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Musicals are time loops. Every night, the same thing happens except for a few minor differences. It always ends the same. If you want the characters to do something different or to make better choices, too bad. The actors are bound by the script and the score. The only way for the time loop to end is for the show to close. But you (the audience) don't want the show to close, nor do the actors who would like to be employed. It's a lose/lose situation. For the actors, audience, technicians, and for the characters, who are forever stuck in the same stretch of time.

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Inspired by this photo that I laughed at for like ten minutes.

[d|p] [More: Comics | PKMN] (I am so sorry for assaulting your dashboard with this).

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Since you're 16 hours ahead, what are the US election results?

Jeb!

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So my latest obsession is apparently the official twitter for the US Consumer Product Safety Commission, which is about half recall announcements for various shitty amazon products and half…..memes? pseudo-memes?? works of surrealist art??? what do i even call these

Whoever made these is either a random middle-aged government worker who’s spent enough time with Young Internet People to be at least 60% sure what a meme is or a Gen Z artistic genius and i can’t decide which

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A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

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A centaur, but the man part is a kangaroo and the horse part is a giraffe.

nightmare idea

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she’s not loving this whole daylight savings thing

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The guy who killed Bin Laden is a dom top!

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now personally I’d rethink this phrasing

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@mishacollins

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Is transitioning from male to female to become a butch lesbian a reasonable option?

it is beyond reasonable, it is one of the coolest things you can do on this bitch of an earth

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me: wow I wish animals from the triassic period were still around, that’d be so cool

the enduring nautilus:

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A lirtle wangxian wip cause I've been rewatching The Untamed <3

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Hey, here is some new frustrating discourse.

I'm going to clear this up super duper quick.

And then we can move on and discuss more important things.

Okay?

Here goes...

Nicolas Cage is an incredible actor who is very bad with money so he has to act in terrible movies because otherwise they will repossess his dinosaur skull collection.

But even when he is in terrible movies with terrible writing he refuses to phone in his performances. And sometimes when you are acting your ass off while saying some of the dumbest dialogue ever conceived it can give the appearance the acting is the issue rather than the writing and story.

Hayden Christensen knows that feeling all too well.

So next time you see Nic Cage in a B movie acting a fool, just know he probably bought some new shrunken heads and forgot to pay the mortgage on his volcano island.

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bender