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Coursera Stats Course - Weslyan
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orthostatsblog · 7 years ago
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Assignment 1
I have decided that I will use my own dataset from my own research in functional clinical outcomes after knee surgery. I am particularly interested in preoperative factors associated with depression or anxiety. I am not sure which variables I will use, so for now I will include all of the relevant variables in my personal codebook.
Research question: what is the relationship between a self-reported diagnosis of depression or anxiety and Patient-Reported Outcomes Measurement Information System (PROMIS) domains?
Hypothesis: Patients with depression or anxiety would have worse preoperative pain, function, and general health status.
Literature review: 
The Patient-Reported Outcomes Measurement Information System (PROMIS) domains have been created by the National Institutes of Health (NIH) to provide an assessment of patient-reported outcomes that is cost effective, time effective, and generalizable over a wide variety of clinical patients. However, the data collected through PROMIS in orthopedic patients is currently limited to foot, ankle, upper extremity, and spine injuries, with a lack of data regarding the use of PROMIS for patients undergoing knee surgery.
Collected data includes patient-reported demographics, treatment expectations, 6 PROMIS domains (Physical Function, Pain Interference, Fatigue, Social Satisfaction, Anxiety, Depression), Tegner Activity Scale, Marx Knee Activity Rating Scale (ARS), Visual Analog Scale (VAS) for pain, International Physical Activity ratings (IPAQ), International Knee Documentation Committee (IKDC) Subjective Knee Evaluation form, as well as information extracted from medical record. 
References
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Thirty-day postoperative complications and mortality following total knee arthroplasty: incidence and risk factors among a national sample of 15,321 patients. J Bone Joint Surg Am 2014;96:20-6. 8. Alattas SA, Smith T, Bhatti M, Wilson-Nunn D, Donell S. Greater pre-operative anxiety, pain and poorer function predict a worse outcome of a total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc 2016. 9. Ali A, Lindstrand A, Sundberg M, Flivik G. Preoperative Anxiety and Depression Correlate With Dissatisfaction After Total Knee Arthroplasty: A Prospective Longitudinal Cohort Study of 186 Patients, With 4-Year Follow-Up. J Arthroplasty 2017;32:767-70. 10. Browne JA, Sandberg BF, D'Apuzzo MR, Novicoff WM. Depression is associated with early postoperative outcomes following total joint arthroplasty: a nationwide database study. J Arthroplasty 2014;29:481-3. 11. Cho CH, Seo HJ, Bae KC, Lee KJ, Hwang I, Warner JJ. The impact of depression and anxiety on self-assessed pain, disability, and quality of life in patients scheduled for rotator cuff repair. J Shoulder Elbow Surg 2013;22:1160-6. 12. Duivenvoorden T, Vissers MM, Verhaar JA, et al. Anxiety and depressive symptoms before and after total hip and knee arthroplasty: a prospective multicentre study. Osteoarthritis Cartilage 2013;21:1834-40. 13. Mollon B, Mahure SA, Ding DY, Zuckerman JD, Kwon YW. The influence of a history of clinical depression on peri-operative outcomes in elective total shoulder arthroplasty: a ten-year national analysis. Bone Joint J 2016;98-B:818-24. 14. Stundner O, Kirksey M, Chiu YL, et al. Demographics and perioperative outcome in patients with depression and anxiety undergoing total joint arthroplasty: a population-based study. Psychosomatics 2013;54:149-57. 15. Werner BC, Wong AC, Chang B, et al. Depression and Patient-Reported Outcomes Following Total Shoulder Arthroplasty. J Bone Joint Surg Am 2017;99:688-95. 16. Wu HH, Liu M, Dines JS, Kelly JD, Garcia GH. Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction. World J Orthop 2016;7:709-17. 17. Kessler RC, Petukhova M, Sampson NA, Zaslavsky AM, Wittchen HU. Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. Int J Methods Psychiatr Res 2012;21:169-84. 18. Driban JB, Morgan N, Price LL, Cook KF, Wang C. Patient-Reported Outcomes Measurement Information System (PROMIS) instruments among individuals with symptomatic knee osteoarthritis: a cross-sectional study of floor/ceiling effects and construct validity. BMC Musculoskelet Disord 2015;16:253. 19. Cella D, Yount S, Rothrock N, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years. Med Care 2007;45:S3-S11. 20. Cella D, Riley W, Stone A, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008. J Clin Epidemiol 2010;63:1179-94. 21. Beckmann JT, Hung M, Voss MW, Crum AB, Bounsanga J, Tyser AR. Evaluation of the Patient-Reported Outcomes Measurement Information System Upper Extremity Computer Adaptive Test. J Hand Surg Am 2016;41:739-44 e4. 22. Brodke DJ, Saltzman CL, Brodke DS. PROMIS for Orthopaedic Outcomes Measurement. J Am Acad Orthop Surg 2016;24:744-9. 23. Ho B, Houck JR, Flemister AS, et al. Preoperative PROMIS Scores Predict Postoperative Success in Foot and Ankle Patients. Foot Ankle Int 2016;37:911-8. 24. Riddle DL, Wade JB, Jiranek WA. Major depression, generalized anxiety disorder, and panic disorder in patients scheduled for knee arthroplasty. J Arthroplasty 2010;25:581-8. 25. Wood TJ, Thornley P, Petruccelli D, Kabali C, Winemaker M, de Beer J. Preoperative Predictors of Pain Catastrophizing, Anxiety, and Depression in Patients Undergoing Total Joint Arthroplasty. J Arthroplasty 2016;31:2750-6. 26. Stordal E, Mykletun A, Dahl AA. The association between age and depression in the general population: a multivariate examination. Acta Psychiatr Scand 2003;107:132-41.
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