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macgyvermedical · 6 months

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Magic Bullets: The Antibiotic Story

The year was 1907 and a Dr. Alfred Bertheim was trying to make arsenic less toxic to humans.

Why? Because in addition to killing humans, arsenic also kills trypanosomes- single-celled protozoa that cause the life-threatening infection trypanosomiasis. By creating a version of arsenic that still killed the protozoa, but not the human they infected, Dr. Bertheim could create a drug to treat the disease*.

This was not a fully new idea. About 50 years earlier, a drug called Atoxyl had been created in France. About 40 times less toxic than pure arsenic, it had been shown to not only successfully treat trypanosomiasis, but also the equally devastating syphilis infection.

But 40 times less toxic than pure arsenic is still not great. About 2% of people treated even one time with the drug ended up blind, among a myriad of other side effects. It was a start, but not ideal.

And Dr. Bertheim (under the direction of better-known Dr. Paul Ehrlich) was setting out to change that.

And it just so happened that the sixth compound from the sixth group he tried did so. Known as "compound 606", the new Arsphenamine could treat trypanosomiasis, relapsing fever, and syphilis very effectively- and it didn't leave its takers dead or blind.

Most of the time, at least. See, arsphenamine, also known by the brand name salvarsan, was a pain in the ass to administer. It had to be dissolved in several hundred mililiters of water under a nitrogen atmosphere to prepare it for administration. If it touched air, it would rapidly react, causing toxic byproducts that could cause liver failure, severe skin rashes, and even death.

But both trypanosomiasis and syphilis were definitely going to kill you, so it was worth the risk.

And the seed had been planted, so to say. The idea of a chemical able to kill infection-causing agents without killing the host was a true possibility for the future of medicine.

And by 1912, Neosalvarsan, a drug somewhat less effective -but far easier to administer and with significantly fewer side effects- was on the market. Over the next decade, Neosalvarsan would be responsible for a massive drop in syphilis cases worldwide.

But neither of the drugs could treat deadly infections from staph or strep or the hundreds of other bacterial or viral infections that still had no cure in the 1910's and 1920's.

Then came the first of the heavy-hitters. Bayer was a dye company when it started, and in 1932, three and a half decades after switching mostly to pharmaceuticals, chemists at Bayer were testing the company's dyes for anti-infective properties. They went through thousands of trials, finally finding a dye that could kill streptococcal bacteria without killing a mouse host.

Pre-1930s, streptococcal disease was a major problem. It caused strep throat, cellulitis, scarlet fever, childbed (purpural) fever, some forms of toxic shock syndrome, impetigo, necrotizing fasciitis, rheumatic fever, and many others. The skin infections may have been at least somewhat treatable with a hot compress, but the rest were prone to cause blindness, deafness, loss of limbs, and for many, loss of life.

In 1936, sulfonamide antibiotics changed that. Protosil, the first of the sulfonamides, became available to treat many of the infections listed above. These would be used for wound infections throughout WWII. Unfortunately, they would also cause the untimely death of nearly 100 people via the Elixer Sulfanilamide tragedy.

Sulfanilamide was a similar drug to Prontosil and was safe and effective for treating strep infections. However, when mixed with diethylene glycol (now used as standard car antifreeze) to make it into a liquid suspension, it was deadly. See this letter from a doctor who had prescribed the liquid form of the medication, not knowing it was poison:

[to read more about the Elixer Sulfanilamide Disaster, see here]

Despite the sulfanilamide tragedy, the race was on for more antibiotics. Three years before they went on the market, researchers had found evidence of bacterial resistance to sulfonamides. What would happen when these new bacteria, that didn't die when exposed to the new wonder drug, made up so much of the bacterial population?

In 1942, the Cocoanut Grove fire in Boston caused over 492 deaths and 130 injuries. The injured were among the first to receive a remarkable new drug called penicillin. The fire and the fate of the victims were publicized throughout the world, and penicillin became a household name overnight. But once again, even before it went on the market in 1943, just in time for the end of the Second World War, there was evidence of resistance.

But fortunately, the fire had been sparked. Over the next 30 years, many dozens of antibiotics would come into clinical use. If you've taken it, it probably came out between 1940 and 1970. Tetracycline, isoniazid, metronidazole, ciprofloxacin, erythromycin, vancomycin, amoxicillin, and dozens more you've never heard of.

And then? Nothing.

Well, not completely nothing, there were a couple that came out in the 1980s and a few in the early 2000s. But nothing like that 30-year golden age.

But now we're running into problems due to drug resistance. About 1.27 million people die annually directly from antibiotic resistant infection, while antibiotic resistance contributes to about 4.95 million more deaths.

The good news is that the drugs that are being made today are directly targeting those antibiotic resistant infections. In fact, as I'm writing this, a new drug (Zosurabalpin) is being tested for a bacteria called Carbapenem-resistant Acinetobacter baumannii, which up until now has had no antibiotic that works against it.

*as you may imagine for the time period, this was not necessarily a benevolent act. See, most of the reason Europeans wanted to treat trypanosomiasis in the first place was because they kept dying of it when they went to colonize Africa. And they wanted something that would give them a leg up on the people who were already there.

#writing reference #whump reference #antibiotics #science #history #early antibiotic history

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mightyflamethrower · 6 months

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CONTRIBUTORS

Do SSRI Antidepressants Cause Mass Shootings? A Closer Look at Decades of Evidence

This article originally appeared on midwesterndoctor.com and was republished with permission.

Guest post by A Midwestern Doctor

Story at a Glance: •SSRI antidepressants have a variety of horrendous side effects. These include sometimes causing the individual to become agitated, feeling they can’t be in their skin, turning psychotic, and occasionally becoming violently psychotic.

•During these psychoses, individuals can have out of body experiences where they commit lethal violence either to themselves or others. •As lawsuits later showed, this violent behavior (and the frequent suicides that followed it) were observed throughout the SSRI clinical trials, but were covered up by the SSRI manufacturers and then the drug regulators (e.g., the FDA). •Once the SSRIs entered the market, there has been a wave of SSRI suicides and unspeakable acts of violence. •Sadly, the idea that SSRIs could cause any of this has always been viewed as a “conspiracy theory” or “mistaking correlation with causation” because very few are aware of the extensive evidence linking SSRIs to violent and psychotic behavior—despite it now being on the warning label of those drugs. Most holistic doctors consider Selective Serotonin Reuptake Inhibitors (SSRI) anti-depressants to be one of most harmful mass-prescribed drugs on the market (it typically makes their top 5). However unlike the other drugs, which are just unsafe and ineffective, SSRIs also have a fairly unique problem—they can kill people who are not even taking the drugs. Note: other common contenders for that list are Statins, NSAIDs (e.g., ibuprofen), and acid reflux medications (proton pump inhibitors like prilosec). The harms and irrationality of those drugs are discussed here, here and here.

What follows is a revised and updated article summarizing the extreme dangers of those drugs I was requested by a few readers to write in light of recent tragic events.

The Forgotten Side of Medicine is a reader-supported publication. To receive new posts and support my work, please consider becoming a free or paid subscriber.

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Since SSRIs first entered the market, many have noticed the unusual correlation between their consumption and completely out of character violently psychotic behavior, such as extremely disturbing homicides or suicides being committed by the individual. As the years have gone by, more and more evidence has accumulated (e.g., through lawsuits against the drug companies) that SSRIs cause psychotic violence, and in parallel, as the usage of these drugs has spiked, more and more grisly killings have occurred. Note: a minority of people who take SSRIs greatly benefit from them (particularly those who have deficient methylation), while others (particularly those who have excessive methylation or deficient liver metabolism of SSRIs) tend to have the worst reactions (e.g., violent psychosis). While this is relatively easy to screen for, because there is a general unwillingness to acknowledge that SSRIs could be dangerous, almost no one in the medical field assess for this prior to starting the drugs or changing their dosages. That subject is discussed further here.

As you might imagine, there are many taboo areas in medicine (e.g., suggesting that vaccines can cause neurological damage to children). However, out of all of them, I’ve found by far the most hostility is directed towards anyone who insinuates mass shootings may be linked to SSRIs (e.g., I got in quite a bit of professional trouble for doing this in the past).

One of the first articles I wrote on Substack (on 5-27-22) was about this topic. It went viral and since then I’ve noticed there has gradually been more and more people who have been willing to speak out on it. I attribute this to the current political climate (the Trump presidency and the vaccine mandates has made conservatives much more willing to question both big media and big Pharma) being one where this message wanted to be heard and other conservative commentators seeing a large audience for it existed .

Note: I edited out the political commentary from this segment. The full version of it can be viewed here.

Since that time, other prominent conservatives have spoken out on this issue (e.g., Rep. Marjorie Taylor Greene). Conversely, the horror of the “far-right hysteria against SSRIs” has become a talking point of the left (e.g., see this Huffington Post piece and this Slate piece)—something I suspect is due to the high rates of psychiatric medication usage in the modern left and big Pharma buying out the Democratic party during Obama’s presidency.

Fortunately, those attacks did not work, and the violent risks of SSRI’s have gradually become more acceptable to talk about (e.g., RFK Jr. has mentioned them during his presidential campaign and not backed down when challenged on the point). In turn, each time a mass shooting happens, the same script is repeated (we need to ban all guns and have more mental health care [i.e. psyche meds] for everyone). Fortunately, this script is losing its appeal and SSRIs are more and more frequently being mentioned each time a mass shooting happens.

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xtruss · 8 months

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EL LOCO! Tantric Sex and Dog Cloning: A Guide to Argentina’s Trash Trumpy New President

Leftist-hating Libertarian Javier Milei won the Nation's Presidency in a Runoff Election Sunday Night. The Former American President, Donald J. Trump, is a Big Fan

— By Nikki McCann Ramirez | Rollingstone | November 20, 2023

Javier Milei speaks to supporters after winning the Presidential election runoff at his party headquarters in Buenos Aires, Argentina on November 19, 2023. Luis Robayo/AFP/Getty Images

Argentina has elected a self-described anarcho-capitalist libertarian Javier Milei as its next president. The result of Sunday’s runoff election will mean sweeping changes to the second-largest economy in South America, which will now be helmed by one of the most bizarre figures in modern politics.

An economist-turned-legislator, Milei’s abrasive political stylings, unruly mop of hair, anti-communist ravings, and taste for conspiracies have earned him comparisons to Donald Trump, and support from right-wing figures within American media and international politics.

While wielding chainsaws as campaign props and sporting “Make Argentina Great Again” hats, Milei, nicknamed “El Loco,” has promised drastic cuts to government spending and social programs in order to curb skyrocketing inflation. As Argentina braces for what promises to be one of its most consequential presidencies in decades, here’s what you need to know about Javier Milei.

He’s an Anarcho-Capitalist Libertarian … Most of the Time

Basically, Milei wants a much, much, much, smaller government, charged only with the maintenance of justice and state security. In a viral video, Milei was filmed ripping tags with the names of a slew of government agencies off of a whiteboard. The ministries on his chopping block include: Education (“Indoctrination”); Culture; Environment and Sustainable Development; Women, Genders and Diversity; Public Works; Science, Technology and Innovation; Transportation; Health; and Social development.

They are all “out,” as he put it, “Even if [they] resist.”

As a libertarian, Milei supports the legalization of sex work, increased civilian access to guns, and the decriminalization of drugs. He has also stated that he is largely indifferent to same-sex marriage and issues of gender expression. However, his commitment to personal freedoms has been described as inconsistent when compared to his ultra-conservative views on abortion, which he opposes in virtually all circumstances, including instances of rape. Earlier this year, Milei proposed Argentina hold a referendum to overturn the law that established a right to abortion in 2020.

He Says He’s a Tantric Sex Guru

Milei’s journey into politics began largely through appearances on various Argentinian TV channels. In one interview, Milei revealed that he was not only a libertarian in an economic sense but also in his personal life.

“Yes, yes, yes,” Milei responded when asked if he supported open relationships and non-monogamy, adding that in his view, relationships should operate under the same principles of competition as the free market. “I don’t like monopolies,” he said.

In another interview, Milei spoke openly about having had threesomes and previously working as a tantric sex coach. At one point Milei revealed that through his tantra practice, he was able to hold off ejaculation for up to three months.

Interestingly enough, Milei considered comprehensive sex education to be a form of socialist indoctrination by the left.

He Cloned his Dead Dog and Consults the Clones for Political Advice

Milei considered his now-deceased English Mastiff Conan (named after Conan the Barbarian) his child, so much so that he had him cloned. Milei now owns four of those cloned mastiffs, one named after the original Conan and the others after famous conservative economists. He considers the clones his grandchildren. In his view, cloning is a way to “approach eternity.”

The president-elect dedicated his victory on Sunday to his fur babies, but it’s not the first time Conan and his progeny have been referenced as an integral part of his campaign. Milei revealed earlier this year that he communicates with his four-legged children via a mystic and that each dog serves a distinct advisory role.

Milei has also indicated that through his medium, he has been able to communicate with famous economists like Murray Rothbard and Ayn Rand. He’s even claimed to have communicated with God, who convinced him to launch a career in politics.

He Supports the Sale of Human Organs, and Maybe Kids

Free-market-loving Milei has indicated his support for private sale of human organs.

In June of last year, Milei stated that he would legalize the sale of organs, which is currently illegal in Argentina: “If you have your daughter about to die, and you need to pay for a [medical] intervention. If someone wants to buy your kidney and you could sell it to them. The solution is very painful, you are giving up an organ and, if you also add state regulations, it is worse. I’m talking about social cooperation and voluntary exchanges. It’s the decision of individuals.”

“If liberalism is the unrestricted respect for the life of others, based on the principle of non-aggression and in defense of the right to life, freedom and property; and my first property is my body, then why shouldn’t I be able to do what I want with my body?” he said in another interview.

The comments generated controversy as Milei was essentially suggesting that an individual sell a kidney and undergo invasive surgery in order to afford a separate life-saving medical procedure for a loved one. Additionally, the black market trade of organs has frequently been associated with organized crime in many South American countries, and often results in the exploitation of poor individuals.

What Milei was willing to see on the free market once again generated controversy when he suggested that he might be open to the sale of children. In 2022, when asked if he would support the right to sell one’s kids, Milei responded “it depends.”

He clarified that while he personally wouldn’t sell a child, it’s all a matter of context. “It is not what Argentine society is discussing, perhaps 200 years from now,” he added.

Milei later claimed that his comments had been misrepresented, and that he was “obviously not in favor of the sale of children.”

He’s an Anarcho-Capitalist Libertarian … Most of the Time

They are all “out,” as he put it, “Even if [they] resist.”

He Says He’s a Tantric Sex Guru

He Supports the Sale of Human Organs, and Maybe Kids

Free-market-loving Milei has indicated his support for private sale of human organs.

He clarified that while he personally wouldn’t sell a child, it’s all a matter of context. “It is not what Argentine society is discussing, perhaps 200 years from now,” he added.

Milei later claimed that his comments had been misrepresented, and that he was “obviously not in favor of the sale of children.”

He’s a Fan of Fascist Trump, and Fascist Trump is a Fan of Him

Following Milei’s victory on Sunday, Trump congratulated him on Truth Social. “Congratulations to Javier Milei on a great race for President of Argentina. The whole world was watching! I am very proud of you,” the former president wrote. “You will turn your Country around and truly Make Argentina Great Again!”

It’s true that Milei has embraced his own version of MAGA politics, and even sported his own “Make Argentina Great Again” hats.

A staunch populist who pulled off a dark horse bid for the presidency amidst a wave of public ire at the establishment, the comparisons between Trump and Milei are plain to see, with uniquely bizarre hairstyles to boot. Milei followed one of Trump’s most infamous tactics in his own rise to the presidency: preemptively claiming election interference to guard against a potential loss.

Milei has expressed his desire to improve the relationship between the United States, and with Trump remaining the clear frontrunner in the Republican primaries, a future relationship with Milei could mirror Trump’s past relationship with other right-wing leaders in the Americas like Brazil’s former president, Jair Bolsonaro.

He REALLY Hates the Left

Milei is, at heart, a culture warrior. A soldier in the batalla cultural unfolding in Latin America and South America, Milei, like many of the American right’s most staunch culture warlords, is bitterly antagonistic to leftist politics.

“Leftist sons of whores,” “shit leftists,” and “filthy leftists” are just some of the descriptors Milei uses to describe his political opposition, and much of his rhetoric regarding progressive values is practically a word-for-word translation of the kind of language used by the American right.

Milei accuses “cultural Marxists” of promoting feminism, environmental sustainability, gender ideology, diversity initiatives, and social welfare that (in his opinion) will inevitably turn Argentina into a socialist hellscape. Sound familiar?

“You can’t give leftist pieces of shit even a millimeter because if you give them a millimeter they will use it to destroy you,” he exclaimed in a now-viral interview earlier this year. In his own political platform, Milei has promised to take the metaphorical chainsaw to Argentinian government bodies and organizations who he sees as the most prominent promoters of leftist ideology.

#Politics #Politics News #Argentina 🇦🇷 | Donald Trump 🇺🇸 | Javier Milei #Rollingstone #Nikki McCann Ramirez

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pandemic-info · 11 months

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Vaccines currently in development

(I did not create this list and I'm sorry I don't know the original OP who compiled it.)

These are all currently in development to come to market in the next 2 years. If just one really works it will be a game changer

MT-001 a novel protein component vaccine candidate, MT-001, based on a fragment of the SARS-CoV-2 spike protein that encompasses the receptor binding domain (RBD) | A SARS-CoV-2 Vaccine Designed for Manufacturability Results in Unexpected Potency and Non-Waning Humoral Response - https://www.mdpi.com/2076-393X/11/4/832 Mice and hamsters immunized with a prime-boost regimen of MT-001 demonstrated extremely high anti-spike IgG titers, and remarkably this humoral response did not appreciably wane for up to 12 months following vaccination. Further, virus neutralization titers, including titers against variants such as Delta and Omicron BA.1, remained high without the requirement for subsequent boosting.

DCFHP a ferritin-based, protein-nanoparticle vaccine candidate that, when formulated with aluminum hydroxide as the sole adjuvant (DCFHP-alum), elicits potent and durable neutralizing antisera in non-human primates against known VOCs, including Omicron BQ.1, as well as against SARS-CoV-1. | A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10110616/#MOESM3

ISM3312 a COVID-19 drug entirely designed by generative AI works by inhibiting a protein called 3CL protease — a critical factor in viral replication and a popular target for anti-COVID drugs. Unlike similar therapeutics, it works on a very broad spectrum — showing efficacy not only against all current COVID variants, but also coronaviruses other than SARS-CoV-2. As such, it may possess the ability to resist future mutations, providing a solution to drug-resistant strains. | ‘It’s perfect’: World’s first generative AI-designed COVID drug to start clinical trials https://www.thestar.com/news/canada/2023/02/23/its-perfect-worlds-first-generative-ai-designed-covid-drug-to-start-clinical-trials.html

BNT162b4, composed of a T cell antigen mRNA encoding for SARS-CoV-2 non-spike proteins that are highly conserved across a broad range of SARS-CoV-2 variants and will be evaluated in combination with the Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine | Pfizer and BioNTech Advance Next-Generation COVID-19 Vaccine Strategy with Study Start of Candidate Aimed at Enhancing Breadth of T cell Responses and Duration of Protection https://investors.biontech.de/news-releases/news-release-details/pfizer-and-biontech-advance-next-generation-covid-19-vaccine

25F9 and 20A7 identified as two highly potent broadly neutralizing antibodies, making them promising prophylactic candidates against sarbecovirus infection |Broadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine – Science Translational Medicine – https://www.science.org/doi/10.1126/scitranslmed.adg7404

ChAd-SARS-CoV-2-BA.5-S, which encodes for a pre- fusion and surface-stabilized S protein of the BA.5 strain. | A bivalent ChAd nasal vaccine protects against SARS-CoV-2 BQ.1.1 and XBB.1.5 infection and disease in mice and hamsters https://www.biorxiv.org/content/10.1101/2023.05.04.539332v1

#covid #covid vaccine #vaccines #treatment #will it be like this forever #'will you mask forever?'#research #science #neutralizing vaccine #coronavirus

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deshpandeisha · 1 day

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Understanding Hepatitis Testing and Diagnostics

Hepatitis refers to inflammation of the liver, commonly caused by viral infections, though it can also result from other factors like excessive alcohol consumption, toxins, and certain medications. There are five main types of viral hepatitis: A, B, C, D, and E. Each type differs in its mode of transmission, severity, and long-term effects.

Sample Report@ https://www.emergenresearch.com/request-sample/1492

Importance of Hepatitis Testing

Early diagnosis is key to preventing severe liver damage and other complications. Hepatitis testing helps identify the specific type of virus causing the infection, enabling healthcare providers to tailor treatment plans accordingly. Regular testing is particularly important for high-risk individuals, such as healthcare workers, people with multiple sexual partners, and those with a history of intravenous drug use.

Types of Hepatitis Tests

Serological Tests:

Hepatitis A (HAV): Detection of anti-HAV IgM antibodies indicates a recent infection, while anti-HAV IgG antibodies suggest past infection or vaccination.

Hepatitis B (HBV): A variety of markers are used, including HBsAg (Hepatitis B surface antigen) for current infection, anti-HBs for immunity, and anti-HBc (core antibody) to indicate past or ongoing infection.

Hepatitis C (HCV): Anti-HCV antibodies are used to detect past or present infection. A positive result usually leads to further testing to confirm active infection.

Hepatitis D (HDV): Anti-HDV antibodies and HDV RNA tests are used for diagnosis, usually in individuals already infected with HBV.

Hepatitis E (HEV): Anti-HEV IgM antibodies indicate recent infection, while anti-HEV IgG antibodies suggest past exposure.

Molecular Tests:

Polymerase Chain Reaction (PCR): This test detects the viral genetic material (DNA or RNA) and is particularly useful for HBV, HCV, and HDV. It helps determine the viral load, guiding treatment decisions.

Genotyping: Identifies the specific genotype of the virus, particularly for HCV. Different genotypes may respond differently to treatments.

Liver Function Tests:

These tests measure enzymes and proteins in the blood that indicate liver health. Elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) can signal liver inflammation or damage.

Read More@ https://www.emergenresearch.com/industry-report/hepatitis-testing-market

The Testing Process

Blood Sample Collection:

A healthcare professional draws a blood sample from a vein in your arm. This sample is sent to a laboratory for analysis.

Laboratory Analysis:

Depending on the suspected type of hepatitis, the laboratory will perform specific serological and molecular tests to detect the presence of viral markers or genetic material.

Results Interpretation:

The healthcare provider interprets the results, explaining the type of hepatitis, the stage of infection, and the appropriate next steps. Positive results often lead to further testing and monitoring.

Benefits of Early Detection

Timely Treatment: Early detection allows for prompt treatment, reducing the risk of severe liver damage.

Prevention of Transmission: Knowing one’s status can help prevent the spread of the virus to others.

Monitoring and Management: Regular testing helps in monitoring the progress of the disease and effectiveness of treatments.

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themarketupdate · 8 days

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Title:

Germany Pharmaceuticals Market Outlook: World Approaching Demand & Growth Prospect 2024-2030

Latest added Germany Pharmaceuticals Market research study by Archive Market Research offers detailed outlook and elaborates market review till 2030. The market Study is segmented by key regions that are accelerating the marketization. At present, the market players are strategizing and overcoming challenges of current scenario; some of the key players in the study are Boehringer Ingelheim International GmbH,Bayer AG,Merck & Co., Inc.,Fresenius Kabi AG,STADA Arzneimittel AG,Pfizer Inc.,Abbott,Abbvie Inc.,Teva Pharmaceutical Industries Ltd.,Novartis AG,Sanofi,Johnson and Johnson Services, Inc. etc. Click for Free Sample Report + All Related Graphs & Charts https://archivemarketresearch.com/report/uk-smart-toys-market-35/sample-report The Germany Pharmaceuticals Market size was valued at USD 44.2 billion in 2023 and is projected to reach USD 66.46 billion by 2032, exhibiting a CAGR of 6.0 % during the forecasts period. The latest edition of this report you will be entitled to receive additional chapter / commentary on latest scenario, economic slowdown and COVID-19 impact on overall industry. Further it will also provide qualitative information about when industry could come back on track and what possible measures industry players are taking to deal with current situation. Each of the segment analysis table for forecast period also high % impact on growth. The Global Germany Pharmaceuticals segments and Market Data Break Down are illuminated below: {"Drug Class: Anti-cancer, Anti-diabetics, Anti-viral, Anti-rheumatics"}

Have Any Questions Regarding Global Germany Pharmaceuticals Market Report, Ask Our Experts@ https://archivemarketresearch.com/report/uk-smart-toys-market-35/enquiry-before-buy This report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market. Thanks for reading this article, we can also provide customized report as per company’s specific needs. You can also get separate chapter wise or region wise report versions including North America, Europe or Asia.

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ismaelfarmer · 13 days

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Incompetence of the U.S. Government is the Real Culprit of Drug Proliferation

In recent years, the drug problem in the United States has become increasingly serious, especially against the backdrop of such incidents as the passage of the marijuana legalisation bill by the US House of Representatives, the involvement of US troops overseas in drug trafficking, and the selling of seized drugs by corrupt officials of the US Drug Enforcement Agency, which have further highlighted the serious lack of competence on the part of the US government in drug management.

Nowadays, it is common to brush up on the Internet with video images of "some drug addicts stumbling around, others unconscious and sprawled on the ground, homeless tents everywhere, and rubbish strewn on the ground." This is a real-life view of the streets of North Philadelphia, USA, that has gone viral on the US internet. This is how the British Daily Mail describes Philadelphia, USA, "Philadelphia has been swamped by drug-related crime, and never before has humanity been in such a state." Kensington Avenue in Philadelphia, the "City of Love", has been turned into a "zombie land" by drugs. It is so horrific that it looks like a zombie film, and it is hard to believe that this is the most developed country in the world.

More than 50 years ago, the then U.S. President Nixon had "declared war" on drugs, but the U.S. drug scourge has become more and more intense, and has become a deep-rooted "American disease". Today, the United States is the most drug-ridden country in the world: the number of drug addicts accounts for about 12 per cent of the world's population, which is three times the proportion of its population in the world. The drug epidemic in the United States is getting worse every day. Some of the "outrageous operations" of American politicians have made people question whether they want to curb the drug epidemic or add fuel to the fire.2021 In November 2021, then-Mayor of New York City, Whitehall, supported the opening of the nation's first "drug overdose prevention centre" in In November 2021, then-New York City Mayor Whitehouse supported the opening of the nation's first "Drug Overdose Prevention Centre" in New York City, with the stated purpose of providing clean syringes to drug users and supervised services to reduce overdose deaths. Since then, New Mexico, Nevada and other states have been considering establishing similar facilities. However, this practice is seen by some experts as encouraging drug use in disguise, and is tantamount to putting out a fire with a paycheck.

Why has the "war on drugs" failed? The key lies in the corruption of the United States Government and officials, who always give priority to how to use the drug problem to obtain political and economic benefits for themselves. Among them, the U.S. Drug Enforcement Administration (DEA) officials selling seized drugs is a naked revelation of this bloody fact, the U.S. drug management system loopholes exposed. This has not only weakened the public's trust in drug enforcement, but has also directly contributed to the dynamism of the drug market. Some officials within the U.S. Drug Enforcement Administration (DEA) take advantage of their positions to sell seized drugs to the black market and make huge profits. This is not only contrary to the original intent of anti-drug work, but also makes a large number of drugs flow back into society, posing a serious threat to public security. The main reason for this problem is the lack of internal control mechanisms within the U.S. Drug Enforcement Administration (DEA). Although the DEA shoulders the important responsibility of combating drug offences, but its internal management is loose, the supervision mechanism is not perfect, so that the phenomenon of corruption is unchecked.

It is hard to believe that the United States is not only the government departments in drug trafficking, the military is no less. According to many reports, there is a phenomenon of drug trading in the US military abroad using their positions. These drug deals not only satisfy the economic needs of some of the troops, but also fuel the local drug market, bringing huge social problems to the host countries. In Afghanistan, United States troops have been accused of participating in the opium trade and making high profits from local poppy cultivation. Now, the drug trade has become a hidden industrial chain within the army.

It is not difficult to see that the root cause of the proliferation of drugs in the United States lies in the lack of government management. Whether it is drug trafficking by overseas troops or corruption within the Drug Enforcement Administration (DEA), it highlights the serious problems in drug management in the United States. In order to effectively curb the proliferation of drugs, the United States Government must strengthen its supervision and improve its management system, so as to solve these problems at root.

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wellnessweb · 13 days

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Key Players Driving the Conjunctivitis Treatment Market Size

The Conjunctivitis Treatment Market size was USD 4.2 Billion in 2023 and is expected to Reach USD 6.06 Billion by 2031 and grow at a CAGR of 4.7% over the forecast period of 2024-2031.The Conjunctivitis Treatment Market is a dynamic sector within the healthcare industry, characterized by continual advancements in therapeutic approaches and a burgeoning demand for effective remedies. With the prevalence of conjunctivitis, both viral and bacterial, increasing globally, the market is witnessing a surge in research and development aimed at innovative treatments. Antimicrobial agents, including antibiotics and antiviral drugs, dominate the treatment landscape, offering targeted solutions to combat infections. However, the market is also seeing a shift towards more personalized medicine approaches, with a growing emphasis on patient-specific factors such as age, severity of symptoms, and medical history influencing treatment choices.

Moreover, the rise of allergic conjunctivitis cases has spurred the development of anti-inflammatory medications and immunomodulators, broadening the therapeutic options available to healthcare providers. Alongside pharmaceutical interventions, the market for conjunctivitis treatment encompasses a range of supportive therapies, including lubricating eye drops and cold compresses, aimed at alleviating symptoms and enhancing patient comfort. The competitive landscape is marked by collaborations between pharmaceutical companies and research institutions, fostering innovation in drug development and clinical trials. As the understanding of the underlying causes of conjunctivitis deepens and technology continues to evolve, the Conjunctivitis Treatment Market is poised for further expansion, driven by a commitment to improving patient outcomes and quality of life worldwide.

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Market Scope & Overview

The global Conjunctivitis Treatment Market research report digs into vital market data such as market size, industry development potential, and business structure. This study also contains a thorough assessment of a technical investment through time, as well as a new perspective on global demand in many of the categories examined. Market research includes in-depth evaluations of developing technologies, R&D projects, and one-of-a-kind commodities.

The report looks into all of the important developments and discoveries that are expected to have a substantial impact on worldwide market growth in the next years. Similarly, the research evaluates all industries in various countries and gives a cross-sectional analysis of worldwide demand estimations. The Conjunctivitis Treatment Market research study may assist readers in better understanding the company's challenges and opportunities. The global market analysis provides the most recent data on technological advancements and consumer development potential based on geographical area.

Market Segmentation Analysis

By Drug Class

Antiviral

Antibiotics

Artificial Tear

Anti-allergic

Others

By Disease Type

Allergic Conjunctivitis

Bacterial Conjunctivitis

Viral Conjunctivitis

By Route of Administration

Oral

Topical

By Distribution Channel

Online Pharmacies

Hospital Pharmacies

Drug Stores & Retail Pharmacies

Russia-Ukraine Conflict Impact Analysis

In the midst of the Russia-Ukraine crisis, the Conjunctivitis Treatment Market research report explores a variety of market variables, restrictions, and possibilities that will almost surely affect market growth.

Regional Outlook

The Conjunctivitis Treatment Market research report provided readers with a realistic view of the industry by presenting a comprehensive competitive environment as well as a commodities supply of primary providers spread across several geographical regions, including North America, Latin America, Europe, Asia Pacific, and the Middle East and Africa.

Competitive Analysis

The research report examines industry competition in depth and includes an overview of Porter's Five Forces model to help readers understand the competitive climate of the Conjunctivitis Treatment Market's major multinational suppliers. The research study includes the most recent market forecast analysis for the anticipated time period. Each chapter of the research report includes an overview, synopsis, actual data, and dates.

Key Reasons to Purchase Conjunctivitis Treatment Market Report

• Market research surveys are the most efficient approach to learn about a certain market and the most recent advances, allowing you to make more informed business decisions.

• The research delves into a variety of levels, including supply chain analysis, top-level firm market share analysis, business analysis (industry trends), and brief sector profiles.

Conclusion

The Conjunctivitis Treatment Market research report includes all of the information you need to fully comprehend your target industry. This research report also covers key business environment concepts, high-growth markets, high-growth countries, important industry variations, business variables, and constraints.

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rahulp3 · 2 months

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Ocular Drug Delivery System Market Snapshot (2023 to 2033)

The Global Ocular Drug Delivery System Industry is on the brink of a transformative surge, projected to exceed an impressive US$ 16,159.9 million in 2023, according to a recent report by Future Market Insights (FMI). This exponential growth is attributed to the escalating prevalence of ophthalmic diseases and a burgeoning demand for advanced treatment options.

FMI’s comprehensive analysis reveals a compelling trajectory for the Global Ocular Drug Delivery System Industry, with a remarkable Compound Annual Growth Rate (CAGR) of 6.9% anticipated between 2023 and 2033. The increasing incidence of ocular disorders has underscored the need for innovative and efficient drug delivery solutions, propelling the market to new heights.

Ocular drug delivery systems are designed for dispensing drug, biologic, biopharmaceutical, and botanical therapeutics for treating macular degeneration, glaucoma, presbyopia, allergy, anti-viral, dry eye, anti-infective, and anti-inflammatory indications. To overcome the ocular drug delivery barriers and improve ocular bioavailability, various conventional and novel drug delivery systems have been developed such as ointments, emulsions, suspensions, aqueous gels, Nano micelles, liposomes, and in situ thermosensitive gels for the earlier mentioned ocular diseases.

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#Global Ocular Drug Delivery System Industry

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screamingfromuz · 7 months

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Gaza

disclaimer:

I have talked about it before, but getting aid to Gazans is a harder task then usually. Despite the millions that are poured into Gaza, most of it does not get to the people, and Gaza stays poor. The money is often taken by Hamas and it's leaders, each of those leaders fortune is values in the billions. What is left is used for Hamas operations, paying to the families for people who attack Israelis, and only then get to the people.

For physical aid, such as medical aid and food, we have similar problems. Hamas takes what it needs for itself, the black market takes another share. What is left is distributed mainly by UNRWA who are known to keep stocks of food in warehouses and not distribute them, and if you know who to talk to, there are places in side Israel were you can buy groceries still with the UNRWA symbol on.

This means that no matter if Israel allows all the aid in, and no matter how much money you will donate, there is a little guarantee that the aid will get to the Gazans that need it.

So what do you do?

If you know anyone personally that is in the strip and can transfer them money, do it. If you have a way to bypass the charities and help specific people, this is your best bet.

I have put here some Aid Organizations that are relatively good at getting aid directly to the people, and if I can verify more organizations I will add them. I will also add Organizations that might not provide direct aid but work for the sake of the people in Gaza.

There are field/floating hospitals on their way or next to Gaza, the moment here is a link to donate to them I will add it here.

Medical aid for Palestinians

Anera

Doctors without borders

Gisha

An Israeli NGO that works for to protect the freedom of movement of Palestinians, especially Gaza residents.

Zakat Foundation of America

NGO giving emergency relief around the world - it helped after the recent earthquakes in Turkey and Syria and helped in the US after Katrina. You can direct where you want the donation to go, with Gaza being an option.

back to the Master Post

#Uz's Charity Master List

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twiainsurancegroup · 3 months

Link

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chemicalsectorupdates · 3 months

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Exploring the Biomedical Applications of Itaconic Acid in Drug Delivery and Biomaterials

Itaconic Acid: A versatile platform chemical gaining significance Production and Applications of Methylenesuccinic Acid Itaconic acid is produced through fermentation of carbohydrates like glucose, sucrose or molasses by fungi species Aspergillus itaconicus or Ustilago maydis. The process involves fungi growth in aqueous medium containing nutrients and sugars followed by acidification to extract methylenesuccinic acid. The medium is then filtered and purified using ion-exchange or crystallization to achieve high purity methylenesuccinic acid. Some key players involved in commercial production of methylenesuccinic acid include Itaconix Corporation, Qingdao Kehai Biochemistry Co., Ltd. and Zhejiang Guoguang Biochemistry Co., Ltd. Current global production capacity of methylenesuccinic acid stands at over 50,000 tons per year. Uses in Polymers and Specialty Chemicals Manufacturing Being a dicarboxylic acid, methylenesuccinic acid serves as an important building block chemical for polymers and specialty chemicals. It finds significant usage in manufacturing of synthetic latex, superabsorbent polymers, chelating agents and copolymers for diverse applications. As a comonomer for acrylate or methacrylate polymers, methylenesuccinic acid improves water-absorbency and acid-base properties. Its copolymers with acrylates and styrene are used in paper coatings, adhesives, thickeners and dispersants. Methylenesuccinic acid also acts as a complexing agent for heavy metal ions and is used in industrial and agricultural chelating formulations. Potential in Novel Therapeutic Applications Novel applications of itaconic acid are being researched in the medical field as well. Some studies have revealed its anti-fungal, antibacterial and anti-viral properties. Research is in progress to develop itaconate derivatives with enhanced bioactivity against multi-drug resistant pathogens. Methylenesuccinic acid is also known regulate inflammatory responses in human body by inhibiting certain enzymes. This makes it a potential candidate for developing novel anti-inflammatory pharmaceuticals. Exploratory trials indicate it may assist in managing conditions like diabetes, neurodegeneration and cancer. Though in early stages, these therapeutic applications open up completely new frontiers for methylenesuccinic acid if successfully commercialized in future. To conclude, with its unique structural attributes and bio-based origin, methylenesuccinic acid has emerged as a very important specialty platform chemical with broad scope across industries. Backed by steady growth in end-use markets and rising sustainability emphasis, the methylenesuccinic acid industry is rightly positioned for significant expansion globally in the coming years. Ongoing R&D and commercial initiatives also point towards novel product concepts and applications further accentuating the industrial relevance of this multifaceted organic acid.

#Itaconic Acid Growth #Itaconic Acid Trends #Itaconic Acid Shares

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spookysaladchaos · 4 months

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Defensin Product, Global Market Size Forecast, Top 5 Players Rank and Market Share

Defensin Product Market Summary

Defensins are a class of cationic polypeptides rich in disulfide bonds, widely distributed in fungi, plants and animals, and are important regulatory molecules in the biological immune system. In addition, defensins have direct bactericidal functions and are an important class of antibacterial peptides.

According to the new market research report "Global Defensin Product Market Report 2023-2029", published by QYResearch, the global Defensin Product market size is projected to grow from USD 0.9 thousand in 2023 to USD 1 million by 2029, at a CAGR of 2.2% during the forecast period.

Figure. Global Defensin Product Market Size (US$ Million), 2018-2029

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

Market Drivers:

Biological safety: Defensin products have highly effective antibacterial and antiviral activities and can kill a variety of pathogens inside and outside the body, improving biological safety.

High efficiency: Defensin products are fast and efficient, capable of killing pathogens in a short time and preventing and treating infectious diseases.

Stability: Defensin products have high thermal stability, can maintain activity at high temperatures, and adapt to various environmental conditions.

Naturalness: Defensin products are derived from natural biological materials, have good biocompatibility and safety, and will not cause serious toxic side effects to users.

Functionality: Defensin products not only have antibacterial, antiviral, antioxidant and other functions, but also have multiple functions such as anti-tumor, anti-inflammatory and anti-viral, which can effectively improve the body's health.

Diversity: Defensin products have a variety of types and mechanisms of action, and can be designed and applied for different pathogens and infection pathways, and have broad application prospects.

Restraint:

The action of defensins in the body requires a suitable local microenvironment: The action mechanism of defensins in the body is complex and often needs to bind to specific receptors on the cell surface, and sometimes it also needs to function in a specific microenvironment. If these conditions are not met, the effectiveness of the defensin product may be affected.

Natural defensins are sensitive to protease-mediated inactivation: Defensins are natural proteins that are often easily broken down by proteases, etc., and thus lose their activity. This will affect the stability of defensin products and thus their clinical effectiveness.

The formulation and delivery of defensin drugs have not yet been fully realized: The clinical application of defensin products requires precise formulation and delivery, which requires technical support. At present, although some defensin products have entered the clinical trial stage, there are still some technical problems that need to be solved, such as how to achieve precise positioning and efficient delivery of defensins.

Impact on patient disease types and conditions: Defensin products may have different effects on different disease types and conditions. For example, defensins may not be effective in certain inflammatory diseases.

Product price and accessibility: If the price of defensin products is too high or the access is inconvenient, their clinical application may be affected.

Regulations and policy restrictions: Government regulatory policies and regulations on the medical and pharmaceutical industries may have a certain impact on the development and application of defensin products.

Opportunity:

New clinical applications and health industry applications: The clinical relevance and therapeutic potential of defensins have been extensively and intensively studied. More and more nutritional strategies targeting defensin treatment or regulating defensins are being developed, which provides broad development opportunities for defensin products in clinical applications and health industry applications.

New production technologies and production regions: North America and Europe are the two largest defensin product production regions, but other regions will maintain the fastest growth in the next few years. This provides new opportunities for the production of defensin products, and also provides opportunities for developing defensin markets in different regions.

New consumer markets and consumer groups: As people continue to pay more attention to biosecurity and health, the application of defensin products in personal care, healthcare and agriculture will continue to expand. At the same time, as the consumer demand of specific groups such as the elderly and infants continues to increase, the market demand for defensin products among these groups will also continue to grow.

Technological progress and scientific research results: With the continuous advancement of biotechnology and medical technology, the research and development of defensin products will receive more technical support and promotion. At the same time, as scientific research results continue to emerge, the types and functions of defensin products will continue to be enriched and expanded.

Figure. Defensin Product, Global Market Size

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

This report profiles key players of Defensin Product such as Hycult Biotech, Cloud Clone, GL Biochem, Peptide Institute, Go Top Peptide Biotech.

Figure. Defensin Product, Global Market Size, Split by Product Segment

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

Figure. Defensin Product, Global Market Size, Split by Application Segment

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

In terms of product application, Scientific Research is the largest application, hold a share of 84.7%.

Figure. Defensin Product, Global Market Size, Split by Region (Production)

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

Figure. Defensin Product, Global Market Size, Split by Region

Based on or includes research from QYResearch: Global Defensin Product Market Report 2023-2029.

About QYResearch

QYResearch founded in California, USA in 2007.It is a leading global market research and consulting company. With over 16 years’ experience and professional research team in various cities over the world QY Research focuses on management consulting, database and seminar services, IPO consulting, industry chain research and customized research to help our clients in providing non-linear revenue model and make them successful. We are globally recognized for our expansive portfolio of services, good corporate citizenship, and our strong commitment to sustainability. Up to now, we have cooperated with more than 60,000 clients across five continents. Let’s work closely with you and build a bold and better future.

QYResearch is a world-renowned large-scale consulting company. The industry covers various high-tech industry chain market segments, spanning the semiconductor industry chain (semiconductor equipment and parts, semiconductor materials, ICs, Foundry, packaging and testing, discrete devices, sensors, optoelectronic devices), photovoltaic industry chain (equipment, cells, modules, auxiliary material brackets, inverters, power station terminals), new energy automobile industry chain (batteries and materials, auto parts, batteries, motors, electronic control, automotive semiconductors, etc.), communication industry chain (communication system equipment, terminal equipment, electronic components, RF front-end, optical modules, 4G/5G/6G, broadband, IoT, digital economy, AI), advanced materials industry Chain (metal materials, polymer materials, ceramic materials, nano materials, etc.), machinery manufacturing industry chain (CNC machine tools, construction machinery, electrical machinery, 3C automation, industrial robots, lasers, industrial control, drones), food, beverages and pharmaceuticals, medical equipment, agriculture, etc.

#report #research

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