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Ketamine is thought to be used by vets to sedate horses, but somehow it’s made its way into a multiple of our (much smaller) bodies. If you’re guessing about taking it, here’s what you require to know to stay safe while having a satisfactory time.

It’s a powerful anesthetic, the sort of thing they use to knock you out in hospital multiplied by A LOT. Vets use it to sedate horses. If humans take it, it works as a painkiller. It can furthermore result in amnesia.

What does ketamine look like?

The impression of ketamine varies according to the way it’s taken. Normally speaking, it’s a white powder a.k.a ketamine powder. If you ever see yourself thinking ‘what does ketamine glimpse like’ to figure out if you should take the drug, it’s likely safest to drive clear. It’s significant to know what you’re putting in your body.

Why do people take ketamine?

In large doses, ketamine crystals create consequences in humans similar to phencyclidine (PCP) such as dream-like dissociative states and hallucinations. It has a numeral of contradictory effects, comprising stimulant, sedative, anesthetic, and hallucinogenic properties. Users describe feeling like they are drunk, stoned, and tripping all at once.

Ketamine is a novel treatment alternative for chronic pain that has been gaining popularity in recent years. Also, gives rapid and sustainable improvements in pain and working for some people with chronic pain conditions.

From us at the Ketamine shop, you can purchase real and authentic Ketamine crystals. It is the power of Ketamine. Get apparent and graded Ketamine powder at a fair price. Powder Ketamine is generally snorted fast by the majority of users. Ketamine users usually talk about taking a bump, which means snorting a small dose. 

Also, studies suggest that ketamine crystals work by acting on specific types of receptors in the brain and spinal cord to block pain signals. Therefore, suggesting that ketamine has other effects. Modulating the release of neurotransmitters like serotonin and glutamate, which may furthermore assist to help pain symptoms.

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This article is the result of a collaboration with Estonian publishing partner Postimees. You can find Postimees’ corresponding piece here.

A young woman dressed in a school uniform poses in front of a bag resembling breadcrumbs. A phone number, an email, and two QR codes are listed above her head. At the center of the image, in large yellow-and-red font, is the word “Isotonitazene”. 

The description says “delivery is guaranteed” and that the brown powder can be shipped safely to Europe, the US, the UK and beyond: “If you are interested,” it says, “kindly contact with me.”

The advertisement appears harmless, but it is far from it: isotonitazene is a type of nitazene, a class of synthetic opioids up to 40 times stronger than fentanyl and up to 500 times more powerful than heroin.

Nitazenes were developed in the 1950s by a Swiss chemical company as a new type of painkiller, but the drug was so potent that it was never approved as a medicine. Even trace quantities can cause an overdose.

Decades later, nitazenes have re-emerged in the underground drug market: they have been detected in counterfeit prescription medicines, including fake oxycodone and benzodiazepines pills, and in street drugs, including cocaine, heroin and ketamine.

The UN drugs agency and countries around the world have warned of the major health risks posed by nitazenes. The super-strength opioid has already caused hundreds of deaths in Europe, the UK and North America.

A months-long open source investigation by Bellingcat and publishing partner Postimees has identified a trove of more than 1,000 online adverts selling six of the most common types of nitazenes and offering worldwide delivery.

The investigation team analysed the websites, social media accounts and contact details related to the ads, and searched business registries for information on companies associated with the drug sales. 

It established that a series of entities linked to the advertisements match listings for companies on China’s corporate register — including one registered company that is advertising scores of nitazenes online.

Requests for public information, including court files and customs records, uncovered additional evidence linking nitazenes shipments seized in Europe back to China.

The findings come as recent geopolitical events threaten to exacerbate the flood of nitazenes globally. In 2019 China banned all variants of fentanyl, a potent opioid that is fuelling the most lethal drug crisis in America’s history. And in 2022, a “poppy ban” imposed by the Taliban led to a massive drop in opium production in Afghanistan, the source of virtually all the heroin supplied to Europe.

Experts say these factors have opened up a vacuum for alternative synthetic opioids – such as nitazenes – to emerge. “At some stage we know for sure heroin will dry out, and then there’s a danger that some of those people [drug users] may go into nitazenes,” said Thomas Pietschmann, a senior research officer with the United Nations Office on Drugs and Crime. “And that’s a particular danger because of its high potency.”

[foursaints]

🍓- hiya!! I was wondering, what do Evan and Barry think of suits? Do they like them? Would they wear them? What kinds? This is a really random question that popped in my head in school and I feel like I will explode if I don’t discuss it with someone 😭😭

🍓🍓 <- so cute! i am of the firm belief that barty spent an entire childhood squeezed into suits at ministry functions and is pretty nonchalant about them as a result. i never buy the whole "barty resists formalwear" schtick... barty's clothes are an extension of the "he sees his body as an impersonal tool used to achieve his ends" rule

i think he dresses like a sentient crumpled can of liquid death on purpose because he likes conveying the not-inaccurate impression of someone who sells bathtub ketamine to college students. (and he likes rolling out of bed already dressed 💀). but that's all on PURPOSE. he's not going to be incapable of switching that up when he needs to. i could very easily picture him rocking a suit, and it would be tailored, and expensive, and he would find the whole effect highly entertaining, and leave the tie undone all night.

evan rosier in a suit... i can only conjure the image of trying to force a belligerent feral cat into a costume. sensory nightmare. he would do it every single day if his job required it, because he runs the inside of his skull like an Impersonal Algorithm that doesnt compute for his own discomfort outside of a brief, dispassionate acknowledgement— but he doesn't like being constricted. someone get that man back into the beige sack he wears every day

also evan would probably get his suit from a dubious estate sale and it would still smell like a corpse. and barty would find this hot

[nohoney]

been feeling dreamy over the song you that i want by divine lately…. anyway here’s us series smut. takes place between part 3 and part 4.

warnings: drugs (selling but no taking), brief mentions of past assault (not in explicit detail), voyeurism, just a teeny bit of humiliation

It takes a lot for Touya to decide that he won’t sell to someone anymore. He’s still sold to guys he hates and in turn hate him, but cordial enough to complete a transaction. There’s few that he’s willing to have a conversation with and others that he’d rather not stick around for. So Touya’s disgruntled to meet with a group that involve your ex-boyfriend with them. Motherfucking Jun, the one who put his hands on you and the one before he came along.

There’s an obvious tension when he pulls up but he keeps his composure even as Jun stares back at him.

Four adderall, a gram of ketamine, and fourteen grams of shrooms was the request and he’s just about to hand it off before he pulls back. He was already given cash and one venmo transaction with a fee tacked on so payment was made. He doesn’t care about anyone else from the group who are all waiting for their goods; he just fucking hates that Jun is apart of them.

“You, what the fuck do you plan on having?” Touya points his finger towards your ex-boyfriend. His mind flashes to the memory of when you had bruising on your neck, a frown set on his face that he swears is getting angrier the longer he looks at him.

Jun exhales through his nose, his nostrils flaring at first before he answers, “Shrooms.”

“I’m not selling to you if he’s going to take anything from me. He gets nothing.”

There’s a collective groan from the group, “C’mon Dabi, let’s not make it personal okay?”

But it is personal and Touya can’t forget the disrespectful and snide attitude from your ex from when they first met. He hates him, hates that Jun had ever fucked you first even if it was destiny that was supposed to pave the path for you and him to meet. The asshole mistreated you and didn’t give one shit about your feelings in the way he was supposed to. And the motherfucker who actually hurt you even if he ‘didn’t mean to’ as he claimed from that time just because he was drunk.

He wants to walk out but a better idea comes to mind. “You want all this shit for half off? I’ll cut you a real nice deal.” Touya offers, pulling the cash out from his pocket to count and returning half of the payment. “I’m just going to borrow you. You cooperate with me and you get to have fun at your little party.”

All eyes look to Jun and he himself is surprised along with everyone else. “We’re kinda looking to get fucked up now…” he says carefully, “What exactly do you want?”

Touya holds up one finger as a way to tell him to wait as he starts to fish out his phone, walking back towards the other room to get some distance and keeping his back turned away from the group. The phone rings a couple of times before it’s picked up, “Touya?”

He expected to hear Keigo’s voice but you picked up the phone instead, “Hey princess, give the phone to Keigo for me.”

“What, you can’t tell me?” You feign hurt before laughing and telling him to wait a second, “Kei, it’s Touya. He wants to have a secret, man-to-man conversation with you.”

Touya speaks a little lowly into the phone, his voice a little urgent but he knows that he’ll get the cooperation he’s seeking. As he glances back at the group, he can see everyone conversing with Jun as his eyes nervously look back to him. He’s getting the pressure from the group because no guy wants to be the asshole that made the plug mad and fucked up a sale. So he knows that it’s going to work exactly to his favor what he’s about to do. “Yeah, yeah you got it. How fast would you say that you’re going to be here?”

“Fifteen minutes.” Touya answers, “just make a show of it when I walk through the door but don’t drag it on either. No softy shit like I heard a few days ago. And keep the lighting good when I make the call.”

Keigo just agrees before hanging up the phone and Touya walks back to the group to stand in the spot he was in before. “Either half off or none at all, that’s the only choices you get. I’ll give it to you once I get what I want from you.” he poses it like a choice but everyone in the room knows that it’s not. Someone complains what they’re supposed to do in the mean time and they’re told to shut up. “Just get drunk, Jun here will pull through because he’s a good friend to all of you. Get in your car and follow behind me.”

Jun is apprehensive but he knows that he needs to cooperate.

Touya is polite enough to wait for Jun to find a parking spot near Keigo’s complex and leads him up the staircase after letting him in through the lobby. He’s pulling out his phone and making the video call but is sure to keep the speaker volume low so that the prick behind him isn’t privy to what he’s about to sit through. Keigo answers the video call and props his phone up quickly only to walk back in the view of the camera where you lay in the bed naked and with a hand waving the blond back over to you.

Good, just as Touya instructed him to.

Just right at the front door, he can hear your muffled moans from the inside and he doesn’t bother to look back to see Jun’s expression. He only wordlessly unlocks the door and allows your asshole ex-boyfriend in first before following in after and shutting the door. The symphony of your moans resounds through the apartment as both of them take their shoes off first. Touya directs to Jun to sit in the living room, passing by Keigo’s bedroom where you’re getting fucked by him roughly.

“You fucking sick or something? You want me to listen to your girlfriend getting fucked by your friend?” Jun is completely disgusted as he sits in the armchair but there’s no mistaking the flush in his face as he listens to your cute, choked up voice.

“Feeling good songbird? Yeah? You love this, right?” Keigo is heard grunting along with the creak of the bed frame.

God you’re as pretty as you sound. “Nngh! S’amazing… Kei’s cock s’good!”

Touya loves to hear this, whether he’s just listening or he’s joining in. 

“You can watch too. Here, set up just for you.” Touya props his phone up against a decorative vase you purchased for Keigo’s apartment, “Since you were such a pervert listening to us fuck that one time. She told me that you were into listening and watching other people so thank me for being so kind. Thank me for letting you get another look at your ex-girlfriend get fucked pretty.”

Jun frowns at the distaste of the situation, his hand clenching into a fist as he hears you just in the other room and his eyes watch through the video call on Touya’s phone. “You’re a sick asshole, you know that?

Touya gestures to the phone and puts on an insincere smile, “I’ll have you know that I’m rather kind and generous.” Your voice parallels everything happening in the video call. Jun is forced to watch you on screen just in the room over, Keigo making himself comfortable on the bed as you’re set on his lap and move your hips to ride him. Touya watches rather fondly as he sees Keigo’s hands smooth to your cute ass, spanking you hard first that elicits a yelp from you before he spreads your cheeks. “Fucking look, you miss that right?”

“Dabi, this is some petty shit from you.”

He doesn’t fucking care; he just wants to humiliate Jun. if Jun walks away then that means he and his friends don’t get the shit they wanted.

“Fuuuck, Kei! I’m cumming—fucking cumming!” you’re heard from the bedroom and you’re seen through the phone getting on the flats of your feet onto the bed to bounce up and down on Keigo’s dick. The smacking of skin can be heard clearly and Touya just looks so giddy as he watches his two favorite people get lost in one another. He knows that Keigo is making a show of it like he told him to, he knows it in the way you’re getting choked and how harsh you’re getting spanked with a loud smack. “Keigo!”

It’d be nice to join but Touya places a priority of humiliating Jun first.

“I can sweeten the pot. You stay until he cums in her, I’ll throw in a gram of snow.” Touya offers as he pulls a measured baggy from his wallet. Truthfully it’s the gram he’s supposed to give to you later on but he’s just having too much fun with this. “Don’t let your friends down now, right? I saw the way they were all bugging down on you. Sucks to be friends with people who choose drugs over your well-being, huh? S’okay, you can admit if this isn’t worth it. You can keep your dignity and walk away. I’ve done worse to you.”

But he knows that Jun won’t walk away because that fucker wants his shit and he can’t be the reason why his friends lost out on a good plug. And even if he went around looking for another, he could just tell Shigaraki to be on the lookout and inform anyone else that deals within this area and nearby. He could spin a story and get him killed by his own young boss if he wanted.

Touya won’t go that far though.

It pisses him off but you’d probably be sad if Jun were to die; you were still soft like that even though you should hate your ex-boyfriend for hurting you.

“… How much longer would that be?” Jun asks quietly, his foot tapping impatiently and a shameful erection being hidden beneath his folded hands in his lap.

Glancing down to his phone, Keigo has put you on all fours and presses your head to the mattress. He recognizes the excited laugh you let out but it’s cut short when Keigo fucks hard and fast behind you. Touya just knows you’re creaming on his dick and he can’t wait to get in afterwards. There’s just something about sliding into you and have you still dripping wet with Keigo’s cum in you that turns him on so damn much. The first time it ever happened, he had almost cum embarrassingly fast when he discovered how much he liked it.

He watches Keigo put in the work, shaking his bangs out of his face as the hairs stick to his forehead from sweat before throwing his head back. Touya hears how desperate you and Keigo are becoming. Your sweet pleas and the nasty curses of fucking slut and stupid bitch coming from Keigo gets him just a little too excited.

Touya just wants to go in there and help press your head deeper into the mattress to hear you whine more and make Keigo loll his tongue out so that he can spit in his mouth.

He wants a nasty fuck now.

Keigo’s vocal as he snaps his hips hard into you, almost whining alongside you too as he shoots his load into your cunt and oh—Touya is for sure going to get filthy in there. Just right after he sends Jun out. He ends the video call on his phone before Jun sees anything too intimate and vulnerable. But just as promised he tosses the all the party favors into his lap and tells him to get the fuck out, “Take your shoes and put them on outside. And remember how kind I was to you after everything that’s gone down between us.”

Jun leaves quietly and with his tail tucked between his legs and Touya’s sure to audibly close the front door that’s heard by you. “Touya? Are you back?” you call out, slightly breathless and whining as Keigo shallowly thrusts into your pussy before pulling out completely. You roll to your back and crook a finger to Touya when opens the bedroom door to make his appearance. “C’mere…”

“I’m here doll, I’m here.” he croons as he starts to undress. Everything drops to the floor with an audible thump and he hears your happy little sigh as he approaches. He caresses his hand against your cheek but leans in to kiss Keigo hard on the mouth, groaning lowly before pulling back and hissing out a satisfied cursed. “Did Kei treat you good?” he asks he starts to get in position between your legs.

“Always.” you answer with a happy smile before letting out a small gasp when the back of Touya’s hands roughly grasp the back of your knees and push them towards you.

Keigo leans back against his pillow to catch his breath. He flashes a little smile and sends him a wink, keeping another secret between the two of them and your pretty little self is blissed out of your mind and unknowing of the presence of your ex-boyfriend in a personal space not too long ago.

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South Park AU where all the characters have a signature drug:

(I personally thought this was absolutely hilarious, and also this was just an excuse to make bad puns)

Mr Mackey:

- Crack/smack

His street name is Mr. Crackey, and later on Mr. Smackey.

He feels down in the dumps and “accidentally” does some crack, after which he immediately gets addicted. He goes on the bender of a lifetime and ends up in severe dept to a scary drug dealer, notorious for cutting off the balls of those who don’t pay him back. He decides to sell crack to the elementary students, with the help of Craig Tucker (also known as Crack Tucker), to pay off his dept. Instead of paying the guy back, though, he decides to try some Heroin and thus becomes Mr. Smackey.

Stan Marsh:

- Weed

Street name is Stan The Stoner, (Stanner for short)

Starts selling weed to replace his father, who gave up on weed for his new acid addiction. When you buy his weed you are legally obligated to say you’re “stanned.”

Eric Cartman:

- Cocaine

Street name is Eric Cokeman.

You can buy either Cocaine, or Coca-Cola flavored anything (including Coke flavored coke). He starts selling it because he can. Nothing you buy from him is safe or clean. But his shit is also extremely addictive, so he somehow still has costumers. Sneaks it into ppl’s food on occasion, trying to get them hooked. He hides the cocaine up his ass, every goddamn time (even though it’s not really necessary) and the stench is foul. He claims that it’s just his signature.

Kyle Broflovski:

- Ketamine

Street name is Kytamine or Ketty-B (Kyley-B)

Doing it as a fuck you to his mom, and because Eric wouldn’t get off his ass about how he could “never be as good at selling drugs” as him. Every time you try to buy from him, he goes on a whole monologue of all the dangers and everything you should and shouldn’t do. He’ll tells you exactly how much mg you should use and strongly advocated for people to buy a scale to perfectly measure it. People usually walk away before he’s done talking, and he constantly rants about it to Stan.

Kenny McCormick:

- Methamphetamine/Cocaine

Street name is Kenny MethCokeMick or just Methcokemick. MC for short

Fought with Kyle over the Ketamine, because he personally thinks “Kennymine/Kennamine” would be a better name than Kytamine. But je settled for selling Meth with Marjorine. He’s also addicted to cocaine and “helps out” Cartman with selling; Hence, MethCokemick. His charm is the key to his sales. Richard Tweak is their #1 buyer.

Marjorine Stotch:

- Methamphetamine

Street name is Metharine

Sells meth with Kenny. Just happy to be there. Really convincing seller. Really sweet but if you fuck her over she’ll do worse than snip your balls.

Tolkien Black:

- Tylenol

Street name is Tylenol Black

Has a whole room dedicated to the “craft” of selling prescription drugs. Steals the drugs from his mom who’s a chemist for a pharmaceutical company. His dad knows this but he secretly loves how pissed off Randy gets when he claims that Tolkien steals his business, even though they don’t even sell the same shit.

Tweek Tweak:

- Meth, obviously

Referred to as The Tweak, or just “tweak” for short.

Doesn’t know he’s addicted to meth. He doesn’t know people refer to him as as The Tweak. His parents put meth in his coffee.

Craig Tucker:

- Crack

Street name is Crack Tucker

Helps sell crack to elementary students with Mr. Mackey. Intimidates people into buying his shit or guilts them into buying it: “Oh you don’t want my Crack? Why? Is it because I’m gay? What? You think a a gay guy can’t sell good crack?! I see how it is...” and it’s super effective. Ends up getting more money than he asked for, to show their support for his queerness. Really saves his ass when his former partner, Mr. Crackey, ditches him in exchange for Heroin and blames the money he hasn’t payed back yet on Craig. Started the nickname: “The Tweak.”

Randy Marsh:

-Acid

Street name is Rancid

He chose this name. No, he does not see what’s wrong with it. He’s trying to get his kids hooked on the stuff so that they can “Finally do some fucking family bonding time.” He calls them pathetic, whiny pussies every single time they refuse. And sulks about his lame kids. Actively shit talks Tolkien to costumers. To the point where he’ll see Tolkien sell someone something and he’ll follow them home and stalk them so that he can “coincidentally” run into them and just so happen to bring up how Tolkien peed his pants once back in third grade. He knows this because he constantly bugs Stan about embarrassing moments in Tolkien’s life and if Stan doesn’t wanna tell him any, he’ll ground him for being a “blood betraying judas.”

Heidi Turner:

- Hash

Steet name is Highdi

Hippie. Sells Hash. Wanted to sell weed but could not compete with Stan, so she switched. Advertises all of it as environmentally friendly, cruelty free and vegan. Gets her girls to hand out business cards to everyone around town. The business cards are cute and pink with “WE DONT TEST ON ANIMALS” written in big, bold letters. Her shit is FDA approved.

Rebecca McArthur, AKA Red:

- Red ice (if you ever played Detroit Become Human, yk what that is)

Street name is Red Ice

Red ice isn’t a real drug, but in this universe it is and it was invented by miss Red herself. According to google, red Ice is “a synthetic stimulant composed of trace amounts of thirium, acetone, lithium, toluene, and hydrochloric acid. The molecular formula for Red Ice given in graphics is C17H21NO4 (the chemical formula for cocaine).” Though the contents doesn’t actually really match cocaine, it looks more like meth that is red.

Jimmy Valmer:

- Viagra

Street name is Jimmy Viagra, but people just say Jimmy V

His cerebral palsy isn’t going to stop him from getting it up. His mission is to give his paralyzed buddies the opportunity to get their dick wet. And he advocates for “Boners For The Handicapped” (BFTH) and is very passionate about his cause.

Timmy Burch:

- Shrooms and LSD

Street name is Trippy Timmy

Jimmy V’s number one customer. Got his nickname by selling LSD/shrooms with extremely powerful hallucinations.

Thank you for your time!

Ps: I realize these street names are actually ridiculous and nowhere near realistic, but that’s why it’s fun

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[abigailspinach]

The Food and Drug Administration approved Johnson & Johnson’s nasal spray to be used alone in adults with a major depressive disorder that is difficult to treat, as sales of the drug grow. 

The spray, called Spravato, is now the first-ever standalone therapy for treatment-resistant depression, which is when trying at least two standard treatments does little to nothing to improve depression symptoms in a patient. 

Spravato is on its way to becoming a blockbuster product, with the drug bringing in $780 million in sales during the first nine months of 2024 as doctors grow more comfortable using it.

The approval is based on a phase four trial, which showed that Spravato alone improved depressive symptoms beginning about 24 hours after treatment and lasting through at least one month. The company has said that the safety profile was consistent with previous clinical data on Spravato’s use in combination with oral antidepressants.

Martin said that demonstrates “not only rapid symptom relief, but also a durable symptom relief” when patients take Spravato by itself. 

Spravato’s long road to rapid growth

Spravato blazed a new trail in 2019 as the first new major depression treatment to win FDA approval in more than three decades. The drug is related to ketamine, a common anesthetic that can have hallucinogenic effects and is sometimes misused recreationally. J&J made it into a nasal spray to get it into the brain quickly. 

Spravato “turns on neural networks in a way that’s different,” said Mattingly. 

“Our standard oral antidepressants took weeks to months to see if they’re going to work,” he added. “Quite often with the same day, the very next day, the very next day, people can already start to feel they’re feeling somewhat better” with Spravato.

Spravato’s warning label cautions about the risk of sedation and dissociation, respiratory depression, suicidal thoughts and abuse or misuse of the drug, among other potential side effects. Because of that, Spravato is only available through a restricted program, meaning it can’t be purchased at a pharmacy and is only administered in certified health-care settings under strict supervision. 

Users of the medication must also be monitored by a health-care professional for two hours following administration.

Spravato’s launch had a sluggish start, especially as pandemic-related challenges complicated arrangements for the drug’s necessary medical supervision. But J&J began to market Spravato more heavily after in-person doctor visits became the norm again, and physicians became more aware of its benefits. 

“The mental health community wasn’t really used to doing procedures at that point. We weren’t used to having a space set aside. We weren’t used to thinking about how to do Spravato,” Mattingly said. “I think the good news is now we’ve all seen the benefits to our patients. So many of us have become really strong advocates” for it. 

Five years of real-world data on the drug and a head-to-head study demonstrating Spravato’s superior efficacy to an oral antidepressant also gave doctors higher confidence in the treatment, according to J&J’s Martin.

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