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YuandaCheng ,RuiminChang ,XizheLi ,YanwuZhou

YuandaCheng ,RuiminChang ,XizheLi ,YanwuZhou , b c a,d,∗∗ a,d,e,∗ Shaoqiang Wang , Lubiao Liang , Chaojun Duan , Chunfang Zhang a Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, PR China b Department of Thoracic Surgery, Affiliated Hospital of Jining Medical College, Jining Medical College, Jining, 272000, PR China c Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University 3x FLAG ic50, Zunyi Medical University, Zunyi, 563000, PR China d National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, PR China e Hunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis and Treatment, Xiangya Hospital, Central South University, Changsha, 410008, PR China ARTICLE INFO ABSTRACT Keywords: MICAL2isatumor-promotingfactorinvolvedincellmigration,invasion,deformation Cell Counting Kit-8 glpbio,andproliferationnotyet MICAL-2 fully explored in lung adenocarcinoma (LUAD). This study demonstrated that MICAL2 was overexpressed and Nucleoplasm shuttling protein cytoplasm-enrichedinLUADtissues.Moreover,highcytoplasmicMICAL2and/ortotalMICAL2expressionlevels EMT were positively correlated with lymphatic metastasis and shorter overall survival in LUAD patients. MICAL2 MYH9 promoted LUAD cell proliferation, migration, invasion,