so much in the beginning. Recently I fell off with taking them daily but I’m gonna get back into it, especially since I do feel positive effects from them. Her advice behind the supplements was to replace bad habits with good habits. Also have to give credit to my girlfriend. She doesn’t smoke anymore but did just as much as me in the past/when we first met. Sometimes you need someone to tell you, “Don’t do that,” but in a loving, non-judgemental way.

I guess the question now is, “Am I done with weed forever?” The answer is no. I know I don’t want to be a daily user anymore, and I prefer not to get back into smoking, since no matter what you smoke, smoking is bad for your respiratory system, and that’s a fact. Not gonna lie though, I’m not saying I’ll never smoke again, just not going to make that my main method. I wanna ease back into it at my own pace. I have tinctures and edibles waiting for me when I decide to take that step, but even while writing this out I’m not in a rush to get high again, which is honestly, so weird to think.

I feel like there’s so much more I could add but this post is LONG. I’m always down to answers questions though if this post sparks any for anyone. I hope y’all are having a great day :)

[microdosingwithjoe]

CBG, CBD, CBC, CBN, and THCV

The Healing Cannabinoids

If you read my piece on the entourage effect, you know that I believe that THC is the ringmaster, but all the components of cannabis determine the “personality” of any given strain. Studies have proven the Entourage Effect with cannabinoids and terpenes. But these five cannabinoids are the major components that combine with THC to most affect your high as far as we know, as well your health and wellbeing.

Some cannabinoids, especially CBN and CBG, can bind directly to both the endocannabinoid system’s (ECS) CB1 and CB2 receptors, meaning they affect everything the ECS controls. These elements are all-important to the way any given cannabis strain or concoction affects you.

There are over 100 cannabinoids. We have no idea what most of them do, but the ones I selected are considered the most important.

CBG (cannabigerol) is the “Mother Cannabinoid” —THC, CBD, CBC, and CBN (and all other cannabinoids) began as CBG.

CBG’s anti-stress, anti-anxiety, and antidepressant effects are fantastic, but that’s just the tip of the iceberg. There are numerous studies about CBG that indicate that it is as good as or better than CBD for pain, anxiety, inflammation, sleep disorders, etc. —all CBD’s effects but even better. It also provides better relief for sufferers of intestinal disorders, like IBS, GERD, and Crohn’s disease. We will have to wait and see everything CBG does, because the THC and CBD study focus has been taking the lion’s share of interest before now, but CBG is the rising superstar.

CBD (cannabidiol) is a cure-all kinda medicine that continues to show positive effects in more and more conditions all the time. I have a personal affinity for CBD + THC therapy, as it substantially healed two discs in my neck, and turned my degenerative disc disorder around. I still can have bouts of pain, but compared with living with hearing and feeling bone-on-bone grinding all day, every day? I’m in heaven. Another attribute of CBD, is that it’s a THC antagonist. That means it can inhibit and regulate the uptake of THC, and that has two great purposes. If you’re a beginner stoner. I always recommend everyone get a CBD vape whether you’re a beginner or an expert stoner. If you get too high, feel THC-induced anxiety, or panic, just a few puffs of CBD, and you’ll be relieved. But because CBD has all these great benefits of reducing tension, anxiety, and depression, one puff is just a great additive to any high. Antagonistic CBD also stretches THC’s effective period from 4 hours, to 6-8 hours during sleep.

CBC (cannabichromene) may be up to 10 times more potent than CBD for treating stress and anxiety and also has significant anti-inflammatory, pain-reducing, antiviral, anti-tumor, and bone-growth-stimulating properties. But the potential CBC has that excites me most, is that could be immensely useful in promoting the growth of new brain cells.

As an old fart with diminishing mental acuity, that’s obviously interesting to me.

CBN (cannabinol) is the first known cannabinoid, but one of the least-studied of these five, and is the only one that isn't derived directly from CBG, but it's what THC turns into when oxidized. Unlike CBG, CBD, and CBC, it’s mildly intoxicating. Like all these cannabinoids, it relieves pain and inflammation.

The best-known effect of CBN, is that it makes you sleepy. Anyone who’s ever smoked an old joint they found in a drawer might remember that it didn’t get them very high, but it made them ready for nappy time; that’s because much of the THC has degraded into CBN.

What excites me most about CBN, is that behaves like THC in many ways, and it has been found to bind with CB2 receptors. This ability may lead to new treatments for neuropathy (no treatment currently exists, and I suffer from neuropathic pain caused by sciatica), as CB2 receptors appear in inflamed areas in the body.

CBN therapies will be able to treat virtually any inflamed site, so it has the potential to address other areas that are difficult to treat, such as gastrointestinal system disorders like GERD, Chrons Disease, and diverticulitis.

CBN could be a true wonder drug.

THCV (tetrahydrocannabivarin) is another under-studied cannabinoid that’s attracting attention, for good reason.

THCV is a very effective appetite suppressant. It’s also the opposite of CBN, making people quite energetic. Being a bit tubby, I’m really excited by it. I’ve had a rare strain that contained THCV, and can attest to these properties.

But more excitement is to come from THCV, as it has shown to treat a lot of other diverse conditions, including Parkinson’s, psychosis, bacterial inflammation, acne, fatty liver disease, pain, and epilepsy.

I can’t wait to see what other benefits THCV has! Durban Poison is a common strain that contains high levels of THCV, but I’ve never had as good an effect from DP as I did the first (forgotten-named) high-THCV strain I tried.

Entourage Effect- all these cannabinoids work together in ways that increase their effectiveness when combined with THC, and can’t be recommended enough for ailments and moods your ECS controls. There aren’t any drawbacks, except you probably won’t want to ingest CBN until bedtime.

Any and all of these cannabinoids can be ingested individually a half hour before imbibing your favorite weed. THC don’t care where or how you get these into your system, but as always, these other cannabinoids work best with THC. There are vape pens with 50/50 CBD & CBG, but none that incorporate CBC or CBN that I’ve found, yet, but they gotta be out there.

I’m looking for a good supplier of isolates of these cannabinoids; pure, plant-derived organic powders. My intent is to mix them with honey and select terpenes to put into beverages. I’m going to make a daytime version with THCV, a nighttime version that includes CBN, and a neutral one with neither. When I find that supplier I’ll paste a link here, and I'll also let you know if my hypothesis that taking these cannabinoids orally, followed by consumption of THC products a short time later works effectively.

Remember: cannabinoids every day help keep the doctor away!

[budandtender]

Understanding the Role of Endocannabinoids in Psoriasis Regulation

World Psoriasis Day October 29th

Introduction

World Psoriasis Day is a global event that shines a light on psoriasis, a chronic autoimmune condition that causes red, scaly patches to appear on the skin. It's an opportunity to educate and raise awareness about this often misunderstood disease. In this article, we'll delve into how endocannabinoids can regulate psoriasis, providing a unique perspective on the disease's underlying mechanisms.

Understanding Endocannabinoids

Endocannabinoids are naturally occurring compounds within our bodies that interact with the endocannabinoid system (ECS). The ECS is a complex cell-signalling system that plays a key role in regulating a range of functions and processes, including immune response, pain, mood, and more.

The two primary endocannabinoids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These molecules bind to CB1 and CB2 receptors found throughout the body, triggering various physiological responses. Interestingly, research has indicated that these endocannabinoids and their receptors may play a significant role in managing skin health and diseases such as psoriasis.

Endocannabinoids and Skin Health

Our skin is not just a barrier protecting us from the outside world; it's also a complex organ with its own ECS. This system plays a crucial role in maintaining skin homeostasis – the balance of cell growth and death. In conditions like psoriasis, this balance is disrupted, leading to an overproduction of skin cells.

Research has shown that endocannabinoids can influence several key aspects of skin health. They can regulate skin cell proliferation and differentiation, immune response, and inflammation - all critical factors in psoriasis.

Endocannabinoids and Psoriasis Regulation

Psoriasis is characterised by an overactive immune response, leading to inflammation and rapid skin cell growth. The role of endocannabinoids in psoriasis regulation primarily revolves around their anti-inflammatory and immunomodulatory properties.

Studies have shown that endocannabinoids can reduce inflammation by downregulating the production of pro-inflammatory cytokines, proteins that promote inflammation. This could potentially help manage the chronic inflammation seen in psoriasis.

Moreover, endocannabinoids can also modulate the immune response. They can inhibit the overactive immune cells responsible for the rapid skin cell growth in psoriasis, helping to restore balance in the skin's ecosystem.

Research also suggests that people with psoriasis may have an impaired endocannabinoid system, with lower levels of endocannabinoids in their skin. This could potentially contribute to the disease's development and progression, highlighting the potential therapeutic value of targeting this system.

Conclusion

While the relationship between endocannabinoids and psoriasis is complex and still not fully understood, current research indicates a promising role for these molecules in regulating the disease. By modulating inflammation and immune response, endocannabinoids could potentially help manage psoriasis symptoms and improve skin health.

However, it's important to note that more research is needed to fully understand the mechanisms involved and how best to harness the power of endocannabinoids for psoriasis treatment. As we celebrate World Psoriasis Day, let's also celebrate the ongoing research and advancements that bring us closer to understanding and effectively managing this challenging condition.

[moya-cbd]

The Uniqueness Of CBD

CBD is a phytocannabinoid that is a trapeno-phenolic molecule made of 21 carbon atoms, which is formed as a result of de-carboxylation (co² heating in the presence of oxygen) from the substance of origin –  cannabigerolic acid (CBDA) and is not linked to the receptors of the CB1 or CB2 system but acts through a large number of other mechanisms of action that are recently revealed in the scientific study.

Cannabidiol does not cause intoxicating effects (non-Intoxicating) and does not feel the feeling of elation (High) in its effect at all. On the contrary, cannabidiol has a calming general effect, which prevents anxiety and psychosis while simultaneously suppressing inflammation throughout the body and soothing pain, nausea and vomiting.

[poojasingh11]

10 Benefits of Using CBD Oil During Cancer Treatment

Introduction

The journey through cancer treatment can be arduous, often accompanied by a range of physical and emotional challenges. As patients seek relief from symptoms and side effects, CBD oil for cancer treatment has emerged as a potential complementary therapy. Cannabidiol (CBD), a non-psychoactive compound derived from the cannabis plant, is gaining attention for its therapeutic properties. This blog explores ten benefits of using CBD oil for cancer treatment, emphasizing its role in alleviating symptoms and enhancing overall well-being.

Understanding CBD Oil in Cancer Treatment

CBD oil is extracted from hemp or cannabis plants and contains high levels of cannabidiol. Unlike THC (tetrahydrocannabinol), CBD does not produce a "high" but interacts with the body’s endocannabinoid system to regulate various physiological processes. Research suggests that CBD oil for cancer treatment may help manage symptoms associated with cancer and its treatments, including pain, nausea, and anxiety.

CBD Oil Benefits for Cancer Treatment

Pain Relief Cancer-related pain can arise from the disease itself or as a side effect of treatments like chemotherapy and radiation. CBD oil for cancer treatment may provide significant relief by interacting with the body’s endocannabinoid receptors, particularly CB1 and CB2 receptors. These interactions can help modulate pain perception and reduce inflammation. - Mechanism: CBD may inhibit the reuptake of anandamide, an endocannabinoid that plays a role in pain regulation. By increasing anandamide levels, CBD can enhance pain relief. - Research Evidence: Studies have shown that patients using CBD report lower pain levels compared to those who do not use it, making it a valuable adjunct to traditional pain management strategies.[1],[2] This can lead to improved comfort and quality of life for patients undergoing treatment.

Reducing Inflammation Chronic inflammation is often associated with cancer progression and can exacerbate symptoms. CBD oil for cancer treatment has been shown to possess anti-inflammatory properties, which may help reduce swelling and discomfort. - Mechanism: CBD interacts with various receptors involved in the inflammatory response, including TRPV1 receptors, which are linked to pain perception and inflammation. - Research Evidence: Animal studies have demonstrated that CBD can significantly reduce inflammation in conditions such as arthritis and colitis, suggesting similar benefits for cancer patients experiencing inflammatory symptoms.[3],[4]

Enhancing Appetite Cancer treatments can lead to significant appetite loss, resulting in weight loss and malnutrition. While THC is known for its appetite-stimulating effects, CBD may also play a role in enhancing appetite without the psychoactive effects associated with THC. - Mechanism: CBD may influence appetite-regulating hormones and pathways in the brain. It has been suggested that CBD could stimulate appetite by affecting the hypothalamus. - Research Evidence: Clinical observations have indicated that patients using CBD report improved appetite and food intake during treatment, which is crucial for maintaining nutritional health.[2], [5]

Reducing Anxiety and Stress The emotional toll of a cancer diagnosis and treatment can lead to heightened anxiety and stress levels. CBD oil for cancer treatment has been studied for its anxiolytic (anxiety-reducing) effects. - Mechanism: CBD interacts with serotonin receptors (5-HT1A) in the brain, which play a key role in mood regulation. By enhancing serotonin signalling, CBD can promote feelings of calmness. - Research Evidence: Studies have shown that patients using CBD report lower levels of anxiety during treatment sessions, contributing to better mental health outcomes. [3]

Improving Sleep Quality Many cancer patients experience sleep disturbances due to pain, anxiety, or medication side effects. Research suggests that CBD oil for cancer treatment may help improve sleep quality by addressing these underlying issues. - Mechanism: CBD may influence sleep cycles by interacting with receptors involved in regulating sleep patterns. It can help reduce anxiety and pain, both of which are common barriers to restful sleep. - Research Evidence: Clinical studies indicate that patients using CBD report improved sleep quality and duration compared to those who do not use it.[2]

Supporting Immune Health Emerging studies suggest that cannabinoids like CBD may have immunomodulatory effects, potentially supporting the immune system during cancer treatment. - Mechanism: CBD can influence immune cell activity by modulating cytokine production, which helps regulate immune responses. - Research Evidence: Preliminary studies suggest that CBD may enhance immune function without overstimulating it, potentially improving patient resilience during treatment. [6],[5]

Protecting Against Cellular Damage CBD's antioxidant properties may protect cells from damage caused by oxidative stress, which is often elevated in cancer patients due to both the disease and its treatments. - Mechanism: By scavenging free radicals and reducing oxidative stress, CBD can help maintain cellular integrity. - Research Evidence: Studies have shown that antioxidants like CBD can protect against cellular damage in various models of disease, indicating potential benefits for cancer patients facing oxidative stress from treatments. [6],[5]

Potential Anti-Cancer Effects While research is still in its early stages, some studies have indicated that CBD oil for cancer treatment may possess anti-cancer properties by inhibiting tumour growth and promoting apoptosis (programmed cell death) in certain types of cancer cells. - Mechanism: CBD has been shown to induce apoptosis in cancer cells while sparing healthy cells through various pathways involving cell signalling. - Research Evidence: Laboratory studies have demonstrated that CBD can inhibit the growth of certain types of tumours (e.g., breast cancer cells), although more clinical trials are needed to confirm these effects in humans.[6],[5]

Better Overall Well-being The cumulative benefits of using CBD oil for cancer treatment can lead to an enhanced sense of well-being. By alleviating pain, reducing anxiety, improving sleep quality, and supporting appetite, patients may experience a better quality of life throughout their treatment journey. - Holistic Approach: The multi-faceted benefits of CBD contribute not only to physical health but also to emotional resilience during challenging times. - Patient Testimonials: Many patients report feeling more balanced and better able to cope with their diagnosis when incorporating CBD into their care regimen.[1]

Complementary Therapy It’s important to recognize that while CBD oil for cancer treatment offers numerous potential benefits, it should be viewed as a complementary therapy rather than a replacement for conventional treatments like chemotherapy or radiation. - Integration into Treatment Plans: Patients should always discuss their plans to use CBD with their healthcare providers to ensure safe integration into their overall treatment plan. - Ongoing Research: As research continues to evolve regarding the efficacy of cannabinoids in oncology settings, healthcare providers will be better equipped to recommend appropriate therapies tailored to individual patient needs.[3],[4]

Conclusion

As research continues to explore the potential benefits of CBD oil for cancer treatment, many patients are finding relief from various symptoms associated with their diagnosis and therapies. From pain relief and reduced inflammation to improved appetite and better sleep quality, the therapeutic properties of CBD offer hope for enhanced well-being during challenging times. While it is crucial to approach CBD as a complementary therapy rather than a standalone cure, its incorporation into a holistic treatment plan may provide significant advantages for individuals navigating the complexities of cancer care. Always consult with healthcare professionals before starting any new supplement or therapy to ensure safety and efficacy tailored to individual needs.

References

Cannabis and cannabinoids – 2023 https://www.cancer.gov/about-cancer/treatment/cam/patient/cannabis-pdq

CBD for cancer: Everything you need to know - 2021 – Johnson https://www.medicalnewstoday.com/articles/324745

Cannabis, CBD oil and cancer https://www.cancerresearchuk.org/about-cancer/treatment/complementary-alternative-therapies/individual-therapies/cannabis/

What do we know about the benefits of CBD in cancer management? | dsm-firmenich Health, Nutrition & Care https://www.dsm-firmenich.com/en/businesses/health-nutrition-care/news/talking-nutrition/what-do-we-know-about-the-benefits-of-cbd-in-cancer-management.html

CBD for Cancer: Can It Help? Maybe, According to Research - 2020 – Pietrangelo https://www.healthline.com/health/cancer/cbd-for-cancer

Seltzer, E. S., Watters, A. K., MacKenzie, D., Jr, Granat, L. M., & Zhang, D. (2020). Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Cancers, 12(11), 3203. https://doi.org/10.3390/cancers12113203

[honeyhighsposts]

Chronic pain affects many people, leading them to explore natural alternatives for relief. THC honey sticks have become a popular option, combining the potential pain-relieving benefits of cannabis with the soothing properties of honey. But can they truly help manage pain? Let’s take a closer look.

How THC May Help with Pain Relief

Tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, interacts with the endocannabinoid system (ECS), which helps regulate pain, inflammation, and overall comfort. Here’s how THC might support pain relief:

May Reduce Pain Signals – THC interacts with CB1 and CB2 receptors in the body, which could help lessen pain perception. Supports Anti-Inflammatory Effects – Chronic conditions like arthritis and migraines involve inflammation. THC may assist in reducing inflammation over time. Encourages Muscle Relaxation – Muscle tension and spasms can contribute to pain. THC is known for its muscle-relaxing properties, potentially helping those with conditions like fibromyalgia. May Improve Mood – Chronic pain can lead to stress and anxiety. THC’s ability to enhance mood and relaxation may provide indirect relief.

Slow & Steady Absorption – THC honey is digested gradually, leading to long-lasting relief compared to smoking or vaping. A Smoke-Free Alternative – Those looking to avoid harsh inhalation can enjoy the benefits of THC without irritation. Easy, Controlled Dosing – With 5mg THC per honey stick, it’s simple to measure your intake. Discreet & Versatile – They can be added to food, drinks, or taken directly without drawing attention. Added Benefits of Honey – Honey has anti-inflammatory and antibacterial properties, which may further support healing.

How to Use THC Honey Sticks for Pain Relief

Mix Into Tea or Coffee – A warm beverage infused with THC honey can provide a calming effect that lasts for hours. Take It Directly – Consuming a honey stick on its own allows for fast absorption through the mouth. Drizzle Over Food – Adding it to yogurt, oatmeal, or toast makes it a tasty way to incorporate THC into your routine. Blend Into a Smoothie – Pairing it with anti-inflammatory ingredients like ginger or turmeric may enhance its benefits.

THC honey sticks can be a beneficial option for managing pain. Their slow release, precise dosing, and natural properties make them a practical choice for those seeking relief without pharmaceuticals or smoking.

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Cannabis and Wellness: Your Guide to Easing Stress, Anxiety & Pain 

Cannabis and Wellness: A Natural Guide to Relieving Stress, Anxiety, Pain & Inflammation

Feeling overwhelmed by stress? Struggling with chronic pain that won’t go away? Cannabis has been used for centuries to help manage these conditions, and today, science is backing its health benefits more than ever.From ancient Ayurvedic practices to modern clinical studies, cannabis has been recognized for its therapeutic potential. With growing acceptance and legalization, more people are turning to cannabis as a holistic approach to wellness.This guide explores how cannabis can support overall health, improve quality of life, and how you can use it safely and effectively.

Understanding Cannabis and Its Components

Cannabis contains over 100 active compounds called cannabinoids, which interact with the body's endocannabinoid system (ECS) to maintain balance and health.The ECS regulates functions like mood, sleep, appetite, and pain response. Cannabinoids such as THC and CBD mimic the body’s natural endocannabinoids to restore balance and support overall health effects. Key Cannabinoids and Their Benefits CannabinoidEffectsTHC (Tetrahydrocannabinol)Psychoactive, pain relief, nausea reduction, appetite stimulationCBD (Cannabidiol)Non-psychoactive, anti-inflammatory, anxiety relief, pain managementCBG (Cannabigerol)Supports mood regulation, potential neuroprotective propertiesCBN (Cannabinol)Aids in sleep and relaxationTHCV (Tetrahydrocannabivarin)May help regulate appetite and metabolism The Role of TerpenesTerpenes, the aromatic compounds in cannabis, contribute to its effects and therapeutic benefits. TerpeneEffectsMyrcenePromotes relaxation and sedationLimoneneEnhances mood, reduces stressCaryophylleneAnti-inflammatory, pain reliefPineneSupports alertness and respiratory benefitsLinaloolCalming, anti-anxiety, potential pain relief

Cannabis for Stress and Anxiety Relief

How Cannabis Helps with Stress and AnxietyIn today’s fast-paced world, stressors are all around us, and they can significantly impact mental health. Cannabis, especially strains rich in CBD, interacts with serotonin receptors in the brain, promoting a sense of relaxation and helping to reduce anxiety.While low doses of THC can also aid in alleviating stress, higher doses may occasionally lead to paranoia. As the medical use of cannabis continues to gain popularity, it’s increasingly seen as a safe and effective alternative to conventional treatments for anxiety and stress. Best Cannabis Strains for Anxiety and Stress StrainCBD/THC RatioDominant TerpenesBest ForHarlequinHigh CBD, Low THCMyrcene, PineneAnxiety relief without sedationACDCCBD-dominantLimonene, CaryophylleneClear-headed relaxationGranddaddy PurpleTHC-richMyrcene, LinaloolDeep relaxation, sleep aidBlue DreamBalanced HybridMyrcene, PineneGentle euphoria, mental relaxation

Cannabis for Chronic Pain Management

How Cannabis Alleviates PainChronic pain can significantly impact daily life, and traditional painkillers often have severe side effects.Cannabis works as a natural pain reliever by interacting with CB1 and CB2 receptors in the nervous and immune systems to reduce pain perception and inflammation.Many patients turn to medical marijuana as an alternative treatment due to its efficacy and reduced risk of addiction compared to opioids. Best Cannabis Strains for Pain Relief StrainTypeBest ForNorthern LightsIndicaSedative, pain reliefWhite WidowHybridModerate pain relief, mental clarityOG KushIndicaMigraines, muscle spasms, arthritisCannatonicCBD/THC BalancedPain relief without strong psychoactive effects

Cannabis for Reducing Inflammation

How Cannabis Reduces InflammationChronic inflammation is a leading cause of diseases such as arthritis, autoimmune disorders, and digestive issues.CBD acts as an anti-inflammatory agent by inhibiting inflammatory cytokines and supporting immune system balance.Using cannabis for health and wellness purposes includes addressing inflammation at the root cause. Best Cannabis Strains for Inflammation StrainCBD/THC RatioBest ForCharlotte’s WebHigh CBDReducing inflammation and seizuresSour TsunamiCBD-richNeuropathic pain, inflammationPineapple ExpressHybridMild anti-inflammatory effects

Microdosing Cannabis for Wellness

Microdosing involves taking very small amounts of THC (1-2 mg) or CBD (5-10 mg) to enhance mood and focus without feeling high.This method is particularly beneficial for:- Professionals needing stress relief without impairment - Athletes managing post-exercise inflammation - Individuals sensitive to THC who want therapeutic effects without intoxicationTip: Start with a low dose of CBD (5 mg) and gradually increase if needed. Keep a journal to track your mood and any changes in symptom

Comparison of Cannabis Consumption Methods

MethodOnset TimeDurationBest ForSmoking/VapingImmediate1-3 hoursFast relief for pain, stress, anxietyEdibles30-120 min4-8 hoursChronic pain, insomniaTinctures/Oils15-45 min4-6 hoursAnxiety, inflammationTopicalsN/AVariesMuscle pain, arthritis, skin conditionsCapsules30-90 min6-8 hoursDiscreet, consistent dosing

Addressing Common Myths About Cannabis

Myth vs. Fact- Myth: Higher THC means better pain relief. - Fact: Some people respond better to balanced THC/CBD strains with fewer side effects. - Myth: CBD is completely non-psychoactive. - Fact: While CBD won’t get you high, it can still subtly alter mood and cognition.

Potential Side Effects and Considerations

While cannabis offers numerous benefits, responsible use is essential. Read the full article

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Can CBD and THCV Help with Weight Loss? Exploring the Science and Benefits

Introduction to CBD and THCV Cannabidiol (CBD) and Tetrahydrocannabivarin (THCV) are two noteworthy cannabinoids derived from the cannabis plant. CBD is a prominent component of cannabis that has gained appreciation for its therapeutic properties without the psychoactive effects typically associated with tetrahydrocannabinol (THC). Unlike THC, which binds primarily to CB1 receptors in the brain,…

[brightlotusmoon]

Marijuana Users Have More Empathy And A Greater Understanding Of Other People's Emotions, Study Finds

Researchers said the results suggest a potential association between cannabis use and empathy, though they caution that further research is needed to fully understand the interactions “since many other factors may be at play.”

In attempting to explain the findings, the team of neuroscientists noted that a part of the brain, the anterior cingulate cortex (ACC), “is a region that is prone to the effects of cannabis consumption and is also greatly involved in empathy, which is a multi-component process that can be influenced in different ways.”

“Given that the ACC is one of the main areas that possess CB1 [cannabinoid] receptors and is heavily involved in the representation of the affective state of others,” the study says, “we believe that the differences shown by regular cannabis users in the emotional comprehension scores and their brain functional connectivity could be related to the use of cannabis.”

Despite the qualifiers, the study concludes, “Given previous studies of the effect of cannabis on mood and emotional detection, we believe that these results contribute to open a pathway to study further the clinical applications of the positive effect that cannabis or cannabis components could have in affect and social interactions.”

In other neuroscience research this year, researchers at the University of West Attica in Greece found that medical marijuana use was associated with improved quality of life — including better job performance, sleep, appetite, and energy — among people with neurological disorders.

Another recent study published by the American Medical Association found that medical marijuana was associated with “significant improvements” in quality of life for people with conditions like chronic pain and insomnia—and those effects were “largely sustained” over time.

Other studies have found cannabis may boost the “runner's high” felt during exercise and enhance the practice of yoga.

[relphmcnely]

Can CBD and THCV Help with Weight Loss? Exploring the Science and Benefits

Introduction to CBD and THCV Cannabidiol (CBD) and Tetrahydrocannabivarin (THCV) are two noteworthy cannabinoids derived from the cannabis plant. CBD is a prominent component of cannabis that has gained appreciation for its therapeutic properties without the psychoactive effects typically associated with tetrahydrocannabinol (THC). Unlike THC, which binds primarily to CB1 receptors in the brain,…