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I’m gonna say something that’s gonna upset some of you but it needs to be said

If you are willing to sacrifice the most vulnerable and marginalised people to “keep the far right out” you are not different than the far right

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They keep taking down this video on tiktok and censoring search terms for it

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This is very interesting and I have been Afflicted with this my whole life and not one single doctor has ever explained it clearly enough that I understood what was happening. Yet I come here on Tumblr and get a clear explanation after 60 years of struggling and suffering with this. This is why I think I'm going to stick around on Tumblr for a while because there are some great insights to be found here

Wait, PMDD and GERD are connected to MCAS? Because I have both of those. Would you please talk a little more about that?

They can be connected to MCAS, yes.

If you google it, the current AI answer will tell you that mast cells are present in the esophagus, which is true, but only because mast cells are present in every part of the body.

What would be more helpful to say is that the esophagus is lined with histamine receptors, and when these receptors are activated it leads to chronic inflammation caused by several mast cell mediators which can make you more prone to acid damage.

Mast cells also release chemicals that can cause the stomach to overproduce acid, as well as relax the esophageal sphincter, which makes it easier for the acid to wash back up into the esophagus, causing further damage.

This is why some of the treatment aimed at GERD is actually antihistamines like Famotidine (Pepcid), which are type 2 histamine blockers, though I’ve yet to meet a GERD patient whose doctor has explained to them why this antihistamine works to relieve their GERD. The answer is mast cells.

(Note: MCAS is a multi system spectrum disorder that requires multiple factors to be present. Having some mild form of mast cell instability is actually far more common that is actually realized even by the broader medical community, with mast cell dysfunction now being linked to things like fibromyalgia, IBS, endometriosis, etc and I suspect in the next few decades, research is going to pivot drastically to focusing on mast cell treatment as a form of prevention instead of treating these disorders as things with no known cause and only symptom management.

My point of this whole section is to say: if you have GERD, that doesn’t automatically mean you have MCAS. You might have some form of mast cell instability that is causing issues, but so does a significant chunk of the population. It just isn’t discussed or recognized by current medical literature, though that is thankfully changing. Slowly, but the change is there.)

For PMDD there’s unsurprisingly a limited amount of research but the EDS clinic page on it is fairly comprehensive. Basically, hormonal fluctuations linked to the pre-menstrual stage of the menstrual cycle can prime mast cells to overreact, liberating several mast cell inflammatory chemicals but chief among them histamine which has been shown to have an effect on pain perception but also mood stability. There’s very little official studies related to histamine and PMDD, but looking at other studies such as the effect of histamine on major depressive disorder, you can sort of cobble together a bigger picture of how mast cells affect mental health and how hormonal fluctuations may impact this. Among the mast cell syndrome community you’ll sometimes see people talking about ‘masto rage’ or ‘histo rage’ and that’s because excess histamine in the brain can lead to extreme anger that can seem to come out of nowhere.

For me, this primarily happens with my PMDD and it feels like someone dropped a match into a barrel of napalm. My entire brain becomes a fucking mess that has gotten better with mast cell treatment, but not entirely eradicated.

This may be why some individuals who experience PMDD are self reporting relief from taking a histamine blocker like Famotidine during the luteal phase of their cycle.

Again, having these conditions doesn’t mean you have MCAS, but it can be an indication of some mast cell fuckery, especially if you have multiple things going on at once.

It wasn’t until I got diagnosed by my specialist that all these seemingly random unconnected disorders that I struggled with for nearly my entire life made sense because their primary instigation in my body was my untreated mast cell disorder. Everything from the chronic acid reflux that started as a child right down to my interstitial cystitis which started the moment my menstrual cycle kicked in at age 11.

Honestly it’s all been down hill since then.

Anyway, I hope this was useful.

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���This is what galls me, then. Writers and journalists are being ‘replaced’ not wholesale, not entirely or directly but in kind, by automated gimmicks and features. And rather than confront the tech sector that’s landed most of the existential body blows to journalism, management is once again trying to cut deals with AI companies, to build engagement-generating features, in hopes of wringing out a slice of revenue or relevance in darkening skies; meanwhile more and more journalism jobs disappear every year. The Wall Street Journal just laid off its tech reporters!”

— So the LA Times replaced me with an AI that defends the KKK

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Consider that he was on the North Coast drunk as a skunk every day smoking weed and trying to fuck women without anybody knowing it. If you've never been to Firefly Cottage don't waste your time

I been reading Ian Fleming's original James Bond books, and I'm gonna be honest, y'all

So far they have all been pretty bad

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i feel like we don’t talk about things like this enough

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More deceit from DOGE

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Once you discover that you can, then you must. And it's not easy. You have to take direct steps. You really have to count your blessings and you have to make a decided effort to not get seduced by the blues.

–Al Jarreau, American Singer and Songwriter

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Pretty happy to create in color this year. I haven’t made anything in a while due to just feeling so sad and out of it. It felt like forever. I think not being so hard on myself during the process helps too. Every artist should just try to create with ease and flow. Be more easy on themselves during the process and letting things just be. 

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Appreciation post from a very grateful Black man. We love you Black man! 🙏🏽🖤