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Another step in personalize medicine.
In Small Packages
Immune cells patrol our bodies looking for threats, but sometimes medical therapies are wrongly identified as the enemy. These capsules made from jelly-like hydrogel are designed to carry drugs or transplanted cells deep into damaged organs. They’ve been attacked – mobbed by immune cells (dyed green here, with blue nuclei) and overgrown with fibrosis (red). As well as being painful for patients, fibrosis (or scar tissue) can prevent these devices from releasing their cargo effectively. To elude the immune defences, crafty researchers ignored the logic of spy films. Making the devices bigger, not smaller – increasing from half a millimetre up to two millimetres in diameter – prevented their detection. Investigating how and why the immune system reacts to differently-sized capsules could have huge implications – drug delivery that is more ‘biocompatible’ may be a simple matter of making these tiny devices just a little bit bigger.
Written by John Ankers
Image from work by Omid Veiseh and colleagues
Koch Institute at MIT, USA
Copyright held by original authors
Research published in Nature Materials, May 2015
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“When you come to a fork in the road, take it”- Yogi Berra. RIP to one greatest Yankees ever. #yankees #yogiberra #ripyogiberra #greatestcatcherever
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"When you come to a fork in the road, take it"- Yogi Berra. RIP to one greatest Yankees ever. #yankees #yogiberra #ripyogiberra #greatestcatcherever
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Laura at the color bar-- a true artist. #jamesanthonysalon #chicago #oakpark #beststylistever (at James Anthony Salon)
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Researchers Trigger ‘Virus Alert’ to Thwart Cancer Cells
Working with human cancer cells and mice, researchers found that the drug 5-azacytidine can help boost the immune system’s fight against cancer by first activating viral genes hidden in the cells’ genome. This starts a chain reaction that leads tumor cells to release signals that rouse cancer-fighting immune cells.
Image Courtesy of National Institutes of Health.
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