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Mental Illness, Genetics, MTHFR and The Domino Effect

Mental Illness, Genetics and MTHFR – Methylenetetrahydrofolate Reductase (MTHFR), it’s a code word, suddenly talked about and the question everyone is asking is does this silly gene and a possible defect really matter? Let me assure you, MTHFR is the new curse word in medicine, because often providers don’t understand its impact and patients are lost with little information about where to seek expertise in how to treat misleading, confusing and detrimental issues related to the gene.

The basics of understanding MTHFR is understanding that variances in this gene cause difficulty in the process of chemical reaction involving forms of the vitamin folate (also called B9). The lack of the normal mechanism of this chemical reaction taking place impacts multiple process in the body, from a role in processing amino acids, making proteins, compounds, hormones, and the trickling of this leads to a domino like catastrophe. In a cascade of problems, the most detrimental is when this impacts the brain, the way people think, act, and function. In a society where we are diagnosing innumerous mental illness like: ADHD, Autism, learning differences, worsening dementias and Alzheimer’s and Parkinson’s earlier than ever. Questions regarding a root cause of mental illness and strategic plans for individual wellness must be formulated and executed to promote healing and decrease greater mental decline. Fixing a sequela of events is time consuming, requires health providers and patients to adhere to healing treatment plans and requirements to replenish and decrease further depletion the body. Unfortunately, by the time many are diagnosed with this genetic issue, they have further depleted the body with medications, and their mentation has declined where they need extra help for essential healing.

In practice, school, and seminars for medical professionals there are multiple familial links with specific diseases that affect the brain. Commonly, it is asked and thought the diseases are “passed down” from mothers, fathers, grandparents, even aunts and uncles. As the study of the genome progresses, this is not entirely ludicrous in thought but instead of looking at fixing a gene disruption often patients are receiving the same medications and treatments as their relatives. What if instead of prescribing the medication that a relative took or takes, instead we look at optimizing the gene process and bypassing the defect?

Understanding that the inability to process folate, the resulting abundance of homocysteine and the lack of methionine, resulting deficiencies in S-adenosylmethionine (SAMe), then leading to deficiencies of monoamine neurotransmitters may add some clarity to ways to treat many of the neurological disorders that are identified today. The answer may not be the medications that we are readily prescribed, but instead protocol in practice should start leaning toward the deficiencies that can cause these “brain” diseases and altered ways of processing and responding to information.

Basic understanding of the cellular processes that occur in the body show how MTHFR can affect almost every process in the body. An article could be written for numerous disease modalities that can be treated nutritionally as MTHFR impacts so many different areas of the body. The gene dysfunction can be easily bypassed but it takes an acute provider to realize this may be the cause of the allusive symptoms and mental illness. The cycle of dysfunction can create normal functioning mitochondria that repair tissues and promote brain healing as well as healing the havoc of other systems impacted by this gene. From basic cellular biology, most people remember the powerhouse of the cell responsible for cellular energy, detoxification and promoting many processes within the cell. Yes, the mitochondria promote energy and optimal function of the cell. When cells go awry, the mitochondria fail to clean out the pollutants, cause slow processing and delivery of cell output and then cellular function demise causes dysfunction, and cellular disease. Groups of these diseases and defective cells result in tissue dysfunction, then organ dysfunction and whole body dysfunction as understood chemical processes are skewed further and further with resulting demise. This specifically effects the brain as slow neurons (brain cells) receive deficiencies in cellular membranes and what is allowed to cross barriers into the cells, barriers into the brain, with resulting increases in toxicity and decreases of optimal neurotransmitters, hormones, and natural processes of individual cells which then results in suboptimal firing, thought process, functioning and eventually mental illness like dementia.

The following diagram explains much of chemical processes involved and specifically shows the break in the chemical cycles that impact how the brain processes. The complex nature and understanding of these cycles, the individual impacts on all places L-methyl folate impacts helps to see that MTHFR is a building block, for chemical processes, decreased inflammation at the cellular level, but genetic changes related to methylation specifically impact from a basic chemical and cellular level to an abundant brain change impacting neurotransmitters and overall functioning.

This image describes multiple processes, dominoes that affect the brain. Although the chemical processes are rather complex, the breaks in the connected cycles show the sequela of devastation related to the specific gene. Methylated folate in Red shows the disruptions that it may be able to fix, especially for specific genes. The image also indicates that if there are other breaks related to the process of the cellular uptake or conversion of folic acid such as an upregulation this can also impact brain function. Multiple psychologists, understanding this process are beginning treatments in new ways for these specific disorders. The new era of understanding the genome, its effect on processes like above give great hope to the psychological disorders, dysfunctions and the literature showing the increases in disorders related to nutritional issues having to do with folate.

This new era in medicine is going to create a functional approach to health. MTHFR is one of the genetic markers that is paving the way of greater integration of illness, health, and helping to even understand more about the way individuals think and act. The brain, neurotransmitter regulation, understanding the impact within families, and hereditary groups fascinates and indicates the needs for greater research in the areas of genetic markers that might be impacting individuals. The diagram indicates an area to fix in the broken chain of methylation, and gives hope to repair of cells, tissues, and persons suffering from folate deficiency related to their gene processing. The brain, psychiatric disorders, disorders and illnesses of the body can be studied in relation to hereditary, nutritional, and cellular dysfunction and what markers are predisposing illness. The more we understand about the markers of MTHFR, the more we can help the population suffering from mental illness that are not cured but often masked, and supplements can be used to fix the problems faced for those with this genetic marker.

You may order a home test kit for MTHFR here. For more information about MTHFR test, visit our website https://www.mthfrdoctors.com

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Folic Acid – Why You Should Avoid it With an MTHFR Mutation

Consult your doctor before making any changes in your dietary intake related to folic acid. This article is for informational purposes only and not a substitute for medical advice.

Nowadays, many people have issues such as fatigue, irritability, brain fog, anxiety, insomnia and other aches and pains without an apparent cause. Some might think that genetic disorders are the obvious cause. There are many minor genetic differences that influence the way we look and can cause many health problems.

MTHFR stands for methylenetetrahydrofolate reductase. MTHFR is the enzyme that activates folic acid by adding a methyl group to it. MTHFR physicians say that if you have an MTHFR gene mutation then you should stop consuming folic acid and replace it with its active form, Methylfolate. Our bodies can’t process excess folic-acid and it is stored as toxins in our organs and tissues. MTHFR practitioners say that the human body needs to convert folic acid into a form of folate that the body can use. The human body, without the MTHFR enzyme, can’t convert folic acid into methylfolate and it builds up in the body as endogenous toxins. As a part of MTHFR gene mutation treatment, you should avoid consuming folic acid or the products that contain it and replace it with methylfolate. Do so only under the guidance of an MTHFR physician.

MTHFR doctors warn people with low activity of MTHFR enzyme that may it cause elevated homocysteine levels. Homocysteine is an amino acid that could be inflammatory. Homocysteine is directly related to cardiovascular disease.

Treatment for MTHFR includes avoiding sources of non-metabolized folic acid which may cause other health problems that might not develop for years. Replace folic acid with methylfolate. An increase in the level of folic acid may also decrease natural killer cell cytotoxicity and weaken the body from fighting arthritis, cancer and anti-malarial drugs.

In older people who have B12 deficiencies, folic acid can cause cognitive impairment and anemia but methylfolate will not. Folic acid has the capacity to fight against many cancers but it can also accelerate the growth of tumors that are already present in the body that is suffering from MTHFR deficiency. The degree to which the body doesn’t activate folic acid to methylfolate increases your susceptibility to allergic responses and can also cause blood clots, strokes, anxiety, depression, high blood pressure, migraines and more.

Many thyroid issues have been associated with having an MTHFR mutation problem as thyroid hormones must be activated within the nucleous of each cell and it depends on methylation for this activiation. As part of a treatment for MTHFR gene mutation, women with a positive MTHFR status should consult an MTHFR doctor during pregnancy. MTHFR practitioners and also encourage pregnant women to check their MTHFR mutations and suggest that they consume appropriate levels of methylfolate instead of folic acid.

Without knowing the genetics and exposure to toxins, it is better to follow the advice of MTHFR physicians and start the intake of activated folate instead of folic-acid. As a part of treatment for MTHFR, you should consume plenty of organic green leafy vegetables as they contain good quantity of folates. Eat more broccoli and spinach, and always shop organic. MTHFR gene mutation treatment also includes checking B complex and multi-vitamins to make sure the label says methylfolate and not folic acid.

For the naysayers who think this is all rubbish look at the prescribed drug for folic acid deficiency, Deplin’s active ingredient is L-Methylfolate and not folic-acid. The scientists know this is true so when supplement companies use folic acid it is because it is cheaper, not better.

MTHFR gene mutation treatment can help those with MTHFR mutation to reduce their risk of health problems. Find out if you have a mutation by ordering a home test kit now. For more details visit our website https://www.mthfrdoctors.com

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Find Doctors Who Treat MTHFR Symptoms at MTHFRdoctors.com

MTHFR is an enzyme that adds a methyl group to folic acid to make it usable by the body. The MTHFR gene produces this enzyme that is necessary for properly using vitamin B9. This enzyme is also important for converting homocysteine into methionine, which the body needs for proper metabolism and muscle growth and which is needed for glutathione creation. The process of methylation also involves the enzyme from the MTHFR gene, so those with a mutation may have trouble effectively eliminating toxins from the body. 

Now for MTHFR Mutation you can find a Practitioner, MTHFR Doctors who treats MTHFR at MTHFRdoctors.com. MTHFR is a very important gene and its mutations may affect your health in many different ways. MTHFRdoctors.com experts have gathered a list of 10 important steps to help you learn what to do. 

MTHFRdoctors.com offers to find MTHFR doctors, search for MTHFR practitioners who offer treatment for MTHFR mutation, MTHFR gene mutation treatment, MTHFR cancer treatment. The MTHFR practitioners offer help syndrome genetic, MTHFR epigenetics, MTHFR DNA and more. 

The MTHFR gene test provides instructions for making an enzyme called methylenetetrahydrofolate reductase. This enzyme plays a role in processing amino acids, the building blocks of proteins. Methylenetetrahydrofolate reductase is important for a chemical reaction involving forms of the vitamin folate. Precisely, this enzyme transforms a molecule called 5, 10-methylenetetrahydrofolate to a molecule called 5-methyltetrahydrofolate. This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds. 

Individuals with a MTHFR gene mutation and MTHFR Symptoms have a highly reduced ability to convert folic acid or even folate into a usable form. There are many variations of the mutation, depending on how the gene was passed down from the parents. Individuals with low activity of the MTHFR enzyme may present with elevated homocysteine levels, which have been associated with inflammation and heart disease, birth defects, difficult pregnancies, and potentially an impaired ability to detoxify. 

About MTHFRdoctors.com: As a leading online resource for everything related to MTHFR, MTHFRdoctors.com you will find Doctors, physicians and practitioners that are trained in treatments for MTHFR, Methylation Genetics, DNA, MTHFR test, COMT test and Genetic health reports. You can find information related to MTHFR Gene Mutation, Test Kits, Treatments and Health Tips at https://www.mthfrdoctors.com