bitchardhendricks

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[bitchardhendricks]

buffy the vampire slayer's commitment to acab is kind of beautiful actually. in seven seasons and 144 episodes, not once was a cop in any way useful or good at their job. at best cops are a nuisance and at worst they're actively trying to kill buffy and friends. you've really got to admire the thematic consistency.

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i betcha carlos luna was having a fucking BLAST being tabby. which, good for him. he deserves it.

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You are angry about something. “Clam down,” I text you. You assume I have made a typo, but in fact I am holding a small soldier clam in my hands. He died so young. War is hell

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Move past it.

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very big fan of when shows put wigs on actors and say ‘yeah. That’s him when he was younger fuck you’. No anti aging ai, no teen actor hired. Just. The same guy with a fuckass wig

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First time posting art to tumblr…. Kinda nervous ☺️😊

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vehicular manslaughter chappell roan be like you can hit a hundred boys with cars

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She haunts me in the best way possible

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BRENNAN LEE MULLIGAN Make Some Noise - S02E03 Shakespeare's 'Two Gentlemen of Coronavirus'

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idk if this is a boomer take but I think ppl should make more of an effort to go see movies in theaters bc I couldn’t bear it if the movie theater industry went down and the only way to watch movies was through streaming I’m not strong enough

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and with your help it can rack up 700k notes on tumblr in 2024

no tumblr this doesnt need tags im releasing it into the wild as god intended

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Tell me a soft memory

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hope is a skill

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so. bad news. we have to keep going tomorrow. good news is that I’ll keep going with you

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A new treatment combining ReCET and semaglutide could eliminate the need for insulin in type 2 diabetes, with 86% of participants in a study no longer requiring insulin therapy. The treatment was safe and well-tolerated, and further trials are planned to confirm these results.

Groundbreaking research presented at UEG Week 2024 introduces a promising new treatment approach for type 2 diabetes (T2D) that has the potential to greatly reduce or even eliminate the need for insulin therapy.

This innovative approach, which combines a novel procedure known as ReCET (Re-Cellularization via Electroporation Therapy) with semaglutide, resulted in the elimination of insulin therapy for 86% of patients.

Globally, T2D affects 422 million people... While insulin therapy is commonly used to manage blood sugar levels in T2D patients, it can result in side effects... and further complicate diabetes management. [Note: Also very importantly it's fucking bankrupting people who need it!!] A need therefore exists for alternative treatment strategies.

Study Design and Outcomes

The first-in-human study included 14 participants aged 28 to 75 years, with body mass indices ranging from 24 to 40 kg/m². Each participant underwent the ReCET procedure under deep sedation, a treatment intended to improve the body’s sensitivity to its own insulin. Following the procedure, participants adhered to a two-week isocaloric liquid diet, after which semaglutide was gradually titrated up to 1mg/week.

Remarkably, at the 6- and 12-month follow-up, 86% of participants (12 out of 14) no longer required insulin therapy, and this success continued through the 24-month follow-up. In these cases, all patients maintained glycaemic control, with HbA1c levels remaining below 7.5%.

Tolerability and Safety

The maximum dose of semaglutide was well-tolerated by 93% of participants, one individual could not increase to the maximum dose due to nausea. All patients successfully completed the ReCET procedure, and no serious adverse effects were reported.

Dr Celine Busch, lead author of the study, commented, “These findings are very encouraging, suggesting that ReCET is a safe and feasible procedure that, when combined with semaglutide, can effectively eliminate the need for insulin therapy.”

“Unlike drug therapy, which requires daily medication adherence, ReCET is compliance-free [meaning: you don't have to take it every day], addressing the critical issue of ongoing patient adherence in the management of T2D. In addition, the treatment is disease-modifying: it improves the patient’s sensitivity to their own (endogenous) insulin, tackling the root cause of the disease, as opposed to currently available drug therapies, that are at best disease-controlling.”

Looking ahead, the researchers plan to conduct larger randomized controlled trials to further validate these findings. Dr. Busch added, “We are currently conducting the EMINENT-2 trial with the same inclusion and exclusion criteria and administration of semaglutide, but with either a sham procedure or ReCET. This study will also include mechanistic assessments to evaluate the underlying mechanism of ReCET.”

-via SciTechDaily, October 17, 2024

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Note: If it works even half as well as suggested, this could free so many people from the burden of the ongoing ridiculous cost of insulin. Pharma companies that make insulin can go choke (hopefully).