screaminjay

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Prof. John Mearsheimer PREDICTS the FATE of the US Empire in a Multipola...

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Untitled from screaminjay on Vimeo.

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Untitled from screaminjay on Vimeo.

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What do you think about Lianne?

https://go.tinder.com/WpgJTl25TEY-Lianne

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MACKLEMORE & RYAN LEWIS - THRIFT SHOP FEAT. WANZ (OFFICIAL VIDEO)

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MF Barb Run Diablo 2 Path of Diablo from screaminjay on Vimeo.

Here is a very barebone barb build to do a combo of decent clearspeed with decent MF. I know the crazy MF barb go... 4 socks skullder, 2 socks stealskull, 40 MF nagel, 6 ist GF. But I find this completely counter-productive.

I find it really just starts to ramp up at 100, then at 200 you start seeing a lot and 300 is about the top I'd aim for if it doesn't hurt clear speed. Usually, I'm happy if one slot does most of the MF, like 4 os tal armor or 6 os weapon with ists.

This video is also a demonstration of why people keep saying (myself included) that Enigma is the barb armor of choice, especially for solo. You notice clearly what it does there. You have your barb merc, he have lawbringer (obviously), you see those blunderbore dudes (70% resistant to phys damage), you teleport on them and hope it proc decrep. Then they go down easy, because you just do near 3x damage (70% resistant down to 20, 80% damage instead of 30%).

When I record those, I get lag from the program running, so it is scuffed a bit. But I did route pretty nicely toward t1 boss.

No special drop this time, but I get the most drops per hour I think doing this quick t1+t2 routine to up some t3s.

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Bandicam 2019-05-26 13-03-42-384-1 from screaminjay on Vimeo.

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Bandicam 2019-05-23 15-14-35-481-1 from screaminjay on Vimeo.

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Raven Druid Diablo 2 POD Path of Diablo from screaminjay on Vimeo.

My endgame raven/hurricane druid:

Not the best build around, but wanted to push it in a sensible way to best outcome. Enigma is sort of nice for running t4 maps and tried different setup that were less than ideal. The goal is to sustain 163% FCR, which I do with 2x 20% FCR rings and FCR ammy. I have a 20% FCR +2 summon skills ammy that I could use with vipermagi and doom for optimal pierce cold of hurricane. But the cold mastery switch does some piercing of its own.

I should have thawing potions in belt, but meh. That multishot dude in the middle hit like a brick and made me drink a rarely used rejuv.

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large flock of geese, very far away

flying formation: in the shape of a penis tip

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Tony Hawk is a real one lol

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Scientists produce strongest evidence yet of schizophrenia’s causes

An international team of scientists led by Cardiff researchers has provided the strongest evidence yet of what causes schizophrenia - a condition that affects around 1% of the global population.

Published in the journal Neuron, their work presents strong evidence that disruption of a delicate chemical balance in the brain is heavily implicated in the disorder.

In the largest ever study of its kind, the team found that disease-linked mutations disrupt specific sets of genes contributing to excitatory and inhibitory signalling, the balance of which plays a crucial role in healthy brain development and function.

The breakthrough builds on two landmark studies led by members of the Cardiff team, published last year in the journal Nature.

“We’re finally starting to understand what goes wrong in schizophrenia,” says lead author Dr Andrew Pocklington from the University’s MRC Centre for Neuropsychiatric Genetics and Genomics.

“Our study marks a significant step towards understanding the biology underpinning schizophrenia, which is an incredibly complex condition and has up until very recently kept scientists largely mystified as to its origins.

“We now have what we hope is a pretty sizeable piece of the jigsaw puzzle that will help us develop a coherent model of the disease, while helping us to rule out some of the alternatives.

"A reliable model of disease is urgently needed to direct future efforts in developing new treatments, which haven’t really improved a great deal since the 1970s.”

Professor Hugh Perry, who chairs the Medical Research Council Neuroscience and Mental Health Board said: “This work builds on our understanding of the genetic causes of schizophrenia - unravelling how a combination of genetic faults can disrupt the chemical balance of the brain.

"Scientists in the UK, as part of an international consortium, are uncovering the genetic causes of a range of mental health issues, such as schizophrenia.

"In the future, this work could lead to new ways of predicting an individual’s risk of developing schizophrenia and form the basis of new targeted treatments that are based on an individual’s genetic makeup.”

A healthy brain is able to function properly thanks to a precise balance between chemical signals that excite and inhibit nerve cell activity. Researchers studying psychiatric disorders have previously suspected that disruption of this balance contributes to schizophrenia.

The first evidence that schizophrenia mutations interfere with excitatory signalling was uncovered in 2011 by the same team, based at the University’s MRC Centre for Neuropsychiatric Genetics and Genomics.

This paper not only confirms their previous findings, but also provides the first strong genetic evidence that disruption of inhibitory signalling contributes to the disorder.

To reach their conclusions scientists compared the genetic data of 11,355 patients with schizophrenia against a control group of 16,416 people without the condition.

They looked for types of mutation known as copy number variants (CNVs), mutations in which large stretches of DNA are either deleted or duplicated.

Comparing the CNVs found in people with schizophrenia to those found in unaffected people, the team was able to show that the mutations in individuals with the disorder tended to disrupt genes involved in specific aspects of brain function.

The disease-causing effects of CNVs are also suspected to be involved in other neurodevelopmental disorders such as intellectual disability, Autism Spectrum Disorder and ADHD.

Around 635,000 people in the UK will at some stage in their lives be affected by schizophrenia. The estimated cost of schizophrenia and psychosis to society is around £11.8 billion a year.

The symptoms of schizophrenia can be extremely disruptive, and have a large impact on a person’s ability to carry out everyday tasks, such as going to work, maintaining relationships and caring for themselves or others.