#Ankylosing Spondylitis Market Analysis

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Ankylosing Spondylitis Market Projected to Show Strong Growth

The Latest research coverage on Ankylosing Spondylitis Market provides a detailed overview and accurate market size. The study is designed considering current and historical trends, market development and business strategies taken up by leaders and new industry players entering the market. Furthermore, study includes an in-depth analysis of global and regional markets along with country level market size breakdown to identify potential gaps and opportunities to better investigate market status, development activity, value and growth patterns. Access Sample Report + All Related Graphs & Charts @: https://www.advancemarketanalytics.com/sample-report/35094-global-ankylosing-spondylitis-market

Major & Emerging Players in Ankylosing Spondylitis Market:- AbbVie Inc. (United States), Janssen Pharmaceuticals Inc. (Belgium), Pfizer Inc. (United States), Sandoz International GmbH (Germany), Amgen Inc. (United States), Protalix BioTherapeutics, Inc. (Israel), Reliance Life Sciences Pvt. Ltd. (India), Momenta Pharmaceuticals Inc. (United States), Celgene Corporation (United States), Regeneron Pharmaceuticals (United States), Merck & Co. Inc. (United States) The Ankylosing Spondylitis Market Study by AMA Research gives an essential tool and source to Industry stakeholders to figure out the market and other fundamental technicalities, covering growth, opportunities, competitive scenarios, and key trends in the Ankylosing Spondylitis market. Ankylosing spondylitis (AS) is a type of arthritis that mostly affects the back. It causes infection in the joints of the spine, leading to pain and stiffness. Ankylosing spondylitis affects people in diverse ways some people can almost forget they have the condition, while for others it can have a big effect on their quality of life and sometimes joints other than those in the spine can be affected too. Sometimes, other parts of the body may also be affected. Ankylosing spondylitis is a type of spondyloarthritis is a group of conditions that share many of the same symptoms.

The titled segments and sub-section of the market are illuminated below: by Application (Hospitals, Clinics, Ambulatory Surgical Centers), Route of Administration (Oral, Parenteral), Treatment Type (Nonsteroidal Anti-Inflammatory Drugs (Ibuprofen and Naproxen), Disease-Modifying Antirheumatic Drugs (Methotrexate), Biologics (Secukinumab, Certolizumab Pegol, and Infliximab)), Molecule Type (Small Molecules, Biologics, Biosimilars) Market Trends: Increasing Number of Treatment Seeking Population

Opportunities: Rising Research and Development Expenditure

Market Drivers: Increasing Prevalence of Ankylosing Spondylitis

Rising Awareness about Diagnostics and Treatments

Enquire for customization in Report @: https://www.advancemarketanalytics.com/enquiry-before-buy/35094-global-ankylosing-spondylitis-market Some Point of Table of Content: Chapter One: Report Overview Chapter Two: Global Market Growth Trends Chapter Three: Value Chain of Ankylosing Spondylitis Market Chapter Four: Players Profiles Chapter Five: Global Ankylosing Spondylitis Market Analysis by Regions Chapter Six: North America Ankylosing Spondylitis Market Analysis by Countries Chapter Seven: Europe Ankylosing Spondylitis Market Analysis by Countries Chapter Eight: Asia-Pacific Ankylosing Spondylitis Market Analysis by Countries Chapter Nine: Middle East and Africa Ankylosing Spondylitis Market Analysis by Countries Chapter Ten: South America Ankylosing Spondylitis Market Analysis by Countries Chapter Eleven: Global Ankylosing Spondylitis Market Segment by Types Chapter Twelve: Global Ankylosing Spondylitis Market Segment by Applications What are the market factors that are explained in the Ankylosing Spondylitis Market report?

– Key Strategic Developments: Strategic developments of the market, comprising R&D, new product launch, M&A, agreements, collaborations, partnerships, joint ventures, and regional growth of the leading competitors.

– Key Market Features: Including revenue, price, capacity, capacity utilization rate, gross, production, production rate, consumption, import/export, supply/demand, cost, market share, CAGR, and gross margin.– Analytical Tools: The analytical tools such as Porter’s five forces analysis, SWOT analysis, feasibility study, and investment return analysis have been used to analyze the growth of the key players operating in the market. Buy This Exclusive Research Here: https://www.advancemarketanalytics.com/buy-now?format=1&report=35094 Definitively, this report will give you an unmistakable perspective on every single reality of the market without a need to allude to some other research report or an information source. Our report will give all of you the realities about the past, present, and eventual fate of the concerned Market. Thanks for reading this article; you can also get individual chapter wise section or region wise report version like North America, Europe or Asia. Contact US : Craig Francis (PR & Marketing Manager) AMA Research & Media LLP Unit No. 429, Parsonage Road Edison, NJ New Jersey USA – 08837 Phone: +1 201 565 3262, +44 161 818 8166 sales@advancemarketanalytics.com

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Global Ankylosing Spondylitis Treatment Market Report 2023-2031

Ankylosing spondylitis is a chronic inflammatory disease that primarily affects the spine, causing pain, stiffness, and reduced mobility. The condition may also affect other joints and organs in the body. 

More Information Visit Site: Global Ankylosing Spondylitis Treatment Market

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Innovative Biologics: Trends in the Etanercept Market

"Etanercept Market Size And Forecast by 2032

The global Etanercept Market study offers a thorough examination of the industry, highlighting the influence of leading companies on market dynamics and growth. These key players set the benchmark for innovation and operational excellence, contributing significantly to the development of the market. The study delves into their strategic initiatives, offering insights into how they navigate challenges and capitalize on opportunities. By focusing on these companies, the report paints a vivid picture of the competitive environment and its evolution.

Global etanercept market is expected to gain market growth in the forecast period of 2021 to 2028. Data Bridge Market Research analyses the market to account to USD 22.36 million by 2028 growing at a CAGR of 3.7% in the above mentioned forecast period

the outlook for the Etanercept Market remains optimistic, with significant opportunities for growth and innovation. The market’s competitive environment, shaped by leading companies and their strategies, underscores the importance of adaptability and foresight. With a focus on insights, trends, and data-driven analysis, this report serves as a comprehensive guide for stakeholders navigating the complexities of the Etanercept Market.

Get a Sample PDF of Report - https://www.databridgemarketresearch.com/request-a-sample/?dbmr=global-etanercept-market

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Get More Detail: https://www.databridgemarketresearch.com/nucleus/global-etanercept-market 

Which are the top companies operating in the Etanercept Market?

The Top 10 Companies in Etanercept Market are known for their strong presence and innovative solutions. These include industry leaders.  Each of these companies has made significant contributions through cutting-edge products, strategic partnerships, and global reach. Their ability to adapt to market trends and consumer demands has helped them maintain leadership positions in the market, driving growth and setting industry standards.

**Segments**

- By Indication: Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriasis, Psoriatic Arthritis, Juvenile Idiopathic Arthritis, Others. - By Distribution Channel: Hospital Pharmacies, Retail Pharmacies, Online Pharmacies.

The Etanercept market can be segmented based on indication and distribution channel. In terms of indication, the market is categorized into Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriasis, Psoriatic Arthritis, Juvenile Idiopathic Arthritis, and others. Rheumatoid Arthritis is anticipated to be a prominent segment owing to the rising prevalence of the disease globally. Ankylosing Spondylitis is also expected to witness significant growth due to increased awareness and advancements in treatment options. Psoriasis and Psoriatic Arthritis segments are likely to show steady growth due to the increasing incidence of these conditions. The Juvenile Idiopathic Arthritis segment is expected to gain traction with a rise in pediatric patients requiring biologic treatments. Regarding the distribution channel, the market is segmented into Hospital Pharmacies, Retail Pharmacies, and Online Pharmacies. Hospital Pharmacies are expected to lead the market share due to the high footfall of patients seeking treatment in hospitals. Retail Pharmacies and Online Pharmacies are also projected to witness substantial growth driven by convenience and the increasing trend of e-commerce in the healthcare sector.

**Market Players**

- Amgen Inc. - Pfizer Inc. - Johnson & Johnson - Novartis AG - Merck & Co., Inc. - Biogen - AbbVie Inc.

Key players in the Etanercept market include Amgen Inc., Pfizer Inc., Johnson & Johnson, Novartis AG, Merck & Co., Inc., Biogen, and AbbVie Inc. These companies have a strong presence in the global market and are actively engaged in strategic initiatives such as mergers and acquisitions, collaborations, and productThe global Etanercept market is highly competitive with key players such as Amgen Inc., Pfizer Inc., Johnson & Johnson, Novartis AG, Merck & Co., Inc., Biogen, and AbbVie Inc. dominating the industry. These companies have established a strong foothold in the market through their extensive product portfolios, robust distribution networks, and significant investments in research and development activities. Amgen Inc. is a leading player in the market with its flagship product Enbrel, which is a key revenue generator for the company. Pfizer Inc. is another major player that offers Etanercept under the brand name Erelzi and has a strong presence in key markets worldwide. Johnson & Johnson, through its subsidiary Janssen Biotech, markets Etanercept under the brand name Remicade and remains a key player in the biologics market. Novartis AG, Merck & Co., Inc., Biogen, and AbbVie Inc. also have a significant market presence and contribute to the growth of the Etanercept market globally.

These key players in the Etanercept market are actively involved in strategic initiatives to strengthen their market position and gain a competitive edge. Mergers and acquisitions are a common strategy employed by these companies to expand their product offerings, enhance their geographical presence, and leverage synergies to drive growth. Collaborations and partnerships with other pharmaceutical companies, research institutions, and healthcare providers are also prevalent among market players to foster innovation, develop novel therapies, and improve patient outcomes. Product launches and pipeline advancements are crucial for sustaining growth in the highly competitive market landscape, with companies investing in research and development activities to bring new and improved treatment options to market.

The Etanercept market is witnessing several trends and developments that are shaping its growth trajectory. The increasing prevalence of autoimmune diseases such as Rheumatoid Arthritis, Psoriasis, and Ankylosing Spondylitis is driving the demand for biologic therapies like Et**Market Players**

- GlaxoSmithKline plc - Novartis AG - F. Hoffmann-La Roche Ltd. - Pfizer Inc. - Cipla Inc. - CELLTRION INC. - Samsung Bioepis - Takeda Pharmaceutical Company Limited

The major players covered in the etanercept market report are GlaxoSmithKline plc, Novartis AG, F. Hoffmann-La Roche Ltd., Pfizer Inc., Cipla Inc., CELLTRION INC., Samsung Bioepis, and Takeda Pharmaceutical Company Limited., among other domestic and global players. Market share data is available for Global, North America, Europe, Asia-Pacific (APAC), Middle East, and Africa (MEA) and South America separately. DBMR analysts understand competitive strengths and provide competitive analysis for each competitor separately.

The Etanercept market is highly competitive, with key players like Amgen Inc., Pfizer Inc., Johnson & Johnson, Novartis AG, Merck & Co., Inc., Biogen, and AbbVie Inc. dominating the industry. These companies have maintained their leading positions through extensive product portfolios, robust distribution networks, and significant investments in research and development. Strategic initiatives such as mergers and acquisitions, collaborations, and product launches have been vital for these players to strengthen their market presence and drive growth. Amgen Inc. leads with its Enbrel product, while Pfizer Inc. markets Erelzi, and Johnson

Explore Further Details about This Research Etanercept Market Report https://www.databridgemarketresearch.com/reports/global-etanercept-market

Key Insights from the Global Etanercept Market :

Comprehensive Market Overview: The Etanercept Market is growing rapidly, driven by technological advancements and evolving consumer preferences.

Industry Trends and Projections: The market is expected to grow at a CAGR of X% over the next five years, with increasing automation and digitalization.

Emerging Opportunities: New market segments, such as sustainable and eco-friendly solutions, are creating significant growth prospects.

Focus on R&D: Companies are investing heavily in R&D to innovate and improve product offerings, ensuring market leadership.

Leading Player Profiles: Major player dominate the market with strong portfolios and strategic partnerships.

Market Composition: The market is diverse, with a mix of large enterprises and emerging startups driving competition and innovation.

Revenue Growth: The market has witnessed a steady increase in revenue, primarily driven by growing demand and product diversification.

Commercial Opportunities: There are considerable opportunities for business expansion in emerging regions and through technological innovations.

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[healthcarefuture]

Strategic Market Trends Shaping the Future of Exocrine Pancreatic Insufficiency Solutions

Etanercept is a biopharmaceutical drug commonly used to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and ankylosing spondylitis. As a biologic, it functions by targeting and inhibiting tumor necrosis factor (TNF), a protein that plays a role in causing inflammation in the body. By blocking TNF, Etanercept helps reduce symptoms like joint pain, swelling, and skin inflammation, which are prevalent in autoimmune conditions. The Etanercept market is experiencing growth due to the increasing prevalence of these diseases globally, alongside advancements in biologic treatments, which have proven to be effective for patients who do not respond well to traditional drugs.

The Etanercept Market  Size was projected to be 17.98 (USD Billion) in 2022 based on MRFR analysis. By 2032, it is anticipated that the Etanercept Market Industry would have grown from 18.93 billion USD in 2023 to 30.1 billion USD. Throughout the forecast period (2024–2032), the Etanercept Market CAGR (growth rate) is anticipated to be approximately 5.29%.

Market Size of Etanercept

The market size for Etanercept has shown significant growth over the past decade, driven by the rising demand for biologic drugs and the expanding patient base of autoimmune conditions. The global Etanercept market size was estimated in billions of dollars, with projections indicating continued growth. Key regions driving this growth include North America, where advanced healthcare infrastructure and higher diagnosis rates contribute to higher Etanercept consumption, as well as regions in Asia-Pacific, where an increase in healthcare spending and awareness of autoimmune diseases is opening new market opportunities.

Etanercept Share in the Biologic Drug Market

Etanercept occupies a significant share within the biologic drug market. It is one of the leading biologics used for autoimmune diseases, competing with other TNF inhibitors and newer classes of biologic drugs. The presence of Etanercept biosimilars has diversified the market, leading to increased accessibility and competition, which helps expand its overall market share. As biosimilar drugs grow in acceptance globally, Etanercept’s share continues to be influenced by factors like pricing and the competitive landscape with alternative biologics. However, it remains a preferred treatment option for physicians and patients, maintaining its strong position in the global market.

Etanercept Analysis: Market Dynamics

The analysis of the Etanercept market reveals several dynamic factors that influence its growth and adoption. Key drivers include the rise in autoimmune disease cases, improved access to healthcare, and technological advances in drug production. Additionally, regulatory support for biologics and biosimilars contributes to the growth potential for Etanercept. However, factors like high costs associated with biologic drugs, strict regulatory requirements, and competition from alternative therapies can pose challenges. The Etanercept market analysis also indicates a trend toward patient-centric approaches, with ongoing research into more effective administration methods and dosage adjustments tailored to individual needs.

Etanercept Trends Shaping the Future Market

Emerging trends in the Etanercept market reflect the evolving healthcare landscape and technological advancements. Notably, the rise of biosimilars is a trend shaping Etanercept’s market, as it makes the drug more affordable and accessible. Another trend is the increasing focus on personalized medicine, allowing healthcare providers to tailor treatment with Etanercept based on individual patient factors. Additionally, advancements in drug delivery methods, such as self-injection devices, enhance patient convenience. Telemedicine and remote monitoring also support Etanercept adherence and usage by enabling better patient-doctor communication.

Reasons to Buy Etanercept Market Reports

Comprehensive Market Insights: Reports provide a detailed understanding of Etanercept market size, share, trends, and growth projections, offering crucial information for decision-making.

Competitive Analysis: Access to analysis on major players, emerging competitors, and market dynamics that influence Etanercept’s market position.

Trend Forecasting: Reports offer insights into emerging trends, including advancements in biosimilars, telemedicine, and personalized treatments.

Regional Market Breakdown: Detailed data on regional differences in Etanercept demand, providing insights into market opportunities across North America, Europe, and Asia-Pacific.

Investment Guidance: Insights on market drivers and potential challenges assist investors and stakeholders in making informed financial decisions.

Recent Developments in Etanercept Market

Recent developments in the Etanercept market highlight advancements in biosimilar approvals, which broaden access to treatment and reduce costs. Some pharmaceutical companies have introduced biosimilars in key markets, which could lower the price of Etanercept therapy, making it more accessible for patients. Additionally, research has continued to focus on improving Etanercept’s efficacy and safety profile, with some clinical trials exploring combination therapies with other biologics to enhance treatment outcomes. Digital health tools have also emerged, allowing for better monitoring of Etanercept usage and patient adherence, reflecting the shift towards integrated healthcare solutions. These innovations indicate an evolving market with new growth opportunities in the coming years.

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Adalimumab Market - Forecast(2024 - 2030)

Adalimumab Market Overview

Adalimumab Market Size is forecast to reach $3245.8 Million by 2030, at a CAGR of 6.20% during forecast period 2024-2030. Adalimumab is a monoclonal antibody and disease-modifying antirheumatic medication that acts by inactivating tumor necrosis factor-alpha. It is marketed under the brand names Humira and Exemptia, among others. The original adalimumab drug is sold under the brand name Humira. New versions of adalimumab are known as adalimumab biosimilars. Biosimilars are similar versions of original biological medicines. Adalimumab is a drug used to treat rheumatoid arthritis and ankylosing spondylitis��which affects the musculoskeletal system, Crohn’s disease, ulcerative colitis, psoriatic arthritis, hidradenitis suppurativa, and other diseases. It was first introduced in the United States by Abbvie and was approved by the FDA in 2002. It is used to alleviate inflammation by acting on the immune system. The growing prevalence of arthritis and skin disorders, adoption of a sedentary lifestyle, and growing obese population are some of the factors driving the Adalimumab Market growth during the forecast period 2024-2030.

 𝐃𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐒𝐚𝐦𝐩𝐥𝐞

Report Coverage

The report: “Adalimumab Market Forecast (2024-2030)", by Industry ARC covers an in-depth analysis of the following segments of the Adalimumab Market.

By Disease- Crohn’s disease, Psoriatic arthritis, Rheumatoid arthritis, Ulcerative colitis, and others. By Type- Adalimumab, Adalimumab Biosimilar. By End-Users- Hospitals, Specialty Clinics, and Others. By Geography- North America (U.S., Canada, Mexico), Europe (Germany, United Kingdom (U.K.), France, Italy, Spain, Russia, and Rest of Europe), Asia Pacific (China, Japan India, South Korea, Australia, and New Zealand, and Rest of Asia Pacific), South America (Brazil, Argentina, and Rest of South America), and Rest of the World (the Middle East, and Africa).

Key Takeaways

Geographically, North America held a dominant market share in the year 2021 on account of the increasing prevalence of psoriasis arthritis, highly informed people knowing the benefits of adalimumab, and high healthcare expenditure. Asia-Pacific is expected to offer lucrative growth opportunities to the manufacturers owing to increasing prevalence of Crohn's disease and ulcerative colitis., demand for better healthcare facilities as well a boost in the investments done by government and private companies in pharma industry. The proliferation of Rheumatoid arthritis is predicted to augment the market growth during the forecast period of 2022-2027.

The growing prevalence of arthritis and skin disorders is estimated to drive the market growth of the Adalimumab Market. High cost as well as lack side effects of adalimumab poses threat to the market growth.

A detailed analysis of strengths, weaknesses, opportunities, and threats will be provided in the Adalimumab Market Report.

[amrutatbrc1]

Rheumatology Therapeutics Market 2024 : Size, Growth Rate, Business Module, Product Scope, Regional Analysis And Expansions 2033

The Rheumatology Therapeutics Global Market Report 2024 by The Business Research Company provides market overview across 60+ geographies in the seven regions - Asia-Pacific, Western Europe, Eastern Europe, North America, South America, the Middle East, and Africa, encompassing 27 major global industries. The report presents a comprehensive analysis over a ten-year historic period (2010-2021) and extends its insights into a ten-year forecast period (2023-2033).

Learn More On The Rheumatology Therapeutics Market: https://www.thebusinessresearchcompany.com/report/rheumatology-therapeutics-global-market-report

According to The Business Research Company’s Rheumatology Therapeutics Global Market Report 2024, The rheumatology therapeutics market size is expected to see steady growth in the next few years. It will grow to $51.42 billion in 2028 at a compound annual growth rate (CAGR) of 4.9%. The growth in the forecast period can be attributed to the shift towards personalized medicine approaches, rising adoption of biosimilars in rheumatology, increasing investment in research and development, integration of digital health technologies, and regulatory approvals for novel therapies. Major trends in the forecast period include growth in telemedicine and remote monitoring solutions, expansion of targeted therapies for specific rheumatic conditions, emphasis on patient-centric care models, expansion of biologic treatments beyond monoclonal antibodies, and adoption of value-based pricing models.

The rising prevalence of autoimmune diseases is expected to propel the growth of the rheumatology therapeutics market going forward. An autoimmune disease is a condition where the immune system mistakenly attacks and damages the body's tissues. The prevalence of autoimmune diseases is growing due to a combination of genetic, environmental, and lifestyle factors, including increased awareness and improved diagnostic capabilities. Rheumatology therapeutics are required for autoimmune diseases to manage inflammation, alleviate symptoms, and prevent joint and tissue damage caused by the immune system attacking the body. For instance, in June 2024, according to the Australian Institute of Health and Welfare, an Australia-based government agency, around 514,000 people in Australia, or 2.0% of the population, were estimated to be living with rheumatoid arthritis in 2022. Rheumatoid arthritis accounted for 2.0% of the total disease burden and 16% of the burden for all musculoskeletal conditions in 2023. Therefore, the rising prevalence of autoimmune diseases is driving the growth of the rheumatology therapeutics market.

Get A Free Sample Of The Report (Includes Graphs And Tables): https://www.thebusinessresearchcompany.com/sample.aspx?id=17246&type=smp

The rheumatology therapeutics market covered in this report is segmented –

1) By Drug Class: Disease Modifying Anti-Rheumatic Drugs, Nonsteroidal Anti-Inflammatory Drugs, Corticosteroids, Uric Acid Drugs, Other Drugs Classes 2) By Distribution Channel: Hospital Pharmacy, Retail Pharmacy, Online Pharmacy 3) By Disease Indication: Rheumatoid Arthritis, Osteoarthritis, Gout, Psoriatic Arthritis, Ankylosing Spondylitis, Other Disease Indications

Major companies operating in the rheumatology therapeutics market are developing innovative solutions, such as intravenous (IV) formulations, to enhance treatment efficacy and patient convenience. An intravenous (IV) formulation refers to a medication or substance that is administered directly into a vein through a needle or catheter. For instance, in October 2023, Novartis AG, a Switzerland-based pharmaceutical company, announced that the US Food and Drug Administration (FDA) had approved Cosentyx, an intravenous (IV) formulation. This form of Cosentyx is uniquely approved to treat adults with psoriatic arthritis (PsA), ankylosing spondylitis (AS), and non-radiographic axial spondyloarthritis (nr-axSpA). It works by specifically targeting and inhibiting interleukin-17A (IL-17A) and is the only non-tumor necrosis factor alpha (TNF-α) IV treatment available for these conditions.

The rheumatology therapeutics market report table of contents includes:

1. Executive Summary

2. Rheumatology Therapeutics Market Characteristics

3. Rheumatology Therapeutics Market Trends And Strategies

4. Rheumatology Therapeutics Market - Macro Economic Scenario

5. Global Rheumatology Therapeutics Market Size and Growth ...........

32. Global Rheumatology Therapeutics Market Competitive Benchmarking

33. Global Rheumatology Therapeutics Market Competitive Dashboard

34. Key Mergers And Acquisitions In The Rheumatology Therapeutics Market

35. Rheumatology Therapeutics Market Future Outlook and Potential Analysis

36. Appendix

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Biosimilars Market Size, Trends, Growth Analysis 2032

Biosimilars Market Overview

An integral component of the Biosimilars Market is the emergence of follow-on biologics. These biologics, which closely resemble existing biologic drugs, offer additional options for patients and healthcare providers. Follow-on biologics undergo rigorous testing to demonstrate similarity to the reference product, ensuring interchangeability and therapeutic equivalence. With their introduction, follow-on biologics stimulate competition in the biopharmaceutical industry, driving down prices and promoting innovation. As the demand for cost-effective biologic therapies continues to grow, the Biosimilars Market stands to benefit from the availability and acceptance of follow-on biologics, expanding treatment options and improving patient outcomes.

According to Market Research Future (MRFR), the biosimilars market insights was valued at USD 29.7 billion in 2023 and is projected to grow from USD 36.79 Billion in 2024 to USD 161.95 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 20.35% during the forecast period (2024 - 2032).

Biosimilars Market: Latest News and Developments

The FDA has approved the first Humira biosimilar. Adalimumab-bwwd (Cyltezo), a Humira biosimilar, received FDA approval in January 2023 for the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, Crohn's disease, ulcerative colitis, plaque psoriasis, and hidradenitis suppurativa.

Rising use of biosimilars in the treatment of cancer. A growing number of biosimilars are being used to treat cancer. The FDA authorised filgrastim-sndz (Zarxio), pegfilgrastim-jmdb (Onpro), and trastuzumab-dkst (Herzuma) as three biosimilars for the treatment of cancer in 2022.

Market Segmentation

Biosimilars industry can be considered with respect to product, applications, and end users.

The products based on which the market has been split into are recombinant glycosylated proteins, recombinant peptides, and recombinant non-glycosylated proteins. Recombinant non-glycosylated proteins are the biggest segment in the global market, thanks to the soaring cases of chronic disorders ranging from growth hormone deficiency to diabetes. As a result, recombinant non-glycosylated proteins are therapeutically used as they are readily available and are cost-effective.

Application-wise, the biosimilars market caters to chronic diseases, oncology, blood disorders, autoimmune diseases, infectious diseases, growth hormone deficiency, and more. Blood disorders have emerged as the top segment, as a result of the rising burden of the condition worldwide and the increased use of biosimilars by virtue of their low cost and the overall reduction in the treatment cost.

Major end users in the global market are hospitals and clinics as well as research institutes. Hospital and clinics are healthcare settings where treatment options and skilled professionals are easily available, and therefore, have emerged as the leading segment in the global industry.

Regional Status

Europe, MEA or Middle East & Africa along with the Americas, APAC or Asia Pacific are the primary markets for biosimilars.

Europe has taken the lead in the global market, as the region houses a vast elderly pool, with close to one fifth of the overall EU population aged more than 65 years. This has given way to several lifestyle-related disorders such as oncology, autoimmune diseases, diabetes, to name a few. Presumably, the scenario has raised the demand for biosimilars and can mean higher market growth over the next few years. In addition to this, numerous blockbuster biologics are on track to lose patent in the coming years, which should present lucrative opportunities to the biosimilar manufacturers.

The North American market displays a bright outlook and can emerge quite lucrative in the coming years, in view of the surging burden of chronic ailments in Canada and the United States. The rising spending on research activities by the healthcare agencies also fuels the market expansion in the region. Favorable reimbursement landscape in the region, especially in the US, encourages healthy competition as it results in lower incentives for the players to compete based on price.

The APAC market is slated to witness considerable growth, with China, South Korea and India offering a host of lucrative opportunities for drug development as well as commercialization. These are generics-driven countries and are known for frequently launching new and advanced manufacturing platforms, which has brought down the costs associated with biosimilar production. In the coming few years, majority of the patent expiries is touted to be in biosimilars, which is deemed as a profitable aspect by leading manufacturers and can translate into substantial market growth.

Eminent Vendors

Top global key players listed by biosimilars market outlook report include Stada Arzneimittel AG (Germany), Teva Pharmaceuticals (Israel), Biocon (India), Pfizer (US), Sandoz International (Germany), Eli Lily & Company (US), Actavis, Inc. (US), Dr. Reddy’s Laboratories (India), Cipla Ltd (India), Amgen, Inc. (US), Samsung Biologics (South Korea), Hospira Inc.(US), Mylan, Inc.(US), Celltrion (South Korea), to mention a few.

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[wellnessweb]

Regional Variations in Immunology Market Size

The Immunology Market is estimated to be valued at US$ 100117 Million in 2023 and is expected to reach US$ 183000 million by 2031, at a CAGR of 9% during the forecast period (2024–2031).The Immunology market stands at the forefront of medical innovation, a dynamic landscape where research converges with clinical need to shape the future of healthcare. With a relentless focus on understanding the intricate dance between immune response and disease, this field propels breakthroughs in biologics, diagnostics, and therapeutics. From pioneering monoclonal antibodies that target specific immune pathways to advanced genomic tools unraveling the genetic underpinnings of autoimmune disorders, the Immunology market is a crucible of discovery. It bridges the gap between benchtop experiments and bedside treatments, offering hope to millions grappling with conditions once deemed untreatable.

The market research is a thorough and in-depth examination of the market, with a focus on global market trends. The goal of this study is to give readers a comprehensive overview of the market as well as a detailed segmentation of the market. The study examines market drivers and prospects, as well as key investment pockets, key segments, Porter's Five Forces, value chain, and competitive landscape. The Immunology Market  analysis investigates market dynamics at the regional and national levels. There is also a competitive study, which covers corporate market shares as well as profiles for key revenue sources.

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Market Segmentation

By Drug Class

Monoclonal Antibody (mAb)

Fusion Proteins

Immunosuppressants

Polyclonal Antibody (pAb)

By Disease Indication

Rheumatoid Arthritis,

Psoriatic Arthritis

Plaque Psoriasis

Ankylosing Spondylitis

Inflammatory Bowel Disease

Prophylaxis of Organ Rejection

By Distribution Channel

Hospital Pharmacies

Retail Pharmacies

Online Pharmacies

Competitive Analysis

To gain a competitive advantage, businesses employ a variety of growth and expansion strategies. Industry actors monitor value chain integration with firm actions at various stages of the value chain. The Immunology Market  research report covers data on future profitability, company portfolios, and industry leaders trying to improve supply chain logistics, expand their global footprint, and get a competitive advantage in the global market. The market demand is expected to climb as large corporations and government bodies seek more information about the current scenario.

Key Objectives of Immunology Market  Report

Market segmentation analysis by types, applications, and end-use across regions.

To conduct a national market analysis, covering current market size and future prospects.

To provide a complete breakdown of important market participants' fundamental competencies as well as a clear image of the market.

To present an in-depth study of the market structure, as well as forecasts for the main sections and sub-fragments for the following years.

About Us

SNS Insider is a market research and insights firm that has won several awards and earned a solid reputation for service and strategy. We are a strategic partner who can assist you in reframing issues and generating answers to the trickiest business difficulties. For greater consumer insight and client experiences, we leverage the power of experience and people.

When you employ our services, you will collaborate with qualified and experienced staff. We believe it is crucial to collaborate with our clients to ensure that each project is customized to meet their demands. Nobody knows your customers or community better than you do. Therefore, our team needs to ask the correct questions that appeal to your audience in order to collect the best information.

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[rohans18]

Certolizumab Pegol Market Analysis and Forecast to 2029

Global Certolizumab Pegol Market, By Type (Single-dose Vial, Single-dose Prefilled Syringe), Application (Crohn’s disease, Active Psoriatic Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Axial Spondyloarthritis, Others), Dosage Form (Solution, Injection, Others), Route of Administration (Subcutaneous, Others), End-Users (Clinic, Hospital, Others), Distribution Channel (Hospital Pharmacy, Retail Pharmacy, Online Pharmacy), Country (U.S., Canada, Mexico, Brazil, Argentina, Peru, Rest of South America, Germany, France, U.K., Netherlands, Switzerland, Belgium, Russia, Italy, Spain, Turkey, Hungary, Lithuania, Austria, Ireland, Norway, Poland, Rest of Europe, China, Japan, India, South Korea, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, Vietnam, Rest of Asia-Pacific, Saudi Arabia, U.A.E, Egypt, Israel, Kuwait, South Africa, Rest of Middle East and Africa) Industry Trends and Forecast to 2029

The consistent Certolizumab Pegol market report analyzes many points that help businesses to solve the toughest questions in less time. The major topics of this business report are global growth trends, market share by manufacturers, market size by type, market size by application, production by region, consumption by region, company profiles, market forecast, value chain and sales channels analysis, opportunities & challenges, threat and affecting factors. The report gives market definition in the form of market driving factors and market restraints which helps estimating the demand of particular product depending on several aspects. Certolizumab Pegol market survey report studies the global market status and forecast, categorizes the global market size, market value & market volume by key players, type, application, and region.

Key Players

Some of the major players operating in the certolizumab pegol market are UCB S.A., LGM Pharma, ADM, BASF SE, Cargill Incorporated, Land O'Lakes, Inc., Dallas Keith, Agridyne LLC, Ridley Corporation Limited, and Liquid Feeds Inc., among others.

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One of the principal objectives of a high-ranking Certolizumab Pegol industry report is to analyze and study the global sales, value, status, and forecast. The market report also analyzes the global and key regions market potential and advantage, opportunity and challenge, restraints and risks. The report assists to define, describe and forecast the market by type, application and region. It estimates the region that is foretold to create the most number of opportunities in the global Certolizumab Pegol market. This market research report comprises of estimations of CAGR values which are quite significant and aids businesses to decide upon the investment value over the time period. An insightful Certolizumab Pegol market report assists clients to stay ahead of the time and competition.

Key questions answered in the report:

Which product segment will grab a lion’s share?

Which regional market will emerge as a frontrunner in coming years?

Which application segment will grow at a robust rate?

Report provides insights on the following pointers:

Market Penetration: Comprehensive information on the product portfolios of the top players in the Certolizumab Pegol Market.

Product Development/Innovation: Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Table Of Content

Part 01: Executive Summary

Part 02: Scope Of The Report

Part 03:  Global Market

Part 04: Global Market Sizing

Part 05: Global Market Segmentation By Product

Part 06: Five Forces Analysis

About Us:

Data Bridge Market Research set forth itself as an unconventional and neoteric Market research and consulting firm with unparalleled level of resilience and integrated approaches. We are determined to unearth the best market opportunities and foster efficient information for your business to thrive in the market

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[clearmusictheorist]

Ankylosing Spondylitis Drugs Market by Size, Key Players, Regional Trends and Growth Trends with Forecast 2023 to 2030

Global Ankylosing Spondylitis Drugs market report is a well-conceived and accurately delivered market intelligence report depicting crucial elements across the current and historic market states that play a crucial role in influencing unfaltering forecast and predictions in the Ankylosing Spondylitis Drugs market.

The report is so designed to address the crucial facets of the market such as market dimensions and size, market trends, investment strategies, pricing structure and driver specific analytical review that lend real time access to all aspects of the market in real time parameters, thus encouraging market players operational across global and regional domains to inculcate lucrative business decisions to channelize optimum revenue generation despite cut throat competition in global Ankylosing Spondylitis Drugs market.

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COVID-19 Analysis on Ankylosing Spondylitis Drugs Market

Considering the lingering spread of COVID-19 and its devastating implications on holistic growth trajectory, are research team experts have devised specially designed sections pertaining to the implications of COVID-19 on businesses, and their probable come-back journey that would successfully align their business activities towards revenue generation practices, allowing them to harness winning opportunities despite the odds.

This intricately devised market research protocols encourage ours research experts and analysts to traverse the extra mile towards information procurement, thus enabling us to become requisite research partners and knowledge scavengers to optimally source multidimensional information for superlative market understanding.

This extensive research documentation is designed to align with the interests of budding entrepreneurs as well as established market participants along with other stakeholders and readers willing to analyze the market across various domains to encourage lucrative business decisions. In its commencement, the report on global automotive semiconductor market demonstrates a holistic overview section of the market developments that includes veritable details on market definition, followed by other relevant highlights such as prominent trends, noteworthy regional and country specific developments as well as vendor activities across regional hubs.

Investment in the Report: Key Reasons

A thorough evaluation and detailed assessment of global Ankylosing Spondylitis Drugs market

Tangible and significant alterations in influential dynamics

A thorough assessment of market segmentation

Upcoming market segments, regional diversification

Past, current and crucial forecast analysis, details on volume and value projections

An in-depth reference of frontline players

Details on market share and overall value assessment, global Ankylosing Spondylitis Drugs market

A crystal-clear sectioning on best industry practices and list of major players as well as aspiring ones in global Ankylosing Spondylitis Drugs market.

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Parallel to the above mentioned, the report meets the crucial needs to guide appropriate growth strategies to enable high end growth across regional domains as well as global perspectives in global Ankylosing Spondylitis Drugs market. Leading market participants as well as their growth efficient marketing activities and business models are also elaborated in the report to serve as efficient cues for report readers.

This market report is a thoroughly researched analytical review of the current market scenario that directly affect onward growth trajectory of the Ankylosing Spondylitis Drugs market.

The report is a ready-to-refer, mindfully manifested scenario of the current market spectrum which is envisioned to equip its target audience and esteemed readers with decisive insights guiding them to leverage high potential growth and heavy revenue sustainability.

We are team of highly skilled research professionals aimed to offer next gen promising insights about a slew of industries. Our expertise lies in business analytics and consulting services that have earned an impressive clientele with promising investment returns.

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[healthcaredbmrnews]

Axial Spondyloarthritis Treatment Market Global Trends, Share, Industry Size, Growth, Opportunities and Forecast By 2029

Recent study report released by Data Bridge Market research titled Global Axial Spondyloarthritis Treatment Market (covering USA, Europe, China, Japan, India, South East Asia and etc) that highlighting opportunities, risk analysis, and leveraged with strategic and tactical decision-making support. The Axial Spondyloarthritis Treatment Market has witnessed continuous growth in the past few years and is projected to grow at a good pace during the forecast period of 2022-2029. The exploration provides a 360° view and insights, highlighting major outcomes of Axial Spondyloarthritis Treatment industry.

These insights help the business decision-makers to formulate better business plans and make informed decisions to improve profitability. This Report studies industry growth, regional trends, size, market share, product scope, entry barriers, distributors profile, statistics, business opportunity, top players profile. The Axial Spondyloarthritis Treatment research report also provides marketing strategy, value chain, industry challenges, business risk, Porter's Five Forces analysis, revenue and development plans in coming years.

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Axial spondyloarthritis treatment market is expected to gain market growth in the forecast period of 2022-2029. Data Bridge Market Research analyses the market to account to grow at a CAGR of 7.87% in the above mentioned forecast period.

Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder that affects the axial skeleton. The most common disorder that occurs from this disease family is ankylosing spondylitis. The individual suffers from severe discomfort, stiffness in the affected area, and fatigue as a result of this disorder. This disease family's treatment options include a variety of therapeutic methods and drugs such as nonsteroidal anti-inflammatory drugs (NSAID), TNF inhibitors, and conventional disease modifying anti-rheumatic drugs and glucocorticoids.

The major driving factors of the market are favourable conditions being implemented for pharmaceutical manufacturers and the focus of various authorities on improving existing healthcare infrastructure. In the near future, there will be an increase in global demand for various treatment options for axial spondyloarthritis. The market may grow as a result of significant investment in research and development, favourable reimbursement conditions, and rising incidences and prevalence.

Moreover, the rise in the research and development activities and high unmet need of current treatment will provide beneficial opportunities for the Axial spondyloarthritis treatment market in the forecast period of 2022-2029. Also, developments in the healthcare technology and emerging new markets will escalate the growth rate Axial spondyloarthritis treatment market in future.

However, the lacks of treatment options, as well as the existing high costs for these treatment options, are the major limiting factors of potential growth for the axial spondyloarthritis treatment market during the forecasted period.

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Some of the major players operating in the Axial spondyloarthritis treatment market are UCB S.A., Pfizer Inc., Abbott, Johnson & Johnson Services, Inc., Merck & Co., Inc., AbbVie Inc., Novartis AG, Eli Lilly and Company, Amgen Inc., Kyowa Kirin Co., Ltd. Industries Ltd., Pfizer Inc., GlaxoSmithKline plc, Merz Pharma, Medytox, Smith+Nephew, Sanofi, Novartis AG, Teva Pharmaceutical Industries Ltd., LGM Pharma., Lannett, NorthStar Rx LLC, and Par Pharmaceutical, among others.

The Axial Spondyloarthritis Treatment Market competitive landscape provides details by the competitors. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, production sites and facilities, production capacities, company strengths and weaknesses, product launch, product width and breadth, and application dominance.

Key points covered in the report: -

The pivotal aspect considered in the global Axial Spondyloarthritis Treatment Market report consists of the major competitors functioning in the global market.

The report includes profiles of companies with prominent positions in the global market.

The sales, corporate strategies and technical capabilities of key manufacturers are also mentioned in the report.

The driving factors for the growth of the global Axial Spondyloarthritis Treatment Market are thoroughly explained along with in-depth descriptions of the industry end users.

The report also elucidates important application segments of the global market to readers/users.

This report performs a SWOT analysis of the market. In the final section, the report recalls the sentiments and perspectives of industry-prepared and trained experts.

The experts also evaluate the export/import policies that might propel the growth of the Global Axial Spondyloarthritis Treatment Market.

The Global Axial Spondyloarthritis Treatment Market report provides valuable information for policymakers, investors, stakeholders, service providers, producers, suppliers, and organizations operating in the industry and looking to purchase this research document.

Table of Content:

Part 01: Executive Summary

Part 02: Scope of the Report

Part 03: Global Axial Spondyloarthritis Treatment Market Landscape

Part 04: Global Axial Spondyloarthritis Treatment Market Sizing

Part 05: Global Axial Spondyloarthritis Treatment Market by Product

Part 06: Five Forces Analysis

Part 07: Customer Landscape

Part 08: Geographic Landscape

Part 09: Decision Framework

Part 10: Drivers and Challenges

Part 11: Market Trends

Part 12: Vendor Landscape

Part 13: Vendor Analysis

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Reasons to Buy:

Review the scope of the Axial Spondyloarthritis Treatment Market with recent trends and SWOT analysis.

Outline of market dynamics coupled with market growth effects in coming years.

Axial Spondyloarthritis Treatment Market segmentation analysis includes qualitative and quantitative research, including the impact of economic and non-economic aspects.

Regional and country level analysis combining Axial Spondyloarthritis Treatment Market and supply forces that are affecting the growth of the market.

Market value data (millions of US dollars) and volume (millions of units) for each segment and sub-segment.

and strategies adopted by the players in the last five years.

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[healthcarefuture]

Competitive Landscape and Key Players in the Etanercept Industry

Etanercept is a biopharmaceutical drug commonly used to treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and ankylosing spondylitis. As a biologic, it functions by targeting and inhibiting tumor necrosis factor (TNF), a protein that plays a role in causing inflammation in the body. By blocking TNF, Etanercept helps reduce symptoms like joint pain, swelling, and skin inflammation, which are prevalent in autoimmune conditions. The Etanercept market is experiencing growth due to the increasing prevalence of these diseases globally, alongside advancements in biologic treatments, which have proven to be effective for patients who do not respond well to traditional drugs.

The Etanercept Market  Size was projected to be 17.98 (USD Billion) in 2022 based on MRFR analysis. By 2032, it is anticipated that the Etanercept Market Industry would have grown from 18.93 billion USD in 2023 to 30.1 billion USD. Throughout the forecast period (2024–2032), the Etanercept Market CAGR (growth rate) is anticipated to be approximately 5.29%.

Market Size of Etanercept

The market size for Etanercept has shown significant growth over the past decade, driven by the rising demand for biologic drugs and the expanding patient base of autoimmune conditions. The global Etanercept market size was estimated in billions of dollars, with projections indicating continued growth. Key regions driving this growth include North America, where advanced healthcare infrastructure and higher diagnosis rates contribute to higher Etanercept consumption, as well as regions in Asia-Pacific, where an increase in healthcare spending and awareness of autoimmune diseases is opening new market opportunities.

Etanercept Share in the Biologic Drug Market

Etanercept occupies a significant share within the biologic drug market. It is one of the leading biologics used for autoimmune diseases, competing with other TNF inhibitors and newer classes of biologic drugs. The presence of Etanercept biosimilars has diversified the market, leading to increased accessibility and competition, which helps expand its overall market share. As biosimilar drugs grow in acceptance globally, Etanercept’s share continues to be influenced by factors like pricing and the competitive landscape with alternative biologics. However, it remains a preferred treatment option for physicians and patients, maintaining its strong position in the global market.

Etanercept Analysis: Market Dynamics

The analysis of the Etanercept market reveals several dynamic factors that influence its growth and adoption. Key drivers include the rise in autoimmune disease cases, improved access to healthcare, and technological advances in drug production. Additionally, regulatory support for biologics and biosimilars contributes to the growth potential for Etanercept. However, factors like high costs associated with biologic drugs, strict regulatory requirements, and competition from alternative therapies can pose challenges. The Etanercept market analysis also indicates a trend toward patient-centric approaches, with ongoing research into more effective administration methods and dosage adjustments tailored to individual needs.

Etanercept Trends Shaping the Future Market

Emerging trends in the Etanercept market reflect the evolving healthcare landscape and technological advancements. Notably, the rise of biosimilars is a trend shaping Etanercept’s market, as it makes the drug more affordable and accessible. Another trend is the increasing focus on personalized medicine, allowing healthcare providers to tailor treatment with Etanercept based on individual patient factors. Additionally, advancements in drug delivery methods, such as self-injection devices, enhance patient convenience. Telemedicine and remote monitoring also support Etanercept adherence and usage by enabling better patient-doctor communication.

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Trend Forecasting: Reports offer insights into emerging trends, including advancements in biosimilars, telemedicine, and personalized treatments.

Regional Market Breakdown: Detailed data on regional differences in Etanercept demand, providing insights into market opportunities across North America, Europe, and Asia-Pacific.

Investment Guidance: Insights on market drivers and potential challenges assist investors and stakeholders in making informed financial decisions.

Recent Developments in Etanercept Market

Recent developments in the Etanercept market highlight advancements in biosimilar approvals, which broaden access to treatment and reduce costs. Some pharmaceutical companies have introduced biosimilars in key markets, which could lower the price of Etanercept therapy, making it more accessible for patients. Additionally, research has continued to focus on improving Etanercept’s efficacy and safety profile, with some clinical trials exploring combination therapies with other biologics to enhance treatment outcomes. Digital health tools have also emerged, allowing for better monitoring of Etanercept usage and patient adherence, reflecting the shift towards integrated healthcare solutions. These innovations indicate an evolving market with new growth opportunities in the coming years.

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[biogenericpublishers]

Latent Crohn’s Disease Uncovered During Treatment with Secukinumab in a Patient with Ankylosing Spondilitis by Moșteanu Elena Ofelia* in Open Access Journal of Biogeneric Science and Research

Keywords: Crohn’s disease, IL-17A Inhibitors, Secukinumab

Introduction

The inflammatory bowel diseases (IBD) are defined as a group of heterogeneous disorders with multifactorial etiology, in which a chronic inflammation of the digestive tract is caused by disturbances in the immune response to the pathogenic low-diversity gut microbiota [1]. IBD includes two major entities: Crohn’s disease (CD) and Ulcerative Colitis (UC). Current data estimates an impressive prevalence of over 0.3% globally [2]. CD is defined as transmural inflammation of any part of the gastrointestinal tract (GTI), from mouth to the perianal area, with a mainly ileal localization, while UC is an autolimited disease, of localization and histology, affecting only the colorectal mucosa. The clinical presentation of CD typically includes non-specific symptoms as abdominal pain, diarrhea, low-grade fever and weightloss, and with a low prevalence, extraintestinal manifestations. Complications of the disease include stricturing with secondary bowel obstruction, penetrating fistulas or abcesses.

Ankylosing spondylitis (AS) is a disease of spondyloarthropathies’ (SpA) class, which includes arthritis of different etiology. AS is a chronic inflammatory rheumatic disease involving primarily the axial skeleton, clinically expressed by back pain. It’s progressive character leads to continuosly increasing stiffnes of the spine, leading to spine fusion in late stages. In the light of epidemiologic studies of SpA associated with IBD, it was found an association of these pathologies in a third of the patients [3,4]. The overexpression and the complex immunoregulation of IL-17/IL-23 axis is of main importance in the interconnection of these entities [5]. Secukinumab is a human monoclonal antibody, a IL-17A inhibitor that was approved on the market in 2015, 20 years after Th-17, and consequently IL-17, was discovered. The novelty of the current case report is the long-term follow-up of a patient with new-onset of CD during treatment with Secukinumab, describing the resolution of the newly-emerged disease.

Case Report

We present the case of a 40 years old male, smoker, diagnosed with AS in 2006, for which he was treated with sulphasalazine for 4 years, etoricoxib for the next 2 years and etanercept (a TNFα inhibitor) for 7 years, until 2019, when the treatment with Secukinumab started. In 2016, he started having brief episodes of mesogastric abdominal pain, nausea, diarheea, episodes that didn’t remit with any medication, but did spontaneuosly after aproximately 24 hours. Because of the short duration and the low frequency, one episode every 6 months, the patient was not referred. After only 2 weeks of treatment with Secukinumab, in February 2019, these episodes worsened and became more frequent, almost weekly at the moment of the first gastrointestinal assessment in April. The abdominal ultrasound and the colonoscopy didn’t reveal any pathologic modifications. The symptoms were to be controlled by diet. In November, the patient was admitted again as the symptomatology worsened. Physical evaluation revealed pain at the abdomnial palpation in the right flank. Paraclinical examination show only an elevated C-reactive Protein of 2.88 mg/dl. Stool examination excluded any gastrointestinal infection. Abdominal ultrasound was nomal. A colonoscopy was performed and revealed cecal pseudopolyps, but the terminal ileon could not be inspected. The MRI Enterography revealed an ileal inflammatory stenosis, right next to the ileocecal valve, explaining the impossibility of ileocecal valve intubation (Figures 1&2).

The diagnosis was of ileocecal CD due to the inflammatory stenosis with subsequent upstream bowel dilatation (Figure 3). Secukinumab administration was discontinued and treatment with Adalimumab was indicated. At 3-months follow-up, the patient’s gastrointestinal symptomatology completely remmited, the remission being controlled by maintaining the treatment with Adalimumab, daily administration of inulin and simeticone and diet.

Discussion

It is widely known that there is a close association between IBD and SpA in terms of genetics, microbiota and immunology discorders [3,4]. In the etiopatogenesis of IBD, CD4 Th cells play a major role by starting and maintaining the autoimmune inflammation of the gastrointestinal tract, by producing pro-inflammatory cytokines. Beside CD4 Th cells, another subset of Th cells, Th17 cells, are overexpressed at this level and are positively regulated by IL-23, another proinflammatory cytokine produced by antigen-presenting cells, after the contact with the compounds of the pathological microbiota [6]. The activation of IL-17/IL-23 axis is fundamentally connected to the etiology of both CD and AS, IL-17 being found extensively in the blood, the synovial fluid in AS and in the intestinal lamina propria of CD patients [7,8].

Human interleukin IL-17 was found to be involved in different autoimmune diseases, such as systemic sclerosis, multiple sclerosis, systemic lupus erythematosus, psoriasis, asthma, SpAs and IBD [9-14]. While IL-17 is a pro-inflammatory cytokine, current data suggests a protective role on the gastrointestinal tract in IBD patients [15]. The importance of this paradox is to be seen in patients that benefit of biological treatment with IL-17 inhibitors and might associate a latent IBD.

Studies conducted with the objective of administering Secukinumab on CD animal models studies (2 ref trial) and on one human trial, which had to be completed prematurely because of the diseases’ unfavorable evolution compared to placebo, enforcing so the theory of IL-17 as being, in an unknown manner, a protective factor in the natural inflammatory evolution of CD. It is suggested that this difference may be due to the pathological microbiota found in IBD [16-18]. Using the data of these trials and knowing the statistical association between CD and SpA, the IL-17 molecule being overexpressed and playing different roles in both diseases, it might come handy that by inhibiting the IL-17/IL-23 path in SpA, the inflammation of the gut might worsen.

In Secukinumab’s summary of product characteristics, IBDs are mentioned in the section of special warnings and precautions for use, warning that the patients should be closely monitored. The latest retrospective analysis of pooled data from 21 clinical trials, containing 7355 patients, concluded that the cases of IBD during treatment with Secukinumab were uncommon [19]. The reported incidence of CD among 794 patients treated for SpA was 0,1 per 100 patients/year, with 5 new onset cases of CD (0,63%) and an exacerbation found in 3 out of 5 patients with a history of CD. The question this case raised was whether our patient was having a silent CD that was activated by this treatment or he developed the disease on a normal gastrointestinal tract. Anamnestically, the patient did associate in time the onset of gastrointestinal manifestations with the use of Secukinumab.

Diarrhea is a common side effect of this treatment and the patients should be informed of the possibility of having an inactive IBD that might activate during this treatment and they should be advised to adress a specialist if the gastrointestinal symptoms persist. IL-17 positive cells are not detected in the mucosa of healthy individuals, infectious colitis or ischaemic colitis patients, but IL-17 levels are significantly elevated in active and even in inactive CD [20]. Therefore, we can’t state that a subclinical CD was not present, taking into consideration also the frequency of IBD and SpA associating. Using the patient’s history and the current data available in the literature, we strongly believe that Secukinumab was the trigger of CD in this case.

Currently there are treatment guidelines just for IBD and SpA individually, but not any for both IBD and SpA, which would be needed in the near future, as more specific biological therapies emerge, targeting different inflammatory pathways. As written in the summary of product characteristics of Secukinumab, a close follow-up for IBD patients is needed, but, even if the new onset of CD is reported to have a low incidence, a gastroenterological monitoring would be recommended even for healthy individuals, because of the reported prevalence of IBD and SpA association.

Conclusion

A gastroenterological consult before the initiation of the treatment would be beneficial, since SpA may precede the onset of IBD [21,22] or may associate with an underlying asymptomatic intestinal inflammation [23]. This case report is also enforcing the current data of IL-17 having a protective role in IBD, it’s path inhibition leading to exacerbation or to activation of a silent IBD. Of biological therapies, there are safer treatment schemes for a patient with AS and symptomatic or silent CD, which could include Ustekinumab, a human monoclonal antibody that is targeting the IL-12/IL-23 path, Infliximab, a chimeric monoclonal antibody that inhibits tumor necrosis factor alpha (TNFα) or Adalimumab, the first human monoclonal antibody that bind and neutralizez TNFα. The statistics and this case report are underlining the importance of a multi-disciplinary approach when prescribing biological therapy, including rheumatologists and gastroenterologists. Why the IL-17/IL-23 axis is having a „paradoxal” role on the gastrointestinal tract it still a question that’s laking an answer and represents a future research direction.

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