sl-walker

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It’s not even funny how relatable this is.

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More Democrats need to be like Sen Brian Schatz [D-HI]. Stand up. Have courage.

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Listen. Listen, ducks:

No one owes you content catered to your particular interest.

No one owes you a discussion. If you want content that caters to your interests, take some fucking responsibility and make it your damn self. Want a conversation about something? Facilitate one. Engage with people, rather than waiting for other people to do it for you.

And if you don't like something, you know-- fucking grow up and scroll on.

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"READ MY DNI" no. use your block button like an adult. i'm not scrolling through the many-paragraphs-long pinned posts of every blog i reblog something from. if you insist certain types of people aren't welcome in the notes of your posts then it's your responsibility to curate that. or choose a closed social media platform like facebook or instagram. or go and live in a barn away from humanity if you really don't like sharing the world with people who are different from you

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How you can have an entire comic centered on any members of the JLI, referencing K³, and yet not a single person scratches their head and goes, "Wow, it feels like there's kind of a hole in the world--"

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"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the body’s own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosis—and in the process have won a prestigious prize.

Normally, the body’s immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.

Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.

They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.

“They have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,” says Olle Kämpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).

Neutralize B cells

In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.

Thanks to this year’s Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.

“This also paves the way for development of new forms of therapies that eventually can cure these diseases—or might prevent them in the future,” said one professor of clinical immunology at the Royal Swedish Academy of Sciences...

More details from the video, since the article glosses over the particulars:

"The laureates discovered what is now called B cell tolerance.

When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.

The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.

The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues – leading to autoimmune diseases.

Thanks to the laureate’s discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.

Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."

Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. That’s what I want, hope for, and believe in.""

-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.

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How you can have an entire comic centered on any members of the JLI, referencing K³, and yet not a single person scratches their head and goes, "Wow, it feels like there's kind of a hole in the world--"

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I think every computer user needs to read this because holy fucking shit this is fucking horrible.

So Windows has a new feature incoming called Recall where your computer will first, monitor everything you do with screenshots every couple of seconds and "process that" with an AI.

Hey, errrr, fuck no? This isn't merely because AI is really energy intensive to the point that it causes environmental damage. This is because it's basically surveilling what you are doing on your fucking desktop.

This AI is not going to be on your desktop, like all AI, it's going to be done on another server, "in the cloud" to be precise, so all those data and screenshot? They're going to go off to Microsoft. Microsoft are going to be monitoring what you do on your own computer.

Now of course Microsoft are going to be all "oooh, it's okay, we'll keep your data safe". They won't. Let me just remind you that evidence given over from Facebook has been used to prosecute a mother and daughter for an "illegal abortion", Microsoft will likely do the same.

And before someone goes "durrr, nuthin' to fear, nuthin to hide", let me remind you that you can be doing completely legal and righteous acts and still have the police on your arse. Are you an activist? Don't even need to be a hackivist, you can just be very vocal about something concerning and have the fucking police on your arse. They did this with environmental protesters in the UK. The culture war against transgender people looks likely to be heading in a direction wherein people looking for information on transgender people or help transitioning will be tracked down too. You have plenty to hide from the government, including your opinions and ideas.

Again, look into backing up your shit and switching to Linux Mint or Ubuntu to get away from Microsoft doing this shit.

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i love when fic writers who have clearly never tried any kind of alcohol in their lives try to write someone drinking bc they're always like

"he ordered a tall glass of hard liquor. after three large glasses he was feeling tipsy" like babygirl i can't be sure but i think u just sent this man to the hospital

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I MISS CROWLEY!!

This is a little old but yea.. I’m working on a pretty long animatic. So may be lacking in art briefly.

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Hello, friend SL Walker! I had previously found your "Second book of James" fanfic about Castiel and Jimmy Novak and really enjoyed it! I was scrolling through my bookmarks today and saw that it is part of an unrevealed collection and can no longer be accessed. Would there be a way that I could get a copy that I could download/keep for myself? I would love to be able to read it again! If not, I'll understand, and shall just be thankful I got to read it the first time. Thank you and all the best!

I've generally been willing to put stuff back up if it's actually being requested and isn't available somewhere else. So, since you asked: https://archiveofourown.org/series/137733

I loved that story, too. Wrote it in just a couple of months, if I remember right, I was so jazzed for it. Led to me RPing Cas for years, too. LOL!

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They're making what

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Yesterday was insane and today is shaping up to be likewise and by god, I hate waking up in the early morning. LOL! And Tuesday is my least favorite day of the week.

But sound off, those of you conscious: How are you? Do anything good and fun? Creative?

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as a huge lover of birds, 90% of the concern against wind turbines being used for energy is literally just pro fossil fuel propaganda. birds ARE at a risk however there is a lot of strategies even as simple as painting one of the blades that reduces a lot of accidental deaths. additionally renewable energy sources will do more in favor of the environment that would positively impact birds (and all of us). one study found over one million bird deaths from wind turbines. while that is a shockingly high number and we should work to drastically shrink it, at least 1.3 billion birds die to outdoor cats on a yearly basis. it was never about caring about birds