bitchardhendricks

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so. bad news. we have to keep going tomorrow. good news is that I’ll keep going with you

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A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).

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I feel like Danielle is really hitting her stride with Sam this season. Like, it must be difficult to feel the same level of comfort as Aabria, Lou, Erika, and Brennan because those 4 play together all the time. But it seems like she's really letting herself/Sam be vulnerable (b/c let's be real, in an actual play it's both yours & your character's) and saying some of the most beautiful things.

I've always loved Sam & Danielle and it's really wonderful seeing them both shine this season.

*also shoutout for the Black women in wigs rep 🫶🏾 You love to see it!

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#The destiel confession scene but it's just text posts from this day because I still can't believe this was real

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I don't know who needs to hear this, but it has been a central Republican strategy in the final week before an election to claim that the polls are breaking their way, that a red wave is coming, that Republicans are engaging in victory tours at least since the presidential election of 2000. (That's when I stopped watching CNN regularly, as the network promoted this line despite the fact that Gore would go on to win the popular vote.)

Given that Republicans have, in fact, only won the popular vote once in this period (2004), this is a strategy, not a statement of fact.

Don't sweat the narrative. Vote. Turnout wins, not news stories.

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Dutch artist, Redmer Hoekstra.

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I am obsessed with fictional guys being really weird about each other. Hard at work in the plausible deniability mines. You know those pairings who would jerk each other off before they'd kiss

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I feel normal about this

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Janey Godley unfortunately passed away this morning from cancer. She’s known online for a variety of things, but protesting Trump’s visit to his Scottish golf course with this sign is probably the most important one.

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My fiancee and I were discussing the worst metal to use to make armor, and the obvious answers are lead and gold, but she cunningly suggested mercury. Which is a fair point, but then I wondered if solid mercury is any good. Googling told me that the melting point of mercury is -38° c (-37° f), so first you get it really fucking cold. At that point, it turns out that mercury has a tensile strength of 1900 mpa, compared to lead’s 18 and steel’s ~500-940 (depending upon the kind of steel).

Now, I know that tensile strength is not necessarily the best measure of a material’s ability to function as armor, but I’m a liberal arts major and didn’t care to actually do that much more research before going straight to, “EVIL ICE DEMONS IN MERCURY ARMOR. THE PCS CAN’T LOOT IT BECAUSE WHEN THEY PUT IT ON IT MELTS AND KILLS THEM.”

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You know...I've been thinking...and like...

If Sam turned evil...

No, listen, obviously it would never happen, but like hypothetically, if Sam turned evil...

...The group has simply no recourse for that, I feel. Like, if Jammer, K, or Evan turned evil, someone (if not everyone) else would immediately be like "Hey, stop, this isn't you."

But if Sam turned evil, I feel like they would just be like, "I guess we're evil now." Like, she could play it so well; she would still be smiling and persuasive and caring, and I for one would support her so hard, and I think everyone else would, too. 🤣

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A friendly reminder to USians: if you are planning to vote on Election Day, your mantra is "Nothing I see today convinces me not to go vote."

Exit polls suggest DT cannot be caught? YOU STILL GO VOTE.

Exit polls suggest KH has it in the bag? YOU STILL GO VOTE.

Pundits are saying the country is swinging overwhelmingly red? YOU STILL GO VOTE.

Pundits are saying the country is swinging overwhelmingly blue? YOU STILL GO VOTE.

Polls can be misleading (intentionally or not). The methodology can be biased (or simply poor). Early results may not reflect what the full count will show. There may be a red mirage. NOTHING YOU SEE CONVINCES YOU NOT TO VOTE.

The biggest Democratic win in swing states means nothing if democrats don't turn out everywhere to keep the reliably blue states blue.

VOTE. Wear appropriate weather gear if you think you may have to stand in a line outside (coat, hat, gloves, umbrella, sunhat, whatever, you know where you live). Bring water and a snack and something to do (book, game on your phone, podcast and headphones, whatever, you know what you like). GO VOTE.

NOTHING YOU SEE ON ELECTION DAY CONVINCES YOU NOT TO VOTE.

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yesterday's halloween piece