#Anticancer activity

[poemsfor-her]

TYPES OF TEA'S AND THEIR BENEFITS ♡⠀࣭⠀ֹ⠀͡꒱

hello! today i'll be talking about the benefits of drinking tea. the only thing i drink besides water is tea and i love it (except the fruit ones). my personal favorite is green tea and it's so beneficial for our health.

1. green tea - the best tea there is for weight loss and treating your skin, good for diabetes and it boosts heart and brain health.

2. chamomile tea - amazing for sleep, reducing anxiety, good for the heart, for soothing coldes and sore throats. (in my country we also use it for treating conjunctivitis)

3. peppermint tea - good for bad breath, improves energy and digestion, helps in relieving menstrual cramps, good for sleep and relieves clogged sinuses.

4. white tea - improves immune system, promotes weight loss and heart diseases, good for skin health, dental health and cancer prevention.

5. black tea - promotes heart health, reduces the risks of strokes, improves focus, lowers blood sugar levels.

6. matcha tea - helps you manage weight, makes you think more clearly and reduces disease risks.

7. jasmine tea - boosts immune system, improves mental clarity and alertness, aids in digestion and reduces inflammation.

8. hibiscus tea - lowers blood pressure, fights inflammation and bacteria, good for liver health, promotes weight loss and it lowers cholesterol.

9. lemon tea - reduces anti-aging, good for mental health, antibacterial activity, anticancer activity and good in lowering blood pressure.

10. yellow tea - promotes digestion health and heart health.

with love, ���

[breezingby]

Potential Health Benefits

Honey has many potential health benefits, including: (here's just a Few)…

Anti-inflammatory

Honey contains an enzyme called catalase that can help relieve minor inflammation. It can be used topically to treat burns and wounds, and orally to treat coughs and sore throats.

Antibacterial and antiviral

Honey can help fight infections caused by bacteria, viruses, and fungi. It can also be used to treat acne by dabbing a small amount onto pimples to reduce swelling and fight bacteria.

Antioxidant

Honey contains antioxidants like phenolic acids and flavonoids, which may help improve cholesterol levels and decrease the risk of heart disease. Honey can also help prevent and treat degenerative diseases.

Studies suggest that honey might offer antidepressant, anticonvulsant and anti-anxiety benefits. In some studies, honey has been shown to help prevent memory disorders. Wound care. Topical use of medical-grade honey has been shown to promote wound healing, particularly in burns.

-------

Cinnamon has many potential health benefits, including:

Blood sugar

Cinnamon may help lower blood sugar levels, which can be beneficial for people with type 2 diabetes. It may also improve insulin sensitivity and glucose tolerance factor (GTf), which can help with weight loss.

In addition to being an antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against neurological disorders, such as Parkinson's and Alzheimer's diseases.

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Ginger has many health benefits, including:

Digestion: Gingerol, a natural compound in ginger, can help with digestion, nausea, and vomiting from motion sickness, pregnancy, and cancer chemotherapy. It can also help with mild stomach upset.

Anti-inflammatory: Ginger contains over 400 natural compounds, some of which are anti-inflammatory. It can help with bloating, gas, and reducing inflammation.

Pain relief: Ginger can help with osteoarthritis pain, menstrual cramps, and sore muscles.

Blood sugar: Ginger can help improve blood sugar regulation and lower blood sugar.

Heart health: Ginger can help lower blood pressure and cholesterol, which can help prevent heart disease. It can also improve circulation and promote the breakdown of fats in the bloodstream.

Immune system: Ginger can help strengthen the immune system and fight germs.

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Turmeric ~ In addition to these conditions, research studies have shown some possible benefits of turmeric for:

Inflammation

Degenerative eye conditions

Metabolic syndrome

Arthritis

Hyperlipidemia (cholesterol in the blood)

Anxiety

Muscle soreness after exercise

Kidney health

In India, it was traditionally used for disorders of the skin, upper respiratory tract, joints, and digestive system. Today, turmeric is promoted as a dietary supplement for a variety of conditions, including arthritis, digestive disorders, respiratory infections, allergies, liver disease, depression, and many others.

.......

Chili peppers contain many compounds that may have health benefits, including:

Capsaicin The chemical that gives chili peppers their heat, capsaicin may help with:

Pain relief: Chili peppers can help with headaches, migraines, and joint pain. You can apply chili peppers directly to the skin to reduce the amount of a chemical that sends pain signals to the brain.

Metabolism: Capsaicin can increase your metabolic rate, which can help you burn more calories and eat fewer unhealthy foods. Some studies have also shown that capsaicin can reduce appetite and increase fat burning, which may help with weight loss.

Inflammation: Capsaicin is one of the most studied natural ingredients for its anti-inflammatory properties.

Digestion: Capsaicin can help clear phlegm and congestion, and may promote a healthy gut microbiome, which is important for a healthy immune system.

Vitamin A and vitamin C: Chili peppers are a great source of both vitamins, which can help boost your immune system and support eye health. Vitamin C can also help your body absorb iron and promote healthy skin.

Carotenoids: Chili peppers contain carotenoids, which may help protect against cancer. Some research suggests that capsaicin may also contribute to cancer cell death.

Keep in Mind

Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions.

Using Dietary Supplements Wisely

Know the Science: How Medications and Supplements Can Interact

Know the Science: How To Make Sense of a Scientific Journal Article

[tiredwitchplant]

Everything You Need to Know About Fruits and Veggies: Pumpkins

Pumpkin (Cucurbita pepo)

*Culinary *Medical *Masculine *Samhain

Folks Names: Big Tom, Jack Be Little, Baby Boo, Autumn Gold, Jumpin’ Jack, Sweetie Pie, Pepon, Winter Squash

Planet: Moon

Element: Earth, Water

Deities: Selene, Nuit, Luna, Artemis, Sin, Inannur, Khonsu, Nicneven, Morrigan and Crom-Cruach

Abilities: Granting wishes, Love, Prosperity, Fertility, Protection, Banishment, Health

Characteristics: Part of the gourd family. Native to North America but are planted worldwide. They are annual plants with twining stems, lobed leaves, yellow flowers, and large orange fruit. Can be harvested in autumn.

History: The pumpkin has been much used as a medicine in Central and North America. The Maya applied the sap of the plant to burns, the Menominee used the seeds as a diuretic, and European settlers grounded and mixed the seeds with water, milk, or honey to make a remedy for worms. Is the symbol of harvest and used as a beloved jack-o-lantern to protect the hearth and home by scaring away trickster fairies, evil spirits, and other restless souls wandering the Earth.

How to Grow:

Is it easy to grow: Yes

Rating: Beginner/Moderate

Seeds Accessible: Yes

How to Grow Pumpkins

Video Guide

Where to Buy Seeds

Magical Properties:

On October 31st, illuminating a carved, hollowed out pumpkin with white candle inside of it will protect one from intrusive and pesky negative spirits.

Magical energy of pumpkins can transport you to the land of dreams where wishes come true

Can bring prosperity and attract positive vibrations

Can be used in full moon ritual because its shape resembles a full moon

You can use its seeds to cast magical circles. It will give you energy and feed the animals at the same time

Offering it on Samhain can help with bringing fertility and abundance

Medical Usage:

Is a great deworming agent, most effective in tapeworms

Pulp of the fruit used as a decoction can relieve intestinal inflammation

Has antioxidant and anticancer activity in the body

Sources

[azelleannenavarro]

Flowers bloom.. and so are you

Colors make our life more exciting and creative. Colors bring life, and sometimes give us hope in our mess up world. But what if these colors have shapes? Fragrance? What if these colors were combined with mysteries in the world such as.. sciences?

Flowers. The silent speakers of love.

Ever since we were children, flowers have never failed to amaze us from their scientific structures to their philosophical meaning in life. It plays a significant role not just in our environment but also in its relationship with people. Flowers are the reproductive system of flowering plants. Just like us, flowers have different ranges of color, sizes, and form. They bloom in their own way, and they are equally beautiful and unique.

And if no one ever expresses their love to you through flowers, may you be reminded who is the most important person who should give that to you. You.

Hibiscus rosa-sinensis

Hibiscus or Gumamela, also known as tropical hibiscus, have different colors and represent different significance, especially in history. Purple hibiscus are tied in royalty, knowledge and wisdom. The yellow hibiscus usually found in Hawaii and represents joy, friendship, and happiness. Pink hibiscus represents platonic love. Lastly, red hibiscus symbolizes love, passion, and relationships. Hibiscus grows in soils with good drainage as well as moist roots.

Bougainvillea spectabilis

This flower usually has green and oval leaves and often color pink. This flower has medical and ornamental purpose. This flower’s extraction was used to control fertility. Anticancer, anti-inflammatory, antihepatotoxic, antibacterial, antioxidant, antihyperlipidemic, and antiulcer activities are also reported to be present in Bougainvillea spectabilis.

Lagerstroemia indica or Crepe-Myrtle

All summer long, the deciduous Purple Crape Myrtle shrub (Lagerstroemia indica 'Purpurea') offers a lovely purple hue! The striking purple display that this Crape Myrtle puts on every year is undoubtedly its best feature.

“When a flower doesn’t bloom, you fix the environment in which it grows, not the flower.”

- Alexander Den Heijer

Theme: Landscapes and Wildlife

Subject: Flowers

Location: Addas 4 Village. Home.

Date: April 10, 2024

[tinyshe]

as a disclaimer, not endorsing but sharing interesting reseach

[didanawisgi]

Papers Reviewed:

2020 (Jalili et al) - An Overview of Therapeutic Potentials of Taraxacum Officinale (Dandelion): A Traditionally Valuable Herb with a rich historical background

2020 (Xie et al) - Research Progress of Anti-tumor Active Ingredients in Dandelion

2020 (Wu et al) - Dandelion exerts anti-cancer effects in triple negative breast cancer (TNBC) by killing tumour cells via multiple cell death pathways

2021 (Venezuela et al) - Dandelion Root Extract Affects the Proliferation, Survival and Migration of Cervical Cancer Cell Lines

2023 (Liu et al) - Effect of dandelion polysaccharide on migration and invasion of triple-negative breast cancer cells based on PI3K/Akt/GSK-3β pathway

2023 (Stoutjesdyk et al) - In Vitro Anticancer effects of Taraxacum Genus Extracts: A Review

2024 (Kerry Yang et al) - Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways

2024 June (Hua Gui et al) - Anti-tumor effect of dandelion flavone on multiple myeloma cells and its mechanism

[medchemexpressinhibitor-blog]

Exploring the Potential of a Glutamine Transporter Inhibitor

Introduction

Cancer cells exhibit distinct metabolic characteristics, and targeting specific metabolic pathways has become an area of intense research in cancer therapeutics. JPH203, a glutamine transporter inhibitor, has emerged as a promising drug candidate for disrupting the metabolic processes crucial to cancer cell survival and proliferation. This article aims to explore factual evidence regarding the efficacy and potential applications of JPH203.

Understanding JPH203

JPH203 is a selective inhibitor of the glutamine transporter ASCT2 (alanine, serine, cysteine-preferring transporter 2). ASCT2 plays a critical role in transporting glutamine, an amino acid essential for cancer cell growth and survival[¹^]. By targeting ASCT2, JPH203 aims to disrupt glutamine uptake and subsequently alter cancer cell metabolism.

The Mechanism of Action

Inhibition of Glutamine Uptake: JPH203 binds to ASCT2, preventing the transport of extracellular glutamine into cancer cells. This disruption hampers the availability of glutamine, an essential nutrient for cancer cell metabolism, thereby impairing their growth and survival[²^].

Factual Evidence Supporting JPH203

Preclinical Studies: Initial preclinical studies have demonstrated the efficacy of JPH203 in inhibiting cancer cell growth across various types of cancers, including lung, breast, pancreatic, and colorectal cancers[³^][⁴^]. These studies have shown that JPH203 treatment led to reduced glutamine uptake, impaired cell proliferation, and increased cell death.

Combination Therapy: JPH203 has been investigated in combination with other anticancer agents, such as chemotherapeutic drugs and targeted therapies. Preclinical studies have suggested synergistic effects when JPH203 is used in combination with other treatments, leading to enhanced anticancer activity[⁵^][⁶^]. These findings highlight the potential of JPH203 as an adjunct therapy to improve treatment outcomes.

Metabolic Reprogramming: Glutamine is a crucial nutrient for cancer cells, serving as a building block for macromolecules and as a source of energy. By inhibiting glutamine uptake, JPH203 disrupts cancer cell metabolism. This metabolic reprogramming can render cancer cells more susceptible to other therapies and potentially overcome drug resistance[⁷^].

Clinical Development

JPH203 is currently undergoing clinical trials to evaluate its safety, tolerability, and efficacy in patients with advanced solid tumors. These studies aim to determine the optimal dosage, treatment duration, and potential side effects to further establish the therapeutic potential of JPH203 in clinical settings[⁸^].

Conclusion

JPH203, a selective inhibitor of the glutamine transporter ASCT2, shows promise as a targeted approach to disrupt cancer cell metabolism. Preclinical studies have demonstrated its ability to inhibit glutamine uptake, impair cancer cell growth, and enhance cell death. The ongoing clinical trials will provide valuable insights into the safety and efficacy of JPH203 in human patients and its potential as part of combination therapies.

While JPH203 holds significant potential as a novel anticancer agent, further research is needed to fully understand its mechanisms of action, optimize treatment strategies, and identify the patient populations that may benefit most from its use. The development of JPH203 represents an exciting advancement in the quest for more effective and targeted cancer therapeutics.please visit MedChemExpress

(Note: This article is for informational purposes only and should not replace professional medical advice. Always consult your healthcare provider for personalized treatment recommendations.)

[hunters-angel]

ty for tagging me @khihi & @bojansrippedsleeves <3

Last song: insomnia by LPS (on repeat)

Fav colour: petrol blue

Currently watching: the magicians (again)

Last movie: imagine me and you (again)

Currently reading: the potent oxidant anticancer activity of organoiridium catalysts by sadler et all (it's been nothing but scientific papers and fanfic for years)

Sweet/Savoury/Spicy: savoury, but specifically salty and crunchy

Relationship status: It's Complicated

Current obsession: jo, hiking

Last google: taps buffer pka sigma aldrich

Currently working on: phd bullshit and my coloring book

tagging: @casthefallenangel @blanketforcas @highkingpenny @anxious-witch

[trodelvy]

Trodelvy Injection: A Game-Changer in Cancer Care

Trodelvy contains the active pharmaceutical ingredients sacituzumab govitecan. The medicine is used for the treatment of patients with triple-negative breast cancer (TNBC), HR+/HER2- metastatic breast cancer, and advanced bladder cancer. If you are searching for a genuine Trodelvy supplier from India, then Indian Pharma Network (IPN) can be your most reliable source/platform. IPN is WHO GDP & ISO 9001 2015 Certified Trodelvy Supplier, Wholesaler, Importer, and Exporter from India. Trodelvy which is Manufactured by Gilead Sciences, Inc, is available in a strength of 180 mg/mL. Trodelvy 180 mg is supplied for Tenders/ exports/ imports/ Named patient program/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples for Clinical trials. Indian Pharma Network is the legitimate source of Trodelvy (sacituzumab govitecan-hziy) for injection, all the customers can get in touch with us to buy/order/procure this pharmaceutical product in approved quantity.

Buy Trodelvy 180 mg Injection at Lowest Price from India

Trodelvy 180 mg for injection is designed to carry cancer-fighting drug to cells that have Trop-2 proteins. Certain tumor cells have high Trop-2 proteins. The medicine trodelvy 180 mg injection is approved for 3 different types of cancer:

Advanced Bladder Cancer

HR+/HER2- Metastatic Breast Cancer

Metastatic Triple Negative Breast cancer Trodelvy injection 180 mg is a type of antibody-drug conjugate (ADC) treatment that is designed to work differently than traditional chemotherapy. It is designed to deliver promising anticancer drug directly into cells with Trop-2 proteins.

Buy Trodelvy in India I Sacituzumab Govitecan 180 MG Vial

Trodelvy (sacituzumab govitecan) is a type of medicinal product known as antibody-drug conjugate, or ADC for short. Unlike typical (traditional) chemotherapy, ADCs consist of three parts: an antibody, an anticancer medicine, and a linker. If you want to buy trodelvy in India for triple-negative breast cancer, HR+/HER2- metastatic breast cancer, and advanced bladder cancer, then Indian Pharma Network (IPN) can be your one-stop solution.

We are famed and esteemed in the pharmaceutical industry for our best quality service, vast industry experience, market credentials, and timely delivery. Our all the tie-ups and sourcing from the reputed brands allow us to offer the best price for Trodelvy 180 mg vial. Trodelvy (sacituzumab govitecan 180 mg vial) is an intravenous (IV) infusion (10mg/kg). Proposed doses are administered once weekly for two weeks (Day 1 and 8) of 21-day treatment cycles. Each treatment cycle is 21 days (3 weeks).

Sacituzumab Govitecan- Trodelvy Price for 180 MG Vial in India

Trodelvy is made of two different drugs joined together: a monoclonal antibody drug (which attaches to Trop -2 receptors, present on the outside of some cancer cells, and a chemotherapy drug (which stops all cells including unhealthy cells from growing and dividing). The monoclonal antibody drug attaches to the unhealthy cells and then releases the chemotherapy medicine directly into the cell. All pharmaceutical products – comparator drugs, adjunctive therapies, RLDs, co-meds and rescue meds, and Exports/Imports drugs – are transported in standard temperature-controlled conditions with active monitoring in order to ensure the integrity of products. Contact us today to get/buy your hard-to-access prescription medicine at the lowest price from India.

[reagan-slayer69]

“Turmeric has been studied over the past few decades to understand its potential health benefits. One 2020 study found [curcumin, the biologically active compound in turmeric,] to be associated with anti-inflammatory, anticancer, antidiabetic, antidiarrheal, antimicrobial, antiviral, and antioxidant properties”

you can eat as many spices as you like there's no nutrients in there it's free. 15 ounces of smoked paprika yes a great meal for a growing boy

[sarabherbs]

Unlocking the Secrets of Neem Leaves

Neem leaves, derived from the Neem tree (Azadirachta indica), are one of nature's most versatile gifts. Renowned for their medicinal properties, these leaves have been used in traditional medicine for centuries. With a growing interest in natural remedies, neem leaves have regained popularity as a powerhouse of health benefits. This article explores the numerous advantages of neem leaves, supported by both ancient wisdom and modern research.

1. Rich in Antioxidants

Neem leaves are a rich source of antioxidants such as flavonoids, tannins, and vitamin C. These compounds combat oxidative stress by neutralizing free radicals, which can damage cells and lead to chronic diseases like cancer and heart disease. Antioxidants also play a crucial role in maintaining healthy skin and slowing down the aging process.

2. Boosts Immunity

Neem leaves have been traditionally used to enhance immunity. They contain active compounds like nimbin and nimbolide, which exhibit immunomodulatory effects. Regular consumption of neem tea or neem leaf extract can help the body fight off infections more effectively.

3. Promotes Oral Health

The antibacterial properties of neem make it a popular ingredient in toothpaste and mouthwash. Chewing neem leaves or using neem twigs as a natural toothbrush helps in reducing plaque, fighting bad breath, and preventing gum diseases such as gingivitis.

4. Skin Health and Acne Treatment

Neem leaves are celebrated for their skin-healing properties. Neem leaf paste or neem-infused water can:

Reduce acne due to its antibacterial properties.

Calm skin irritation and redness.

Promote wound healing and minimize scars.

Its ability to purify the blood also contributes to clearer skin from within.

5. Supports Digestive Health

Neem leaves can be used to treat various gastrointestinal issues. Their anti-inflammatory and antibacterial properties help in reducing symptoms of ulcers, indigestion, and gastritis. Neem tea is often recommended for improving gut health.

6. Regulates Blood Sugar Levels

Neem leaves have been found to be effective in managing diabetes. Compounds in neem help in lowering blood glucose levels by improving insulin sensitivity. Studies have shown that consuming neem leaf extract can reduce fasting blood sugar levels in diabetic patients.

7. Antimicrobial and Antifungal Properties

The antimicrobial properties of neem leaves are highly effective against a wide range of pathogens, including bacteria, viruses, and fungi. Neem leaf extracts are often used to treat fungal infections like athlete’s foot, ringworm, and candida infections.

8. Detoxification and Blood Purification

Neem leaves help in detoxifying the body by purifying the blood and eliminating toxins. This detoxifying property contributes to overall health and wellness, including healthier skin and a robust immune system.

9. Hair Health

Neem leaves can address several hair-related problems:

Dandruff: Neem’s antifungal properties help combat dandruff and dry scalp.

Hair Growth: Regular use of neem water as a rinse can strengthen hair roots and reduce hair fall.

Lice Treatment: Neem oil or neem-infused shampoos are effective in eliminating lice.

10. Anti-inflammatory Properties

Chronic inflammation is linked to numerous health conditions, including arthritis and cardiovascular diseases. Neem leaves contain anti-inflammatory compounds that can alleviate symptoms of inflammation and pain.

11. Cancer Prevention Potential

Emerging research indicates that neem leaves may have anticancer properties. Certain bioactive compounds in neem have shown promise in inhibiting the growth of cancer cells in laboratory studies. However, more extensive research is required to confirm these findings.

12. Helps in Weight Management

Neem leaves can aid in weight management by boosting metabolism and improving digestion. Drinking neem tea or consuming neem capsules can help in maintaining a healthy weight.

13. Improves Eye Health

Neem leaves are beneficial for eye health. Washing the eyes with neem-infused water can help reduce irritation, redness, and infection.

14. Pest and Mosquito Repellent

Neem leaves are a natural insect repellent. Burning dried neem leaves can keep mosquitoes and other pests at bay, reducing the risk of vector-borne diseases like malaria and dengue.

15. Promotes Liver Health

Neem leaves play a role in supporting liver health by aiding detoxification. Regular consumption of neem tea or extract can help in reducing liver damage caused by toxins or medications.

How to Use Neem Leaves

1. Neem Leaves for Skincare

Neem leaves are a popular choice for addressing various skin problems due to their antibacterial and anti-inflammatory properties.

Acne Treatment:

Method: Boil a handful of neem leaves in water, let it cool, and use the water as a face rinse.

Effect: Reduces acne, prevents breakouts, and controls excess oil production.

Skin Brightening:

Method: Make a paste by grinding neem leaves with turmeric and a few drops of water. Apply as a face mask for 15 minutes and rinse off.

Effect: Enhances skin tone and reduces blemishes.

Eczema and Psoriasis Relief:

Method: Prepare a neem leaf infusion and soak a cotton cloth in it. Apply to the affected area to soothe irritation.

Effect: Reduces inflammation and alleviates itching.

2. Neem Leaves for Hair Care

Neem leaves can promote a healthy scalp and hair growth.

Dandruff Treatment:

Method: Boil neem leaves in water, strain, and use the cooled liquid to rinse your hair after shampooing.

Effect: Eliminates dandruff and soothes an itchy scalp.

Hair Strengthening:

Method: Blend neem leaves into a paste with yogurt and apply it to your scalp. Leave it on for 30 minutes before washing.

Effect: Strengthens hair follicles and reduces hair fall.

3. Neem Leaves for Oral Health

Neem leaves are effective in maintaining oral hygiene due to their antimicrobial properties.

Mouthwash:

Method: Boil neem leaves in water and use the cooled liquid as a natural mouthwash.

Effect: Prevents bad breath, gum infections, and cavities.

Toothpaste Additive:

Method: Dry neem leaves, powder them, and mix with your regular toothpaste.

Effect: Enhances gum health and reduces plaque buildup.

4. Neem Leaves for Internal Health

Neem leaves can also be consumed to address internal health issues.

Neem Tea:

Method: Steep a few fresh or dried neem leaves in hot water for 5 minutes. Add honey to taste.

Effect: Supports immunity, improves digestion, and purifies the blood.

Neem Leaf Capsules:

Method: Take neem leaf capsules as per the recommended dosage on the product label.

Effect: Convenient way to enjoy the health benefits of neem leaves.

5. Neem Leaves in Gardening

Neem leaves are beneficial in organic gardening as a natural pesticide.

Pest Control:

Method: Prepare a neem leaf spray by boiling leaves in water and spraying it on plants.

Effect: Protects plants from pests and fungal infections.

Final Thoughts

Neem leaves are a treasure trove of health benefits, from boosting immunity and improving skin health to regulating blood sugar levels and promoting oral hygiene. Their versatility and efficacy make them a valuable addition to a holistic lifestyle. For those looking to embrace the goodness of neem, SarabHerbs® offers premium-quality neem-based products crafted with care to enhance your well-being.

For premium-quality neem-based products, consider exploring offerings from SarabHerbs®. With a commitment to quality and authenticity, SarabHerbs® ensures that you experience the full potential of neem and other herbal solutions. Embrace the power of nature with SarabHerbs® today!

[dhakshin-ayurveda]

Piper Longum Extract: Uncovering the Ancient Healing Properties of Long Pepper

Introduction

Originally from the tropical regions of South Asia and Southeast Asia, Piper longum commonly referred to as long pepper, is a flowering vine renowned for its medicinal value in both traditional Ayurvedic and Chinese practice. Long pepper is the native to India and South East Asian countries and has been used in traditional medicines from ancient days for digestive problems, respiratory disorders and anti-inflammatory disorders. In the present time, the performance of clinical analyses points to the medicinal value of Piper Longum Extract as the extract comprises certain essential alkaloids, lignans, and other valuable bioactive constituents that play diverse roles in the overall health of the body. The article focuses on the history of Piper Longum Extract, its chemical profile and recent evidence for therapeutic uses.

1.Historical Background and Cultural Significance of Long Pepper

Long pepper is as old as many ancient civilizations as it has been widely used since prehistoric times. Fixed strongly in India, Greece and Rome it was considered very dear as spice and medicine until the arrival of black pepper. Charaka Samhita and Sushruta Samhita mention long pepper as: The conditions that can be treated with the help of long pepper are gastrointestinal problems, cough, and fever .

TCMdescribes the use of Piper longum to tone up the areas that are cold, eliminate cold and to treat pain. With the past centuries, long pepper has been used as a traditional remedy to cure many diseases ; now it remains a key component of herbal medicine in Asia .

2. Chemical Composition of Piper Longum Extract

Actually, Piper Longum Extract is a complex of active compounds: alkaloids, lignans and volatile oils, as well as amides. They include piperine, which in fact bears ninety percent of this product’s therapeutic value, piperlongumine, and piperanine. 

Piperine(C₁₇H₁₉NO₃): A bitter principle contributing to the pungent flavor and numerous physiological activities, such as promotion of nutritional uptake and reduction of inflammation .

Piperlongumine (C₁₇H₁₉NO₅): A privileged amide with demonstrable anticancer and free radical scavenging properties, piperlongumine has been recommended for its pro-apoptotic effect in cancerous cells. 

Lignans:Suchassesamin and cubebin, which has antioxidant and hepatoprotective effects and other biologically active compounds. 

EssentialOils: These oils which include myristicin and elemicin play a role in the antimicrobial and carminative properties of the extract .

3. Health Benefits of Piper Longum Extract

a) Enhanced Digestive Health and Nutrient Absorption

Piper Longum Extracts have generally been used to activate digestive enzymes and bile that are used in the digestion of foods as well as facilitating nutrient digestion. Long pepper increases gastric secretions and helps keep gastrointestinal issues, such as swelling and indigestion, at bay. 

Mechanism of Action: The two phytochemicals present in the extract include piperine and piperlongumine that enhances the concoction’s capability to stimulate digestive enzymes like amylase, proteases, and lipases. Piperine has also been established to reduce enzymes such as UDP-glucuronosyltransferase thus enhancing intake of nutrients and herbal compounds such as curcumin and beta-carotene.

b) Anti-inflammatory and Antioxidant Effects

Piper Longum Extract is potent on antioxidation and anti-inflammatory activity which are useful in combating oxidative stress and inflammation in the body system.

Anti-inflammatory Pathways: Long pepper extract compounds interfere with the NF-κB and COX-2 enzymes involved in signalling inflammation. Since Piper Longum Extract inhibits these pathways it has anti-inflammatory properties that can help manage diseases such as arthritis.

Oxidative Stress Reduction: Research has pointed out that piperlongumine and piperine boost the amounts of antioxidant enzymes like catalase and superoxide dismutase which are very important in eliminating free radicals from the cells and adding to the overall wellness of the cells.

c) Respiratory Health and Immune Support

In traditional medicine systems, Piper Longum Extract has often been turned to for respiratory disorders such as cough, asthma, and bronchitis owing to its expectorant and bronchodilator activity. 

Expectorant Action: The extract is useful in the breakdown of thickened mucous and phlegm in the respiratory system hence easy clearance. This to a great extent is advantageous if the patient has a chronic respiratory illness which may cause obstructions of the airway. 

Immune Modulation: Piper Longum proved to have an immune enhancing property which was evident by promoting the activity of macrophage as well as lymphocytes which are responsible for defensive mechanisms against infections.

d)Metabolic and Weight Management Benefits

The bioactive present in long peppers includes those associated with the functionality for appropriate metabolic appropriate lipid metabolism in management of obesity with related thermogenesis.

•Thermogenic Properties: The found alkaloids; piperine, and piperlongumine elevate the levels of thermogenesis which is the burning of calories to generate heat. This effect can help in Weight Loss and Fat loss because it will help increase the Metabolism rate.

 •Lipid Profile Improvement: Piper Longum Extract is also considered to reduce concentration of LDL Cholesterol and augment that of HDL cholesterol thus supporting the cardiovascular system.

e)Potential Anti-Cancer Properties

Among all the realizations of Piper Longum Extract, the most significant area of focus is its anti-carcinogenic properties, especially because of piperlongumine. 

Inducing Apoptosis in Cancer Cells: Piperlongumine kills the cancerous cells by the production of ROS in cancer cells while sparing normal cells leads to the apoptosis of cancer cells .

Inhibition of Angiogenesis: Piperlongumine also has an effect on the suppression of angiogenesis; a process through which tissue formation initiates new blood vessels which supply nutrients to the tumor. It also plays a major role in decelerating the growth and development of tumors

4.Mechanisms of Action in Piper Longum’s Therapeutic Effects

Piper Longum Extract’s therapeutic effects are attributed to several biological mechanisms: 

1.Enzyme Inhibition: Piper Longum Extract being an enzyme inhibitor to cytochrome P450 and UDP- glucuronosyltransferase, the other therapeutic compounds it releases is then made bioavailable. 

2.Immune System Modulation: Long pepper also includes macrophages and cytokine production of the immune system and hence improves its defense to pathogens. 

3.Oxidative Stress Reduction: Piperlongumine stimulates the formation of antioxidant enzymes and reduces levels of reactive oxygen species preventing the oxidative damage of cells

5.Modern Applications of Piper Longum Extract in Health and Wellness

In traditional medicine, Piper Longum Extract is frequently used to address respiratory issues like cough, asthma, and bronchitis due to its expectorant and bronchodilator properties.

 Expectorant Action: The extract helps in loosening mucus and phlegm in the respiratory tract, making it easier to expel. This effect is beneficial for clearing airway obstructions in individuals with chronic respiratory conditions . 

Immune Modulation: Piper Longum has been shown to stimulate the immune response by activating macrophages and lymphocytes, which play a critical role in immune defense against infections

Nutraceuticals for Digestive Health: Due to its properties, it has been incorporated in the digestion enzyme blends with emphasis on the blends containing curcumin.

 Immune and Respiratory Supplements: Being an official expectorant and acting on the immune system, it is used in respiratory and immune affirmative preparations. 

Anti-inflammatory Supplements: Such as joint support and anti-inflammatory properties observed with Piper Longum Extract most supplements containing this extract are aimed at supporting joint health and inflammation .

6.Safety and Side Effects

Piper Longum Extract is relatively safe but side effects may present themselves when it is taken in large quantities; people should note that courses of any kind may have unwanted effects on the stomach. People on medication should seek advice from their doctors because the herb can interfere with drug metabolism owing to its enzyme inhibition properties.

Conclusion

The Piper Longum Extract is a mix of piperine, piperlongumine and the essential oil and has many medical benefits that’d been predicted by both cultural flexibility and research. Providing useful dietary and respiratory benefits and showing signs of possible anti- cancer properties, long pepper remains one of the most important ingredients in natural medicines today. Enduring positive effects with Piper Longum Extract on its therapeutic uses remain largely received in integrative medicine and other practices of wellness.

[baijian188]

Nutritional testing of red mushroom

The methods of nutritional testing of red mushrooms involve multiple aspects, aiming to comprehensively evaluate their nutritional components and bioactive substances. The following are some common methods for nutritional testing of red mushrooms:

1. Conventional nutritional component testing Moisture testing: The 105℃ atmospheric pressure drying method is used to determine the moisture content by measuring the mass change of the sample before and after drying. Ash testing: The 550℃ high-temperature burning oxidation method is used to burn the sample at high temperature to constant weight to determine the ash content. Fat testing: The Soxhlet fat extraction method is used to extract the fat in the sample using a solvent, and the fat content is determined by weighing. Protein testing: The protein content in red mushrooms can be determined by methods such as the Kjeldahl method. 2. Mineral element testing The content of various mineral elements such as potassium, iron, sodium, phosphorus, calcium, magnesium, and zinc in red mushrooms can be determined using instruments such as atomic absorption spectrophotometers and inductively coupled plasma mass spectrometers (ICP-MS). 3. Vitamin testing The content of vitamins such as vitamins B, D, and E in red mushrooms can be determined by methods such as high-performance liquid chromatography (HPLC). 4. Amino acid detection Using an amino acid analyzer, the content of 17 or more amino acids in red mushrooms can be determined, including 7 essential amino acids for the human body. 5. Fatty acid detection The content of fatty acids such as oleic acid, linoleic acid, and palmitic acid in red mushrooms can be determined by gas chromatography (GC) or gas chromatography-mass spectrometry (GC-MS). 6. Bioactive substance detection Polysaccharide detection: Polysaccharides can be extracted and purified, and then the content of polysaccharides can be determined by spectrophotometry, chromatography, and other methods. Anticancer substance detection: For anticancer substances that may be contained in red mushrooms, such as polysaccharide anticancer substances, their anticancer activity can be evaluated by cell experiments, animal experiments, and other methods. Antioxidant substance detection: DPPH free radical scavenging experiments, Fenton reaction, and other antioxidant activity determination methods can be used to evaluate the antioxidant capacity of red mushroom extracts. 7. Microbial detection Microbial detection of red mushrooms to ensure their sanitary quality and safety. This usually includes the determination of total bacteria, total mold and yeast counts, and the detection of specific pathogenic bacteria (such as Salmonella, Staphylococcus aureus, etc.). VIII. Testing process Sample preparation: Collect red mushroom samples, and properly process and preserve them to ensure the stability and representativeness of the samples during the test. Selection of testing methods: Select appropriate testing methods according to the purpose of the test and the nutrients to be measured. Sample processing: According to the test method requirements, the samples are crushed, extracted, purified, etc. Instrumental analysis: Analyze the processed samples using the corresponding instruments to determine the content of nutrients. Data processing: Process and analyze the data obtained from the instrumental analysis to obtain accurate test results. Report writing: Write a test report based on the test results, including the purpose, method, results, and conclusions of the test. In summary, the methods of nutritional testing of red mushrooms involve many aspects, including conventional nutrients, mineral elements, vitamins, amino acids, fatty acids, bioactive substances, and microbial testing. Through comprehensive testing, we can understand the nutritional composition and bioactive substance content of red mushrooms, and provide a scientific basis for their development and utilization.

[indigopari]

from headspace-hotel.tumblr.com/post/740355263548342272/yeah-and-the-widely-held-belief-that-glyphosate

valiantgallus

Jan 23

Yeah one thing I've learned by being in an agriculture school is that most of what's "mainstream" knowledge is false or at the very least very watered down and not presented in a way that makes it easier to understand. Like there's a soil bacterium that's used as a pesticide that only effects caterpillars and west Nile carrying mosquitos and also works as an anticancer in lab settings but people see the big scary pesticide and run away even though you could drink it and be fine.

headspace-hotel

Jan 23

Yeah, and the widely held belief that Glyphosate (Roundup) is uniquely dangerous as a pesticide when the active ingredient is actually significantly safer than most of the other stuff out there. (I say active ingredient because there are inactive ingredients that may actually be more harmful but are less regulated)

Or just...a lot of things about pesticides. Like USA consumers freaking out over the possibility of pesticide residues on their food, and pesticide residues driving all the safety concerns, when there are underpaid and oppressed migrant workers being forced to touch and breathe the stuff all the damn time, probably without proper PPE, because a lot of agricultural laborers in the USA are undocumented and if they complain about unsafe labor practices their boss (You're not a farmer if you just own a farm and don't touch dirt yourself, lol) can squeal on them to ICE.

Like no, one nanogram of roundup having been in the same room of your food isn't going to give you cancer, but inhaling and having skin contact with roundup day in and day out for 30 years just might.

Also I hope you don't use Raid or any kind of bug-killing spray in your house on a regular basis and turn around and complain about pesticides on your food.

Reading in depth about the active ingredients of pesticides and the content of their safety data sheets, how they've been tested, and their rules for handling and using them made me much less afraid of pesticides on food, and much MORE afraid of pesticides in houses.

Like to be completely honest with you, as long as they're not bedbugs or some other kind of parasite, I would prefer to just have the bugs in my house, thanks.

(Predators like spiders and house centipedes are actually helping to STOP actually harmful creatures from moving in to those niches, so there's also that.)

Don't even get me started on GMO's.

Why are agriculture classes the first time I've learned extremely basic info about nutrition and how digestion works. Why isn't this stuff in health textbooks or any easily accessible resource about healthy eating.

[willyskristina]

Liposomal Doxorubicin Market

Liposomal Doxorubicin Market Size, Share, Trends: Johnson & Johnson (Janssen) Lead

Increasing Focus on Combination Therapies and Personalized Medicine

Market Overview:

The global Liposomal Doxorubicin Market is projected to grow at a CAGR of 7.2% from 2024 to 2031. The market size is expected to reach XX in 2024 and YY by 2031. North America dominates the market, accounting for approximately 45% of the global market share. Key metrics include increasing cancer prevalence, advancements in drug delivery technologies, and growing adoption of targeted therapies in oncology.

The liposomal doxorubicin market is growing steadily, owing to an increase in the frequency of various diseases, particularly ovarian and breast cancer. Liposomal formulations' superior efficacy and lower side effects when compared to traditional doxorubicin are driving market growth. Furthermore, ongoing research and development activities targeted at expanding the use of liposomal doxorubicin in combination therapies are helping to drive market expansion.

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Market Trends:

The liposomal doxorubicin market is shifting significantly towards combination medicines and personalised treatment options. This trend is being driven by a better understanding of cancer heterogeneity and the need for more effective treatment approaches. Liposomal doxorubicin is increasingly being researched in combination with other anticancer drugs, such as immunotherapies and targeted treatments.

Recent clinical trials have yielded excellent results for liposomal doxorubicin combos. A phase III study of 450 ovarian cancer patients found that liposomal doxorubicin coupled with a PARP inhibitor improved progression-free survival by 30% compared to conventional treatment alone. Industry analysts expect that by 2026, more than half of liposomal doxorubicin prescriptions would be part of combination regimens, possibly driving significant market growth and improving patient outcomes.

Market Segmentation:

The branded segment dominates the liposomal doxorubicin market, accounting for over YY% of the market share.

Doxil/Caelyx and other branded liposomal doxorubicin treatments have retained market leadership because to known effectiveness profiles, brand familiarity, and patent protection. The complexity of liposomal formulations has hindered generic competitors' entry into this area, contributing to its dominance.

Market research suggests that the branded segment will continue to thrive. A survey of 500 oncologists found that 75% prefer branded liposomal doxorubicin for their patients, citing reliability and consistent quality as important reasons.

Market Key Players:

Johnson & Johnson (Janssen)

Sun Pharmaceutical Industries Ltd.

Merrimack Pharmaceuticals, Inc.

Ipsen Pharma

Teva Pharmaceutical Industries Ltd.

Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.

Contact Us:

Name: Hari Krishna

Email us: hari.krishna@aurorawaveintellects.com

Website: https://aurorawaveintellects.com/