#CB1 Receptors

[ashokan-kannaarth]

Marijuana's Influence on Brain Health: Unraveling Complex Cognitive and Psychiatric Effects

Marijuana is a category of drug, it has many medical uses abut abuse causes many complications and leads to many unpredictable life issues.

Marijuana, particularly its psychoactive component Δ9-tetrahydrocannabinol (THC), has significant effects on the brain, primarily through its interaction with the endocannabinoid system. This system includes cannabinoid receptors, mainly CB1 and CB2, distributed throughout the brain and body https://www.webmd.com/mental-health/addiction/marijuana-use-and-its-effects Mechanisms of Action CB1…

[time4hemp]

What Is Tetrahydrocannabinol?

(THC) naturally occurs in the brain.

Delta-9-Tetrahydrocannabinol: A Short Summary About THC.

Tetrahydrocannabinol (THC) is the primary psychoactive component of the cannabis plant. This cannabinoid was first isolated in 1964 by an Israeli Professor Dr. Raphael Mechoulam and Dr. Yechiel Gaoni. THC is currently a schedule I drug in the United States, meaning that it is deemed by the federal government to have no medicinal value whatsoever. One of the best ways to highlight this absurd notion is through the the double-standard of synthesizing of THC, a synthetic chemical that has been developed and legally sold in the United States under the name Marinol, which is available as a schedule III drug requiring a prescription.

THC is also a naturally occurring chemical with the human brain; this is where the psychoactive properties of THC come from. When you inhale or otherwise consume THC you flood your brain as well as the rest of your body with more THC than your body would naturally create on its own.

Tetrahydrocannabinol (THC) has a wide range of pain relief effects.

 THC has a wide range from mild to moderate analgesic or pain relieving effect, and has been used to treat pain by alerting the release of signals from various bodily components such as the spinal cord. There are often a number of other effects, including relaxation and a modification of the senses such as sight and auditory response, in addition to an increase in appetite.

It is well known that cannabis consumption increases appetite and food intake in humans, which is believed to be a result of THC effects on the CB1 receptors in the hypothalamus of the human brain. A study with mice suggests that cannabis stimulates taste as well as the pleasure experienced in the consumption of food. These studies are showing that increased pleasure may not be the only cause for an increase in appetite under the influence of THC.

Cancer patients benefit from the use of THC. 

Cancer patients often experience nausea from their chemotherapy as well as a loss in appetite. One of the hardest things cancer patients often deal with is a lack of nutrition as their appetite is either very low or nonexistent. Many of those suffering from cancer are finding marijuana and the THC within it to be a lifesaving appetite-stimulant which increases their appetite so they can eat, helping them take in the nutrition they desperately need. These same patients have also noticed a decrease in nausea, pain and other debilitating symptoms that other drugs have been unable to resolve without major addictions or side effects.

HIV/AIDS patients have also found relief from their conditions with THC, which reduces symptoms such as neuropathic pain induced by their therapy as well as an increase in weight gain. Because Marinol does not contain many of the other therapeutic components within real marijuana, like CBD, terpenoids, and flavonoids. AIDS/HIV sufferers who use this product may not achieve maximum benefit. Furthermore, some patients report that a single Marinol tablet frequently causes the patient to sleep or experience an all-day high that inhibits their cognitive ability throughout the day. Natural THC does not have the same effects, however, as the patient is able to carefully control their dose as well as take in the many other components of the natural drug.

Please share this with your friends.

[stonedcoast]

Artificial Intelligence

It's been a week, again! Here's my first Ramble since starting the blog. It's a little off topic, but it should lead to some interesting writing in the future. I hope you enjoy!

I could see myself doing an insane deep dive into Artificial Intelligence: there’s no lack of writing on the topic, it’s constantly improving, and we’re gaining access to it casually more and more every day. But this is a cannabis blog, and this was meant to be a filler post this week, as I am (as is noted in the AI chat I’m linking below) in between anniversary bookends, with my own having been…

[brightlotusmoon]

(9) Question

Cannabis is probably the least toxic therapeutically active substance known to man. Its Therapeutic Ratio (TR) is so high as to be virtually impossible to calculate but is believed to be between 1:20000 and 1:40000. Thus if 100mg of cannabis would produce an effect, between two to four kilos (taken at once) would be fatal. This amount is, of course, impossible to consume.

Therapeutic Ratio (TR) is the ratio of effective dose for 50% of users (ED50) to lethal dose for 50% of users (LD50). The TR of alcohol is 1:20. TR of heroin is 1:5.

Also, cannabis works on our body because it modulates the endocannabinoid system which consists of a network of CB1 and CB2 receptors throughout the body and endocannabinoids which are the body’s natural chemicals equivalent to the chemicals in the cannabis plant. The CB1 receptor is now believed to be the most prevalent receptor in the brain but does not exist in the brain stem which controls the cardiovascular and pulmonary systems. This is why, unlike opiates, alcohol or other drugs, cannabis cannot depress basic life functions to the point of death.

Many doctors are unaware of the endcocannabinoid system because it was only discovered in 1988 and so has only recently been documented in medical education. It is now believed to be the most important physiological system in our body, regulating the central nervous system, immune, cardiovascular, gastrointestinal and reproductive systems. This is why mankind has found cannabis such a safe and effective medicine for at least 5,000 years for such a wide variety of conditions.

_

INTERESTING.

[kratomcapsules12]

THC vs THCA- What are the Differences and Benefits

Cannabinoids, which are the amassed substances that are found in marijuana plants, have sparked interest because of the potential benefits they could bring to clinical treatment. Two such combinations, tetrahydrocannabinolic destructive (THCA) and tetrahydrocannabinol (THC), are discussed occasionally. Knowing the qualifications between THCA, and THC, is fundamental, particularly when you are looking for ordinary arrangements like CBD chewy dessert tablets for stress help and a brief look at joy. This article will examine these substances' definitions, contrasts, and purposes.

The marijuana plant is a mind-boggling animal overflowing with different mixes, which adds to its properties and benefits. Among these combinations, THC (tetrahydrocannabinol) and THCA (tetrahydrocannabinolic destructive) are habitually discussed for their primary positions. Even though they have a comparative name and are synthetically related, their purposes and properties might be very particular. This article centres on the specific qualities of THC and THCA, their benefits and weaknesses, and an investigation of THCA Best Price which is more established.

What is Mellow Fellow Disposable Vapes?

Mellow fellow disposable vapes are pre-filled, single-use devices that contain many cannabinoids. They're made to offer an easy and discrete method of experiencing the benefits of CBD with no hassles of maintaining or refilling. They are prepared to use right out of the package and are suitable for novices and experienced users. In the ever-changing marketplace of products containing cannabinoids, Mellow Fellow has carved its niche by offering high-end, lab-tested products. Mellow Fellow disposable vapes are well-known for their ease of use, portability and efficiency in their wide range of products. If you want to try these new products, Smokegem is the top online shop for selling Mellow Fellow Disposable Vapes in the Florida, United States with best price and doorstep shipping, we'll explore the factors that make Mellow Fellow disposable vapes worth a try, their characteristics and applications, and why Smokegem will be your desirable option to purchase the products online. 

The main differences between THC and THCA

Psych activity the most striking difference is the way that THC has psychoactive properties, while THCA doesn't. This implies that THCA is the ideal choice for people who need to stay away from a high connection with THC.

Compound Development: THCA has an extra carboxyl social event in contrast with THC that keeps it from getting into the CB1 receptors in the frontal cortex, in this manner keeping away from psychoactive impacts.

Usage Procedures: THC is usually disposed of by smoking, vaping, or biting. Yet, THCA is frequently consumed through straightforward weed crushes, tones, or even cases in which individuals have been warmed.

Legitimate Status: In numerous areas, THC is totally coordinated because of its psychoactive and endless impacts. At the same time, THCA is non-psychoactive and constantly under less severe rules.

The benefits of THC

Help with uneasiness THC is famous for its properties to ease torment and is a decent decision in facilitating the enduring of a leader.

Hunger Excitation is frequently used to help patients with ailments, for example, HIV and infections, to support their craving.

Decreased nervousness is particularly advantageous for chemotherapy patients who experience the ill effects of outrageous sickness.

Mental health might help facilitate burdensome and apprehensive feelings. Still, it could also cause more unfriendly, pessimistic impacts on specific individuals.

Benefits of THCA

Quieting THCA is known for its mitigating solid properties, which are advantageous for conditions like joint agony and lupus.

Neuroprotective Expected benefits for neurodegenerative infections like Parkinson's illness and Alzheimer's.

Antiemetic decreases queasiness and produces a heaved like THC, yet without the psychoactive impacts.

Threatening to proliferate early examinations recommend THCA could support the development of specific illness cells.

Which is more grounded? THC or THCA

The strength of a substance most frequently alludes to its psychoactive capability. In this occurrence, THC is unequivocally more grounded than THCA because of its capacity to give a lift. In any case, on the likelihood that we consider the strength of THCA regarding unwinding potential, without psychoactive impacts, THCA might be viewed as more helpful to specific clients; especially the people who are hoping to unwind or have neuroprotective benefits, without an adjustment of mental state.

Legitimate and Prosperity Thoughts

The lawful Status of THCA, when contrasted with THC Online Shop, varies given the ward. THC is named as a controlled substance in various areas, while THCA might be lawful because of its essential design. In any case, it's necessary to know the way that warming or taking care of THCA can adjust it into THC and create legitimate issues.

Where to Buy THC and THCA Items

If you're keen on purchasing combinations, numerous web-based stores provide a range of items. Here are a few techniques to find reasonable choices

THCA Online Shop: Quest for organizations that are given to crude cannabis items to ensure you are purchasing THCA without decarboxylation. Our Smokegem stores ordinarily offer the most minimal costs and the best items.

THC Online Supplier: Search out reliable suppliers offering an immense determination of THC items, going from blossoms to edibles. You should rest assured that they will give outside research facility tests to check the quality and strength.

The best THC Online Store: Look at the most recent internet-based stores, explore clients' reviews, and determine and assess to chase the top THC items for your necessities.

Every one of THC and THCA enjoys unmistakable benefits, and the decision between them depends on individual inclinations and requirements for prosperity. Whether you're looking for the psychoactive impacts that come from THC or the positive benefits of THCA, the developing business market of maryjane-related items guarantees you'll track down something for everybody. Continuously talk with a certified clinical expert before starting any new treatment given cannabis, and just buy from respectable providers to guarantee security and quality.

[dafitness4shawn]

Hey y’all! Went for a run today. It was meh but what should I expect from the first run back. I’ll blame it on not being at sea level anymore. That’s not what I wanted to talk about though!

After smoking weed almost daily for 10 years, tonight marks 28 days of not smoking or ingesting THC. The significance of the number came from this video (https://youtu.be/7u_cm5b1s7Y). According to the video that’s when your “affected endocannabinoid system and CB1 receptors return to baseline.” I take that info with a grain of salt because we are not all built the same but it’s still nice to say I made it to that number, it’s the longest I’ve ever gone. I actually took a home-drug test at Day 14 (brand was Equate) and passed, which I was very surprised about and didn’t want to believe. I feel one reason people never touch the stuff is because you hear things like “it’s detectable for months!” However my lab tech girlfriend who deals with test very similar says it’s accurate and that the time it stays detectable is going to differ from person to person.

Anyway, if you’ve followed for a while you know that I’ve struggled in the past with taking breaks so of course I wanted to share this milestone. Definitely couldn’t do it without support. @emilweeb suggested supplements (specifically the Ashwagandha) and I heard the Magnesium Glycinate helps with sleep so I gave that a try as well. They definitely helped so much in the beginning. Recently I fell off with taking them daily but I’m gonna get back into it, especially since I do feel positive effects from them. Her advice behind the supplements was to replace bad habits with good habits. Also have to give credit to my girlfriend. She doesn’t smoke anymore but did just as much as me in the past/when we first met. Sometimes you need someone to tell you, “Don’t do that,” but in a loving, non-judgemental way.

I guess the question now is, “Am I done with weed forever?” The answer is no. I know I don’t want to be a daily user anymore, and I prefer not to get back into smoking, since no matter what you smoke, smoking is bad for your respiratory system, and that’s a fact. Not gonna lie though, I’m not saying I’ll never smoke again, just not going to make that my main method. I wanna ease back into it at my own pace. I have tinctures and edibles waiting for me when I decide to take that step, but even while writing this out I’m not in a rush to get high again, which is honestly, so weird to think.

I feel like there’s so much more I could add but this post is LONG. I’m always down to answers questions though if this post sparks any for anyone. I hope y’all are having a great day :)

[microdosingwithjoe]

CBG, CBD, CBC, CBN, and THCV

The Healing Cannabinoids

If you read my piece on the entourage effect, you know that I believe that THC is the ringmaster, but all the components of cannabis determine the “personality” of any given strain. Studies have proven the Entourage Effect with cannabinoids and terpenes. But these five cannabinoids are the major components that combine with THC to most affect your high as far as we know, as well your health and wellbeing.

Some cannabinoids, especially CBN and CBG, can bind directly to both the endocannabinoid system’s (ECS) CB1 and CB2 receptors, meaning they affect everything the ECS controls. These elements are all-important to the way any given cannabis strain or concoction affects you.

There are over 100 cannabinoids. We have no idea what most of them do, but the ones I selected are considered the most important.

CBG (cannabigerol) is the “Mother Cannabinoid” —THC, CBD, CBC, and CBN (and all other cannabinoids) began as CBG.

CBG’s anti-stress, anti-anxiety, and antidepressant effects are fantastic, but that’s just the tip of the iceberg. There are numerous studies about CBG that indicate that it is as good as or better than CBD for pain, anxiety, inflammation, sleep disorders, etc. —all CBD’s effects but even better. It also provides better relief for sufferers of intestinal disorders, like IBS, GERD, and Crohn’s disease. We will have to wait and see everything CBG does, because the THC and CBD study focus has been taking the lion’s share of interest before now, but CBG is the rising superstar.

CBD (cannabidiol) is a cure-all kinda medicine that continues to show positive effects in more and more conditions all the time. I have a personal affinity for CBD + THC therapy, as it substantially healed two discs in my neck, and turned my degenerative disc disorder around. I still can have bouts of pain, but compared with living with hearing and feeling bone-on-bone grinding all day, every day? I’m in heaven. Another attribute of CBD, is that it’s a THC antagonist. That means it can inhibit and regulate the uptake of THC, and that has two great purposes. If you’re a beginner stoner. I always recommend everyone get a CBD vape whether you’re a beginner or an expert stoner. If you get too high, feel THC-induced anxiety, or panic, just a few puffs of CBD, and you’ll be relieved. But because CBD has all these great benefits of reducing tension, anxiety, and depression, one puff is just a great additive to any high. Antagonistic CBD also stretches THC’s effective period from 4 hours, to 6-8 hours during sleep.

CBC (cannabichromene) may be up to 10 times more potent than CBD for treating stress and anxiety and also has significant anti-inflammatory, pain-reducing, antiviral, anti-tumor, and bone-growth-stimulating properties. But the potential CBC has that excites me most, is that could be immensely useful in promoting the growth of new brain cells.

As an old fart with diminishing mental acuity, that’s obviously interesting to me.

CBN (cannabinol) is the first known cannabinoid, but one of the least-studied of these five, and is the only one that isn't derived directly from CBG, but it's what THC turns into when oxidized. Unlike CBG, CBD, and CBC, it’s mildly intoxicating. Like all these cannabinoids, it relieves pain and inflammation.

The best-known effect of CBN, is that it makes you sleepy. Anyone who’s ever smoked an old joint they found in a drawer might remember that it didn’t get them very high, but it made them ready for nappy time; that’s because much of the THC has degraded into CBN.

What excites me most about CBN, is that behaves like THC in many ways, and it has been found to bind with CB2 receptors. This ability may lead to new treatments for neuropathy (no treatment currently exists, and I suffer from neuropathic pain caused by sciatica), as CB2 receptors appear in inflamed areas in the body.

CBN therapies will be able to treat virtually any inflamed site, so it has the potential to address other areas that are difficult to treat, such as gastrointestinal system disorders like GERD, Chrons Disease, and diverticulitis.

CBN could be a true wonder drug.

THCV (tetrahydrocannabivarin) is another under-studied cannabinoid that’s attracting attention, for good reason.

THCV is a very effective appetite suppressant. It’s also the opposite of CBN, making people quite energetic. Being a bit tubby, I’m really excited by it. I’ve had a rare strain that contained THCV, and can attest to these properties.

But more excitement is to come from THCV, as it has shown to treat a lot of other diverse conditions, including Parkinson��s, psychosis, bacterial inflammation, acne, fatty liver disease, pain, and epilepsy.

I can’t wait to see what other benefits THCV has! Durban Poison is a common strain that contains high levels of THCV, but I’ve never had as good an effect from DP as I did the first (forgotten-named) high-THCV strain I tried.

Entourage Effect- all these cannabinoids work together in ways that increase their effectiveness when combined with THC, and can’t be recommended enough for ailments and moods your ECS controls. There aren’t any drawbacks, except you probably won’t want to ingest CBN until bedtime.

Any and all of these cannabinoids can be ingested individually a half hour before imbibing your favorite weed. THC don’t care where or how you get these into your system, but as always, these other cannabinoids work best with THC. There are vape pens with 50/50 CBD & CBG, but none that incorporate CBC or CBN that I’ve found, yet, but they gotta be out there.

I’m looking for a good supplier of isolates of these cannabinoids; pure, plant-derived organic powders. My intent is to mix them with honey and select terpenes to put into beverages. I’m going to make a daytime version with THCV, a nighttime version that includes CBN, and a neutral one with neither. When I find that supplier I’ll paste a link here, and I'll also let you know if my hypothesis that taking these cannabinoids orally, followed by consumption of THC products a short time later works effectively.

Remember: cannabinoids every day help keep the doctor away!

[budandtender]

Understanding the Role of Endocannabinoids in Psoriasis Regulation

World Psoriasis Day October 29th

Introduction

World Psoriasis Day is a global event that shines a light on psoriasis, a chronic autoimmune condition that causes red, scaly patches to appear on the skin. It's an opportunity to educate and raise awareness about this often misunderstood disease. In this article, we'll delve into how endocannabinoids can regulate psoriasis, providing a unique perspective on the disease's underlying mechanisms.

Understanding Endocannabinoids

Endocannabinoids are naturally occurring compounds within our bodies that interact with the endocannabinoid system (ECS). The ECS is a complex cell-signalling system that plays a key role in regulating a range of functions and processes, including immune response, pain, mood, and more.

The two primary endocannabinoids are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These molecules bind to CB1 and CB2 receptors found throughout the body, triggering various physiological responses. Interestingly, research has indicated that these endocannabinoids and their receptors may play a significant role in managing skin health and diseases such as psoriasis.

Endocannabinoids and Skin Health

Our skin is not just a barrier protecting us from the outside world; it's also a complex organ with its own ECS. This system plays a crucial role in maintaining skin homeostasis – the balance of cell growth and death. In conditions like psoriasis, this balance is disrupted, leading to an overproduction of skin cells.

Research has shown that endocannabinoids can influence several key aspects of skin health. They can regulate skin cell proliferation and differentiation, immune response, and inflammation - all critical factors in psoriasis.

Endocannabinoids and Psoriasis Regulation

Psoriasis is characterised by an overactive immune response, leading to inflammation and rapid skin cell growth. The role of endocannabinoids in psoriasis regulation primarily revolves around their anti-inflammatory and immunomodulatory properties.

Studies have shown that endocannabinoids can reduce inflammation by downregulating the production of pro-inflammatory cytokines, proteins that promote inflammation. This could potentially help manage the chronic inflammation seen in psoriasis.

Moreover, endocannabinoids can also modulate the immune response. They can inhibit the overactive immune cells responsible for the rapid skin cell growth in psoriasis, helping to restore balance in the skin's ecosystem.

Research also suggests that people with psoriasis may have an impaired endocannabinoid system, with lower levels of endocannabinoids in their skin. This could potentially contribute to the disease's development and progression, highlighting the potential therapeutic value of targeting this system.

Conclusion

While the relationship between endocannabinoids and psoriasis is complex and still not fully understood, current research indicates a promising role for these molecules in regulating the disease. By modulating inflammation and immune response, endocannabinoids could potentially help manage psoriasis symptoms and improve skin health.

However, it's important to note that more research is needed to fully understand the mechanisms involved and how best to harness the power of endocannabinoids for psoriasis treatment. As we celebrate World Psoriasis Day, let's also celebrate the ongoing research and advancements that bring us closer to understanding and effectively managing this challenging condition.

[moya-cbd]

The Uniqueness Of CBD

CBD is a phytocannabinoid that is a trapeno-phenolic molecule made of 21 carbon atoms, which is formed as a result of de-carboxylation (co² heating in the presence of oxygen) from the substance of origin –  cannabigerolic acid (CBDA) and is not linked to the receptors of the CB1 or CB2 system but acts through a large number of other mechanisms of action that are recently revealed in the scientific study.

Cannabidiol does not cause intoxicating effects (non-Intoxicating) and does not feel the feeling of elation (High) in its effect at all. On the contrary, cannabidiol has a calming general effect, which prevents anxiety and psychosis while simultaneously suppressing inflammation throughout the body and soothing pain, nausea and vomiting.

[aljaishsociety]

How Beta-Caryophyllene Can Transform Your Health Naturally

In the quest for natural wellness solutions, many have turned to plant-based compounds that offer a variety of health benefits. One such compound that has garnered attention in recent years is beta-caryophyllene (also known as β-caryophyllene or BCP). Found in a variety of plants, including black pepper, cloves, and cannabis, beta-caryophyllene offers unique therapeutic properties that can support your overall health. But what exactly is beta-caryophyllene, and how can it benefit your well-being? Let’s dive deeper into this fascinating compound and discover how beta-caryophyllene could be the missing link in your natural wellness routine.

What is Beta-Caryophyllene (BCP)?

Beta-caryophyllene (BCP) is a naturally occurring sesquiterpene, a type of aromatic compound found in the essential oils of several plants. It is most commonly recognized for its spicy, peppery aroma and is widely found in herbs like black pepper, rosemary, oregano, and cannabis. What makes beta-caryophyllene unique compared to other terpenes is its ability to interact with the body's CB2 receptors, which are part of the endocannabinoid system (ECS). This interaction sets BCP apart from other terpenes, as it’s one of the few compounds that can directly bind to cannabinoid receptors without producing any psychoactive effects.

How Does Beta-Caryophyllene Work?

One of the key questions people ask when learning about BCP is: How does BCP work? To understand this, we need to take a closer look at the endocannabinoid system. The ECS plays a critical role in maintaining balance and harmony within the body by regulating mood, pain, immune function, and inflammation. When BCP interacts with the CB2 receptors of the ECS, it helps modulate these processes, leading to various health benefits, such as reduced inflammation and improved pain management.

Unlike THC, which binds to CB1 receptors in the brain and produces a "high," beta-caryophyllene binds only to CB2 receptors, which are primarily located in the immune system and peripheral tissues. This makes BCP an ideal compound for supporting your immune system and reducing inflammation, without causing any psychoactive effects.

Health Benefits of Beta-Caryophyllene

The growing interest in beta-caryophyllene is due to its wide range of potential health benefits. 

Let’s explore some of the most promising therapeutic effects of BCP:

Anti-Inflammatory Properties

One of the most well-documented benefits of beta-caryophyllene is its powerful anti-inflammatory effects. As BCP interacts with the CB2 receptors in the immune system, it helps regulate the production of inflammatory cytokines. This can significantly reduce chronic inflammation, which is often at the root of many health conditions, including arthritis, heart disease, and even autoimmune disorders.

Pain Relief and Analgesic Effects

Another compelling benefit of beta-caryophyllene is its ability to alleviate pain. Research has shown that BCP can serve as a natural analgesic by reducing pain sensitivity and inhibiting pain pathways in the body. This makes it a promising option for those dealing with conditions like chronic pain, fibromyalgia, and even post-surgical recovery.

Promoting Mental Wellness

Beta-caryophyllene’s ability to influence the CB2 receptors also extends to mental health. While it doesn’t interact directly with the CB1 receptors (which are associated with mood and mental clarity), it still plays a role in regulating mood and stress. Beta-caryophyllene has been shown to have anxiolytic (anxiety-reducing) effects, helping to calm the nervous system and reduce feelings of anxiety or stress.

Supporting Gut Health

Emerging research suggests that beta-caryophyllene can also promote gut health. Due to its anti-inflammatory properties, BCP may help protect the gastrointestinal tract from conditions like inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). By reducing inflammation in the digestive system, BCP can help alleviate symptoms such as bloating, cramping, and discomfort.

Boosting Immune Function

Given that beta-caryophyllene interacts with the CB2 receptors in immune cells, it plays an important role in modulating immune responses. Regular consumption of BCP may help strengthen the immune system, making the body more resilient against infections and illnesses.

Sources of Beta-Caryophyllene

If you’re interested in incorporating beta-caryophyllene into your wellness routine, you’ll be glad to know that it’s readily available in several plant-based sources. 

Some of the most notable sources of BCP include:

Black Pepper: One of the richest natural sources of beta-caryophyllene, black pepper is commonly used in cooking or as an essential oil.

Cloves: These aromatic spices also contain high concentrations of BCP.

Cannabis: Certain strains of cannabis, particularly those with a high amount of the terpene beta-caryophyllene, are known to offer a range of health benefits.

Rosemary: This herb, commonly used in culinary dishes, also contains beta-caryophyllene and offers numerous health benefits.

How to Use Beta-Caryophyllene for Maximum Health Benefits

There are several ways to incorporate beta-caryophyllene into your daily routine. Whether through essential oils, supplements, or dietary sources, each method offers unique advantages.

Essential Oils: You can diffuse essential oils containing BCP or apply them topically (when diluted properly).

Dietary Sources: Incorporate black pepper, cloves, and rosemary into your meals for a natural BCP boost.

Supplements: Beta-caryophyllene is available in capsule form, offering a concentrated dose of BCP for those seeking its specific health benefits.

Frequently Asked Questions

What is beta-caryophyllene used for?

Beta-caryophyllene is used for its anti-inflammatory, pain-relieving, and immune-boosting properties. It can help reduce chronic inflammation, manage pain, and support overall wellness without causing psychoactive effects.

Does beta-caryophyllene have any side effects?

Beta-caryophyllene is generally considered safe when consumed in moderate amounts through food or as a supplement. However, it’s always a good idea to consult with a healthcare provider before adding new supplements to your routine, especially if you are pregnant, breastfeeding, or taking medications.

Can beta-caryophyllene help with anxiety?

Yes, beta-caryophyllene has been shown to have anxiolytic effects, meaning it can help reduce feelings of anxiety and stress by interacting with the CB2 receptors in the nervous system.

How do I incorporate beta-caryophyllene into my routine?

You can incorporate beta-caryophyllene into your daily routine by consuming foods rich in BCP (such as black pepper and cloves), using essential oils, or taking BCP supplements. It’s best to start with small amounts and gradually increase as needed.

Can beta-caryophyllene help with chronic pain?

Yes, beta-caryophyllene has demonstrated analgesic properties, making it effective for managing chronic pain conditions, including arthritis and fibromyalgia, by reducing pain sensitivity and inflammation in the body.

Conclusion

Beta-caryophyllene is a versatile and powerful compound that holds immense potential for improving your health naturally. Whether you’re looking to alleviate chronic pain, reduce inflammation, or boost your immune system, BCP could be the key to a healthier and more balanced life. With its remarkable therapeutic properties, beta-caryophyllene is a promising addition to any wellness routine, offering a natural alternative to conventional treatments.

[getbudslegalize]

Does CBD Make You Lose Weight? Science, Benefits, and Products

Does CBD Make You Lose Weight? The Science, Benefits, and Best CBD Products for Weight Management

The wellness world has seen a surge in interest in CBD (cannabidiol) for its potential health benefits, including its role in weight management. But is CBD a miracle solution for weight loss, or is it just another wellness trend?In this post, we’ll dive into the science behind CBD’s effects on weight loss, explore how it may help with fat burning, and give you tips on the best CBD products for supporting a healthy weight. Let’s get started!

What is CBD? Understanding CBD and Its Role in Weight Loss

CBD, or cannabidiol, is a non-psychoactive compound derived from the cannabis plant. Unlike THC, which induces a "high," CBD provides numerous therapeutic benefits without altering your mental clarity. It is particularly valued for its ability to alleviate stress, anxiety, and inflammation—key factors often linked to weight gain.CBD interacts with the body’s endocannabinoid system (ECS), a critical network that regulates essential functions such as mood, appetite, and metabolism. By modulating the ECS, CBD may help control fat storage, appetite cues, and metabolic processes, making it a potential ally in weight management.

How Does CBD Help You Lose Weight?

While research is still in its early stages, several studies suggest that CBD may contribute to weight loss by addressing various mechanisms in the body. Here are three of the most promising ways CBD can support weight loss:1. Appetite RegulationCBD interacts with CB1 receptors in the ECS, which are responsible for hunger signals. By influencing these receptors, CBD may help reduce food cravings and control overeating, making it easier to stick to a balanced diet.Research also suggests CBD may reduce stress-induced eating, which is often triggered by emotional or psychological factors.2. Fat Browning and Metabolism BoostCBD may play a role in "fat browning," the process of converting white fat (energy-storing) into brown fat (energy-burning). This natural metabolic boost can help the body burn more calories, even at rest.Studies have highlighted CBD's ability to promote this fat conversion, suggesting its potential to increase calorie expenditure.3. Stress Reduction and Cortisol ControlStress is a well-known factor in weight gain, particularly around the belly. High cortisol levels, released during stress, promote fat storage. CBD has been shown to reduce stress and anxiety, lowering cortisol levels and decreasing the likelihood of stress-related overeating.By keeping stress levels in check, CBD may make it easier to maintain a balanced eating plan and prevent emotional eating.

What Does the Science Say About CBD for Losing Weight?

While research on CBD’s role in weight management is still in its early stages, initial findings show promise. Below is an overview of key studies investigating how CBD may affect appetite, fat metabolism, and overall weight regulation:1. CBD’s Impact on Appetite and WeightA 2022 systematic review published in Clinical Drug Investigation analyzed 11 randomized controlled trials to evaluate CBD’s effects on appetite and body weight. The findings were:- Appetite suppression: Most trials found that CBD had anorexigenic effects, meaning it reduced appetite and was linked to weight loss. - Mixed results: While some studies confirmed reduced appetite, a few showed no significant changes, and one even reported an increase in appetite. - Activation of fat browning: CBD triggered key markers such as UCP1, which are crucial for thermogenesis and energy expenditure. - Increased fat breakdown: CBD promoted lipolysis (the breakdown of fat) while inhibiting lipogenesis (the storage of fat). - Reduce cortisol levels: By lowering cortisol, CBD may help reduce stress-induced overeating. - Alleviate anxiety: CBD’s calming effects can help mitigate anxiety, leading to healthier eating habits and reduced emotional eating.While early research and anecdotal evidence are promising, more extensive clinical trials are needed to fully understand the relationship between CBD and weight management. However, current studies indicate that CBD may serve as a natural tool for appetite regulation, fat metabolism, and stress reduction.

Best CBD Products for Weight Loss

If you’re ready to try CBD for weight management, choosing the right product is essential. Here are some of the best options:1. CBD Oils and TincturesCBD oils and tinctures offer precise dosing, allowing you to control how much CBD you’re taking. Full-spectrum CBD oils, which include additional cannabinoids like CBG and CBDV, can enhance overall wellness.Best for: Appetite regulation and metabolism support.2. CBD Capsules and SoftgelsCapsules are discreet, easy to dose, and ideal for busy lifestyles. Although they take longer to digest than oils, they provide consistent and controlled doses.Best for: On-the-go users who prefer a simple option.3. CBD-Infused EdiblesGummies, protein bars, and snacks infused with CBD are enjoyable ways to add CBD to your daily routine. However, watch for added sugar in some edible options.Best for: Those seeking a convenient, flavorful way to consume CBD.4. CBD Topicals for Post-Workout RecoveryCBD-infused creams and balms may not directly contribute to weight loss but can aid in muscle recovery and reduce inflammation after workouts.Best for: Enhancing post-workout recovery.

How to Use CBD for Weight Management-

Consistency is key when using CBD for weight management. Here are some tips:1. Start Low and Increase GraduallyBegin with a low daily dose, such as 10-20 mg, and adjust as needed. Pay attention to your body’s response to find your ideal dosage2. Pair CBD with a Healthy LifestyleFor the best results, integrate CBD into a balanced routine that includes:- A nutrient-dense diet: Focus on whole foods like fruits, vegetables, lean proteins, and healthy fats. - Regular exercise: Include cardio, strength training, and flexibility exercises. - Quality sleep: Prioritize rest to enhance metabolism and recovery. - Morning: To regulate appetite and curb cravings throughout the day. - Pre-workout: To support fat burning and promote muscle recovery. - Evening: To reduce stress-related snacking and improve relaxation. - Jessica M., 34: “I’ve been using CBD oil for about a month, and I’ve noticed fewer cravings and feel more balanced. It’s been a helpful part of my overall weight loss plan!” - David S., 45: “After trying CBD-infused gummies, I noticed a decrease in my stress and eating habits. I’ve lost a few pounds, but most importantly, I feel better and less anxious.”

Conclusion: Is CBD the Key to Weight Loss?

CBD shows potential as a natural aid for weight management, providing benefits such as appetite regulation, fat burning, and stress reduction. However, it works best when paired with a holistic approach that includes a balanced diet, regular exercise, and healthy lifestyle choices.With consistency and the right routine, CBD may support your weight management goals effectively.

Frequently Asked Questions (FAQ) about CBD and Weight Loss

Does CBD make you lose weight? While CBD can support weight management, it is not a miracle weight loss solution. It may help regulate appetite, boost metabolism, and reduce stress, but for significant weight loss, it should be combined with a healthy diet and exercise. How does CBD affect body weight? CBD may influence body weight by reducing stress-related eating, promoting fat browning, and regulating appetite. By interacting with the body’s endocannabinoid system, CBD helps control hunger signals and may help prevent overeating. What are the potential benefits of using CBD for weight loss? Some potential benefits of using CBD for weight loss include appetite suppression, increased fat metabolism, stress reduction, and support for overall wellness.CBD can also help reduce cortisol, a stress hormone linked to fat storage, particularly in the belly area. Can CBD replace traditional weight loss methods? No, CBD is not a standalone solution. It should be used alongside a healthy diet, exercise, and other lifestyle changes. How long does it take for CBD to work? The time it takes for CBD to show effects can vary based on factors like dosage, delivery method, and individual body chemistry. Some people experience noticeable changes within a few hours to a few days, while others may require several weeks of consistent use to observe significant results. Patience and regular usage are key to finding what works best for you. Is CBD safe for weight management? Yes, but consult a healthcare provider, especially if you’re taking medications or have underlying health conditions. What’s the difference between CBD isolate and broad spectrum for weight loss? Isolate contains only pure CBD with no other cannabinoids, while broad-spectrum CBD contains CBD along with other beneficial cannabinoids (except THC). For weight loss, both can be effective, but broad-spectrum CBD may offer enhanced benefits due to the “entourage effect,” where different cannabinoids work together to improve overall results Can CBD gummies help you lose weight? Gummies are a convenient and tasty way to incorporate CBD into your routine. While they won’t directly cause weight loss, they may help control appetite, reduce stress, and support healthy digestion, all of which can contribute to a healthier weight over time. What’s the best CBD dosage for weight loss? For weight loss, it’s recommended to start with a low dose of around 10-20 mg of CBD per day. Adjust based on how your body responds.It’s always a good idea to consult with a healthcare provider for personalized dosing recommendations, especially if you’re taking other medications. Does CBD oil help with appetite suppression? Yes, CBD oil may help decrease appetite by regulating hunger signals. It works by interacting with the body’s ECS, which controls various processes including appetite. Read the full article

[drinkcoolout]

What Is Delta 9 and Is It Safe?

Delta 9 THC, short for delta-9-tetrahydrocannabinol, is the compound in cannabis responsible for its psychoactive effects. It's the reason people experience a "high" when consuming marijuana. Recently, Delta 9 has made its way into innovative products like Delta 9 seltzers, offering a new and enjoyable way to consume this popular cannabinoid. But what exactly is Delta 9, and is it safe to consume? Let’s break it down.

What Is Delta 9 THC?

Delta 9 THC is a natural compound found in the cannabis plant. It interacts with the endocannabinoid system in the human body, particularly the CB1 receptors in the brain and central nervous system. This interaction creates effects such as euphoria, relaxation, and enhanced sensory perception.

Unlike CBD (cannabidiol), which does not produce psychoactive effects, Delta 9 is well-known for its ability to alter mood and perception. In products like Delta 9 THC seltzers, this compound is precisely measured to provide a consistent and controlled experience, making it easier for users to enjoy the benefits without overdoing it.

Is Delta 9 THC Safe?

The safety of Delta 9 largely depends on how it’s consumed, the dosage, and individual tolerance. When used responsibly, Delta 9 can be a safe addition to your relaxation or wellness routine. Here’s what you need to know:

Start Low and Slow: If you’re new to Delta 9, it’s important to start with a low dose. Products like Delta 9 seltzers often provide clear labeling, making it easy to measure your intake.

Controlled Consumption: Seltzers infused with Delta 9 offer a safer alternative to smoking, as they eliminate the harmful effects associated with inhaling combusted materials. They are also discreet and convenient, making them ideal for casual use.

High-Quality Products: Always choose trusted brands that prioritize quality and transparency. Drink Cool Out ensures that all Delta 9 seltzers are lab-tested for purity and potency, so you can sip confidently.

Benefits of Delta 9 THC

Delta 9 THC isn’t just for recreational enjoyment; it also offers several potential wellness benefits. These include:

Relaxation and Stress Relief: Many people turn to Delta 9 to unwind after a long day.

Enhanced Social Experiences: Delta 9 seltzers can be a great addition to social gatherings, providing a light, uplifting experience without the drawbacks of alcohol.

Therapeutic Potential: Studies suggest that Delta 9 may help with pain management, appetite stimulation, and even better sleep.

Why Choose Delta 9 Seltzers?

Delta 9 THC seltzers are becoming a popular choice for those who want a modern and refreshing way to experience the benefits of cannabis. They’re non-alcoholic, often low-calorie, and provide a gentle, manageable buzz. Additionally, they come in a variety of flavors, making them a delicious option for relaxation or socializing.

Legal Status of Delta 9

In the United States, Delta 9 THC is legal in products that contain less than 0.3% THC by dry weight, as outlined in the 2018 Farm Bill. This means Delta 9 seltzers, when made from hemp and within these limits, are federally legal. However, it’s always a good idea to check local laws to ensure compliance in your area.

Final Thoughts

Delta 9 THC, when consumed responsibly, is a safe and enjoyable way to experience the benefits of cannabis. Products like Delta 9 seltzers from Drink Cool Out provide a modern, refreshing, and controlled way to relax and unwind.

If you’re curious about exploring Delta 9, start with a high-quality, lab-tested product from a reputable brand. Drink Cool Out offers a range of flavorful Delta 9 seltzers designed for both new and experienced users. Ready to elevate your relaxation? Try one today and discover what makes Delta 9 the buzz of the wellness world!

[bongtastics]

🌿 Why Do Some People Get Higher Than Others? The Science Explained

Cannabis affects everyone differently, and while one person might feel a light buzz, another might feel deeply intoxicated from the same amount. So, what causes these differences? The answer lies in a mix of biology, habits, and environmental factors that shape each person’s unique cannabis experience.

Read the full article on why some people get higher than others here.

🔬 How Cannabis Interacts with the Body

The key player in cannabis’ effects is THC (tetrahydrocannabinol), which binds to CB1 receptors in the endocannabinoid system (ECS). This system regulates functions like mood, memory, and perception. THC mimics the natural compound anandamide, overstimulating the ECS and producing effects like euphoria, altered perception, and relaxation.

However, the way THC interacts with the ECS varies from person to person. Let’s dive into the factors that explain these differences.

🧬 Key Factors That Influence Cannabis Effects

1. Genetics

CB1 Receptor Density: People with more CB1 receptors may feel THC’s effects more strongly.

COMT Gene Variations: Can influence how THC affects mood, with some feeling relaxed while others feel anxious.

THC Metabolism: Genetic differences in liver enzymes (like CYP2C9) impact how quickly THC is processed, affecting intensity and duration.

2. Tolerance Levels

Frequent cannabis use downregulates CB1 receptors, reducing THC sensitivity.

Seasoned Users: May require higher doses or more potent strains to achieve the same effects.

Occasional Users: Feel stronger effects with smaller amounts.

3. Dosage and Consumption Method

Smoking or Vaping: Delivers THC quickly via the lungs, with effects felt almost immediately.

Edibles: Metabolized by the liver into 11-hydroxy-THC, which is more potent and longer-lasting, often leading to a stronger high.

Inhalation Techniques: How deeply you inhale and hold smoke can affect THC absorption.

4. Mindset and Environment

Mindset: A positive or relaxed mental state can enhance the high, while stress or anxiety may lead to paranoia.

Environment: Comfortable and familiar settings promote a better experience.

5. Other Substances

Alcohol: Combining alcohol and cannabis can intensify effects.

Medications: Some medications interact with THC, enhancing or diminishing its psychoactive properties.

6. Strain Composition

High-THC Strains: Deliver a more intense high.

CBD-Rich Strains: Balance THC’s effects and may reduce anxiety.

Terpenes: Compounds like myrcene and limonene enhance THC’s effects through the “entourage effect.”

🛠️ Tips to Customize Your Cannabis Experience

Start Low, Go Slow: Especially for beginners, start with a small dose and increase gradually.

Experiment with Strains: Try different THC/CBD ratios to find what works best for you.

Take Tolerance Breaks: Regular breaks can reset your sensitivity to THC.

Choose Your Setting: Use cannabis in safe, familiar environments to reduce stress or anxiety.

Monitor Interactions: Avoid combining cannabis with alcohol or medications without consulting a professional.

Final Thoughts

Cannabis’ effects are highly personal, influenced by genetics, tolerance, mindset, and strain composition. Understanding these factors can help you tailor your experience and make informed decisions about your consumption.

With a little self-awareness and moderation, cannabis can be a source of relaxation, creativity, and enjoyment for all users.

Learn more about the science of cannabis here.

[brightlotusmoon]

Marijuana Users Have More Empathy And A Greater Understanding Of Other People's Emotions, Study Finds

Researchers said the results suggest a potential association between cannabis use and empathy, though they caution that further research is needed to fully understand the interactions “since many other factors may be at play.”

In attempting to explain the findings, the team of neuroscientists noted that a part of the brain, the anterior cingulate cortex (ACC), “is a region that is prone to the effects of cannabis consumption and is also greatly involved in empathy, which is a multi-component process that can be influenced in different ways.”

“Given that the ACC is one of the main areas that possess CB1 [cannabinoid] receptors and is heavily involved in the representation of the affective state of others,” the study says, “we believe that the differences shown by regular cannabis users in the emotional comprehension scores and their brain functional connectivity could be related to the use of cannabis.”

Despite the qualifiers, the study concludes, “Given previous studies of the effect of cannabis on mood and emotional detection, we believe that these results contribute to open a pathway to study further the clinical applications of the positive effect that cannabis or cannabis components could have in affect and social interactions.”

In other neuroscience research this year, researchers at the University of West Attica in Greece found that medical marijuana use was associated with improved quality of life — including better job performance, sleep, appetite, and energy — among people with neurological disorders.

Another recent study published by the American Medical Association found that medical marijuana was associated with “significant improvements” in quality of life for people with conditions like chronic pain and insomnia—and those effects were “largely sustained” over time.

Other studies have found cannabis may boost the “runner's high” felt during exercise and enhance the practice of yoga.

[amamtrading]

The Role of Cannabis Products in Modern Medicine

Cannabis, a plant long associated with recreational use, is now at the forefront of medical innovation. Thanks to ongoing research and evolving legislation, cannabis products are being widely recognized for their potential therapeutic benefits. From managing chronic pain to treating neurological disorders, cannabis has emerged as a powerful tool in modern medicine.

This article explores the science behind cannabis products, their medical applications, benefits, and the challenges that accompany their use in healthcare.

Understanding Medical Cannabis

Cannabis contains more than 100 biologically active compounds called cannabinoids. The two most well-known cannabinoids are:

THC (tetrahydrocannabinol): The psychoactive compound responsible for the "high" associated with cannabis. In medicine, THC is used for pain relief, nausea reduction, and appetite stimulation.

CBD (cannabidiol): A non-psychoactive compound that provides a range of health benefits, including anti-inflammatory and anti-anxiety effects.

Medical cannabis products are formulated to leverage these compounds, often with varying ratios of THC and CBD, depending on the condition being treated. These products come in forms such as oils, tinctures, capsules, edibles, topicals, and inhalables.

How Cannabis Works in the Body

Cannabis interacts with the body’s endocannabinoid system (ECS), which regulates essential processes like pain, mood, sleep, and immune function. The ECS includes two key receptors:

CB1 receptors, found primarily in the brain and nervous system, interact with THC to manage pain and improve mood.

CB2 receptors, located in the immune system and peripheral organs, respond to CBD to reduce inflammation and support immune health.

By modulating these receptors, cannabis products help restore balance (homeostasis) in the body, making them effective in managing a variety of medical conditions.

Medical Applications of Cannabis Products

1. Pain Management

One of the most significant uses of cannabis is in pain relief. Chronic pain conditions such as arthritis, neuropathy, and back pain often respond well to cannabis.

THC reduces pain perception by affecting the brain’s pain pathways.

CBD acts as an anti-inflammatory agent, reducing the underlying causes of pain. Cannabis is especially useful for patients who have not found relief from traditional painkillers or wish to avoid the risks of opioid addiction.

2. Epilepsy and Seizure Disorders

Cannabis has shown remarkable success in treating epilepsy, particularly drug-resistant forms such as Dravet syndrome and Lennox-Gastaut syndrome.

The FDA-approved drug Epidiolex, made from purified CBD, has demonstrated a significant reduction in seizure frequency.

3. Cancer Symptom Management

Cannabis is widely used by cancer patients to alleviate symptoms caused by the disease and its treatments, including chemotherapy.

Nausea and Vomiting: THC reduces nausea by interacting with serotonin receptors.

Appetite Stimulation: THC is effective in combating weight loss and appetite suppression.

Pain Relief: Cannabis helps manage severe cancer-related pain, often in cases where opioids are ineffective.

Additionally, early research suggests that cannabis might have anti-tumor properties, though more studies are needed.

4. Mental Health Treatment

Cannabis products, especially CBD-dominant ones, are being used to treat mental health conditions such as:

Anxiety: CBD promotes relaxation and reduces stress without causing intoxication.

Depression: THC, in low doses, can help boost mood.

Post-Traumatic Stress Disorder (PTSD): Cannabis aids in reducing nightmares and improving sleep quality.

5. Neurological and Neurodegenerative Disorders

Cannabis has shown promise in managing conditions like:

Parkinson’s Disease: Improves motor symptoms and reduces tremors.

Alzheimer’s Disease: May slow cognitive decline by reducing brain inflammation and oxidative stress.

Multiple Sclerosis (MS): Products like Sativex, a cannabis-based spray, are approved in several countries for reducing muscle spasticity and pain in MS patients.

6. Sleep Disorders

For patients with insomnia or disrupted sleep patterns, cannabis products can offer relief.

THC helps patients fall asleep faster and stay asleep longer.

CBD promotes relaxation by addressing underlying issues like anxiety.

Benefits of Cannabis in Medicine

Natural Pain Relief Cannabis offers a safer alternative to opioids, with fewer risks of addiction and overdose.

Multi-Symptom Treatment Unlike traditional medications that target one symptom, cannabis can address pain, inflammation, nausea, and sleep disorders simultaneously.

Minimal Side Effects When used responsibly, cannabis products are generally well-tolerated, with side effects like dry mouth and mild drowsiness being manageable.

Challenges and Considerations

Despite its medical benefits, cannabis faces several hurdles:

Legal Barriers: The legality of cannabis varies by country and even within regions, limiting patient access.

Stigma: Cannabis still carries a social stigma due to its recreational use, making some patients hesitant to seek treatment.

Lack of Standardization: Inconsistent dosing and product quality make it difficult for patients to receive consistent treatment.

Limited Research: More clinical trials are needed to fully understand cannabis’s long-term effects and medical potential.

The Future of Medical Cannabis

As research advances and public attitudes shift, the future of medical cannabis looks promising. Many countries are legalizing cannabis for medical use, prompting pharmaceutical companies to develop innovative cannabis-based treatments. With increased regulation and standardization, cannabis products will likely become more widely accepted in mainstream healthcare.

Emerging technologies, such as personalized cannabinoid formulations and advanced delivery methods, are also expected to enhance the effectiveness of cannabis therapies.

Conclusion

Cannabis products are revolutionizing healthcare by offering natural, effective treatments for a wide range of medical conditions. From chronic pain and epilepsy to mental health and cancer symptoms, cannabis is helping patients achieve better quality of life.

While challenges remain, the growing body of evidence supporting its medical use suggests that cannabis is more than a trend—it’s a breakthrough in modern medicine. For patients seeking alternatives to conventional treatments, cannabis may provide hope for a healthier future.