drdopamine

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Their friendship means it all to me

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Wicked is a musical based on a book based on a musical based on a movie based on a book.

THE WORLD’S MOST SUCCESSFUL FANFICTION

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holy shit

i knew teslas were bad but "literally twice as deadly as the average vehicle" is something else

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We need less power-couples and more fail-couples. A pair that individually are disasters but together make everything even worse. Not in a toxic sense, they are just both so lacking in common sense that being together creates a shenanigans feedback-loop. They will become everyone's problem.

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Andrew Garfield talks to Elmo about grief and the passing of his mother

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Left-right coding of past and future in language from the journal Cognition in 2010. (behind a paywall)

ok well this blew my mind

This is also true with filmmakers. Western filmmakers pan their cameras mostly left to right and Iranian filmmakers do right to left.

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A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

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Me, fighting a yoga mom in the organic food market circa 2023: take your hand off that peach or I’ll vaccinate your children against polio

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I think it's a common misconception that domesticating animals is somewhat like enslaving them. It really is more of a symbiotic relationship. No wild animal would have willingly put up with early humans if they didn't get something out of it. Wolves wouldn't have stayed with us and become dogs if they weren't getting food and safety out of it. Many large herbivores that are now domesticated could and would have easily trampled their early human captors or broken their enclosures open if they didn't have a reason to stay. Sometimes individual animals still do if we don't give them what they need.

The animals that have stayed with us for thousands of years have evolved to cooperate with us better. Dogs have additional facial muscles around their eyes that wolves lack in order to mimic human facial expressions. Sheep grow their wool perpetually while their wild counterparts don't because a bigger fleece means they're more likely to be allowed to breed and be kept around. Domestic dairy cows produce much more milk than wild bovine species and domestic hens lay more eggs. Do you know how energy costly producing eggs or milk is for an animal? It's pretty intense! They wouldn't be able to do that if we hadn't given them the food and safety from predators and the elements to.

And we really need to show these animals respect and gratitude for what they give us by taking excellent care of them. They gave up a lot to be with us, often including the means to take care of themselves in the wild. That's a huge reason why I'm not against using animal products, but I hate factory farming. They are still living, breathing creatures with needs and feelings. They deserve a comfortable life and, when the time comes, a humane death.

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Apparently this tiktok was deleted hours after I saved it.

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If you're having casual sex with your friend(s) please continue being their friend and communicating and maybe even do that stuff a little more, make it a deeper friendship. Y'all are fucking after all, it's both of you being vulnerable on another level with each other and you owe it to one another to be more supportive and emotionally open with them when you do that. Don't let yourselves feel like you're being used or neglected. Be aware of how your actions and words may impact them and vice versa. Fwb is FRIENDS WITH benenfits, the friendship part is key. Otherwise it's just sex. You're allowed to love your friends and have deep loving connections while also fucking and not be in a relationship or situationship. Just communicate and love each other

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Body image vs. anti fatness

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I genuinely believe that some people could encounter a button that says “if you push this button everyone in the world has the opportunity to live a better life and your life remains exactly the same” and they would not push it.

They’d be like “well that button’s not fair to me, though,” even though there’s literally no other buttons around and nothing newly bad would happen to them if the button was pushed.

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This is an incredible story.

A man assassinates a former prime minister and gives his demands to the government who turn around and go “Actually yeah, these are quite a good ideas.”

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so many snow animals are just white puff with dot eyes. amazing design