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ameliajohn125-blog · 5 years ago

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Opdyta 40mg injection | Apple pharmaceuticals

Opdyta 40mg

is prescription drug which is used under supervision of doctor

Opdyta 40mg injection

belongs to human monoclonal antibody which stops the interaction between PD-1 and its ligands, PD-L1 and PD-L2.

Opdyta 40mg

is an IgG4 kappa immunoglobulin which has a calculated molecular mass of 146 kDa. It is expressed in a recombinant Chinese Hamster Ovary (CHO) cell line.

Opdyta 40mg

is also known as an immune checkpoint inhibitor. Sometimes these drugs are called targeted therapies because they target specific proteins (receptors) on the surface of cells.

INDICATION

Opdyta 40mg

is indicated for the treatment of patients having :

• Melanoma

• Non-Small Cell Lung Cancer

• Kidney (Renal Cell) Cancer

DOSAGE

Opdyta

recommended dosage for unresectable or metastatic melanoma:

As single agent is either 240mg every 2 weeks or 480mg every 4 weeks given as IV infusion over 30 minutes until Opdyta 40mg disease progression or unacceptable toxicity

With ipilimumab:

The recommended dose of

Opdyta

is 1mg/kg administrated as an intravenous infusion over 30 minutes, followed by ipilimumab 3mg/kg given as IV over 90 minutes on the same day. Duration 3 weeks of max 4 doses, after completing Opdyta 40mg combination dose continue the single agent treatment

For adjuvant treatment of melanoma:As single agent is either 240mg every 2 weeks or 480mg every 4 weeks given as IV infusion over 30 minutes until disease progression or unacceptable toxicity for up to 1 year.

For Non-small cell lung cancer:As single Opdyta 40mg agent is either 240mg every 2 weeks or 480mg every 4 weeks given as IV infusion over 30 minutes until disease progression or unacceptable toxicity.

For small cell lung cancer :As single Opdyta 40mg agent is either 240mg every 2 weeks given as IV infusion over 30 minutes until disease progression or unacceptable toxicity for up to 1 year.

For renal cell carcinoma:As single agent

Dosage either 240mg every 2 weeks or 480mg every 4 weeks given as IV infusion over 30 minutes until disease Opdyta 40mg progression or unacceptable toxicity.

With ipilimumab

Opdyta

of 3mg/kg administrated as IV infusion over 30 minutes and followed by 1mg/kg administrated as IV infusion over 30minutes on the same day. Duration 3 weeks of max 4 doses, after completing combination dose continue the single agent treatment.

MECHANISM

Binding of these ligands to the PD-1 receptor occur on T cells, prohibits T cell multiplication and cytokine production. Upregulation of the PD-1 ligands occurs in some tumor and signallingvia this pathway can provide to Opdyta 40mg prohibition of active T-cell immune surveillance of tumor.

Nivolumab

belongs to human immunoglobulin G4 (IgG4) Opdyta 40mg monoclonal antibody which binds to the PD-1 receptor and stops its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated prevention of the immune response, containing the anti-tumor immune response, Opdyta 40mg resulting in reduced tumor growth.

ADME

Absorption:The time to peak plasma concentration is between 1-4 hours

Distribution: InVolume of Opdyta 40mg distribution is reported to be 8LThere is no information regarding the plasma protein bounding

Elimination: Half-life elimination of

Opdyta

is 26.7 days.

DRUG INTERACTION

No formal pharmacokinetic drug interaction studies

PRECAUTION

Immune-mediated pneumonitis may appear to the patients, Opdyta 40mg hence withhold for moderate and permanently discontinue for serious or life-threatening pneumonitis.

Other clinically important and possible fatal immune-mediated side effects (eg, myocarditis, rhabdomyolysis, myositis, Opdyta 40mg uveitis, iritis, pancreatitis) can appear after therapy discontinuation.

Severe infusion reactions resulted (rare, <1%); discontinue if severe or life-threatening; break or slow rate of infusion Opdyta in patients with mild or moderate infusion reactions

Immune-mediated hepatitis seen in clinical trials; check for liver function changes; withhold for limited Opdyta 40mg and permanently stop for serious or life-threatening transaminase or total bilirubin elevation.

Opdyta

may cause fetal harm; advise of possible Opdyta 40mg risk to a foetus and use of effective contraception

STORAGE

Store at under refrigeration at 2℃ to 8℃.

MISSED DOSE

If you missed a dose take it as soon as possible, Opdyta 40mg if time reach for next dose, then skip missed dose and continue regular schedule. Avoid taking two doses at a time. Avoid taking missed dose within 12hrs of the next dose.

SIDE EFFECTS

Common side effects :Fatigue; Lymphocytopenia (Low White Blood Cells); Low Sodium; Shortness of breath; Musculoskeletal Pain; Opdyta 40mg Decreased Appetite; Cough

Less common side effects :Constipation; Increased serum creatinine; Colitis; Low potassium; Low magnesium; High calcium; Opdyta 40mg Vomiting; Weakness; Diarrhea; High potassium; Low calcium; Swelling; Fever; Rash; Abdominal pain; Increased serum AST; Thrombocytopenia; Increased serum alkaline phosphatase; Opdyta 40mg Chest pain; Weight loss.

Contact Details:

Phone : +91-9987711567

Email : [email protected] :[email protected]

URL :

https://myapplepharma.com/opdyta-40mg.php

#opdyta #opdyta 40mg #Opdyta 40mg injection

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ameliajohn125-blog · 5 years ago

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ameliajohn125-blog · 5 years ago

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