#Acellular Dermal Matrices

[creativeera]

The Growing Acellular Dermal Matrices Industry is Thriving on Advanced Wound Care Innovations

The acellular dermal matrices market caters to the need for advanced wound care products that facilitate faster healing of complex wounds and burns. These tissue grafts derived from donated human or animal dermal tissue serve as a scaffold that aids skin or soft tissue regeneration. Comprising an intact matrix of collagen and protein fibers that stimulate cell migration and new tissue formation, acellular dermal matrices reduce healing time and scarring for wounds that fail to heal naturally.

The Global Acellular Dermal Matrices Market is estimated to be valued at US$ 10.14 Mn in 2024 and is expected to exhibit a CAGR of 5.9% over the forecast period 2024 to 2031. Key Takeaways Key players operating in the acellular dermal matrices are Merck & Co., Inc. (Merck Animal Health), Ceva, Zoetis Services LLC, Boehringer Ingelheim International GmbH. The growing prevalence of chronic wounds and ulcers due to the high incidence of diabetes and old age related disorders has bolstered demand for advanced wound care products. North America dominates the market currently due to favorable reimbursement policies and growing awareness about advanced wound management. However, the rising geriatric population in Asia Pacific and Latin America is expected to drive the market expansion in these regions during the forecast period. Market key trends The increased adoption of Acellular Dermal Matrices Market Demand for use in plastic and reconstructive surgeries indicate one of the key trends in the industry. By serving as a dermal substitute, these grafts enable surgeons to repair soft tissue deficits and skin defects with reduced contracture, distortion, and scarring for procedures like breast reconstruction and hernia repair. The advantages over autografts like reduced donor site morbidity have augmented their uptake in cosmetic surgical procedures.

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Alice Mutum is a seasoned senior content editor at Coherent Market Insights, leveraging extensive expertise gained from her previous role as a content writer. With seven years in content development, Alice masterfully employs SEO best practices and cutting-edge digital marketing strategies to craft high-ranking, impactful content. As an editor, she meticulously ensures flawless grammar and punctuation, precise data accuracy, and perfect alignment with audience needs in every research report. Alice's dedication to excellence and her strategic approach to content make her an invaluable asset in the world of market insights.

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[shradhacmi]

Global Acellular Dermal Matrices Market Is Estimated To Witness High Growth Owing To Increasing Adoption of Regenerative Medicine

Market Overview: The global Acellular Dermal Matrices Market is estimated to be valued at US$7,014.0 million in 2021 and is expected to exhibit a CAGR of 12.1% over the forecast period 2022-2030, as highlighted in a new report published by Coherent Market Insights. Acellular dermal matrices are biomaterials derived from human or animal tissues that have been processed to remove cells, leaving behind the extracellular matrix. These matrices are used in a variety of clinical applications, including wound healing, reconstructive surgery, and regenerative medicine. They provide structural support and act as a scaffold for cell growth and tissue regeneration. Market Dynamics: 1. Increasing demand for regenerative medicine: Acellular dermal matrices play a crucial role in regenerative medicine by providing a supportive structure for cell growth and tissue regeneration. The growing prevalence of chronic diseases and traumatic injuries has led to an increasing demand for regenerative medicine solutions, thereby driving the market growth. For instance, according to the World Health Organization (WHO), approximately 15 million people suffer from stroke worldwide each year, creating a significant demand for regenerative therapies. 2. Advancements in technology: The development of advanced processing techniques and innovations in tissue engineering have contributed to the growth of the acellular dermal matrices market. New methods for decellularization and sterilization have improved the safety and efficacy of these matrices. Furthermore, the integration of technologies such as 3D printing and biofabrication has enhanced the customization and precision in the production of acellular dermal matrices, catering to specific patient needs. SWOT Analysis: Strengths: 1. Enhanced tissue regeneration: Acellular dermal matrices provide a favorable environment for tissue regeneration, promoting wound healing and improving patient outcomes. 2. Versatile clinical applications: These matrices can be used in various clinical applications, including reconstructive surgery, wound healing, and regenerative medicine. Weaknesses: 1. High manufacturing costs: The production of acellular dermal matrices can be expensive, limiting their accessibility in certain regions and healthcare systems. 2. Risk of immune reactions: While efforts are made to remove all cells from these matrices, there is still a risk of immune reactions, which may affect patient outcomes. Opportunities: 1. Growing geriatric population: The aging population is more prone to chronic diseases and age-related tissue degeneration, creating a significant opportunity for the use of acellular dermal matrices in regenerative therapies. 2. Increasing research and development: Ongoing research and development activities in the field of tissue engineering and regenerative medicine present opportunities for the development of novel Acellular Dermal Matrices Market with enhanced properties and clinical applications. Threats: 1. Stringent regulatory requirements: The manufacturing and distribution of acellular dermal matrices are subject to stringent regulatory requirements, which may pose challenges for market players.

[kristinahertzz]

Skin Substitutes Market

Skin Substitutes Market Size, Share, Trends: Organogenesis Holdings Inc. Lead

Shift towards bioengineered skin substitutes

Market Overview:

The skin substitutes market is expected to develop at a 7.8% CAGR from 2024 to 2031. The market value is predicted to rise from XX USD in 2024 to YY USD in 2031, with North America emerging as the leading area. Key metrics driving this growth include the expanding occurrence of chronic wounds, the growing geriatric population, and advances in tissue engineering technology. The rising incidence of diabetes and its complications, burn injuries, and increased usage of advanced wound care products are also contributing to market expansion.

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Market Trends:

The skin substitutes market is seeing a considerable increase in the development and acceptance of bioengineered skin substitutes. These sophisticated products are intended to more closely resemble the structure and function of real skin, resulting in better wound healing and tissue regeneration. Bioengineered skin substitutes frequently integrate growth factors, stem cells, and other bioactive substances to improve therapeutic efficacy. For example, living cell-based therapies such as Apligraf and Dermagraft have grown in popularity due to their ability to promote quicker healing in chronic wounds.

Market Segmentation:

The biological skin substitutes segment is expected to dominate the market throughout the forecast period. Biological skin substitutes have emerged as the industry leader due to their superior healing properties and similarity to genuine skin. These products, produced from human or animal tissues, improve wound healing by stimulating cell migration, angiogenesis, and tissue regeneration.

Recent advances in biological skin substitutes have strengthened their market position. For example, the introduction of acellular dermal matrices (ADMs) has transformed difficult wound treatment. These products, such as AlloDerm and DermACELL, serve as scaffolds for tissue regeneration while reducing the risk of immunological rejection.

Market Key Players:

Organogenesis Holdings Inc.

Smith & Nephew plc

MiMedx Group, Inc.

Integra LifeSciences Holdings Corporation

Allergan (now part of AbbVie Inc.)

Tissue Regenix Group plc

Contact Us:

Name: Hari Krishna

Email us: hari.krishna@aurorawaveintellects.com

Website: https://aurorawaveintellects.com/

[wellnessweb]

Forecasting the Biomaterials  Market Size: Future Prospects

The Biomaterials Market size was estimated USD 156.1 billion in 2022 and is expected to reach USD 501.2 billion by 2030 at a CAGR of 15.7% during the forecast period of 2023-2030. The biomaterials market is experiencing rapid growth, driven by advancements in medical technology and increasing demand for innovative healthcare solutions. These materials, which include metals, ceramics, polymers, and natural substances, are pivotal in developing implants, prosthetics, and tissue engineering products. Their biocompatibility and functionality are enhancing the efficacy of medical treatments, particularly in orthopedics, cardiovascular applications, and wound care. The market is also benefiting from an aging global population and rising incidences of chronic diseases, which necessitate advanced medical interventions. Furthermore, ongoing research and development are fostering new applications and expanding the capabilities of biomaterials, positioning the market for sustained expansion and significant contributions to modern medicine.

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Market Scope & Overview

The Biomaterials Market research analyses all industries in terms of demand estimations in various areas to give a cross-sectional perspective of the global economy. The study looks at a number of demand, restriction, and opportunity factors that are anticipated to have an immediate impact on market growth. For the purpose of assisting readers in evaluating the financial stability of important market participants, the study contains an analysis of the industry's competitiveness as well as a structural evaluation of Porter's Five Forces.

The Biomaterials Market research concentrates on the many chances, constraints, and expansions that are expected to have a direct influence on commercial outcomes. The research report will focus on new developments and cutting-edge technologies that will significantly affect the growth of the global market over the course of the projection year.

Market Segmentation Analysis

By Product

Metallic

Natural

Ceramics

Polymers

By Application

Cardiovascular

Sensors

Stents

Guidewires

Implantable Cardiac Defibrillators

Pacemakers

Vascular Grafts

Others

Ophthalmology

Synthetic Corneas

Intraocular Lens

Contact Lens

Ocular Tissue Replacement

Others

Dental

Tissue Regeneration Materials

Dental Implants

Bone Grafts & Substitutes

Dental Membranes

Others

Orthopedic

Joint Replacement Biomaterials

Orthobiologics

Bioresorbable Tissue Fixation Products

Viscosupplementation

Spine Biomaterials

Others

Wound Healing

Fracture Healing Device

Adhesion Barrier

Skin Substitutes

Internal Tissue Sealant

Surgical Hemostats

Others

Tissue Engineering

Plastic Surgery

Facial Wrinkle Treatment

Soft Tissue Fillers

Craniofacial Surgery

Bioengineered Skins

Peripheral Nerve Repair

Acellular Dermal Matrices

Others

Neurology

Neural Stem Cell Encapsulation

Shunting Systems

Hydrogel Scaffold for CNS Repair

Cortical Neural Prosthetics

Others

Others

COVID-19 Impact Analysis

In order to give clients correct information to address market challenges during and after COVID-19, various industry experts and delegates are interviewed for a report on the Biomaterials Market during the main and secondary research phases. The market research report may be used by suppliers, end users, and distributors to find answers to a variety of questions, plan acquisitions, and look for further business prospects. It examines potential solutions as well as present and upcoming difficulties.

Regional Outlook

The research comprises a SWOT analysis model evaluation and a regional market competition analysis to help consumers estimate the regional health of important global business suppliers. All significant geographic areas are covered by the Biomaterials Market analysis, including the Middle East and Africa, North America, Asia Pacific, and Europe.

Competitive Analysis

A global market report that takes into account definitions, classifications, implementations, and supply chain structure also offers a fundamental overview. Information on important market participants, production trends, industry environment analysis, and regional growth trends are just a few of the topics covered in the global Biomaterials Market share report. The research looks at production methods, price trends, and expansion and growth objectives, among other things.

Key Reasons to Purchase the Biomaterials Market Report

By comparing data from prior years, external validation of these segments and sub-segments was also carried out.

The research report includes a cross-section of the global economy as well as market analyses for each geographical location.

Conclusion

All key discoveries and technological advances that will significantly affect the global market over the forecasted time period will be covered in the Biomaterials Market research report.

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[delicatemagazinedreamer]

Developed from human tissues, Acellular Dermal Matrices Acts As a Supportive Structure in The Formation of New Skin Cells

Acellular Dermal Matrices are biologically derived products that do not contain cells. These matrices are derived from a variety of sources, including porcine, human, and bovine. 

Acellular Dermal Matrices are primarily composed of elastic fibres and collagen. Since the outbreak of the COVID-19 virus in December 2019, the disease has spread to over 100 countries worldwide. 

The coronavirus (COVID 19) pandemic and lockdown in various countries around the world have had an impact on the financial health of businesses in all sectors. The COVID-19 pandemic has had a significant impact on the private healthcare sector. As a result, governments and government agencies around the world are launching a variety of initiatives to combat the spread of COVID-19.

Read more @ https://digitalgrowinfo.blogspot.com/2022/03/acellular-dermal-matrices-are.html

[jesse-pinkman123]

Additionally, it offers insight into the competitive landscape, market driving factors, industrial environment, and the latest and upcoming technological advancements to determine the overall scenario of industry and move forward to form lucrative business strategies effortlessly.

[creativeera]

Acellular Dermal Matrices: An Overview of Skin Grafting Materials

Acellular dermal matrices, also known as acellular cadaveric dermal allografts, are tissue grafting materials derived from human donated skin that have had the cellular components removed. The remaining dermal collagen and protein matrix provides a scaffold for tissue regeneration and wound healing. Acellular dermal matrices are commonly used in plastic and reconstructive surgeries as alternatives to autografts. Processing and Types of Acellular Dermal Matrices To create an acellular dermal matrix, donated skin undergoes an extensive processing and sterilization protocol to remove donor cells while preserving the collagen structure and biochemical components. This is typically done through repeated cycles of freezing, thawing, and rinsing in detergents. Acellular Dermal Matrices processing leaves behind an acellular, non-immunogenic dermal scaffold. There are a few main types of acellular cadaveric dermal allografts used in surgery based on their intended applications and processing methods: - Thicker sheets for tissue repair and reconstruction, like AlloDerm and FlexHD. These have a dermal thickness of 1-2mm. - Thinner, malleable sheets for contouring soft tissue defects, like AlloMax. These have a dermal thickness of 0.6mm or less. - Custom-shaped grafts that are specially processed and carved to fit specific anatomical sites. Clinical Applications of Acellular Dermal Matrices Breast Reconstruction: acellular cadaveric dermal allografts are commonly used in two-stage tissue expander/implant-based breast reconstruction to help fill dead space, create an integrated pocket, and improve cosmetic outcomes. They reduce capsular contracture rates. Abdominal Wall Reconstruction: Used to repair complex hernias and defects of the abdominal wall by reinforcing weak tissues and preventing recurrence. Provides strength and durability. Facial Reconstruction: Used for contouring facial contour deformities caused by trauma, infection, or cancer resection. Provides a malleable scaffold for soft tissue regeneration. Other applications include repairs of burn wounds, scar revisions, and other soft tissue defects. The acellular collagen matrix promotes revascularization and soft tissue ingrowth. Get more insights on Acellular Dermal Matrices

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[biomedgrid]

Biomed Grid | Biomechanical Principles of Multipoint Suture Fixation for Abdominal Wall Reconstruction

Introduction

In the United States, approximately 400,000 ventral hernias are repaired every year with an estimated cost of about 3 billion dollars [1] . Ventral hernias are a relatively morbid condition given that an intact abdominal wall is necessary for dynamic activities such as rotation of the torso, respiration, defecation/urination, emesis, and childbirth.

The management of ventral hernias has evolved over the past several decades with advances in technology and knowledge. The first significant improvement was the use of prosthetic mesh reinforcement to simple suture repair alone [2] . As reported by Luijendijk, randomized controlled trials demonstrated a decrease in hernia recurrence rates from 43 percent to 24 percent [3, 4].

Another major advancement was the popularization of the component separation technique as escribed by Ramirez [5] . This technique was found to be particularly useful in the case of large hernias where primary closure of the hernia defect is not possible otherwise. In addition, it eliminates the need for prosthetic mesh and its associated risks, while providing comparable or superior reduction in hernia recurrence [6, 7, 8]. Perhaps more importantly, the component separation technique provides a dynamic abdominal wall reconstruction, using innervated muscle which is critical to reducing hernia recurrence. In addition, component separation procedures provide an anatomic alignment of the muscles, which enhances abdominal wall function.

The advent and implementation of biologic mesh or acellular dermal matrices (ADM) has offered an additional valuable tool in the reconstructive armamentarium for ventral hernias [9] . ADM is superior to prosthetic mesh in setting of contaminated and highrisk cases and is a valuable adjunct to the component separation technique [10, 11, 12]. Abdominal wall reconstruction with human acellular dermal matrices (HADM) has also been described [13] . However, since it has increase elasticity as compared to porcine or bovine ADMs, it can leave a significant bulge if used as an inter-positional bridge when myofascial continuity cannot be reestablished (Figure 1A) (Figure 1B)

Figure 1A: Initial inset HADM over the anterior rectus sheath

Figure 1B: Progressive tension stretching the HADM laterally on each side with multiple fixation points with interrupted sutures

Although component separation with biologic mesh reinforcement is effective, there is still not universal agreement as to the technique and location for mesh fixation [14].For standard mesh fixation, the retro-muscular or underlay placements are most commonly used and are associated with lower recurrence rates [15, 16]. There has been some difference in outcomes with different types of fixation for underlay indicating that the method of fixation is important [17] .Placement of sutures lateral to the junction of the linea alba and the anterior rectus sheath have been found to provide the greatest support and tolerance for tissue tension in studies on laparotomy closure [18] .

The multipoint suture fixation offers a technique that combines these advantages for the patient undergoing abdominal wall reconstruction for ventral wall hernia, including the largest and most complex hernias as well as those with infected mesh and soft tissue deficiencies. The multipoint suture fixation technique is a physiologic approach to hernia reconstruction. The technique utilizes wide exposure to avoid injury to the hernia sac or contents. In patients who have had a prior midline incision, that is used. However, in patients without incisions on the abdomen, an abdominoplasty type incision has been found to have a number of advantages [19] . Local anesthesia with epinephrine is injected along the planned incisions to minimize bleeding and facilitate the dissection. The hernia sac and defect are circumscribed, and dissection is continued cephalad to the xyphoid.

Component release incisions are made lateral to the lateral border of the rectus muscles to mobilize the rectus muscles to the midline. The location of the component release is determined by the width of the anterior rectus sheath. It is made at least 8 cms lateral to the midline inset of the rectus sheath. The fascia is released, and the external oblique muscle preserved. In patients in whom the loss of domain is greater, posterior release of the rectus sheath can be added as well. The two abdominal rectus muscles are brought together in the midline with several interrupted 0 Vicryl sutures to ensure alignment of the muscles. This is critical for two reasons, first as indicated previously, a lower recurrence rate is associated with patients in whom myofascial continuity is reestablished. Second, the proper alignment of is important for proper function of the muscles in the actions on the abdominal wall. Even a small deviation of the line of action can have a significant impact on the how effectively muscles function [20] . A looped 1 PDS is used as a continuous running horizontal mattress suture to imbricate the anterior fascia, which is the most effective suture technique [21] . This facilitates securing the anterior fascia just lateral to the junction of the linea alba and anterior rectus sheath where it is strongest [22] .

The intentional selection of HADM to reinforce the abdominal wall fascia offers several advantages. Fascia takes approximately two months to gain 40% of its original strength, but original strength is never regained [23] . The addition of HADM provides not only a temporary increase in tensile strength of the abdominal, but as it integrates, it reinforces the native abdominal wall structure.

As compared to non-crosslinked xenograft ADMs, HADM provide more rapid vascular ingrowth and integration and greater tensile strength of the musculo-fascial interface [24] . The HADM has greater elasticity than non-cross-linked xenograft ADMS or any of the crosslinked ADMs. While this elasticity is a disadvantage for standard inset or interposition graft placement, with the multipoint fixation it offers the advantage of increased abdominal wall compliance.

The wide exposure open approach facilitates careful placement of the HADM. It is secured along the midline imbrication to bolster the inset of the two rectus abdominus muscles. Additional sutures are then placed in an offset row pattern working from the midline out laterally in each direction. Progressive tension sutures have been well-described to fix soft tissue in abdominoplasties to decrease seroma formation [25] . With each row additional traction displaces the HADM laterally as compared to the underlying fascia. This helps fix the HADM to the fascia to decrease the risk of seroma formation between the HADM and the fascia. In addition, the number of sutures strands used for fixation had been demonstrated to have a critical effect on the strength of fixation [26] . Perhaps more importantly, each row progressively offloads the tension on the midline inset of the muscles.

This technique specifically addresses the underlying concept that recurrences most often occur at the mesh-fascia interface. The structural design provides maximum interface of the anterior rectus sheath and the HADM. The progressive tension sutures provide an increased number of fixation points and off-load the inset of the muscles. The clinical results of this technique show that a multipoint fixation suture technique for abdominal wall reconstruction with component separation and onlay biologic mesh is reproducible and effective with low recurrence rates.

Read More About this Article: https://biomedgrid.com/fulltext/volume7/biomechanical-principles-of-multipoint-suture-fixation.001115.php

For more about: Journals on Biomedical Science :Biomed Grid | Current Issue

[sandlerresearch]

Breast Reconstruction Market by Product (Breast implant (Silicone, Saline), Tissue Expander, Acellular Dermal Matrix), Procedure (Immediate, Delayed, Revision), Type (Unilateral, Bilateral), End User (Hospital, Cosmetology Clinics) - Global Forecast to 2025 published on

https://www.sandlerresearch.org/breast-reconstruction-market-by-product-breast-implant-silicone-saline-tissue-expander-acellular-dermal-matrix-procedure-immediate-delayed-revision-type-unilateral-bilateral-end-user.html

Breast Reconstruction Market by Product (Breast implant (Silicone, Saline), Tissue Expander, Acellular Dermal Matrix), Procedure (Immediate, Delayed, Revision), Type (Unilateral, Bilateral), End User (Hospital, Cosmetology Clinics) - Global Forecast to 2025

“The global breast reconstruction market is projected to register a CAGR of 7.0% during the forecast period.”

The global breast reconstruction market size is projected to reach USD 603 million by 2025 from USD 430 million in 2020, at a CAGR of 7.0%. Growth in this industry is driven by the rising incidences of breast cancer, increasing awareness, and the availability of reimbursements. However, clinical risks and complications associated with breast reconstruction restrain the market growth.

“The acellular dermal matrix segment is anticipated to grow at the fastest growth rate during the forecast period.”

The breast reconstruction market, by product, is categorized into breast implants, tissue expanders, and acellular dermal matrix. The acellular dermal matrix segment is expected to register the highest CAGR during the forecast period. The growth of this segment is mainly driven by the rising incidences of breast cancer, increasing number of mastectomies, and growing use usage of acellular dermal matrices.

“The immediate procedure segment is estimated to grow at a rapid rate during the forecast period.”

On the basis of procedure, the breast reconstruction market is segmented into immediate, delayed, and revision procedures. Immediate procedures are expected to remain the fastest-growing segment of the global breast reconstruction market during the breast reconstruction period. Factors such as the increasing number of surgeries post-mastectomy and rising awareness are driving the market.

“Asia Pacific is estimated to register the highest CAGR during the study period.”

Geographically, the breast reconstruction market is dominated by North America and Europe. However, the Asia Pacific market is estimated to grow at the fastest rate during the forecast period.

Breakdown of Profiles of Primary Participants:

By Company Type: Tier 1: 32%, Tier 2: 44%, and Tier 3: 24%

By Designation: C-level: 30%, Director-level: 34%, and Others: 36%

By Region: North America: 40%, Europe: 28%, Asia Pacific: 20%, and the Rest of the World: 12%

  The key players in the breast reconstruction market include Johnson & Johnson (US), Allergan (Ireland), Ideal Implant Incorporated (US), Sebbin (France), GC Aesthetics (Ireland), Polytech Health & Aesthetics (Germany), Sientra (US), and .

Research Coverage:

The report analyzes the breast reconstruction market by product, procedure, type, end user, and region. Apart from comprehensive geographic product analysis and market sizing, the report also provides a competitive landscape that covers the growth strategies adopted by market players over the last three years. In addition, the company profiles include the product portfolios, developments, and strategies adopted by prominent market players to maintain and increase their shares in the market. Market research data, current market size, and forecast of future trends will help key market players and new entrants to make the necessary decisions regarding product offerings, geographic focus, changes in strategic approach, and levels of output to remain successful in the market.

Key Benefits of Buying the Report:

This report will enable both established firms and new entrants/smaller firms to gauge the pulse of the market, which, in turn, will help these firms garner greater market shares. Firms purchasing the report can use either or a combination of the below-mentioned five strategies for strengthening their market shares.

The report provides insights on the following pointers:

Market Penetration: Comprehensive information on the products of the top players in the breast reconstruction market

Competitive Assessment: In-depth assessment of market strategies, geographic and business segments, and product portfolios of the leading players in the breast reconstruction market

Market Development: Detailed information about emerging markets

Market Diversification: Exhaustive information about new products, untapped geographies, recent developments, and investments in the breast reconstruction market

[jesse-pinkman123]

Acellular Dermal Matrices Market report studies the Acellular Dermal Matrices with many aspects of the industry like the market size, market status, market trends and forecast, the report also provides brief information of the competitors and the specific growth opportunities with key market drivers.

[wiseguy-reports]

Implant-based breast reconstruction is emerging as one of the most preferred surgical treatment by women undergoing procedures such as mastectomy for the reconstruction of amputated breast(s). In addition, increasing awareness about the safety of breast reconstruction options is encouraging women undergoing mastectomy and other breast cancer surgeries to choose the reconstruction process, either delayed or immediate, causing this market to gain momentum in recent years.

[coolluminaryland-blog1]

Breast Reconstruction Market to Reach US$ 1,358.7 Mn by 2026

Transparency Market Research (TMR) has published a new report titled, “Breast Reconstruction Market – Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018–2026”. According to the report, the global breast reconstruction market was valued at US$ 893.7 Mn in 2017 and is projected to expand at a CAGR of 4.8% from 2018 to 2026. Rise in prevalence breast cancer, launch of new products by companies, and use of silicone breast implants and acellular dermal matrix for breast reconstruction are anticipated to augment the global market from 2018 to 2026.

Rise in Prevalence of Breast Cancer to Propel Market

Prevalence of breast cancer among women is increasing. After skin cancer, breast cancer has the highest prevalence among women across the globe. According to the World Cancer Research Fund International, nearly 2 million new cases of breast cancer were reported globally in 2018. Belgium, Luxembourg, and the Netherlands are the top three countries in Europe with the highest rate of breast cancer. According to data provided by the Continuous Update Project Panel of World Cancer Research Fund International, consumption of alcoholic drinks is one of the primary causes of premenopausal breast cancer.

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Launch of New Products by Players to Augment Market

Leading players in the global breast reconstruction market have launched new products such as silicone-filled breast implants, acellular dermal matrix, and tissue expanders. Usage of acellular dermal matrices in breast reconstruction has increased due to rise in awareness about single-stage breast reconstruction. For instance, in September 2018, Mentor Worldwide LLC launched CPX4 Smooth Breast Tissue Expander in the U.S., thereby expanding the line of CPX4 Breast tissue expanders that can be used in prepectoral and submuscular breast reconstruction.

Products Recalls by Regulatory Authorities to Restrain Market

Product recalls by regulatory authorities such as the Food and Drug Administration (FDA) and the National Agency for Medicines and Health Products Safety (ANSM) affect the revenue and market share of companies. In February 2014, ANSM recalled Cereform silicone gel-filled breast implants, as the sterilization process for the manufacture of the implant was not as per the set international standards. Additionally, in November 2014, the Therapeutic Goods Administration (TGA) suspended the sales of Cereform. Hence, product recalls are expected to restrain the market during the forecast period.

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Asia Pacific Market to Witness Strong Growth

In terms of revenue, the breast reconstruction market in Asia Pacific is projected to expand at a high CAGR during the forecast period. Factors driving the market in the region are increase in awareness about breast reconstruction after mastectomy and use of acellular dermal matrix to support breast implant. Furthermore, geographical expansion & launch of new products by market players, product approvals in Japan and China, and increase in the number of women opting for breast reconstruction propels the market in the region. According to the American Society of Plastic Surgeons, in 2017, Japan reported the largest number of breast procedures in Asia Pacific, accounting for 0.3% of the breast procedures performed globally. Moreover, rise in focus on women’s health and availability of technologically advanced medical devices for diagnostic and therapeutic purposes in countries such as China, India, and Australia are expected to boost demand for breast implants. This in turn is likely to augment the market in Asia Pacific during the forecast period.

Competitive Landscape in Breast Reconstruction Market

The report also provides profiles of leading players operating in the global breast reconstruction market. These include Allergan, Mentor Worldwide LLC (Johnson & Johnson), Sientra, Inc., GC Aesthetics, Establishment Labs S.A., POLYTECH Health & Aesthetics GmbH, RTI Surgical, Inc., Groupe Sebbin SAS, Integra LifeSciences, and Wanhe. Increase in sales of breast implants is an important factor for the key players in the market to generate high revenue. Development of customized breast implants and increase in research & development activities in biologics for breast reconstruction are anticipated to create significant opportunities in the market.

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[alicecpacheco]

NovoMatrixTM – the next generation soft-tissue augmentation material

When choosing a biomaterial, there is a strong demand in clinical practice for predictable outcomes. For over 20 years, LifeCellTM, an Allergan affiliate and leading global medical technology company, has developed innovative products for use in a wide range of applications. BioHorizons Camlog expands its soft-tissue portfolio in partnership with LifeCellTM to bring NovoMatrixTM, the next generation of soft-tissue augmentation material, into the European market. Full market release of this product will take place at the Oral Reconstruction Foundation Symposium in New York City in April 2020.  What is NovoMatrixTM? NovoMatrixTM is an acellular extracellular dermal matrix consisting of tissue-engineered porcine material. NovoMatrixTM is a breakthrough in xenogenic processing ensuring a structurally intact, undamaged scaffold that supports cell and microvascular ingrowth. The proprietary tissue processing allows for rapid revascularization, cell repopulation and minimal inflammation. NovoMatrixTM comes pre-hydrated and ready to use and offers a true alternative to autogenous soft-tissue grafts and current products on the market. Indications and clinical evidence The NovoMatrixTM indications include guided tissue regeneration procedures in recession defects for root coverage, localized gingival augmentation to increase keratinized tissue (KT) around teeth and alveolar ridge reconstruction for prosthetic treatment. Dr Edward Pat Allen, one of the pioneer users of NovoMatrixTM, says: “NovoMatrixTM graft exhibits uniform physical characteristics and great surgical handling, enhancing its ease of use in the tunnelling technique. This results in an excellent clinical outcome with minimal post-operative swelling and inflammation.” 

INSPIRING EXCELLENCE IN ORAL RECONSTRUCTION 

“NovoMatrixTM represents a significant addition to our soft-tissue product portfolio,” said Steve Boggan, President and CEO of BioHorizons. “We now offer our customers a differentiated alternative to connective tissue for applications such as root coverage and soft-tissue augmentation around implants and natural teeth.”  Osteology Highlights At this year’s Osteology Symposium, BioHorizons and Camlog will display their complete product line-up and will also be sponsoring a hands-on workshop on Thursday, May 25th on “Novel regenerative concepts using dermal matrices- from integration to regeneration” with Dr Edward P. Allen. In the afternoon of the same day, Dr Gerhard Iglhaut will discuss “Innovative treatment concepts on how to improve efficiency and regeneration” during the corporate forum. Furthermore, at booth #5 during coffee and lunch breaks, BioHorizons and Camlog’s team of experts invite clinicians to participate in interactive demonstrations featuring the PROGRESSIVE line implants, which was recently launched, as well as NovoMatrixTM, led by Dr. Edward P. Allen.  About BioHorizons and Camlog BioHorizons and Camlog are leading suppliers of premium dental implant systems, restorative components, a comprehensive line of biologics products and digital solutions. They are committed to developing evidence-based and scientifically proven products as well as offering continuous education according to highest standards. Headquartered in the U.S. and Europe, respectively, BioHorizons and Camlog’s geographic positions enable them to efficiently serve direct subsidiaries in the Americas and Western Europe as well as their entire distribution network in more than 90 countries around the world. Both companies are part of Henry Schein, Inc., a solutions company for health care professionals powered by a network of people and technology. With more than 18,000 Team Schein Members worldwide, Henry Schein’s network of trusted advisors provides over 1 million customers globally with more than 300 valued solutions improving operational success and clinical outcomes. The Company’s business, clinical, technology, and supply chain solutions help office-based dental and medical practitioners work more efficiently so they can provide quality care more effectively. These solutions also support dental laboratories, government and institutional health care clinics, as well as other alternate care sites. For more information, visit www.biohorizons.com, www.camlog.com and www.henryschein.com.

[cancersfakianakis1]

Prospective unbiased experience with three acellular dermal matrices in breast reconstruction

Background

The use of acellular dermal matrix (ADM) has become the standard of care in breast reconstruction. However, the majority of current studies are biased or combine large databases introducing inherent flaws. Here, we present a prospective single surgeon experience comparing three ADM.

Methods

All expander based breast reconstructions between 2014 and 2015 using ADM were included.

Results

Eighteen patients (32 breasts) underwent reconstruction using Flex Pliable, 15 patients (22 breasts) used Alloderm, and 14 patients (20 breasts) had Dermacell. There were no significant differences in patient demographics or comorbidities. All expanders were placed into a subpectoral position, and there were no direct to implant cases. Average intraoperative fill was comparable, (Flex: 225 cc, Alloderm: 180 cc, Dermacell: 130 cc). There were no differences in seroma, infection, or mastectomy skin flap necrosis rates. There were no cases of red breast, expander explanation or failed reconstruction in any cohort. Time to drain removal was significantly shorter in Flex and Dermacell patients compared to Alloderm (20 days vs 15 days vs 26 days, respectively; P = 0.01).

Conclusions

While there are differences between available ADM, successful outcomes can be achieved with proper patient selection, sound surgical technique, and diligent post-operative management.

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