#been updating the year since 019
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blackbloodteeth · 4 months ago
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just stumbled across your art for the first time & im very curious as to what exactly your starting point for creating soul variants was? by that i mean, what made you begin creating them in the first place, what served as the inspiration for all of this? id also like to add i scrolled your entire archive and i love how expressive your art is! apologies if youve already answered something like this as well. thank you, have a nice day!
Hey, thank you very much! I'm always so glad when people enjoy my varianting, and honestly that's really heartwarming that you went through my archive (especially since I still remember how long it took me to get all of my art up at the time onto here haha)
I've been asked similar questions to this before, but I don't mind it at all, it's always fun to answer even if the history on variants is actually a bit messy haha (to the point I had to kinda just pick a day for keeping track of the Variantverse's anniversary, which I actually use this drawing for reference since it's the first real time there were multiple AU Souls in one art haha).
I'm not joking about the history being messy by the way, you better strap in because this is not a question I'm usually able to answer in just a few neat sentences (for your time there will be art at the end though haha)
So basically, aside from the really old (I'm talking middle school old) AUs I had of Soul (which... don't really have updated art aside from being retroactively really important to Variantverse lore hah), variants initially started as me just finally joining the Soul Eater fandom and just doodling canon Soul in different ways. After that it basically went like I want to draw him in a different outfit, to I want to draw him as Pokemon (context like this involved Discord but that's another story hah), to okay, I want to draw him weird and no one can stop me, and then came one morning where I did a doodle session of drawing him in a lot of non-human designs for the fun of it.
This is the shortened version of it, because there were doodles in between including an entire comic saga and an entire AU that didn't end up on the Variant List (*until much later anyway) because the list hadn't been established yet. Have I mentioned the "List of Soul Variants," by the way? Some know way back when I used to keep a list of all the Soul variants I was making and even gave them all numbers (it was kind've a big deal to the point it was actual in-Variantverse lore), however shortly after it reached 1,000 variants the list went defunct (also a big deal) and I no longer keep track of how many there are. The numbers don't matter anymore, but it contextualizes some things haha.
Now to actually answer the question, where does "variants" start: #019. After the previously mentioned doodle session, I got a Thought™ after waking up to start a [secret project], however I needed a handful more variants for it, and ended up doodling some more. I honestly have no idea if I should still be calling it a secret considering it's been four years now and I never ended up drawing it up despite- Anyway, this is also exactly the point in time I started to call them all variants (theorized by me to be in reference to "regional variant" Pokemon, ones that take a new appearance when adapting to a new region).
So what inspired me? Simply because I just kept going. I started thinking of a reason the variants I'd made so far were all together during the events of [secret project??], I started thinking of a couple Souls watching over the event (that ended up becoming the main characters of the overarching story) and new unrelated variants that were goofing off in the background, I started thinking of an antagonist, not just tied to the events of this, but to the multiverse at large, and I started thinking up what happened afterwards. I ended up giving the first 25 variants lore when I wanted to flesh out their designs, I added new variants to interact with the overarching story, and I just kept doodling new variants for the hell of it, all because it was fun and even if I never really revealed what [secret project] was (at least to only more than a handful of people hah) people in the circles I was in really enjoyed seeing them. Need I remind you that I stopped keeping track of how many there were after about 1090 variants. So yeah, it just kept going.
I guess in a way this is more answering where does the Variantverse start, but it's such an integral core concept that I think is heavily responsible for this madness snowballing to begin with haha, and things like the "Soul Variant Emporium" (an entirely different inside joke) and different Souls interacting out in the multiverse still resurfaces from time-to-time in the little blurbs I give art. I'm just particularly fond of capturing variants from an angle as if writing Pokedex entries, which I think kinda loops back to that idea of where the word variant comes from.
Honestly I just really love character design, and Soul genuinely is my favourite character of all time, so it's very fun to combine the two (especially when integrating concepts I find I like, such as the mass amount of werewolves hah) and I couldn't be happier that people also get a kick out of it even if I feel just a little guilty I don't really draw non-Soul designs much anymore haha (and I will say the madness brought upon my ask box as been an absolute hoot). So yeah, to sum it up: It started because I just had doodle ideas, and I got inspired by never stopping having ideas and everyone unfortunate enough to be caught in my ramble radius happened to enjoy said ideas.
As promised (thank you for enduring, I hope this was at least interesting haha), here's the most notable early variants that got me rolling the snow around:
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Awakened Soul is the one I mentioned starting off the later doodles with the idea of "variants" first in mind, but Trickster (giving Soul a new outfit), the Pokemon variants, and other Souls of other doodlings are also notable to the entire messy history as to where this all started. I'm still planning to continue trying to draw all of the 1000 variants of the old list eventually and I look forward to sharing all these silly Souls as always.
I swear I'll give the first AU Soul I'd ever drawn real art one day.
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kaisooficrec · 5 years ago
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fic search n. 3 🔎
#014
B: Hey I've been looking and looking for the (really long) fic where kyungsoo and jongin are high school best friends and next door neighbors and kyungsoo ends up becoming super famous and travels the world and kyungsoo ends up in Japan and Italy and Brazil and the US and because of miscommunication they don't talk to each other and kyungsoo was about to give jongin a chance but in another drunken haze he sleeps with sehun in kyungsoo's bed and that extends their problems and in the end I think they finally get back together in Hawaii or some kind of island. Kyungsoo is rich famous and successful and they both have always loved each other since they were in high school but they don't end up with each other until many years later Could you guys help me find the fic? Thanks!!
FIGHT FOR YOUR HEART by MillieCat2 (ty @comatosegal !)
#015
puddin: Hello! I need some help finding a specific fic I read. It was top!soo porn!au where soo was the new guy & jongin refused to accept him as a top because he looked like a bottom. Long/slowbuild tsundere
you got me (wrapped around your finger) by arosoo/domkyung (deleted)
#016
Yomi: I had a saved fic but I can't find it..I remember a " star" falling into the forest and Jongin searching for it or something like that It came to my mind after rt A Pocketful of Stardust  fic but isn't that one
#017
Kokoxcoco: a kaisoo fanfic where kai is a king he treats ksoo really bad so ksoo ends up running away in which he meets king lay but then when ksoo leaves lay declares war on kais kingdome cause he wants ksoo
Kings and Consorts + The Missing Royal Consort they fic just got updated :) (thank you KaisooLibrary!)
#018
squirtle: Hey I read a fic a long time ago, it was aout Jongin who was locked up in a psychiatry and all his doctors were giving him a wrong treatment and then Kyungsoo was a new doctor who got assigned to him but then he figured out what was wrong with him? It was a sad fic, but I can't remember what it was at all. i don't even remember what side i read it
@ultskaisoo: #18 sounds like peace of mind by jongnugget - thank you! :)
#019
lovelykaisoo: hi im looking for a fic sekai were cousins and enemies and sehun takes ksoo to the party where ji doesnt take ksoo aka his boyfie saying its a family party and he comes with a girl? ksoo finds out he comes with a girl so thats why he goes with sehun? and sehun introduces him as his boyfriend to his family where ji's family is there as well
@kyu-gsoo: hello!! i’m pretty sure that #19 is Our Season by KingYeoly on ao3 - thank you! :)
#020
Aly: Hi I'm looking for a fic where ksoo goes to a club where ji works as a prostitute and they fall in love. ji confesses his dream is to become a dancer and ksoo agrees to help him. Then ji works part time in a hotel and one day when ksoo finds him having sex with his hotel manager? Then ksoo breaks up with ji?
@ rivexoksoo: #20 is How to Save a Life by justlikegravity - thank you! :)
#021
Lili_Summer: Hola! I'm searching a fic TuT hopefully you can help me. Its a abo-royal au! Soo is found unconscious outside of prince Jongin's castle, and he saves him. I remember that Soo is an omega, But he hides that fact so its treated as an beta, and Jongin likes me but Soo at first is very shy to him. At some point the king and queen start looking for someone to marry their son And Soo goes into heat so the lies ends there, and Jongin has a happy time with Soo and then they get engaged uwu. Any idea? Thanks!
@comatosegal: I think #021 might be Rain Drops by MoonFlower97! (thanks for the link! - KFR)
#022 (also #011)
mina: hello! i am looking for a kaisoo fic i read years ago. the only thing i remember about this fic is that it was supernatural, that kyungsoo died at the fic which left jongin devastated (*at the end) and that lead him to destroy everything around him because of how painful everything was and how sad he was. i know finding it will be super hard as i don’t have a lot of information but i thought i could still ask! thank you so much :)
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1358456 · 5 years ago
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Review Response, June 21-27, 2020
Well, I guess the DE update doesn’t exist. So I’ll see that story again in Valentine’s Day.
But a miracle has happened in this week, so... yay!
Destiny #017
1)  Hi! I know, long time no see. I’m incredibly sorry for not reviewing sooner, but I guess better late than never, huh? In any case I’m here to stay! Reading this chapter reminded me of how interesting this story really is and I can’t wait to read more. But seeing as it’s been some time I’m going to reread it in order to freshen my memory (I decided to review anyways since I can still review the quality of your fic, which is as I remember, very good). I admit when Peter first mentioned that Ruby was easy to control because of his lack of control over his emotions (and whatnot) unlike Sapphire, I was a bit confused. Wouldn’t it be the other way? I thought to myself, but then I remembered that Sapphire had done some growing up herself. She might’ve not had as much control previously but she certainly does now. As this was kinda proven later on when she was contemplating on what emotion she should be feeling at the moment. And this can be seen as indecision, but I rather thought that this was proving your previous statement correct and that this was her way of finding a little control of the situation. Speaking of what happened a bit later, I was pleasantly surprised of Blue sparing Sapphire’s sanity. I always had hope in Blue despite her obvious turning... but this really proves that Blue can (and most likely will) realize that despite Peter’s kindness she’ll have to betray him because what he’s doing simply isn’t right. I realize now that she probably also followed him because of him brainwashing her, but I can’t remember this particular detail... damn maybe I should’ve reread this before reviewing. Ah well, I’m this far into it anyways. In any case, although this chapter was short I fully enjoyed it. Especially Y’s inner monologue at the end. I do have a soft spot for light angst :’) (I’m sure you can call it that, right...?) so, thank you!
WELCOME BACK!! Yes, it’s always better late than never. After all, as I said before...
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I’LL WAIT A THOUSAND SUMMERS!
For Ruby and Sapphire’s “control” issue, I was actually thinking about their little Hidden Power interaction. Sapphire has strong intuition and instincts, and is in full control of her senses. Or at least that was a part of it, anyways. This chapter was written years ago, so I don’t remember all the details. Hehe.
As for Blue... There’s a little character arc for her across all of my stories. If you read my stories in order of creation, you can kind of see it. First is when she’s neglected and is just rolling with it while feigning cheeriness (SE/SA/SR), but then it just piles up and she goes into depression (SA/SL/Destiny), then she kind of snaps and goes rampant (SL/Destiny), then she finds the one piece of true happiness in her life and starts to turn it around (Destiny), and eventually successfully attains happiness and stays that way (Destiny/Legacy). So you’re at the moment in Destiny where Blue has gone rampant but is trying to turn it around.
... I think I need to reread this story too. Hehe. I don’t really remember what happens in each chapter... except for a certain few, that is.
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Destiny #018
1)  That’s... awful... Poor Y, who was already suffering so much, both physically and mentally. She didn’t even get to hear X say what he wanted to say to her. And if they don’t meet again she’d live the rest of her life not truly knowing where she stood with X. Always filled with guilt. Such is the sadness of the situation, but I can still hope! Hope that Y will meet X again and he’ll be able to tell her his thoughts. Though come to think of it, poor X too. He’ll have to speak with his seniors and he’s obviously really uncomfortable with that and doesn’t even have Y around to help him. Welp, to go to another depressing topic there’s also Sapphire’s situation to discuss. It is at the point not that disobeying Peter *would* be interfering with his plans, since it’s crucial that Sapphire be broken. Will Blue be able to disobey? Impossible to know, you can only hope that she does. On another topic, after rereading the fic (oh god I’d forgotten how long this was, it’s truly amazing the dedication you’ve had for this fic) I kept thinking back to Peter’s “blank eyes” you mentioned in the earlier chapters. This is a vague and rather shoddy theory, but the only thing I could think that would be the cause of the blankness is him being brainwashed as well. This is rather obvious, but this leads to who might be brainwashing him. Clearly this would be someone (or something..?) that would benefit from the restoration of the legendary’s and this would bring us to suspect #1: Zygarde. Now, I haven’t actually read the XY arc nor played the game (ik ik but I can still have a fellow feeling for X and Y) so I don’t know what this dude is capable of, but I can assume that this is within the realm of possibilities. And it would make sense with the whole blinking lights thing that Blue noticed that was going on a couple chapters ago. ‘Cause I mean, why else would this random guy help the legendaries, it’s all just a bit too sketchy. I am no detective, so I think these are fairly obvious, but they’re all I have going for me right now. This was a lovely chapter (writing of course, I can hardly apply that to the atmosphere), and I can’t wait to read the next one.
Poor Y indeed. Really. Poor Y... hehehe...
Destiny’s not THAT long, is it? ... 220 000 words... well, it’s not longer than SA which has 225 000, but... that difference is practically negligible. ... I wonder how long Legacy would end up... Anyways.
I don’t know if it’s obvious or not. I have a hard time with that. Sometimes I put in obvious hints in my stories and no one catches on. Sometimes I put vague hints in my stories and no one catches on. So I can’t tell if it’s subtle or blatant. I think for the Mega Hunter, there were a lot of subtle and blatant ones.
Now for Zygarde... well, the Neural Para... er... mind control is not really in its arsenal. Destiny’s plans were written shortly after XY games were released. Zygarde was kind of worthless there, but given what happened with Kyurem, I suspected that it would get a cooler new form. But then in SM, it turned out that its cooler new form was just a massive health buff. And it still gets annihilated by Xerneas, so... pfft. But I think I used its signature moves pretty well. Especially, say... Core Enforcer. Hahaha.
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Destiny #019
1)  Ok, first of all, WHAT KINDA QUESTION IS THAT? How can I choose? Both options of your review survey thing are so sad... but after a moment’s thought, I think the second option is better. If Y were to continuously push herself then she’d just die. End of story. But with the second option, although incredibly risky and kinda pointless for X to go save her, the chances of them both staying alive are possibly higher, and Y would know Ax’s true feelings. This I think, would be what you referred to as the “happy ending”. Unless you actually said it outright that it’s the opposite and I just completely missed it. But anyways I’ve spent enough on Y’s situation lmao. I think I might switch over to Blue now, because something has been nagging me for a while. I feel like slapping this woman. I know she’s partially under the control of Peter (or assuming that my previous theory is correct, Zygarde’s), but, murder? Thankfully she admitted this chapter that she was, in fact, NOT wanting to murder anyone. But when she let anger blind her she was quite willing to do away with Green. And she has reason! Was Green did to her was beyond shitty, but killing him is just a little overtop. And she tried to justify it by saying, “Peter is the only one that has been kind to me” so it’s ok that I betray even my closest friends whom I’ve known for years even if I haven’t kept much in contact (besides Silver smh). She clearly knows what Peter is doing is wrong and while I don’t think that anyone is a saint and everyone makes mistakes, I’m still thinking “come on”. Plus, it’s not difficult to see how Peter’s kindness is really just a way to benefit him. Though I can let that one slide since it’s easy to fool yourself. Despite all that, later on in the chapter after feeling annoyance at Blur for seriously trying to blame Y for wanting to give X back *his* Mega Ring (plus why do they call it ring) just because it’d been a gift to her (and reminding myself that she also had reason to feel that way but whatever) it was very nice to see her being selfless. Which might be an awful thing to ask of her now, but it was the right thing to do. And that’s gratifying on its own, right? I feel as if these reviews have started to just be me ranting at this point. Can you still enjoy these..? But honestly there isn’t much to review at this point. I’ve touched a lot on your actual writing in past reviews, and since it’s the same fic the style hasn’t exactly change. Though I can still admire how seamlessly you seem to write, even while changing point of views. Quickly changing scenes from something a little peaceful, to a battle, which you are able to describe in detail and yet still be engaging. Ah, I got kind of sidetracked, didn’t I? In any case all I have yet to do is speculate what’s going to happen next, but alas, I have no idea. I assume there’s a somewhat happy ending, with a final battle with Peter and the legendaries, not to mention the plot twist. Guess I’ll just have to wait and see.
Huh? ... Oh right. The review survey. Hahaha. Second option, huh? I think I remember most people choosing that option. But... if you look at the choices, it seems pretty clear, right? And I just love to break expectations. Hehe...
Now, as for what’s happening with Blue, it’s explored a lot more in the upcoming chapters, with everything being explained in... 25? 26? And I do believe that all the issues you have will be resolved.
Hehe. Asking a girl, who after being neglected for years is finally trying to find some happiness for herself, to be selfless? How awful! Hahaha.
Of course I still enjoy these! Despite being called “reviews”, they’re more like “comments”, really. Just tell me what you liked about each chapter, what you didn’t like, what you hope to see in the future, what you don’t want to see, and/or just your thoughts/feelings while reading. So precisely what you’ve been doing already. It’s fine~! :)
I greatly look forward to seeing more!
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fmdtaeyongarchive · 5 years ago
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headcanon #019: hair through the eras
word count: 1,375 1,501 1,555 words
updated august 8, 2020 february 13, 2021 !
Mama (2012)
Ash debuted with what I would like to call shaggy emo hair.  It was a little longer and wavier than he’d had normally in the most recent times pre-debut, but Ash quite liked this style for his hair at the time and had no complaints.
Wolf (2013)
It took over a year for Knight to comeback and during that time Ash had mostly kept his hairstyle from Mama era. It was only when it came time to shoot the music video and promotional photos they he was given a new hairdo for the era, which was a reddish-brown coif. The aim was to make him look a little older and a little sportier without making him look too mature since he was still one of the younger members of the group. Though he was only seventeen, he began to earn more attention for his visuals this era than he had in debut. Despite his negative opinions on nearly everything else about this era, he once again didn’t have any major complaints about his hair style, though he was attached to his debut era hair.
Growl (2013)
Growl was the first time Ash had an obviously unnatural hair color, as he was styled with a red bowl cut with angular bangs. As was the styling of the era, the style was chosen to look youthful and easy to style with a backwards baseball cap if they chose to put him in one. He went back to a natural color very quickly after this era finished, as he found the hair dye made his hair more brittle due to being particularly sensitive to it.
Overdose (2014)
For Overdose, Ash went back to an unnatural color with dark purple hair, usually styled in a comma hairstyle. It was a popular look for fans at the time, but Ash wouldn’t personally consider it one of his favorite hairstyles he’s ever had and he went back to a normal dark brown halfway through promotions due to the hair dye irritating him again. It was one of the more popular eras for him visually again, though. Fans seemed to like his hair styled to show his forehead.
Call Me Baby (2015) 
For Call Me Baby, Ash’s hair was somewhat similar to the previous era with dark brown hair, though his bangs were shorter. He didn’t have much of an opinion on his styling this era, to be honest.
Love Me Right (2015)
For Love Me Right, Ash’s hair was lightened to a light brown with long bangs and some blonde highlights. Ash quite liked the longer bangs looks
Sing For You (2015)
While this is one of Ash’s favorite era’s musically, he probably couldn’t tell you what his hairstyle had been for it, but he had brown hair with asymmetrically parted bangs. His hair was pretty healthy at this point and it would continue to be saved from bleach for several more eras.
Monster / Lucky One (2016) & Lotto (2016)
His first two eras after his scandal brought one of his fans’ favorite hairstyles of all time, and Ash was happy that they had something to talk about other than his recent bad press. For Monster/Lucky One promotions, as well as the repackage promotions with Lotto, Ash had black comma hair.
Fanfare (2016) & Gorilla (2016) & Hey Mama! (2016)
The next three eras came incredibly close together with almost no break for Ash, so his hairstyle remained the same throughout all three — a brown wavy style that was easy to maintain.
Can You Feel It? (2016)
This time around, Ash got a medium brown bowl cut. Ash wasn’t a huge fan, but it was a popular style at the time that many other idols had and he didn’t say anything to stylists since he was just grateful he hadn’t been punished for his scandal with outrageous hairstyles.
Roar (2017)
Roar brought the first major hair color change for Ash since Overdose three years prior  —  a light brown/dirty blonde color generally styled with a wavy texture. The bleaching required to lighten his hair had taken a toll on it again, so the color didn’t last long past the end of music show promotions.
Easy Love (2017)
His hair was back to a light brown for Easy Love, one of his favorite eras musically, but again pretty forgettable as far as hairstyle. Stylists did sometimes give him pink highlights this era, namely for the music video and a select few music show performances and fan signs early in the promotion period.
Ko Ko Bop (2017)
For Kokobop, Ash’s hair was pretty much the same as it had been for Easy Love, light brown, though they had long ago given up on the pink highlights by this point. He was also on We Got Married’s special summer season during this time, so they wanted him to have an approachable and friendly look.
365 Fresh (2017) & Power (2017)
For these two eras, which included the first round of promotions Ash had ever done outside of his group, he went slightly darker with the brown and had some highlights to add texture. Unlike the past few eras, his hair was finally styled to expose his forehead again and was often styled for a wavy coif of bangs to frame his face. It was, again, a more popular era for him visually, as most eras where his bangs are styled out of his face tend to be.
I’m Young (2017) & O Sole Mio (2018) & Blooming Days (2018)
For his solo debut as well as the Knight era and the White Knight era following it, Ash ditched the shades of brown to go for a solid black that was generally styled with his bangs parted in the middle to show his forehead again. It could be argued this was the beginning of a more mature styling for him.
Critical Beauty (2018)
For Critical Beauty, Ash kept the black, though it was styled with his bangs to one side and out of his face and he had a bit of an undercut. Compared to his usual middle part, he had a side part this era. Ash liked this style, but it only lasted as long as music show promotions before he changed it again.
Tempo (2018) & Untitled, 2014 (2018)
Ash’s hair was initially dyed pink/red for the filming of his BC Portal “New Heroes”, but due to an overwhelmingly positive response, he kept it through the end of the year. By the time he was promoting Untitled, 2014, it was more of a faded pink or even simply blonde to spare his hair from all of the dye on top of the bleach.
Love Shot (2019)
After the damage his hair had suffered in the back half of 2018, it was obvious Ash would need to go back to a dark brown for Love Shot era. It matched the dark and sexy but sophisticated vibes of the song, anyway.
Troublemaker (2019)
For Troublemaker, Ash’s hair was still dark brown or black, but he had begun letting it grow out.
Now or Never (2019) & Now (2019)
For Knight’s next comeback as well as his second release with Yoona, he had continued letting his hair grow out and it was now dark and curly. Ash was really loving growing his hair out longer than he’d ever been allowed to have it be and if he hadn’t been so exhausted at time time, he would have been really feeling himself. As it hair got longer, it got more divisive, though, and there was a vocal minority of fans (and, even more so, anti-fans jumping on the opportunity to hate) who absolutely hated the new look and were more than happy to make it known in online comments and to his face.
Romanticism / D (Half Moon) (2019) & Enough (2020)
For his third solo album through now, Ash’s hair has been black and wavy, and at its longest. He’s not a very vain person, but he really does like how he looks these days and thinks he’s the closest to how he’d choose to look if he wasn’t an idol and had more of a say in how he presents himself.
Woo Ah (2020)
Ash cut his hair shortly before the release of his song. It was far more BC’s idea than his, but he sported a shorter hair style with blue-green ends for the short promotions of this song, often in a forehead-exposing, comma hair style. For several months after, as his hair began to slowly grow out again, he would still make appearances with green ends.
How Can I Love The Heartbreak, You’re The One I Love (2020)
The sound of this song was more of a classic sound, so Ash lost the dyed ends and instead stuck with dark brown/black hair that had grown out to a similar length as it had been around the same time the year before and generally styled wavy.
Bittersweet (2020)
For this comeback, Ash kept the longer dark hair that he’d had in his viral fancam a month prior, which was pretty similar to his hair from the previous solo album. His hair was permed during this time and throughout this period, he often styled his hair up in buns or ponytails.
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pet-diary · 6 years ago
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【#GradblrChallenge & 100 Days of Productivity】
■ 08.19.18 // (day 019/100) ————————————————
My last #gradblrchallenge post was on Thursday. I’ve been really bad about posting the past few days because I’ve just felt like I didn’t have much to say... I also just haven’t felt very productive school-wise, since I don’t even start until October and there’s only so much pre-planning I can write about before I start to feel like a broken record. I sort of feel silly posting about grad school when I have zero experience with grad school so far (other than interviews), and I haven’t even started my program. I know that will change very soon, so it does matter. It’s also interesting to go through the pre-grad school process, where you’re worried about all the wrong things, learning about everything for the first time, etc. But I feel a little silly posting about it because I feel like I’m just clogging up the real grad student’s posts. Lol, I know I’m being ridiculous. I’ll try to just get back to posting, and hopefully I have something interesting to offer regardless of where I’m at right now. If anyone in grad school for psych or social work or something is reading this, I would love to chat with you about it! I’ve talked to a few people so far about their programs, and it’s been helpful to hear how things work, what they like and don’t like, what they’re going through. I want to have a better understanding of what I’m getting myself into.
Some things I’ve done recently:
spent a lot of time online window shopping (when you “shop” all day but don’t end up buying any of the stuff you added to your cart),
researching new phones (both online and at the phone store),
waiting for my maintenance guy to come and then dealing with all that (clogged sink and bath, clean up),
taught Trev how to play Skyrim,
went out to eat once, and to a coffee shop once,
cooked some yummy meals,
bought some notebooks I didn’t need on Amazon,
took Trev to the theosophical society library,
and generally just being kinda lazy...
Yesterday, we ordered some new phones... Ours were getting old and worn out (battery life, general use, camera failing, etc), so we decided to just bite the bullet and get some new ones. Since phones are RIDICULOUSLY PRICED, it ended up being a better deal to get a brand new Note 9 for me, and an S9 for Trev, because they had a BOGO deal going where you get one phone free and a free pair of headphones and stuff like that. I had to change my phone number though to be eligible, so that’s going to be a pain in the ass to go through and update on every form and account I own..........
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Oh well though. I’m super psyched about the S pen!! It’s a Wacom pen and it’s active, meaning it’s pressure sensitive, meaning I will be able to draw on my phone like it’s an actual Wacom tablet. How cool is that???? I currently own a Jot Pro, which I love, but it’s passive. There’s no pressure sensitivity, it’s not as detailed. It’s great for doodling, but it isn’t very practical for trying to seriously draw something. I know at the end of the day, it’s still a little tiny phone screen and I’m not going to spend my days training to join Clamp, but maybe I can get in enough practice to finally feel comfortable moving forward with my web manga idea! (。・ω・。) It’ll be nice to have a properly working camera again, too. I’d like to start filming videos for YouTube again, and currently my camera crashes even on the lowest quality option... The phone isn’t out yet but once it’s out they’ll ship it and hopefully it’ll be in my hands and working soon! It’ll be kind of sad to say goodbye to my 512 Austin area code number... I felt like it gave me some cred...... But I’ll have a new Seattle number, so I guess I’ll have Seattle cred... It makes me a little sad though. I’ve had that number for YEARS. Plus now I won’t match Trev’s number...
Today my school emailed the orientation schedule, so I’ll be posting about that soon. I’m hoping to go out and buy a few things I need for school (mainly, a decent binder for this loose leaf textbook I just dropped $100 on ಥ‿ಥ ). Hopefully my next gradblrchallenge post will be a little more relevant to gradschool...
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opmsecretsanta · 7 years ago
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OPM Holiday Prompts 2017
This list will be updated every few days as more prompts are added.
You can submit prompts here at the event’s AO3 page. If you absolutely cannot use AO3, submit your prompt to opmsecretsanta via the ask box (rating/characters/prompt) and we will add it for you. You can claim/fill any prompt you want, as many as you want, no AO3 required.
Last day for sending in prompts is Dec 20th Last day to submit fills is Dec 31st
(List below the cut)
Prompt 001
Tag: #OPMSS Prompt 001 Rating: Teen Pairing: Genos/Saitama Characters: Genos, Saitama, Mumen Tags: Oblivious Genos, Demisexual Saitama, Saitama has hair Prompt: “Genfic or a non-sexual Saigenos story” 
Prompt 002
Tag: #OPMSS Prompt 002 Rating: G Pairing: Genos/Saitama Characters: Saitama, Genos, Minibots Prompt: Saitama, Genos and the bots are getting ready for Christmas, baking (or trying to bake...) cookies. More than likely, there is flour everywhere and many reminders to ”stop eating the dough!” - I’ll leave it up to you who those reminders are aimed at though! ;)
Prompt 003
Tag: #OPMSS Prompt 003 Rating: G Pairing: Genos/Saitama Characters: Saitama, Genos Prompt: We follow one of the characters as they are struggling with thinking of a good gift for the other
Prompt 004
Tag: #OPMSS Prompt 004 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Prompt: It’s Christmas and Genos has prepared a very special gift. Saitama comes home to a note on the door. ”Please go to where we met for the first time.” He makes his way to where he destroyed that Mosquito lady, only to find another note, which leads to another, then another... While whining over how much effort this is, he is taken on this trip down memory lane, before finally reaching his final destination and his gift. What is it? You decide.
Prompt 005
Tag: #OPMSS Prompt 005 Rating: Any Pairing: Genos/Saitama Characters: Hero Saitama, Villain Genos Tags: Pre-Relationship, Mistletoe  Prompt: Villain Genos only wants one thing for Christmas: Getting the object of his affection (the Hero Saitama) to kiss him under the mistletoe.
Prompt 006
Tag: #OPMSS Prompt 006 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos, Dr. Kuseno, Mini Bots Tags :Meet the Family, Family Dinners, Murphy's Law, Unconventional Families, Marriage Proposal, Family Drama Prompt: It's time for Genos and Saitama's families to finally meet over a holiday ham, and nothing goes as expected
Prompt 007
Tag: #OPMSS Prompt 007 Rating: Any Pairing: Fubuki/Mumen, King/Sonic (or any combo of characters) Characters: King, Fubuki, Tatsumaki, Mumen, Sonic Tags: Office Party, Gift Exchange, Drunken Confessions, Walking In On Someone, Ugly Holiday Sweaters, Drama Prompt: The annual Hero Association Holiday Party and White Elephant gift exchange is usually boring and lame... but not this year. Someone gets a little too competitive over a gift, someone gets too drunk, someone crashes the party, everyone's sweaters are hideous, and King nearly has a heart attack.  (the tags wouldn't let me say any combination of secondary character relationship with each other, or with the main characters Genos and Saitama. I'm not picky. I ship all the ships)
Prompt 008
Tag: #OPMSS Prompt 008 Rating: Teen Pairing: Genos/Saitama Characters: Saitama, Genos, Fubuki, Mumen, King Prompt: Saitama, Genos, Fubuki, Mumen, King, Zombieman, Metal Bat, and Silver Fang in a Dungeons and Dragons seeing. (Or you can dear then having fun playing a game and obviously have King win) Bonus points if Genosai is in the pic or fic somewhere. Even more if Garou is in there. (No NSFW please)
Prompt 009
Tag: #OPMSS Prompt 009 Rating: G Pairing: Genos/Saitama, Teru/Mob Characters: Saitama, Genos, Mob, Teru Prompt: Crossover with Mob Psycho 100. Fanart of Teru and Shigeo; Genos and Saitama going on a "double date" or training session turning into a date. Bonus if Saitama helps Shigeo up from his exhaustion.
Prompt 010
Tag: #OPMSS Prompt 010 Rating: Any  Pairing: Genos/Saitama Characters: Saitama, Genos, S-Class Heroes, Mumen, King Tags: Fake/Pretend Relationship, Sharing a Bed, Mutual Pining, Oblivious Prompt: The HA organised a Christmas event for all the S-Class Heroes and their "plus one", they get to go to a luxurious hotel for the holidays and there is a competition for couples, where the winner couple wins a lot of prizes and a hotel room to spend the night!
Prompt 011
Tag: #OPMSS Prompt 011 Rating: Any Pairing: Mumen/Sonic Characters: Saitama, Genos, Mumen, Sonic, Fubuki, S-Class heroes Tags: First Dates, First Kiss Prompt: Being Mumen Rider at this time of the year is a lot of stress, there's always one new hero to welcome to the HA, a new gift to think of, a lot of over-excited kids dying to meet Santa that need supervision and oddly holidays related monsters; so when a certain pretty ninja comes looking for him and invites him to "do something i don't know, whatever" well, it's a welcome distraction.
Prompt 012
Tag: #OPMSS Prompt 012 Rating: Any Pairing: Genos/Saitama, Charanko/Garou, Bang/Kuseno Characters: Saitama, Genos, Dr. Kuseno, Bang (Silver Fang), Charanko  Tags: Christmas Party, Mistletoe, Blushing Prompt: Bang invites Saitama and Genos over for Christmas, but Genos and had already made plans with Kuseno, but Bang said to bring him too, the more the merrier. When Genos, Saitama and Kuseno arrive at the dojo, they are happy to find how Bang, Charanko and Garou decorated the place, but a misplaced (or not?) mistletoe finds its way over Kuseno and Bang. Genos is not happy but traditions are traditions.
Prompt 013
Tag: #OPMSS Prompt 013 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Fake/Pretend Relationship, Christmas, Christmas Fluff, Alternate Universe - College/University, Meet the Family, Happy Ending Prompt: College teacher au. Saitama's family has been worrying about his mental health, especially since he started his new job as a junior professor. In a desperate attempt to stop nightly phone calls, Saitama tries to recruit a department intern to pretend to be his significant other for Christmas. The only one who agrees is Genos, who secretly already has a huge crush on him.
Prompt 014
Tag: #OPMSS Prompt 014 Rating: Teen Pairing: Genos/Saitama Characters: Saitama, Genos, Mumen Tags: Angst with a happy ending, Christmas Fluff Prompt: Saitama hasn't had the best Christmas experiences in the past. Genos is missing his family more than ever during the holiday season. Both are simultaneously trying to ignore their own blues to make the other have the best Christmas ever. Granted, it doesn't work out very well until they talk about it and come to mutual understandings.
Prompt 015
Tag: #OPMSS Prompt 015 Rating: G Pairing: Mumen/Saitama, Genos & Saitama Characters: Mumen, Saitama, Genos Prompt: Genos knows that Saitama and Mumen is crushing on each other, and takes advantage when they both ask him for what to give the other for christmas. He HAS to get them together!
Prompt 016
Tag: #OPMSS Prompt 016 Rating: Any Characters: Mumen Prompt: How does Mumen Rider celebrate Christmas? Write or draw whatever comes to mind!
Prompt 017
Tag: #OPMSS Prompt 017 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Prompt: Saitama scavenges abandoned planets for useful objects he then repairs and sells. His most valuable find is an android named Genos. He pulls him out of snow-coated rubble and cleans him up, wondering how much he's worth. Genos doesn't mind being mistaken for a machine. It doesn't help that his voicebox is damaged, or that small parts of his body are missing, showing the mechanical structures underneath. On their journey to the marketplace Saitama realizes that Genos is no android. He's human (a cyborg). Instead of selling him, Saitama offers a new home. (art or fic ❤)
Prompt 018
Tag: #OPMSS Prompt 018 Rating: Explicit Pairing: Genos/Saitama Characters: Saitama, Genos Prompt:  One/both are fuckin' in Santa suits. Ho ho ho. Bonus points if one of them is the reindeer.
Prompt 019
Tag: #OPMSS Prompt 019 Rating: Any Pairing: King/Saitama Characters: Saitama, King Prompt:  King and Saitama decide to go on a date for Christmas because King has never had a real S.O. on Christmas before. (Whether it goes well or not is up to you)
Prompt 020
Tag: #OPMSS Prompt 020 Rating: Any Pairing: Saitama/Sonic Characters: Sonic, Saitama Prompt:  Saitama refuses to have a real fight with him, so Sonic starts challenging him to every competition he can think of, from eating to racing to (insert ridiculous thing). Saitama actually participates and enjoys the pointless contests. Ends with them both admitting they just like spending time together. (Bonus points if Saitama challenges Sonic to a kissing contest)
Prompt 021
Tag: #OPMSS Prompt 021 Rating: Explicit Pairing: Genos/Saitama Characters: Saitama, Genos Tags: First Time Prompt:  Genos and Saitama are trying to have sex for the first time, but Genos keeps getting too enthusiastic about observing all of Saitama’s reactions / erozones / etc and keeps stopping to take notes. Saitama gets increasingly annoyed.
Prompt 022
Tag: #OPMSS Prompt 022 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Alternate Universe - College/University, Friends to Lovers, Long-Distance Relationship, Online Dating Prompt: Saitama and Genos meet online (how/where is up to prompt filler). One day, they finally decide to meet up in real life and spend some time together. After just a few days, they start to fall in love.(Semi-cyborg Genos is a preference--more human than in canon, but still has non-human parts. What parts are up to prompt filler.)
Prompt 023
Tag: #OPMSS Prompt 023 Rating: Teen Pairing: Genos/Saiama Characters: Saitama, Genos Prompt:  It's Christmastime and Genos planned the perfect Christmas Eve for them both. It was going so, so, so not well. Everything kept messing up, something always came up whenever Genos was preparing for it. He probably went to the fight still in the apron and it'd make the front page if it got covered by media. Anyways, yeah, the plan was not going so well and Genos was almost on the brink of tears because of frustration. What's Saitama gonna do to fix this situation?
Prompt 024
Tag: #OPMSS Prompt 024 Rating: Teen Pairing: Genos/Saitama Characters: Saitama, Genos Prompt: Genos knits them both silly Christmas sweaters. Does it go well? Does it become a disaster?
Prompt 025
Tag: #OPMSS Prompt 025 Rating: Any Characters: Tatsumaki, Fubuki Tags: Alcohol, Christmas Eve, Sibling Bonding Prompt: Tatsumaki and Fubuki spend Christmas Eve together... with copious amounts of alcohol, of course.
Prompt 026
Tag: #OPMSS Prompt 026 Rating: Any Pairing: Genos/Saitama, Genos/Saitama/Sonic Characters: Genos, Saitama Prompt: Half-monster Genos and tentacle Saitama Could be anything. Cuddling by an open fire, smutty tentacle fun, Christmas stuff, you name it. Refs: http://78.media.tumblr.com/e601b9bedacdb6d3606c023c774ad233/tumblr_oudkx3iTeh1rzjk5bo1_1280.png (nsfw) https://78.media.tumblr.com/1fbac17ca8cfcf5ad0bd3a81df622acd/tumblr_otx4ziQxn81rzjk5bo1_540.png
Prompt 027
Tag: #OPMSS Prompt 027 Rating: G Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Sickfic, Domestic Fluff, Friendship/Love, Pre-Relationship, Fever, Delusions, Humor, Hurt/Comfort Prompt: Genos gets sick and Saitama has to do his best to take care of him, despite never having taken care of a sick person before (other than himself). At some point, Genos' fever gets high enough that he starts getting a bit loopy. Lighthearted shenanigans ensue.(Can be an AU with human!Genos or canon-compliant, though I'm leaning a bit more towards preferring human Genos. It's also up to you if they end up getting together in the end or not, but please have there to be some clearly developing romantic feelings on Saitama's part either way.)
Prompt 028
Tag: #OPMSS Prompt 028 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Prompt:  For reasons (left to the writer/artist's discretion, but maybe a Hero Association fundraiser? Saitama agreed because they get to keep their tips) Saitama, Genos, and any number of other heroes are roped into serving fans festive food and drinks while wearing Christmas-themed maid costumes. Romance would be nice but that's also left up to you.
Prompt 029
Tag: #OPMSS Prompt 029 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Prompt: One or both of them are trans (bonus points for trans!sai). The rest is up to you. I just need more trans saigenos fics. Any rating is fine.Pls. My crops are dying.
Prompt 030
Tag: #OPMSS Prompt 030 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos, King, Mumen, Fubuki Tags: Mutual Pining ,Story within a Story, Pre-Relationship Prompt: King is looking to run a Dungeons & Dragons campaign and offers to pay for takeout weekly for anyone who comes to play. Saitama and Genos are shoe-ins, as are several other heroes who are either there for the food or for the drama (or both).Genos and Saitama's characters are particularly flirty with one another, despite them not being in a relationship (yet?), and everyone but them can see how pathetically transparent they're both being.TL;DR: Genos and Saitama flirt and/or date in a D&D game because both of them are too silly to try to flirt and/or date in real life. Whether or not they realize what they're doing is up to the author's discretion!
Prompt 031
Tag: #OPMSS Prompt 031 Rating: Any Pairing: Saitama/Tatsumaki, Fubuki & Tatsumaki Characters: Saitama, Tatsumaki, Fubuki, Bang Tags: Friendship/Love Prompt: When Tatsumaki's only family couldn't join her for the holidays, she decides she didn't even want to celebrate it anyway. Then how the hell did she end up in Bang's dojo getting a pep talk from Egghead? add as many characters as you want as long as Tats and Sai are central
Prompt 032
Tag: #OPMSS Prompt 032 Rating: Teen Pairing: Fubuki/Saitama Characters: Saitama, Fubuki Tags: Friendship/Love Prompt: New Years Eve tradition/countdown - Could be rated M or E go wild (by that I mean do whatever you feel like it); add as many characters as you feel like as long as it's centered on Fubuki and Saitama.
Prompt 033
Tag: #OPMSS Prompt 033 Rating: Any Pairing: Mumen/Tatsumaki Characters: Mumen, Tatsumaki Tags: Getting to Know Each Other Prompt:  He's a C-class hero. #1 C-class, but C-class anyway. And her powers don't work on him. One could only expect Tatsumaki to be curious about it. (or a talk over spiced frappuccinos)
Prompt 034
Tag: #OPMSS Prompt 034 Rating: Any Pairing: Genos/Mumen/Saitama/Sonic Characters: Saitama, Genos, Sonic, Mumen Tags: Christmas Fluff, Everyone is Gay Prompt: Last year he spent Christmas alone, cold, and miserable. A monster crashed through his front door and there was nothing on T.V. but romantic movies. At least the last 11 months have been better, and he's gotten THREE boyfriends?! This might be the best Christmas yet, if he can find them the perfect presents of course. OT4 fluff, anyone's POV is fine, nsfw is fine too.
Prompt 035
Tag: #OPMSS Prompt 035 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Tags: AU, Fluff and Angst, Metropolis, Major Character Death Prompt: Humans and robots coexist in the futuristic city of Metropolis, although robots are discriminated against and segregated to the city's lower levels. A lot of Metropolis' human population are unemployed and deprived, and many people blame the robots for taking their jobs. Metropolis (2001) AU. Saitama as Kenichi and Genos as Tima. You can stick to the movie or write an au of an au. You don't have to have watched the movie honestly, but you should it's really good.
Prompt 036
Tag: #OPMSS Prompt 036 Rating: Explicit Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Sex tapes Prompt: Genos is going to be away for a week and he wants to make a sex tape to keep Saitama company until he gets back.
Prompt 037
Tag: #OPMSS Prompt 037 Rating: Mature Pairing: Fubuki/Psykos Characters: Fubuki, Psykos Prompt:  Both fic or art appreciated! It can be set in canon or an AU. I'd love some relaxed, peaceful mood along with it if it's possible :) And some mutual grooming maybe! (It says Mature in the tags, but anything between Gen-Mature is good)
Prompt 038
Tag: #OPMSS Prompt 038 Rating: Any Pairing: None Characters: Genos, Kuseno Tags: Christmas, Family, Past Tense Prompt: A look at Genos and Dr. Kuseno's first Christmas together. Was it awkward, quiet, and uneventful? Or was it full of remiscining, warmth, and budding new family ties?(Angst is welcome, 15 year-old Genos is preffered)
Prompt 039
Tag: #OPMSS Prompt 039 Rating: Explicit Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Established Relationship, Teasing, Flirting, Sexual Frustration, Humor Prompt: Saitama spends an entire day flirting with and teasing Genos when it's impossible for the cyborg to do anything about it. However, he doesn't really consider the fact that, once they get home, he'll be at Genos' mercy...So basically, a fic where the latter half is just Genos having his way with Saitama as revenge for all the teasing >:3cThe sex part is pretty much fair game, write whatever you'd like! As long as Genos is calling the shots. And I'd really appreciate Saitama getting pretty flustered over it all...
Prompt 040
Tag: #OPMSS Prompt 040 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Tags:  Alternate Universe - Role Reversal Prompt: Alternate Universe where Genos survived the Mad Cyborg attack (perhaps with some scars) and never became a cyborg. he tries to train himself to be a better hero and take on the crazed cyborg one day, but can’t seem to become as strong as he needs to be. Then he meets Saitama, and is awed by his strength, but a little discouraged when he realizes that Saitama is at least part cyborg. Saitama feels inhuman and disconnected from the world, until this young, spitfire, hero wannabe comes into his life.
Prompt 041
Tag: #OPMSS Prompt 041 Rating: Any Pairing: Genos/Saitama Characters: Saitama, Genos Tags: Possessive Behavior, Love Bites, Marking Prompt:  Genos is very possessive and demonstrative with his affection. He enjoys leaving marks on Saitama, especially love bites and hickeys on Saitama's neck. Because of Saitama's high tolerance for injury, they don't last very long, so Genos has to keep reapplying them daily. Neither of them see that as a bad thing, and Saitama (secretly?) adores feeling so loved and wanted.
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sciencespies · 5 years ago
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Scientists zero in on cancer treatments using CRISPR
https://sciencespies.com/biology/scientists-zero-in-on-cancer-treatments-using-crispr/
Scientists zero in on cancer treatments using CRISPR
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Credit: CC0 Public Domain
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Chemotherapy works off of a basic premise: kill all rapidly-growing cells in an effort to wipe out tumor cells. The tactic, while generally effective, has quite a few off-target casualties, including cells that produce hair and cells that line the stomach.
  Scientists have tried to skirt the problem by creating missile-like drugs that zero in on cancer cells specifically, sparing healthy cells.
These missile-like drugs, known as antibody-drug conjugates (ADCs), have been in the works for decades, but only in recent years have they made it to clinical trials, Kimberly Tsui, a genetics graduate student, told me.
The advances are at least partially due to a better understanding of how ADCs work: On the surface of every cell are proteins that poke out—some of these proteins are only found on cancer cells, making them a perfect target for tailored drug delivery. ADCs include a shuttle molecule that identifies and clamps down on these cancer-specific proteins, transporting a drug capable of incapacitating the cell.
“ADCs are showing lots of potential in the clinic, but there’s a lot we don’t understand about how they actually work,” said Tsui. “We don’t know enough about how ADCs are taken up into the cells, or how the drug is trafficked into different compartments to ultimately kill the cell.”
Now, Tsui, Michael Bassik, Ph.D., assistant professor of genetics, and a team of researchers are tapping gene editing to better understand how ADCs deliver their deathly blow to cancer cells.
A study detailing their findings appears in Nature Chemical Biology. Bassik is the senior author. Tsui is the first author. The work was done in collaboration with Carolyn Bertozzi, Ph.D., director of ChEM-H at Stanford.
Bassik and Tsui used the gene-editing technology CRISPR to figure out which genes help ADCs weasel their way into cancer cells.
“With our CRISPR screening system, we can shut off one gene at a time to figure out which ones are important for ADC toxicity,” said Tsui. Using this set up, the team is trying to see which genes either help intensify the toxic effect, or conversely, inhibit it.
The idea is to better understand how the ADC interacts with the tumor cell and use the information to make the ADC even more toxic.
“Overall, it starts with basic biology and understanding the genes that could affect ADC toxicity,” said Tsui. For example, if a specific gene is “knocked out” or rendered unable to function, and the ADC stops being toxic against the cancer cells, that’s a sign that the gene is required for the ADC to become active in the cell. “It could even have important implications for potential ADC-resistance mechanisms,” she said.
For an ADC to kill a cell, it has to check a few boxes, most of which are regulated by specific genes. But not all ADCs get into the cell and cause damage through the same mechanism, making it even more critical to understand how ADCs vary when it comes to tumor cell destruction.
It’s been thought that all ADCs have to get chopped up, or “digested,” before they inflict damage. The understanding was that any ADC binds to the surface of the tumor cell and is taken in through a vessel known as an endosome. The endosome then shepherds the drug to a new compartment of the cell called the lysosome.
There, the ADC gets broken down into its parts, and the drug separates from the antibody shuttle. Then, the drug is moved to yet another new location into the cytosol, the goo that fills the open space of the cell. Here, it can finally do its damage.
Exactly what genes underpin that series of steps, however, is not entirely clear. That’s where Bassik and Tsui hoped their screen would come in. Indeed, their experiment revealed a handful of previously unknown genes critical to the trafficking of the drug. In particular, they found that new genes involved in the first stage of endosome-mediated transportation were critical to the success of both varieties of ADCs.
Bassik and Tsui also found evidence to suggest that not all ADCs are digested through the lysosome.
“But the screen revealed genes that implied that the digestion processes happened much earlier, presumably, before the ADC ever even makes it to the lysosome,” said Bassik. “Since ADCs can be metabolized in different ways, we see these types of new insights into their mechanism as crucial for future ADC design and development.”
Join us on Facebook or Twitter for a regular update.
  Explore further
  Recent advances in site specific conjugations of antibody drug conjugates
More information: C. Kimberly Tsui et al. CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity, Nature Chemical Biology (2019). DOI: 10.1038/s41589-019-0342-2 
Provided by Stanford University
  Citation: Scientists zero in on cancer treatments using CRISPR (2019, August 27) retrieved 28 August 2019 from https://phys.org/news/2019-08-scientists-cancer-treatments-crispr.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
  #Biology
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afeelgoodblog · 3 years ago
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Best News of Last Week
Edition #019 - 🐝
1. Man who had open-heart surgery wins a $1 million lottery prize after the ticket came in a get-well card
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A Massachusetts man recovering from open-heart surgery won a $1 million lottery prize on a scratch-off ticket given to him by a friend, according to lottery officials.
Alexander McLeish received three scratch-off tickets in a get-well card from a friend earlier this month, according to a news release from the Massachusetts State Lottery Commission
2. Student who sews sanitary pads for refugees now leads 1,000 volunteers
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A student who began sewing reusable sanitary products for refugees during lockdown is now running a global network of 1,000 volunteers. University of Bristol student Ella Lambert, 21, learned to stitch using YouTube videos during the first national lockdown, and has since launched the Pachamama Project, which aims to end period poverty.
The languages student, from Chelmsford in Essex set up the not-for-profit group with university friend Oliwia Geisler in August last year.
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“I’ve always really struggled with period pain, like absolutely atrocious period pain which would mean that I’d have to miss out on school and cancel plans last minute,” she said.
“So although I’ve been really lucky, and I’ve never had to experience period poverty as such, I do know what it’s like to have to miss out on really important things and appointments because of my period.
3. Parliament of Canada unanimously passes Bill C-4 banning conversion therapy for adults and youth
The federal government's updated bill to ban the practice of conversion therapy has been adopted unanimously by the House of Commons.
MPs voted to fast track Bill C-4 on Wednesday afternoon. The Commons erupted in applause after the vote and several Liberal cabinet ministers walked across the floor to shake hands with and — in some cases — hug their Conservative counterparts.
4. UK; 13-year-old girl uncovered a hoard of 1300 BCE Bronze Age axes on her third metal-detecting trip
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Milly was scouring a field near Royston, Hertfordshire, when she made the find - the first of 65 artefacts dating from about 1300BC. When her father dug out the first one, Milly said they joked it might be an axe - and it was.
Archaeologists were called in to excavate the entire hoard, which will be sent to the British Museum, London.
5. Making aviation history: Madison plants fuel United Airlines aircraft with passengers aboard
For the first time, a jet flown by United Airlines entirely powered by 100% plant based fuel from corn stalks flew from Madison WI to Chicago Illinois. The fuel is made from farm waste corn stalks and cobs, not corn seed based ethanol and is 100% renewable with 50% less green house gasses than regular jet fuel.
6. 30 white rhinoceros have been successfully transported from South Africa to Akagera national park in Rwanda, in the largest translocation of rhinoceros in history. A fantastic measure to protect this amazing species.
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One of the rhinos is released into a temporary enclosure in Phinda game reserve for quarantine ahead of the move to Rwanda. Photograph: Howard Cleland/African Parks
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The 30 white rhinos arrived at their new home, Akagera national park in eastern Rwanda, yesterday. It is hoped Akagera will become a new breeding stronghold to support the long-term survival of the species. Down to an estimated 18,000 animals across Africa, white rhinos are classified by the IUCN as near threatened, with numbers in decline largely due to poaching, driven by demand for their horns.
7. Thousands of bees make it out alive after being buried by La Palma volcano ash for 50 days
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They had sealed themselves in by creating propolis, a resinous material with which they plugged any gaps, and were able to survive on their food reserves.
Yay bees! 🐝
____
That's it for this week. Until next week,
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kgs03 · 5 years ago
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New Post has been published on KG Sinclair
New Post has been published on https://www.kgsinclair.com/2020/06/on1-announces-availability-of-the-new-on1-360-new-on1-photo-raw-2020-5-and-the-new-on1-photo-mobile-for-ios-ipados-and-android/
ON1 Announces Availability of the New ON1 360, New ON1 Photo RAW 2020.5, and the New ON1 Photo Mobile for iOS, iPadOS, and Android.
Portland, OR. Jun 29, 2020: ON1, creators of ON1 Photo RAW, announces ON1 360, ON1 Photo RAW 2020.5, and the new ON1 Photo Mobile are now available. ON1 360 is an all-new end-to-end photography workflow solution to capture, edit, and sync photos seamlessly between multiple computers and mobile devices using the new ON1 Photo RAW 2020.5, and the new ON1 Photo Mobile for iOS, iPadOS, and Android. 
“ON1 360 is the culmination of years of work and feedback from customers around their frustrations with being forced to upload original photos into cloud systems with no way out. ON1 360 solves these problems by letting photographers choose which photos to sync and where their photos are stored while allowing them access to their photos across their computers and devices,” says Dan Harlacher, VP of Product.
In addition to the new ON1 360, a new version of ON1 Photo RAW version 2020.5 is also available for download today. ON1 Photo RAW is a modern photo organizer, raw processor, layered editor, and effects app, all in one affordable application. ON1 Photo RAW 2020.5 includes the new ON1 360 integration, many performance enhancements, support for new cameras and lenses, and additional bug fixes. 
The new and free ON1 Photo Mobile app for iOS, iPadOS, and Android devices is like having a pro-grade camera app and raw processor in the palm of your hand. ON1 Photo Mobile uses the same proprietary raw processing engine developed for ON1 Photo RAW and perfectly compliments the desktop application, ON1 Photo RAW 2020.5, when synced together with ON1 360.
Key Features
One Workflow — A complete end-to-end workflow between multiple computers and mobile devices with ON1 360. ON1 360 connects ON1 Photo RAW 2020.5 on macOS and Windows computers with the new free ON1 Photo Mobile on iOS, iPadOS, and Android devices. Multiple options for syncing files, control in file storage methods, and new capabilities for managing and editing across devices no matter where photos are stored are now available in ON1 360. 
Complete Control of Your Photos — At the core of the new ON1 360 is the new cloud storage service and sync technology, which allows photographers to sync photos, metadata, and edits, as well as albums, cataloged folders, and more between each of their computers, devices, external hard drives, or even network drives. Photographers can choose which photos to sync, how they organize photos, where they store their photos, and how they back up their photos. 
New Editable Previews — Customers can choose to sync their original raw files or sync their photos using the new Editable Previews that utilize ON1’s new compressed-raw file format. This file format allows photographers to store more photos in the same amount of space without noticeable loss in image quality when processing. Photographers can view, edit, and share their photos without having to store the original photo in the cloud using these Editable Previews. The format is 75% smaller than the original raw file and maintains the same tonal and color range. They are perfect for remote editing, sharing, and even printing common sizes, without noticeable loss in quality, saving customers additional storage space and cost. 
New ON1 Photo Mobile Camera Mode — The camera mode in ON1 Photo Mobile works a lot like the camera app on your device, but with more advanced features. The new app can capture raw photos with the tonal range and details you expect from an interchangeable lens camera. The pro-level manual controls include the ability to adjust exposure, shutter speed, manual-focus, and white balance. 
New ON1 Photo Mobile Editing Controls — ON1 Photo Mobile uses the same proprietary raw processing engine developed for ON1 Photo RAW. Adjustments include Exposure, Contrast, Shadows, Midtones, Highlights, Whites, Blacks, White Balance, Noise, and Sharpening. Built-in filters will start with, black and white, adding film grain, darkening the edges with a vignette, and targeted color adjustments. ON1 Photo Mobile is available for iOS, iPadOS and Android devices and is free for anyone. 
Privacy — Privacy is most important, and with ON1 360, all photos will be kept private. ON1 will never analyze any photos using ON1 360 to build ways to market to photographers.
New Supported Cameras in ON1 Photo RAW 2020.5 — Nikon D6, Sony STL-99, Sony ZV-1
New Supported Lenses in ON1 Photo RAW 2020.5 — Apple iPhone XS, Canon EF 24-105mm f/3.5-5.6 IS STM, Pentax-DA 55-300mm f/4.5-6.3 ED PLM WR RE, SAMYANG AF 85mm F1.4, SAMYANG AF 45mm F1.8, Sigma 105mm F1.4 DG HSM | Art 018, Sigma 35mm F1.2 DG DN | Art 019, Sigma 70-200mm F2.8 DG OS HSM | Sports 018, Sony E 16-55mm F2.8 G, Sony E 70-350mm F4.5-6.3 G OSS, Sony FE 200-600mm F5.6-6.3 G OSS, Tamron E 28-75mm F2.8-2.8, Tokina AT-X 24-70mm f/2.8 PRO FX
Availability and Pricing
ON1 360 plans start out with 10x the storage amount for 20% less cost compared to competitive plans available today. ON1 360 plans include the Software and Service option as well as a Service Add-on option in both monthly and annual payment options. The Software and Service plan includes a subscription license to ON1 Photo RAW 2020, any and all software upgrades and updates, the ON1 Photo Mobile connectivity, and the 360 syncing service. The starting plan includes 200GB of storage at the low cost of $7.99 per month or $89.99 for the year. ON1 still offers Photo RAW as a perpetual-license product separate from ON1 360, for those who prefer to own their software. Customers who own Photo RAW can choose the ON1 360 Add-on and those plans start at $5.99 per month or $59.99 for the year and come with 200GB of storage. This also allows customers to upgrade to future versions of ON1 Photo RAW at a time of their choosing, and it allows them to add or cancel any ON1 360 subscription without losing access to ON1 Photo RAW.
What’s Ahead in the ON1 Roadmap
ON1 will continue developing ON1 Photo RAW for the desktop and ON1 Photo Mobile for devices. There is a detailed product roadmap for ON1 Photo Mobile already available from the ON1 website. Future plans include ON1 getting back into developing products that work within other photo editing workflows as well. There will be new integrations and plug-ins for ON1 products no matter what applications photographers are using.
“As we grow, we will continue to deliver a complete line of products for all workflows, whether it be standalone, plug-in, mobile, or video. It’s already in our plans to deliver all-new plug-ins within the year every photographer will want to use to save them time. We’ve always taken pride in that we are a group of photographers creating software applications specifically for the photographer,” says Craig Keudell, ON1 President & CEO. 
About ON1
Since 2005, ON1 has provided award-winning software to millions of photographers worldwide. We accomplish this by being different from other photo software companies. Photography is all we do, we put you the photographer first, and this means our customers have complete control over every aspect of their photography. Our software applications are designed by photographers, for photographers.
The ON1 mission is to deliver the tools photographers need to express themselves through photography. The ability to easily organize, edit, and share their photos anywhere and provide professional quality image processing, the creativity they desire, the service they deserve, and to keep photographers in control of their photography.
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bostonrealtors · 5 years ago
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3 Pembroke St unit 2 Chelsea MA. A renovated 1 bedroom condo in the Chelsea Waterfront area.  This is the only condo for sale in the Chelsea Waterfront Area as of this posting date. Why live with a roommate, when you can live alone? Showings begin on 04/05 after the condo has been cleaned and vacated. Email or text Jeffrey Bowen for access.
  For showings email [email protected] or text 781-201-9488 http://www.bostonjeff.com
MLS # 72631030 – Price Changed Condo – High-Rise, Mid-Rise, Low-Rise, Brownstone, Courtyard
3 Pembroke St – Unit 2 Chelsea, MA 02150-2612 Suffolk County
List Price: $250,000
Unit Placement: Total Rooms: 3 Unit Level: 2 Bedrooms: 1 Grade School: Bathrooms: 1f 0h Middle School: Master Bath: High School: Fireplaces: 0 Outdoor Space Available: Yes – Private Handicap Access/Features: Directions: Entrance is on Tremont Street Across from 7/11
Remarks
Location, Location, Location. Major Price Reductions. Motivated seller. The condo has been recently renovated with a new kitchen that has s/s appliances, granite counters and a breakfast bar. The bath has also been updated. The bedroom has a large walk-in closet. There is laundry in the building. There is a coat & shoe closet next to the entrance. Covered balcony area for relaxing in the warmer months. There are Harvey massport windows for sound and energy efficiency. The original hardwood floors are a beautiful feature. The ceilings are super high. Live in the Chelsea Waterfront neighborhood that is close to everything. East Boston is right over the bridge. Tons of dining and shopping options. Sea Kayak to Charlestown or grab a boat from the Chelsea Yacht Club. There are several parks including a new dog park. Woof! Close to Mary O’Malley Park and Admiral’s Hill. Why live with a roommate when you can live alone? Property will be vacant on 04/04/20 and showings will begin on 04/05/20. This condo requires a 20% minimum down payment with a portfolio lender.
Property Information
Approx. Living Area: 428 Sq. Ft. ($584.11/Sq. Ft.) Approx. Acres: Garage Spaces: 0 Living Area Includes: Heat Zones: 2 Electric Baseboard, Electric, Individual, Unit Control Parking Spaces: 1 Off-Street, Rented, On Street Permit Living Area Source: Public Record Cool Zones: 1 Window AC Levels in Unit: 1 Living Area Disclosures: Disclosures: Buyers must use a portfolio lender like Leader bank and have 20-25% down. There are several capital improvements planned. Driveway, Retaining wall, fence and others. Will have to verify with management. Parking is rented for $120 in nearby lot on a first come first serve basis.
Complex & Association Information
Complex Name: Chelsea Village Condos Units in Complex: 20 Complete: Yes Units Owner Occupied: 10 Source: Management Association: Yes Fee: $278  Monthly Assoc. Fee Includes:
Water, Sewer, Master Insurance, Exterior Maintenance, Refuse Removal, Reserve Funds
Special Assessments:
Yes – $3,000 – Need to verify. Seller will pay off any and all by closing. Will get minutes,budget, financials, past and future planned capital improvements from management.
Room Levels, Dimensions and Features
Room Level Size Features
Features
Area Amenities: Public Transportation, Shopping, Park, Walk/Jog Trails, Bike Path, Conservation Area, Highway Access, House of Worship, Marina, Public School, T-Station Appliances: Range, Dishwasher, Microwave, Refrigerator Association Pool: No Basement: Yes Full, Interior Access Beach: No Construction: Frame Electric Features: 60 Amps/Less Exterior: Brick Exterior Features: Covered Patio/Deck, Decorative Lighting, Screens, Gutters Flooring: Hardwood Hot Water: Electric Interior Features: Cable Available Management: Professional – Off Site, Owner Association Pets Allowed: Yes Sewer Utilities: City/Town Sewer Water Utilities: City/Town Water Terms: Contract for Deed Utility Connections: for Electric Range, for Electric Oven Waterfront: No Water View: No
Other Property Info
Adult Community: No Elevator: Yes Disclosure Declaration: No Exclusions: Laundry Features: In Building Lead Paint: Unknown UFFI: Warranty Features: Year Built/Converted: 1900 Year Built Source: Public Record Year Built Desc: Approximate, Renovated Since Year Round: Yes Short Sale w/Lndr. App. Req: No Lender Owned: No
Tax Information
Pin #: M:019 P:193B Assessed: $216,300 Tax: $2,896 Tax Year: 2020 Book: 58097 Page: 99 Cert: 000000052586 Zoning Code: R4 Map: Block: Lot:
Market History for  3 Pembroke St U:2, Chelsea, MA 02150-2612
MLS # Date DOM DTO Price 72631030 3/10/2020 Listed for $279,000 $279,000 3/17/2020 Price Changed to: $269,000 $269,000 3/23/2020 Price Changed to: $265,000 $265,000 3/30/2020 Price Changed to: $250,000 20 $250,000 Market History for  Office Id: AN2195 20 Market History for this property 20
  3 Pembroke St unit 2 Chelsea MA 3 Pembroke St unit 2 Chelsea MA. A renovated 1 bedroom condo in the Chelsea Waterfront area. 
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paradoxicalca · 5 years ago
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r/hockey NHL Power Rankings Week 9: Flying High Edition
/r/Hockey NHL Power Rankings Week Nov 25, 2019 - Dec 1, 2019Thank YouThank you to all of the volunteers doing the power rankings. Each ranker has their own system and have their own reasonings and analyis. It truly is a lot of work.RankersSpoilerOrganizersSpoilerVisualizationThe visualization contains historical data, so you can see how your team has done over time. Hopefully, we can run this for many years in hopes that we can see the rise and fall of teams by /r/hockey opinion.It automatically updates so feel free to bookmark. You can find it hereProcessHow does this work? Throughout the course of the week rankers are able to access an app that will allow them to rank teams. At the end of the period we calculate the average ranking for every team and collate all of the analysis provided by rankers.The app then generates a post that is first proofread and then posted to /r/hockey!Rankings (27/31 Rankers Reporting)Ranking (avg)TeamDeltaOverall RecordRecord This WeekComments1 (1.42)Boston Bruins219-3-54-0-0🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝🍝2 (2.06)Washington Capitals-19-4-53-0-0Squeaking by the Cats and Wings wasn't great, but coming back from way behind against the rounding-into-form Bolts was the kind of victory that makes you believe. I recognize that I'm (mildly) complaining about a 3-0-0 week but the only important thing in regular season hockey is process, am I right or am I right. Nicky come back soon we all miss you dearly, Carlson start scoring again Edmonton's getting ideas, and Sammy my sweet darling muffin keep doing everything you're doing you're a perfect little angel in net. Go Caps.3 (3.97)St. Louis Blues217-5-63-0-1Down our best goal-scorer, our veteran 2-way forward, and our breakout young guys from last year and this year, the Blues haven't lost a step. The O'Reilly-Perron connection continues to be a thing of beauty, our captain is putting up a Norris-worthy season so far, and Binnington looks to be here to stay (Snake isn't half bad either). 5/6 points on a road trip through Tampa, Nashville and Dallas is nothing to scoff at. This team has an incredible amount of balance and resiliency. Once again, it's a great time to be a Blues fan.4 (4.73)New York Islanders-317-5-21-2-0The streak came to a crashing halt with 1 point in 3 games on the California road trip. Thomas Greiss seemed to have hurt something on Saturday night, will be a situation to monitor closely for Isles fans. Another worthwhile note is Anders Lee ended his goal drought during the first game he was reunited with Barzal and Bailey.5 (5.33)Colorado Avalanche216-8-23-0-0The Big Moose is back and I think the NHL needs to be afraid. The Mackinnon show wasn't over earning a 2nd Star of the Month Mr. Novemeber kept this team above .500 in Mikko and Gabes absence. This week saw us take advantage of McDavid and Draisaitl not at their best, then two thrashings of the Hawks. The team is starting to get healthier but we also lost Burakovsky this week, so the hockey gods give and take. Next up is a hockey mecca road trip as we take on Toronto, Montreal & Boston. Makalder update: Makar only had 1 goal this week, but with Johnson out he took over as our #1 RHD. He still has a bit of work to do to become a full blown #1 dman but I would not be surprised if he has that role firmly handled by the time Johnson comes back.6 (8.42)Edmonton Oilers-217-9-31-2-0Small slide for the Oilers with losses to the Avs and the Canucks. They did still pull out a victory against the Canucks today. The Oilers are in a bit of a pickle. McDavid and Drai have slowed for 5-on-5 (for their standards), and Nuge and Kassian are injured. Both losses were thanks to poor games against them. Notably, certain key players are putting together some poor performances (like Nurse). The team still, somehow, remains at the top of the division but now the Blues have create some separation for top of the West. The next week is games against the Sens, Kings and Sabres. Oh, and I forgot. Archibald finally got his goal. Some results for the hard work he's done so far this season.7 (9.21)Carolina Hurricanes-116-10-11-2-0If it wasn’t for the heroics for James Reimer on Saturday this could have been a winningless week. With Boston coming up the boys better be on their A game8 (9.88)Philadelphia Flyers1215-7-54-0-0The flyers have literally gotten the most points out of the NHL (AFAIK) in november, are 5th in the league, yet still only 3rd in the Metro. I hate the Metro. Aside from that, we went a perfect 4-0-0 this week, had a lot of good things happen this week. Ghost was scratched for two games, but that was good for him. Hagg played well enough to then force Myers to sit, which doesn’t sit well with most of the fanbase but was also the right decision. We could still use our veterans contributing more, but we are managing depth contributions pretty well and that’s a definite positive. Hopefully you all had a wonderful thanksgiving, and now its back to the last few weeks of school. NHL PLEASE LET THE SENS/WINGS/KINGS GO ANY ORDER OF 1/2/3 IN THE DRAFT LOTTERY SO THE WEAPONIZATION OF THE METRO CAN BE SLOWED. thanks for coming to my ted talk, Praise Gritty.9 (9.94)Dallas Stars-15-10-31-2-110 (10)Winnipeg Jets116-10-12-1-0This week featured a road trip through California, a trip I fully expected the Jets to emerge 2-1-0. And they did, but they lost to the least expected one of the bunch. Flashes of brilliance and signs of stupidity abound. Our goal differential is finally positive again, so that's a start. Not much to say other than the Jets keep defying the advanced stats underneath them. Next week features a home-and-home with Dallas, the central team that just passed us in the standings. Should be fun, provided Benn doesn't go god mode again.11 (11.45)Arizona Coyotes-214-9-50-1-212 (11.52)Pittsburgh Penguins-114-9-42-2-0As much as he has been the fire since Crosby has been out Malkin cannot carry this team alone.13 (12.85)San Jose Sharks615-12-13-1-0Another solid week for the Sharks, who moved into a divisional playoff spot for the first time this season. The team is still plagued by consistency issues as seen in the 1st Kings game and the Jets game, but picking up 3 wins this week wasn't a bad thing. Very nice to see the first win this season when trailing after the 1st period, all the early deficits this season have felt much bigger than they are and hopefully the team can turn that around. Goodrow and Gregor are looking really confident, and the forward lines are meshing really well. Go Šimek!14 (15.85)Florida Panthers213-8-51-1-0Judge Driedger shined in the Panthers' most complete game of the season against Nashville. Bob has been temporarily taken off the case.15 (16.61)Vegas Golden Knights-13-11-42-1-0Vegas going into their New York road trip winners of two straight hard fought games against Nashville and Arizona. They have not won three straight all season and they get a chance against Rangers on Monday.16 (17.09)Toronto Maple Leafs513-11-42-1-0The search for a backup goalie is on. The Leafs are now 4-1 under new head coach Sheldon Keefe, with their only loss being played with a backup goalie, this time on the front of a back-to-back. Michael Hutchison got another opportunity, and although the team didn't play great in front of him, the Leafs rely on Andersen to make the big saves to keep the momentum on their side, and they always miss it when he's not in net. Earlier in the week, it was a 6-0 win over the almost-emergency-goalie Red Wings, which isn't very impressive because they suck, but it's nice to see if you're a Leafs fan, as this team always seemed to struggle against bad teams under Babcock. On top of that, the PK looks much better and is getting the results, too. PP is looking good in small sample size too. An OT win against the Sabres at home on Saturday night wrapped up a solid week for the team. A tough week ahead, with the red-hot Flyers, Avalanche (B2B) and Blues up next.17 (17.09)Tampa Bay Lightning-412-9-31-2-1Not a good week for the Lightning, collecting only 3 points in 4 games. Kuch seems to be picking it up again, scoring 2/6/8 in 4 games. Point is as well, with 3 goals this week. Stamkos was invisible on the scoresheet this week, which is a concern, but Point a Kuch starting to pick up the pace might be what this team needs to start winning some games. As of right now I really don't have high hopes for this team, I would be surprised with a playoff appearance at this point. Can't get swept in the first round if you don't make the playoffs.18 (17.39)Vancouver Canucks-413-11-41-3-019 (17.48)Nashville Predators-212-10-42-1-1It was the Preds of times, it was the Perds of times, it was the age of Fabbro, it was the age of our third pairing, it was the epoch of comebacks, it was the epoch of playing 59:59.7, it was the season of Carr, it was the season of Olivier, it was the spring of Juuse Startos, it was the winter of being shutout, we had Duchene before us, we had no Turris before us, we were all going direct to the Playoffs, we were all going direct the other way – in short, the period was so far like the present period, that some of its noisiest fans insisted on its being received, for good or for evil, in the superlative degree of comparison only.20 (18.64)New York Rangers513-9-33-0-1Very very solid week. A 3-0-1 record is feeling fantastic. Zucc returned to MSG to start off the week, and we pulled out an OT win against the Wild. Next we took out the Canes and Hank made 41 saves. We fell to the Bruins in OT, but we won't talk about that. But what we will talk about is shutting out the Devils 4-0. We scored 2 shorthanded goals, which was beautiful. I'm hoping we can keep it going with this momentum into next week. LGR.21 (20.52)Buffalo Sabres-312-10-51-1-2Buffalo has managed to squeak out a win and two overtime losses against two teams struck with coaching controversy this week, which isn't bad if you look at the rest of November's record. It feels like Eichel is carrying the team at this point, and if you look at the rest of our team it reinforces that feeling. He's on pace for over 100 points; unfortunately, however, the team is on pace for 88. One more interesting stat: with split starts, Linus Ullmark (13 starts) has allowed 1 fewer goal on 3 more shots than Carter Hutton (14 starts).22 (20.61)Calgary Flames-13-12-42-0-123 (22.64)Montreal Canadiens-1111-10-60-3-1To fully understand how it feels to be a Habs fan right now, I suggest a reading of Byron's "Darkness". #41 is deep! Since that distant win in D.C., the Habs are in free-fall. 8 straight losses and counting. Hope and patience are in short supply, and those fans sober enough to discuss it are often philosophical, with an eye toward history, wondering how long we have to wait until this team is a real contender again. No matter how you measure it, we can all agree it's been a while. Many fans expect change is on the horizon, whether in the form of a trade, or a coaching change, or whatever. Others expect an even darker road ahead. "Their feeble breath blew for a little life, and made a flame which was a mockery." Damn right.24 (22.67)Minnesota Wild412-11-43-0-1Suddenly the Wild are playing...not terrible? They're unbeaten in regulation for 9 straight games now, going 6-0-3; imagine if they knew how to play 3v3 hockey. A stick tap to Kaptain Koivu for the shootout winner Sunday in his 1000th game. No doubt #9 will be the first player to have his number retired with the Wild when he hangs it up. There's a lot of the season left to be played; once mid-December rolls around, the schedule completely flips and Minnesota gets 18 of 22 games at home. How many points they get in that stretch will align perfectly with the trade deadline and GM Bill Guerin should act accordingly based on their chances (even if they're within reach of a spot, the Wild should not be buyers - it's sell or stay put.)25 (23)Anaheim Ducks-212-12-32-1-0This team continues to meet expectations s of a non playoff team with too much talent to tank for a top draft pick. It really sucks watching this team claw to a shootout loss in Arizona and then not show up to play against Winnipeg on Friday. Stay tuned for the battle for the basement on Monday with the first ducks v kings in Anaheim.26 (24.88)Columbus Blue Jackets111-11-42-2-0.500 in a tough week and made up no ground in the standings. Werenski is out for 4 weeks. Elvis is still without a win. The power play does seem to be clicking, so I guess we got that going for us.27 (25.91)Chicago Blackhawks-110-11-51-2-0Saturday, Duncan Keith missed just the 18th game in his 1102 game NHL career due to injury. Drake Caggiula and Dylan Strome are both out with concussions. Patrick Kane extended his point streak to 15 games. His 11G, 13A - 24P in November are the most points of any month in his career. Alex DeBrincat has been held goal-less in 11 straight games, but has managed to contribute 9 assists in that span. After allowing only 1 goal in 2 games against Dallas, the Blackhawks committed defensive atrocities against Colorado, such as this.28 (26.61)Los Angeles Kings111-14-22-1-1Same old hollywood story. Wish I had something exciting to add...29 (28.12)Ottawa Senators-511-15-10-4-0This is exactly the kind of week the Sens needed after our recent success in the standings - a pure focused noseline dive away from "contender" territory and firmly into the "rebuilding" zone. The Wings have really stepped up their tanking game with a remarkable 9 game losing streak, and the Sens have a LOT of ground to cover in Operation DernièrePourLafrenière. It's also reassuring in the midst of this much needed losing streak to see Marcus Hogberg a good game versus the Flames; he will likely be backup to Nilsson next season when we, hopefully, are less interested in picking first overall.30 (29.18)New Jersey Devils-9-12-41-2-0Are you kidding me? Beating the Habs must have been a fluke Thanksgiving miracle. How in the love of hockey gods do you go 0/8 on the powerplay in a single game, including a game misconduct 5 min PP?? Normallyy I try to give a more extensive blurb but at this point there is almost no good to the "Good, Bad, Ugly" breakdown. This team is god damn mess. We put up 6 against the Habs, then lose to the Wild and get shut out by the Rags? I'd be less salty if I didn't have the misfortune of spending Saturday at the Rock to watch that travesty become a home game for the Rangers. There weren't even enough red jerseys at the end of the game to do "Fire Hynes" chant if we wanted too. The only reason that we aren't 31st is because Detroit has come completely unhinged in terms of bad. Hughes is hurt, which is honestly just icing on the 7 layer shit cake. Hall (+Vatanen and Simmonds) is gone unless we get some sort of divine intervention. It's only December 1st, and I'm ready to pack this season in.31 (30.94)Detroit Red Wings-7-19-30-3-0Just a couple notes since thinking about this team gives me a migraine * Fastest team to reach a -50 goal differential in the last 20 years * Mantha out with injury at the usual time of the year * Larkin slumping * Goalies can't stay healthy or buy a save. * Fabbri is the GOAT r/hockey NHL Power Rankings Week 9: Flying High Edition Source
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dreamfeelx · 7 years ago
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I say “DREAM,” you say “FEEL.” DREAM sweat DREAM sweat DREAM faint Okay, okay, we get it. Let’s sort this out.
Okay, we’ve decided to partner with someone to present this melted june/july DREAMFEEL newz update. This post is sponsored by: tap water™. drink deep and descend™.
This is gonna be a JUNE / JULY DOUBLE BILL, definitely not because aido was on holidays when we were meant to post an update last month, xoxo, but because DOUBLE BILL. Most places want to get as many clicks out of you as possible, and we’re here giving you two for the price of one, what’s not to like?!?!?
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NEWZ NEWZ NEWZ TEAM TEAM TEAM
We… hired a lead programmer?
We’ve had our phlegmy team member for a while (me, aido) but we’re happy to introduce our first Flemish team member! Let’s all introduce yiz to our new team mate Tim Sabo. He’s coming on to help us make If Found a marvelously coded mirage-like concoction of bug free beauty. Here’s what he has to say:
“I'm Tim, been trying to make games since I was 12. Started with making levels for the original half-life and slowly getting interested in programming and game art. Now I have around seven years of professional experience making  games. I also play the hurdy-gurdy (google it).”
And a junior unity developer?!
Joining the ranks, Breogán Hackett, game dev, kind person, and prize fighter. Check out their games at https://boaheck.itch.io/ 
We feel v lucky to be working with such a wonderful person!
AND a composer?!?
We’re so super happy to be working alongside Gareth Smyth, otherwise known as Lumigraph, on If Found! Gareth is a wonderful DJ and producer and musician and also a member of the Repeater collective who make lovely zines and run the best radio show in Ireland.
Have a listen @ https://soundcloud.com/lumigraph
and OH! Check out all our lovely faces above! 
Photo by Meghann Hales
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Bitsy X Flatgames at Babycastles
Ebeth and Em and some cool folks are organising a neat Flatgames zine to coincide with a Bitsy X Flatames collaborative show at Babycastles. Read all about it here!
https://medium.com/@midboss/calling-all-flatgame-creators-and-fans-c416ae30c0c9
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~aido’s music dungeon III~
no light breaches these walls, all that shines lies in these harrowed songs, you listen, they listen, we listen, us all listen, trapped cloyingly but content.
BIS Radio Show #939 - Powder https://soundcloud.com/timsweeney/powder2018
Dekmantel Selectors 019 - Strange Boutique https://soundcloud.com/dkmntl/dekmantel-selectors-019-strange-boutique
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GAME_ZONE dot pee h pee
This month presented by Breogán who’s picked some of their BITSYS:
https://itch.io/c/331034/5-bitsy-games-you-should-play
You should also go play the real spooky, atmospheric Bitsy they just released:
Vitreous by Breogán Hackett
https://boaheck.itch.io/vitreous
We asked them if they wanted to say anything about it and they said: “I think it’s better left with as minimal text as possible” - Breogán
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GAME CREW
To round out Bitsy bonanza Llaura is starting a monthly game making group for folks who’ve mostly never made games before. The first one will be in our studio in mid July. We’re gonna be making bitsy games!
We’re currently fully booked, but if you’d like to join the waiting list, shoot us an email at
dreamfeelx [atttt] gmail [dottttt] com
Peace
THE DREAM FEELS
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kgs03 · 5 years ago
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New Post has been published on KG Sinclair
New Post has been published on https://www.kgsinclair.com/2020/06/on1-announces-availability-of-the-new-on1-360-new-on1-photo-raw-2020-5-and-the-new-on1-photo-mobile-for-ios-ipados-and-android/
ON1 Announces Availability of the New ON1 360, New ON1 Photo RAW 2020.5, and the New ON1 Photo Mobile for iOS, iPadOS, and Android.
Portland, OR. Jun 29, 2020: ON1, creators of ON1 Photo RAW, announces ON1 360, ON1 Photo RAW 2020.5, and the new ON1 Photo Mobile are now available. ON1 360 is an all-new end-to-end photography workflow solution to capture, edit, and sync photos seamlessly between multiple computers and mobile devices using the new ON1 Photo RAW 2020.5, and the new ON1 Photo Mobile for iOS, iPadOS, and Android. 
“ON1 360 is the culmination of years of work and feedback from customers around their frustrations with being forced to upload original photos into cloud systems with no way out. ON1 360 solves these problems by letting photographers choose which photos to sync and where their photos are stored while allowing them access to their photos across their computers and devices,” says Dan Harlacher, VP of Product.
In addition to the new ON1 360, a new version of ON1 Photo RAW version 2020.5 is also available for download today. ON1 Photo RAW is a modern photo organizer, raw processor, layered editor, and effects app, all in one affordable application. ON1 Photo RAW 2020.5 includes the new ON1 360 integration, many performance enhancements, support for new cameras and lenses, and additional bug fixes. 
The new and free ON1 Photo Mobile app for iOS, iPadOS, and Android devices is like having a pro-grade camera app and raw processor in the palm of your hand. ON1 Photo Mobile uses the same proprietary raw processing engine developed for ON1 Photo RAW and perfectly compliments the desktop application, ON1 Photo RAW 2020.5, when synced together with ON1 360.
Key Features
One Workflow — A complete end-to-end workflow between multiple computers and mobile devices with ON1 360. ON1 360 connects ON1 Photo RAW 2020.5 on macOS and Windows computers with the new free ON1 Photo Mobile on iOS, iPadOS, and Android devices. Multiple options for syncing files, control in file storage methods, and new capabilities for managing and editing across devices no matter where photos are stored are now available in ON1 360. 
Complete Control of Your Photos — At the core of the new ON1 360 is the new cloud storage service and sync technology, which allows photographers to sync photos, metadata, and edits, as well as albums, cataloged folders, and more between each of their computers, devices, external hard drives, or even network drives. Photographers can choose which photos to sync, how they organize photos, where they store their photos, and how they back up their photos. 
New Editable Previews — Customers can choose to sync their original raw files or sync their photos using the new Editable Previews that utilize ON1’s new compressed-raw file format. This file format allows photographers to store more photos in the same amount of space without noticeable loss in image quality when processing. Photographers can view, edit, and share their photos without having to store the original photo in the cloud using these Editable Previews. The format is 75% smaller than the original raw file and maintains the same tonal and color range. They are perfect for remote editing, sharing, and even printing common sizes, without noticeable loss in quality, saving customers additional storage space and cost. 
New ON1 Photo Mobile Camera Mode — The camera mode in ON1 Photo Mobile works a lot like the camera app on your device, but with more advanced features. The new app can capture raw photos with the tonal range and details you expect from an interchangeable lens camera. The pro-level manual controls include the ability to adjust exposure, shutter speed, manual-focus, and white balance. 
New ON1 Photo Mobile Editing Controls — ON1 Photo Mobile uses the same proprietary raw processing engine developed for ON1 Photo RAW. Adjustments include Exposure, Contrast, Shadows, Midtones, Highlights, Whites, Blacks, White Balance, Noise, and Sharpening. Built-in filters will start with, black and white, adding film grain, darkening the edges with a vignette, and targeted color adjustments. ON1 Photo Mobile is available for iOS, iPadOS and Android devices and is free for anyone. 
Privacy — Privacy is most important, and with ON1 360, all photos will be kept private. ON1 will never analyze any photos using ON1 360 to build ways to market to photographers.
New Supported Cameras in ON1 Photo RAW 2020.5 — Nikon D6, Sony STL-99, Sony ZV-1
New Supported Lenses in ON1 Photo RAW 2020.5 — Apple iPhone XS, Canon EF 24-105mm f/3.5-5.6 IS STM, Pentax-DA 55-300mm f/4.5-6.3 ED PLM WR RE, SAMYANG AF 85mm F1.4, SAMYANG AF 45mm F1.8, Sigma 105mm F1.4 DG HSM | Art 018, Sigma 35mm F1.2 DG DN | Art 019, Sigma 70-200mm F2.8 DG OS HSM | Sports 018, Sony E 16-55mm F2.8 G, Sony E 70-350mm F4.5-6.3 G OSS, Sony FE 200-600mm F5.6-6.3 G OSS, Tamron E 28-75mm F2.8-2.8, Tokina AT-X 24-70mm f/2.8 PRO FX
Availability and Pricing
ON1 360 plans start out with 10x the storage amount for 20% less cost compared to competitive plans available today. ON1 360 plans include the Software and Service option as well as a Service Add-on option in both monthly and annual payment options. The Software and Service plan includes a subscription license to ON1 Photo RAW 2020, any and all software upgrades and updates, the ON1 Photo Mobile connectivity, and the 360 syncing service. The starting plan includes 200GB of storage at the low cost of $7.99 per month or $89.99 for the year. ON1 still offers Photo RAW as a perpetual-license product separate from ON1 360, for those who prefer to own their software. Customers who own Photo RAW can choose the ON1 360 Add-on and those plans start at $5.99 per month or $59.99 for the year and come with 200GB of storage. This also allows customers to upgrade to future versions of ON1 Photo RAW at a time of their choosing, and it allows them to add or cancel any ON1 360 subscription without losing access to ON1 Photo RAW.
What’s Ahead in the ON1 Roadmap
ON1 will continue developing ON1 Photo RAW for the desktop and ON1 Photo Mobile for devices. There is a detailed product roadmap for ON1 Photo Mobile already available from the ON1 website. Future plans include ON1 getting back into developing products that work within other photo editing workflows as well. There will be new integrations and plug-ins for ON1 products no matter what applications photographers are using.
“As we grow, we will continue to deliver a complete line of products for all workflows, whether it be standalone, plug-in, mobile, or video. It’s already in our plans to deliver all-new plug-ins within the year every photographer will want to use to save them time. We’ve always taken pride in that we are a group of photographers creating software applications specifically for the photographer,” says Craig Keudell, ON1 President & CEO. 
About ON1
Since 2005, ON1 has provided award-winning software to millions of photographers worldwide. We accomplish this by being different from other photo software companies. Photography is all we do, we put you the photographer first, and this means our customers have complete control over every aspect of their photography. Our software applications are designed by photographers, for photographers.
The ON1 mission is to deliver the tools photographers need to express themselves through photography. The ability to easily organize, edit, and share their photos anywhere and provide professional quality image processing, the creativity they desire, the service they deserve, and to keep photographers in control of their photography.
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