#Anticancer activity

[poemsfor-her]

TYPES OF TEA'S AND THEIR BENEFITS ♡⠀࣭⠀ֹ⠀͡꒱

hello! today i'll be talking about the benefits of drinking tea. the only thing i drink besides water is tea and i love it (except the fruit ones). my personal favorite is green tea and it's so beneficial for our health.

1. green tea - the best tea there is for weight loss and treating your skin, good for diabetes and it boosts heart and brain health.

2. chamomile tea - amazing for sleep, reducing anxiety, good for the heart, for soothing coldes and sore throats. (in my country we also use it for treating conjunctivitis)

3. peppermint tea - good for bad breath, improves energy and digestion, helps in relieving menstrual cramps, good for sleep and relieves clogged sinuses.

4. white tea - improves immune system, promotes weight loss and heart diseases, good for skin health, dental health and cancer prevention.

5. black tea - promotes heart health, reduces the risks of strokes, improves focus, lowers blood sugar levels.

6. matcha tea - helps you manage weight, makes you think more clearly and reduces disease risks.

7. jasmine tea - boosts immune system, improves mental clarity and alertness, aids in digestion and reduces inflammation.

8. hibiscus tea - lowers blood pressure, fights inflammation and bacteria, good for liver health, promotes weight loss and it lowers cholesterol.

9. lemon tea - reduces anti-aging, good for mental health, antibacterial activity, anticancer activity and good in lowering blood pressure.

10. yellow tea - promotes digestion health and heart health.

with love, 𝒯

[breezingby]

Potential Health Benefits

Honey has many potential health benefits, including: (here's just a Few)…

Anti-inflammatory

Honey contains an enzyme called catalase that can help relieve minor inflammation. It can be used topically to treat burns and wounds, and orally to treat coughs and sore throats.

Antibacterial and antiviral

Honey can help fight infections caused by bacteria, viruses, and fungi. It can also be used to treat acne by dabbing a small amount onto pimples to reduce swelling and fight bacteria.

Antioxidant

Honey contains antioxidants like phenolic acids and flavonoids, which may help improve cholesterol levels and decrease the risk of heart disease. Honey can also help prevent and treat degenerative diseases.

Studies suggest that honey might offer antidepressant, anticonvulsant and anti-anxiety benefits. In some studies, honey has been shown to help prevent memory disorders. Wound care. Topical use of medical-grade honey has been shown to promote wound healing, particularly in burns.

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Cinnamon has many potential health benefits, including:

Blood sugar

Cinnamon may help lower blood sugar levels, which can be beneficial for people with type 2 diabetes. It may also improve insulin sensitivity and glucose tolerance factor (GTf), which can help with weight loss.

In addition to being an antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer, lipid-lowering, and cardiovascular-disease-lowering compound, cinnamon has also been reported to have activities against neurological disorders, such as Parkinson's and Alzheimer's diseases.

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Ginger has many health benefits, including:

Digestion: Gingerol, a natural compound in ginger, can help with digestion, nausea, and vomiting from motion sickness, pregnancy, and cancer chemotherapy. It can also help with mild stomach upset.

Anti-inflammatory: Ginger contains over 400 natural compounds, some of which are anti-inflammatory. It can help with bloating, gas, and reducing inflammation.

Pain relief: Ginger can help with osteoarthritis pain, menstrual cramps, and sore muscles.

Blood sugar: Ginger can help improve blood sugar regulation and lower blood sugar.

Heart health: Ginger can help lower blood pressure and cholesterol, which can help prevent heart disease. It can also improve circulation and promote the breakdown of fats in the bloodstream.

Immune system: Ginger can help strengthen the immune system and fight germs.

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Turmeric ~ In addition to these conditions, research studies have shown some possible benefits of turmeric for:

Inflammation

Degenerative eye conditions

Metabolic syndrome

Arthritis

Hyperlipidemia (cholesterol in the blood)

Anxiety

Muscle soreness after exercise

Kidney health

In India, it was traditionally used for disorders of the skin, upper respiratory tract, joints, and digestive system. Today, turmeric is promoted as a dietary supplement for a variety of conditions, including arthritis, digestive disorders, respiratory infections, allergies, liver disease, depression, and many others.

.......

Chili peppers contain many compounds that may have health benefits, including:

Capsaicin The chemical that gives chili peppers their heat, capsaicin may help with:

Pain relief: Chili peppers can help with headaches, migraines, and joint pain. You can apply chili peppers directly to the skin to reduce the amount of a chemical that sends pain signals to the brain.

Metabolism: Capsaicin can increase your metabolic rate, which can help you burn more calories and eat fewer unhealthy foods. Some studies have also shown that capsaicin can reduce appetite and increase fat burning, which may help with weight loss.

Inflammation: Capsaicin is one of the most studied natural ingredients for its anti-inflammatory properties.

Digestion: Capsaicin can help clear phlegm and congestion, and may promote a healthy gut microbiome, which is important for a healthy immune system.

Vitamin A and vitamin C: Chili peppers are a great source of both vitamins, which can help boost your immune system and support eye health. Vitamin C can also help your body absorb iron and promote healthy skin.

Carotenoids: Chili peppers contain carotenoids, which may help protect against cancer. Some research suggests that capsaicin may also contribute to cancer cell death.

Keep in Mind

Take charge of your health—talk with your health care providers about any complementary health approaches you use. Together, you can make shared, well-informed decisions.

Using Dietary Supplements Wisely

Know the Science: How Medications and Supplements Can Interact

Know the Science: How To Make Sense of a Scientific Journal Article

[tiredwitchplant]

Everything You Need to Know About Fruits and Veggies: Pumpkins

Pumpkin (Cucurbita pepo)

*Culinary *Medical *Masculine *Samhain

Folks Names: Big Tom, Jack Be Little, Baby Boo, Autumn Gold, Jumpin’ Jack, Sweetie Pie, Pepon, Winter Squash

Planet: Moon

Element: Earth, Water

Deities: Selene, Nuit, Luna, Artemis, Sin, Inannur, Khonsu, Nicneven, Morrigan and Crom-Cruach

Abilities: Granting wishes, Love, Prosperity, Fertility, Protection, Banishment, Health

Characteristics: Part of the gourd family. Native to North America but are planted worldwide. They are annual plants with twining stems, lobed leaves, yellow flowers, and large orange fruit. Can be harvested in autumn.

History: The pumpkin has been much used as a medicine in Central and North America. The Maya applied the sap of the plant to burns, the Menominee used the seeds as a diuretic, and European settlers grounded and mixed the seeds with water, milk, or honey to make a remedy for worms. Is the symbol of harvest and used as a beloved jack-o-lantern to protect the hearth and home by scaring away trickster fairies, evil spirits, and other restless souls wandering the Earth.

How to Grow:

Is it easy to grow: Yes

Rating: Beginner/Moderate

Seeds Accessible: Yes

How to Grow Pumpkins

Video Guide

Where to Buy Seeds

Magical Properties:

On October 31st, illuminating a carved, hollowed out pumpkin with white candle inside of it will protect one from intrusive and pesky negative spirits.

Magical energy of pumpkins can transport you to the land of dreams where wishes come true

Can bring prosperity and attract positive vibrations

Can be used in full moon ritual because its shape resembles a full moon

You can use its seeds to cast magical circles. It will give you energy and feed the animals at the same time

Offering it on Samhain can help with bringing fertility and abundance

Medical Usage:

Is a great deworming agent, most effective in tapeworms

Pulp of the fruit used as a decoction can relieve intestinal inflammation

Has antioxidant and anticancer activity in the body

Sources

[azelleannenavarro]

Flowers bloom.. and so are you

Colors make our life more exciting and creative. Colors bring life, and sometimes give us hope in our mess up world. But what if these colors have shapes? Fragrance? What if these colors were combined with mysteries in the world such as.. sciences?

Flowers. The silent speakers of love.

Ever since we were children, flowers have never failed to amaze us from their scientific structures to their philosophical meaning in life. It plays a significant role not just in our environment but also in its relationship with people. Flowers are the reproductive system of flowering plants. Just like us, flowers have different ranges of color, sizes, and form. They bloom in their own way, and they are equally beautiful and unique.

And if no one ever expresses their love to you through flowers, may you be reminded who is the most important person who should give that to you. You.

Hibiscus rosa-sinensis

Hibiscus or Gumamela, also known as tropical hibiscus, have different colors and represent different significance, especially in history. Purple hibiscus are tied in royalty, knowledge and wisdom. The yellow hibiscus usually found in Hawaii and represents joy, friendship, and happiness. Pink hibiscus represents platonic love. Lastly, red hibiscus symbolizes love, passion, and relationships. Hibiscus grows in soils with good drainage as well as moist roots.

Bougainvillea spectabilis

This flower usually has green and oval leaves and often color pink. This flower has medical and ornamental purpose. This flower’s extraction was used to control fertility. Anticancer, anti-inflammatory, antihepatotoxic, antibacterial, antioxidant, antihyperlipidemic, and antiulcer activities are also reported to be present in Bougainvillea spectabilis.

Lagerstroemia indica or Crepe-Myrtle

All summer long, the deciduous Purple Crape Myrtle shrub (Lagerstroemia indica 'Purpurea') offers a lovely purple hue! The striking purple display that this Crape Myrtle puts on every year is undoubtedly its best feature.

“When a flower doesn’t bloom, you fix the environment in which it grows, not the flower.”

- Alexander Den Heijer

Theme: Landscapes and Wildlife

Subject: Flowers

Location: Addas 4 Village. Home.

Date: April 10, 2024

[tinyshe]

as a disclaimer, not endorsing but sharing interesting reseach

[didanawisgi]

Papers Reviewed:

2020 (Jalili et al) - An Overview of Therapeutic Potentials of Taraxacum Officinale (Dandelion): A Traditionally Valuable Herb with a rich historical background

2020 (Xie et al) - Research Progress of Anti-tumor Active Ingredients in Dandelion

2020 (Wu et al) - Dandelion exerts anti-cancer effects in triple negative breast cancer (TNBC) by killing tumour cells via multiple cell death pathways

2021 (Venezuela et al) - Dandelion Root Extract Affects the Proliferation, Survival and Migration of Cervical Cancer Cell Lines

2023 (Liu et al) - Effect of dandelion polysaccharide on migration and invasion of triple-negative breast cancer cells based on PI3K/Akt/GSK-3β pathway

2023 (Stoutjesdyk et al) - In Vitro Anticancer effects of Taraxacum Genus Extracts: A Review

2024 (Kerry Yang et al) - Dandelion root extracts and taraxasterol inhibit LPS‑induced colorectal cancer cell viability by blocking TLR4‑NFκB‑driven ACE2 and TMPRSS2 pathways

2024 June (Hua Gui et al) - Anti-tumor effect of dandelion flavone on multiple myeloma cells and its mechanism

[medchemexpressinhibitor-blog]

Exploring the Potential of a Glutamine Transporter Inhibitor

Introduction

Cancer cells exhibit distinct metabolic characteristics, and targeting specific metabolic pathways has become an area of intense research in cancer therapeutics. JPH203, a glutamine transporter inhibitor, has emerged as a promising drug candidate for disrupting the metabolic processes crucial to cancer cell survival and proliferation. This article aims to explore factual evidence regarding the efficacy and potential applications of JPH203.

Understanding JPH203

JPH203 is a selective inhibitor of the glutamine transporter ASCT2 (alanine, serine, cysteine-preferring transporter 2). ASCT2 plays a critical role in transporting glutamine, an amino acid essential for cancer cell growth and survival[¹^]. By targeting ASCT2, JPH203 aims to disrupt glutamine uptake and subsequently alter cancer cell metabolism.

The Mechanism of Action

Inhibition of Glutamine Uptake: JPH203 binds to ASCT2, preventing the transport of extracellular glutamine into cancer cells. This disruption hampers the availability of glutamine, an essential nutrient for cancer cell metabolism, thereby impairing their growth and survival[²^].

Factual Evidence Supporting JPH203

Preclinical Studies: Initial preclinical studies have demonstrated the efficacy of JPH203 in inhibiting cancer cell growth across various types of cancers, including lung, breast, pancreatic, and colorectal cancers[³^][⁴^]. These studies have shown that JPH203 treatment led to reduced glutamine uptake, impaired cell proliferation, and increased cell death.

Combination Therapy: JPH203 has been investigated in combination with other anticancer agents, such as chemotherapeutic drugs and targeted therapies. Preclinical studies have suggested synergistic effects when JPH203 is used in combination with other treatments, leading to enhanced anticancer activity[⁵^][⁶^]. These findings highlight the potential of JPH203 as an adjunct therapy to improve treatment outcomes.

Metabolic Reprogramming: Glutamine is a crucial nutrient for cancer cells, serving as a building block for macromolecules and as a source of energy. By inhibiting glutamine uptake, JPH203 disrupts cancer cell metabolism. This metabolic reprogramming can render cancer cells more susceptible to other therapies and potentially overcome drug resistance[⁷^].

Clinical Development

JPH203 is currently undergoing clinical trials to evaluate its safety, tolerability, and efficacy in patients with advanced solid tumors. These studies aim to determine the optimal dosage, treatment duration, and potential side effects to further establish the therapeutic potential of JPH203 in clinical settings[⁸^].

Conclusion

JPH203, a selective inhibitor of the glutamine transporter ASCT2, shows promise as a targeted approach to disrupt cancer cell metabolism. Preclinical studies have demonstrated its ability to inhibit glutamine uptake, impair cancer cell growth, and enhance cell death. The ongoing clinical trials will provide valuable insights into the safety and efficacy of JPH203 in human patients and its potential as part of combination therapies.

While JPH203 holds significant potential as a novel anticancer agent, further research is needed to fully understand its mechanisms of action, optimize treatment strategies, and identify the patient populations that may benefit most from its use. The development of JPH203 represents an exciting advancement in the quest for more effective and targeted cancer therapeutics.please visit MedChemExpress

(Note: This article is for informational purposes only and should not replace professional medical advice. Always consult your healthcare provider for personalized treatment recommendations.)

[hunters-angel]

ty for tagging me @khihi & @bojansrippedsleeves <3

Last song: insomnia by LPS (on repeat)

Fav colour: petrol blue

Currently watching: the magicians (again)

Last movie: imagine me and you (again)

Currently reading: the potent oxidant anticancer activity of organoiridium catalysts by sadler et all (it's been nothing but scientific papers and fanfic for years)

Sweet/Savoury/Spicy: savoury, but specifically salty and crunchy

Relationship status: It's Complicated

Current obsession: jo, hiking

Last google: taps buffer pka sigma aldrich

Currently working on: phd bullshit and my coloring book

tagging: @casthefallenangel @blanketforcas @highkingpenny @anxious-witch

[trodelvy]

Trodelvy Injection: A Game-Changer in Cancer Care

Trodelvy contains the active pharmaceutical ingredients sacituzumab govitecan. The medicine is used for the treatment of patients with triple-negative breast cancer (TNBC), HR+/HER2- metastatic breast cancer, and advanced bladder cancer. If you are searching for a genuine Trodelvy supplier from India, then Indian Pharma Network (IPN) can be your most reliable source/platform. IPN is WHO GDP & ISO 9001 2015 Certified Trodelvy Supplier, Wholesaler, Importer, and Exporter from India. Trodelvy which is Manufactured by Gilead Sciences, Inc, is available in a strength of 180 mg/mL. Trodelvy 180 mg is supplied for Tenders/ exports/ imports/ Named patient program/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples for Clinical trials. Indian Pharma Network is the legitimate source of Trodelvy (sacituzumab govitecan-hziy) for injection, all the customers can get in touch with us to buy/order/procure this pharmaceutical product in approved quantity.

Buy Trodelvy 180 mg Injection at Lowest Price from India

Trodelvy 180 mg for injection is designed to carry cancer-fighting drug to cells that have Trop-2 proteins. Certain tumor cells have high Trop-2 proteins. The medicine trodelvy 180 mg injection is approved for 3 different types of cancer:

Advanced Bladder Cancer

HR+/HER2- Metastatic Breast Cancer

Metastatic Triple Negative Breast cancer Trodelvy injection 180 mg is a type of antibody-drug conjugate (ADC) treatment that is designed to work differently than traditional chemotherapy. It is designed to deliver promising anticancer drug directly into cells with Trop-2 proteins.

Buy Trodelvy in India I Sacituzumab Govitecan 180 MG Vial

Trodelvy (sacituzumab govitecan) is a type of medicinal product known as antibody-drug conjugate, or ADC for short. Unlike typical (traditional) chemotherapy, ADCs consist of three parts: an antibody, an anticancer medicine, and a linker. If you want to buy trodelvy in India for triple-negative breast cancer, HR+/HER2- metastatic breast cancer, and advanced bladder cancer, then Indian Pharma Network (IPN) can be your one-stop solution.

We are famed and esteemed in the pharmaceutical industry for our best quality service, vast industry experience, market credentials, and timely delivery. Our all the tie-ups and sourcing from the reputed brands allow us to offer the best price for Trodelvy 180 mg vial. Trodelvy (sacituzumab govitecan 180 mg vial) is an intravenous (IV) infusion (10mg/kg). Proposed doses are administered once weekly for two weeks (Day 1 and 8) of 21-day treatment cycles. Each treatment cycle is 21 days (3 weeks).

Sacituzumab Govitecan- Trodelvy Price for 180 MG Vial in India

Trodelvy is made of two different drugs joined together: a monoclonal antibody drug (which attaches to Trop -2 receptors, present on the outside of some cancer cells, and a chemotherapy drug (which stops all cells including unhealthy cells from growing and dividing). The monoclonal antibody drug attaches to the unhealthy cells and then releases the chemotherapy medicine directly into the cell. All pharmaceutical products – comparator drugs, adjunctive therapies, RLDs, co-meds and rescue meds, and Exports/Imports drugs – are transported in standard temperature-controlled conditions with active monitoring in order to ensure the integrity of products. Contact us today to get/buy your hard-to-access prescription medicine at the lowest price from India.

[reagan-slayer69]

“Turmeric has been studied over the past few decades to understand its potential health benefits. One 2020 study found [curcumin, the biologically active compound in turmeric,] to be associated with anti-inflammatory, anticancer, antidiabetic, antidiarrheal, antimicrobial, antiviral, and antioxidant properties”

you can eat as many spices as you like there's no nutrients in there it's free. 15 ounces of smoked paprika yes a great meal for a growing boy

[biomedres]

Caspase-1/Interleukin-1 (an Eminent Inhibitor): Can be a Future Radioprotector?

Caspase-1/Interleukin-1 (an Eminent Inhibitor): Can be a Future Radioprotector? in Biomedical Journal of Scientific & Technical Research

In the advancement of science, the employment of contemporary radiation therapy (xRT); the most effective way to counter malignancy, in the realm of cancer treatment has been exploited in the last few decades extensively. Although, half of all cancer patients worldwide, treated by radiotherapy may be responsible for the consequential damage to healthy normal cells and acute injuries to tissues which remains an enormous challenge to the radiotherapist and oncologist [1]. On the other hand, tremendous research which involves; novel drug development and innovative strategies are in the phase of progress and is constantly evolving across the globe to help reduce radiation-induced multiple sideeffects. As massive doses of radiation are implemented as a part of radiotherapy to cease the progress of cancerous cells, but at the same time, it is harming enormously to the healthier normal cells. The risk of damaging normal cells can be accomplished by practicing an accurate and improved localization of radiation dose and with the aid of several radioprotectors [2]. The most frequently applied techniques in anticancer treatment include Ionizing radiation (IR), in particular X-rays and gamma-rays owing to their huge potential to penetrate tissues; subsequently rupture chemical bonds resulted in free electrons from atoms which ionized, ultimately destroy the tumor cells. The water molecules existent in the human organisms spontaneously (within a few milliseconds) break down into active oxygen by radiation; eventually, engender free radicals, Reactive Oxygen Species (ROS), and Reactive Nitrogen Species (RNS) [3], which subsequently impair cells and in extreme cases leads to death. The generated free radicals’ interplay with DNA, RNA, proteins and resulted in cell dysfunction and further fatality. Also, these active free radicals induce oxidative stress among healthy organisms in physiological and pathological processes, which is one of the causative factors for tumors, hence, therefore, further exploration and the investigation of a powerful free radical scavenger is urgently needed.

For more articles in Journals on Biomedical Sciences click here bjstr

Follow on Twitter : https://twitter.com/Biomedres01 Follow on Blogger : https://biomedres01.blogspot.com/ Like Our Pins On : https://www.pinterest.com/biomedres/

[indigopari]

from headspace-hotel.tumblr.com/post/740355263548342272/yeah-and-the-widely-held-belief-that-glyphosate

valiantgallus

Jan 23

Yeah one thing I've learned by being in an agriculture school is that most of what's "mainstream" knowledge is false or at the very least very watered down and not presented in a way that makes it easier to understand. Like there's a soil bacterium that's used as a pesticide that only effects caterpillars and west Nile carrying mosquitos and also works as an anticancer in lab settings but people see the big scary pesticide and run away even though you could drink it and be fine.

headspace-hotel

Jan 23

Yeah, and the widely held belief that Glyphosate (Roundup) is uniquely dangerous as a pesticide when the active ingredient is actually significantly safer than most of the other stuff out there. (I say active ingredient because there are inactive ingredients that may actually be more harmful but are less regulated)

Or just...a lot of things about pesticides. Like USA consumers freaking out over the possibility of pesticide residues on their food, and pesticide residues driving all the safety concerns, when there are underpaid and oppressed migrant workers being forced to touch and breathe the stuff all the damn time, probably without proper PPE, because a lot of agricultural laborers in the USA are undocumented and if they complain about unsafe labor practices their boss (You're not a farmer if you just own a farm and don't touch dirt yourself, lol) can squeal on them to ICE.

Like no, one nanogram of roundup having been in the same room of your food isn't going to give you cancer, but inhaling and having skin contact with roundup day in and day out for 30 years just might.

Also I hope you don't use Raid or any kind of bug-killing spray in your house on a regular basis and turn around and complain about pesticides on your food.

Reading in depth about the active ingredients of pesticides and the content of their safety data sheets, how they've been tested, and their rules for handling and using them made me much less afraid of pesticides on food, and much MORE afraid of pesticides in houses.

Like to be completely honest with you, as long as they're not bedbugs or some other kind of parasite, I would prefer to just have the bugs in my house, thanks.

(Predators like spiders and house centipedes are actually helping to STOP actually harmful creatures from moving in to those niches, so there's also that.)

Don't even get me started on GMO's.

Why are agriculture classes the first time I've learned extremely basic info about nutrition and how digestion works. Why isn't this stuff in health textbooks or any easily accessible resource about healthy eating.

[dhakshin-ayurveda]

Zingiber Officinale Standard Extract: Unveiling the Power of Ginger for Health and Wellness

Introduction

Ginger is also scientifically referred to as zingiber officinale is among the most used spices and a medicinal plant. Since time immemorial Ayurveda, TCMs and even the ancient grecounani systems have spoken voluminously of the curative properties of the herb. Some of the somewhat specific benefits of consuming ginger as an integrant of food are relief on inflammation, prevention of loss of digestion, antioxidant proprieties, and dietary properties of gingerols and shogaols. This paper analyzes the chemical composition, health benefits, and current application of Zingiber officinale standard extract which is a type of concentrated extract that delivers consistent levels of bioactive compounds.

1. The History and Traditional Use of Ginger

For more than 5,000 years, ginger has been used as a culinary and medicinal herb. It has been the foundation of traditional medicine for many cultures since its start in Southeast Asia.

· Ayurveda: In ancient scriptures such as the Charaka Samhita, ginger is referred to as Maha-aushadhi (great medicine). It is used to ignite Agni (digestive fire), alleviate nausea, and treat respiratory conditions .

· Traditional Chinese Medicine: Known as Gan Jiang, ginger is used to warm the body, treat colds, and alleviate pain due to its “hot” properties .

 · Greco-Arabic Medicine: Unani medicine employs ginger for treating joint pain, digestive disorders, and colds .

2.Chemical Composition of Zingiber Officinale Standard Extract

Ginger’s wide range of bioactive components, which are fixed in extracts for reliable medicinal effects, are what give it its ability to live. Among the principal compounds are:

Gingerols

o6-Gingerol (C₁₇H₂₆O₄): The most abundant and bioactive compound in fresh ginger, known for its anti-inflammatory and antioxidant properties.

2.Shogaols

oWhen gingerols dry out or boiled, they become natural such as 6-Shogaol (C₁₇H₂₄O₃), which have higher antioxidant and anti-inflammatory benefits than gingerols.

3.Zingiberene (C₁₅H₂₄)

oGinger essential oil has a significant amount of these compounds, which contribute to its microbial and anticancer activities.

4.Paradols and Zingerone

oMinor chemicals have painkiller and warming properties. Standardized extracts contain a specified concentration of gingerols (typically 5%-10%), resulting in consistent medicinal effects.

3.Health Benefits of Zingiber Officinale Standard Extract

a) Anti-inflammatory and Antioxidant Properties:

Inflammation and oxidative stress are major such pathologies including arthritis, diabetes, cardiovascular diseases, and many others. These problems are fought by the ginger’s active compounds.

 •Inhibition of Pro-inflammatory Pathways: Gingerols and shogaols inhibit exogenous and endogenous enzymes including COX-2, TNF-α, and IL-6 .

 •Reduction of Oxidative Stress: A recent study has shown that Gingerols raise superoxide dismutase and glutathione peroxidase antioxidant enzyme levels, thereby countering free radical formation.

b)Digestive Health and Gastrointestinal Support

Most people already know that ginger has healthy effects on the digestive system particularly for the ones with nausea, bloating and indigestion. 

Nausea Relief: They include pregnancy or morning sickness, chemotherapy, and motion sickness and have been eased by use of ginger. It was proposed that gingerols inhibited serotonin receptors in gut to translate the message of nausea to the brain . 

Digestive Stimulation: Ginger incite bile to be released, and digestive enzymes to increase fat digestion and to minimize bloating .

c)Pain Relief and Anti-arthritic Effects

Since ginger contains some anti-inflammatory compounds you can use it in the management of pain and joint problems such as osteoarthritis and rheumatoid arthritis.

Joint Pain Relief: Now, some clinical trials have signed that ginger extract alleviates joint pain and rigidity most notably in osteoarthritis patients via blocking COX and LOX pathways

Muscle Soreness: Ginger has also been found to reduce muscle soreness after some exercises, this reduces muscle soreness after exercise .

d) Cardiovascular Benefits

This makes ginger useful to the heart because it can suppress high blood pressure, high cholesterol levels, and high levels of blood sugar. 

Cholesterol Regulation: In the area of lipid profiles, it has been established that ginger extract leads to a reduction of LDL cholesterol, an increase in HDL cholesterol. 

Anti-thrombotic Effects: Ginger interferes with platelets in the body preventing formation of clots and therefore decreasing chances of heart complications .

e)Anti-cancer Potential

Some of the benefits of ginger that have been discovered recently are those that can be used in the prevention or treatment of cancer.

Apoptosis Induction: 6-Gingerol and 6-Shogaol cause apoptosis (or cancer cell death) selectively in cancer cells without affecting normal cells . 

Angiogenesis Inhibition: Ginger substances reduce formation of new blood vessels that are essential for growth of tumors.

f)Immune-boosting Properties

Ginger increases performance of macrophages, lymphocytes as well as natural killer (NK) cells, which are vital in combating infections and lifting immunity .

4.Mechanisms of Action of Ginger Compounds

Enzyme Inhibition: Suppressing COX and LOX, gingerols and shogaols lessen the generation of prostaglandins and leukotriene that are responsible for inflammation .

Modulation of Signaling Pathways: Substances in ginger reduce inflammation and oxidative stress by regulating nuclear factor- kappa B (NF-κB) and mitogen- activated protein kinase (MAPK) therefore lowering their activation.

Antioxidant Defense: Ginger raises endogenous antioxidants thereby neutralizing ROS, a factor that causes cellular damage .

5.Modern Applications of Zingiber Officinale Standard Extract

The standardized extract of ginger is used in various health and wellness products: 

Nutraceuticals: Ginger supplements are formulated for joint health, digestion, and immunity. 

Functional Foods: Ginger extract is added to beverages and snacks to enhance their health benefits. 

Pharmaceuticals: Used in anti-inflammatory and anti-nausea medications.

6.Safety and Side Effects

Ginger extract can be consumed without worry since, in large quantities it might cause symptoms of heartburn and other digestive issues. It should be taken at 250–1000 mg of the Standardized extract per day as a regular dosage. Patients on anticoagulant or anti-high blood pressure medications, moreover, should seek advice whether to take ginger supplement or not since the ginger has properties that thins the blood.

Conclusion

Zingiber officinale standard extract provides the concentrated form of ginger that has been used by people to improve their health for ages and offers similar benefits. Being scientifically proved to possess the ability to reduce inflammation, fight free radicals and improve digestion, ginger extract is useful all natural.