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Terrill Mcbride from Bill Vick on Vimeo.

Interview with Bill Vick and Terrill McBride on living with IPF.

[billvick]

Their second lead asset is a wholly owned monoclonal antibody Pamrevlumab (FG-3019) directed against CTGF, a growth factor involved in fibrogenesis. Neutralizing this factor has shown promise in multiple preclinical models of fibrosis and in an open label Ph1 study in patients with IPF, a type of fibrosis in the lung. In that clinical study, patients saw a decline in the rate of progression (as measured by Forced Vital Capacity and High Resolution Computed Tomography) on par with both Nintedanib and Pirfenidone, the two competitors on the market. Moreover, in ~25% of patients there was an improvement in lung function, arguably making it the first drug capable of reversing fibrosis in humans. IPF affects around 100K people in the US and sales of IPF drugs are projected to exceed $1B by 2020. FibroGen has now fully enrolled a placebo-controlled Ph2 study with expected results in summer 2017. They will also be including a 6-month sub-study evaluating the efficacy of FG-3019 as a companion product with the standard of care. Data for this study is also expected in summer 2017.

Their second lead asset is a wholly owned monoclonal antibody Pamrevlumab (FG-3019) directed against CTGF, a growth factor involved in fibrogenesis. Neutralizing this factor has shown promise in multiple preclinical models of fibrosis and in an open label Ph1 study in patients with IPF, a type of fibrosis in the lung. In that clinical study, patients saw a decline in the rate of progression (as measured by Forced Vital Capacity and High Resolution Computed Tomography) on par with both Nintedanib and Pirfenidone, the two competitors on the market. Moreover, in ~25% of patients there was an improvement in lung function, arguably making it the first drug capable of reversing fibrosis in humans. IPF affects around 100K people in the US and sales of IPF drugs are projected to exceed $1B by 2020. FibroGen has now fully enrolled a placebo-controlled Ph2 study with expected results in summer 2017. They will also be including a 6-month sub-study evaluating the efficacy of FG-3019 as a companion product with the standard of care. Data for this study is also expected in summer 2017.

FibroGen Set Up For A Big Year Phase 1/2 data for unresectable pancreatic cancer in January. Phase 3 data for Chronic Kidney Disease in 1Q17. Phase 2 data for Idiopathic Pulmonary Fibrosis in More info @ http://ift.tt/2jiJ4Tf Automated post from PF Warrior – http://ift.tt/2jAYxOW January 26, 2017 at 07:27AM

[billvick]

The FDA approval of pirfenidone and nintedanib in October 2014 as the first-ever treatments for idiopathic pulmonary fibrosis (IPF) represented the culmination of decades of research into the mechanisms underlying this devastating disorder. The understanding of this disease as an epithelial-cell-driven aberrant wound healing process orchestrated by transforming growth factor beta (TGF-β) not only led researchers to study these two agents, but opened the door for a number of other therapies. Many of the agents under investigation have the exciting potential to not only slow fibrosis, but halt and even reverse the fibroproliferative cycle in IPF. A number of lines of evidence suggest that no single agent is responsible for the lung injury seen in IPF, but that individuals with IPF have intrinsic epithelial cell defects that render the epithelial cell susceptible to repetitive injury from any number of environmental agents (e.g. cigarette smoke, acid reflux, viral infections). This injury leads to aberrant signaling between the lung epithelium and mesenchyme, resulting in a persistent, abnormal wound healing response.

The FDA approval of pirfenidone and nintedanib in October 2014 as the first-ever treatments for idiopathic pulmonary fibrosis (IPF) represented the culmination of decades of research into the mechanisms underlying this devastating disorder. The understanding of this disease as an epithelial-cell-driven aberrant wound healing process orchestrated by transforming growth factor beta (TGF-β) not only led researchers to study these two agents, but opened the door for a number of other therapies. Many of the agents under investigation have the exciting potential to not only slow fibrosis, but halt and even reverse the fibroproliferative cycle in IPF. A number of lines of evidence suggest that no single agent is responsible for the lung injury seen in IPF, but that individuals with IPF have intrinsic epithelial cell defects that render the epithelial cell susceptible to repetitive injury from any number of environmental agents (e.g. cigarette smoke, acid reflux, viral infections). This injury leads to aberrant signaling between the lung epithelium and mesenchyme, resulting in a persistent, abnormal wound healing response.

Promising Emerging Therapies for the Treatment of Idiopathic Pulmonary Fibrosis – Consult QD Discoveries uncover underlying mechanisms of fibrosis, opening the door to exciting new therapies for fibrotic disorders. More info @ http://ift.tt/2jZ4TuQ Automated post from PF Warrior – http://ift.tt/2jAYxOW January 25, 2017 at 07:27AM

[billvick]

Idiopathic Pulmonary Fibrosis and the Effects of Treatment - XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior - January 24, 2017 at 07:27AM http://ift.tt/2kdoHZ2

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior – January 24, 2017 at 07:27AM http://ift.tt/2kdoHZ2

A great animation of how O2 gets into the blood and what IPF is. The website is a little flaky and brings up a privacy message evert now and then. Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estim… More info @ http://ift.tt/2kdoHZ2 Automated post from PF…

[billvick]

Idiopathic Pulmonary Fibrosis and the Effects of Treatment - XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior - January 24, 2017 at 07:27AM http://ift.tt/2kdoHZ2

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior – January 24, 2017 at 07:27AM http://ift.tt/2kdoHZ2

A great animation of how O2 gets into the blood and what IPF is. The website is a little flaky and brings up a privacy message evert now and then. Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estim… More info @ http://ift.tt/2kdoHZ2 Automated post from PF…

[billvick]

A great animation of how O2 gets into the blood and what IPF is. The website is a little flaky and brings up a privacy message evert now and then.

A great animation of how O2 gets into the blood and what IPF is. The website is a little flaky and brings up a privacy message evert now and then.

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ http://buff.ly/2j8zzsS Automated post from PF Warrior – http://ift.tt/2jAYxOW January 24, 2017 at 07:27AM

[billvick]

Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card - Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on the latest published guidelines. This More info @ Automated post from PF Warrior - January 23, 2017 at 07:27AM http://ift.tt/2k8qP4f

Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card – Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on the latest published guidelines. This More info @ Automated post from PF Warrior – January 23, 2017 at 07:27AM http://ift.tt/2k8qP4f

Complements of Boehringer-Ingelheim – the digital version of this title currently available to all registered users for free! – See more at: Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card – Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on … More info @ http://ift.tt/2k8qP4f Automated post from PF Warrior –

[billvick]

Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card - Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on the latest published guidelines. This More info @ Automated post from PF Warrior - January 23, 2017 at 07:27AM http://ift.tt/2k8qP4f

Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card – Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on the latest published guidelines. This More info @ Automated post from PF Warrior – January 23, 2017 at 07:27AM http://ift.tt/2k8qP4f

Complements of Boehringer-Ingelheim – the digital version of this title currently available to all registered users for free! – See more at: Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card – Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on … More info @ http://ift.tt/2k8qP4f Automated post from PF Warrior –

[billvick]

Complements of Boehringer-Ingelheim – the digital version of this title currently available to all registered users for free! - See more at:

Complements of Boehringer-Ingelheim – the digital version of this title currently available to all registered users for free! – See more at:

Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card – Guideline Central The Idiopathic Pulmonary Fibrosis GUIDELINES Pocket Card is endorsed by the American Thoracic Society and is based on the latest published guidelines. This More info @ http://ift.tt/2jhop55 Automated post from PF Warrior – http://ift.tt/2jAYxOW January 23, 2017 at 07:27AM

[billvick]

All airlines are obliged to follow IATA rules when it comes to assisting their passengers, and they are not allowed to discriminate us based on our illness. But they all have slight variations in their procedures, and we have also experienced huge differences in the quality of service provided.

All airlines are obliged to follow IATA rules when it comes to assisting their passengers, and they are not allowed to discriminate us based on our illness. But they all have slight variations in their procedures, and we have also experienced huge differences in the quality of service provided.

Travelling with oxygen needs Over the years we have accumulated lots of experience when it comes to travelling with oxygen needs. Since I started travelling with oxygen we have been flying all over Europe, to North Africa, and a… More info @ http://ift.tt/2kgldbE Automated post from PF Warrior – http://ift.tt/2jAYxOW January 22, 2017 at 07:27AM

[billvick]

Idiopathic Pulmonary Fibrosis and the Effects of Treatment - XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior - January 21, 2017 at 09:25AM http://ift.tt/2j7vsgL

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior – January 21, 2017 at 09:25AM http://ift.tt/2j7vsgL

This 6.5-minute animation shows in great detail how the lungs work to get oxygen into the blood, how the lung tissue is repaired when damage occurs, and how this repair process goes awry in IPF. – See more at: Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the…

[billvick]

Idiopathic Pulmonary Fibrosis and the Effects of Treatment - XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior - January 21, 2017 at 09:25AM http://ift.tt/2j7vsgL

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ Automated post from PF Warrior – January 21, 2017 at 09:25AM http://ift.tt/2j7vsgL

This 6.5-minute animation shows in great detail how the lungs work to get oxygen into the blood, how the lung tissue is repaired when damage occurs, and how this repair process goes awry in IPF. – See more at: Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the…

[billvick]

This 6.5-minute animation shows in great detail how the lungs work to get oxygen into the blood, how the lung tissue is repaired when damage occurs, and how this repair process goes awry in IPF. - See more at:

This 6.5-minute animation shows in great detail how the lungs work to get oxygen into the blood, how the lung tissue is repaired when damage occurs, and how this repair process goes awry in IPF. – See more at:

Idiopathic Pulmonary Fibrosis and the Effects of Treatment – XVIVO | Scientific Animation About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only 3 years. Patients with IPF deteriorate to the extent that most die of… More info @ http://ift.tt/2j7pLix Automated post from PF Warrior – http://ift.tt/2jAYxOW January 21, 2017 at 09:25AM

[billvick]

The respiratory system is a vital part of the human body for it supplies oxygen to the different parts of the body which is necessary for survival. As the body’s breathing mechanism, it is composed of the nose, mouth, trachea ( or wind pipe ) which collectively serve as the airway, a pair of lungs and a muscle for respiration, the diaphragm. The respiratory system begins with the nose where air is inhaled and then carried through the nasal cavity into the pharynx. Once air passes through the pharynx, it goes into the trachea, and from there, enters into the lungs. H/T - Pieter van den Assum

The respiratory system is a vital part of the human body for it supplies oxygen to the different parts of the body which is necessary for survival. As the body’s breathing mechanism, it is composed of the nose, mouth, trachea ( or wind pipe ) which collectively serve as the airway, a pair of lungs and a muscle for respiration, the diaphragm. The respiratory system begins with the nose where air is inhaled and then carried through the nasal cavity into the pharynx. Once air passes through the pharynx, it goes into the trachea, and from there, enters into the lungs. H/T – Pieter van den Assum

ACLS Guide to the Human Respiratory System This article includes the following sections: About the Human Respiratory System, Parts and Functions of the Human Respiratory System, Lower Respiratory Tract, Breathing Lung Mechanics, Homeostasis… More info @ http://ift.tt/2j6OkMS Automated post from PF Warrior – http://ift.tt/2jAYxOW January 21, 2017 at 07:27AM

[billvick]

Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs Nanoparticles from combustion engines can activate viruses that are dormant in in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), which has now been published in the journal ‘Particle and Fibre Toxicology’. To evade the immune system, some viruses hide in cells of their host and persist there. In medical terminology, this state is referred to as a latent infection. If the immune system becomes weakened or if certain conditions change, the viruses become active again, begin to proliferate and destroy the host cell. A team of scientists led by Dr. Tobias Stöger of the Institute of Lung Biology and Prof. Dr. Heiko Adler, deputy head of the research unit Lung Repair and Regeneration at Helmholtz Zentrum München, now report that nanoparticles can also trigger this process.

Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs Nanoparticles from combustion engines can activate viruses that are dormant in in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), which has now been published in the journal ‘Particle and Fibre Toxicology’. To evade the immune system, some viruses hide in cells of their host and persist there. In medical terminology, this state is referred to as a latent infection. If the immune system becomes weakened or if certain conditions change, the viruses become active again, begin to proliferate and destroy the host cell. A team of scientists led by Dr. Tobias Stöger of the Institute of Lung Biology and Prof. Dr. Heiko Adler, deputy head of the research unit Lung Repair and Regeneration at Helmholtz Zentrum München, now report that nanoparticles can also trigger this process.

Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs Nanoparticles from combustion engines can activate viruses that are dormant in in lung tissue cells. This is the result of a study by researchers of Helmholtz Zentrum München, a partner in the German… More info @ http://buff.ly/2jUDec3 Automated post from PF Warrior – http://ift.tt/2jAYxOW January 20, 2017 at 08:32AM

[billvick]

Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung… More info @ Automated post from PF Warrior - January 20, 2017 at 07:27AM http://ift.tt/2iJaKFh

Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung… More info @ Automated post from PF Warrior – January 20, 2017 at 07:27AM http://ift.tt/2iJaKFh

Chronic exposure to air pollutants is associated with reduced lung function in lung Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function li… More info @ http://ift.tt/2iJaKFh Automated post from PF Warrior – http://ift.tt/2jAYxOW January 20, 2017 at 07:28AM

[billvick]

Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung… More info @ Automated post from PF Warrior - January 20, 2017 at 07:27AM http://ift.tt/2iJaKFh

Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function limits the long-term success in lung transplantation. We evaluated the role of chronic exposure to ambient air pollution on lung function levels in lung… More info @ Automated post from PF Warrior – January 20, 2017 at 07:27AM http://ift.tt/2iJaKFh

Chronic exposure to air pollutants is associated with reduced lung function in lung Chronic effects of air pollution on lung function after lung transplantation in the Systems prediction of Chronic Lung Allograft Dysfunction (SysCLAD) study An irreversible loss in lung function li… More info @ http://ift.tt/2iJaKFh Automated post from PF Warrior – http://ift.tt/2jAYxOW January 20, 2017 at 07:27AM