#antiprolife

[transparentgentlemenmarker]

Black tomatoes are found to have significant antioxidant, anti-inflammatory, antiproliferative and hypnotic effects. They also have beneficial effects on sperm count and motility.

[didanawisgi]

Papers Reviewed:

2021 Aug (Wong et al) - Pomegranate bioactive constituents target multiple oncogenic and oncosuppressive signaling for cancer prevention and intervention

2022 Feb (Cheshomi) - The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

2023 Jan (Teniente et al) - Anticancer Effect of Pomegranate Peel Polyphenols against Cervical Cancer

2023 Apr (Habchi et al) - Determination of the Antioxidant and Antiproliferative Properties of Pomegranate Peel Extract Obtained by Ultrasound on HCT-116 Colorectal Cancer Cell Line

2023 July (Rahman et al) - Pomegranate-specific natural compounds as onco-preventive and onco-therapeutic compounds: Comparison with conventional drugs acting on the same molecular mechanisms

[hnizbnyh]

Artikel Ilmiah

"Obat Herbal Pereda ISPA pada Balita"

Bahan-bahan herbal yang sering dijumpai seperti jahe, kunyit, kencur, dan sebagainya merupakan bahan alam yang selalu menjadi alternatif obat dari berbagai penyakit. Salah satunya ISPA atau Infeksi Saluran Pernapasan Atas adalah radang saluran pernapasan atas yang disebabkan oleh infeksi jasad renik atau bakteri, virus, tanpa atau disertai renkim paru-paru. Penyakit ISPA sering terjadi pada anak karena sistem pertahanan tubuh masih rendah. Salah satu tanda dan gejala penyakit ISPA ialah batuk-pilek, kejadian batuk pilek pada anak di Indonesia diperkirakan 3 sampai 6 kali setahun. Influenza merupakan salah satu penyakit ISPA yang mendapat perhatian, karena penyakit ini dapat menimbulkan wabah sesuai dengan Peraturan Menteri Kesehatan RI No.1501/Menkes/Per/X/2010 Tentang Jenis Penyakit Menular Tertentu Yang Dapat Menimbulkan Wabah Dan Upaya Penanggulangan (Kementerian Kesehatan, 2013).

ISPA mempunyai gejala yang bervariasi, seperti demam, nyeri tenggorokan, pilek, hidung mampet, batuk kering, batuk berdahak, atau bahkan bisa menimbulkan penyakit komplikasi seperti pneumonia dengan gejala sesak napas. Faktor atau cara penularan ISPA ini dapat ditularkan melalui seseorang yang bersin tanpa menutup mulut dan hidung, air ludah, dan bahkan kurangnya ventilasi dan banyaknya asap, seperti asap rokok atau pun asap dari pembakaran sembarangan.

Obat herbal tradisional bisa menjadi pereda dari penyakit ISPA (Infeksi Saluran Pernapasan Atas) pada balita. Dengan pemanfaatan jahe, kunyit, madu, dan sebagainya, bisa menjadi pereda untuk penderita ISPA khususnya pada balita.

Lalu, apa saja kandungan yang terdapat dalam obat herbal tersebut?

1. Jahe (Zingiber officinale)

Pemberian minuman jahe madu dapat menurunkan keparahan batuk pada anak, karena kandungan minyak atsiri dalam jahe yang merupakan zat aktif yang dapat mengobati batuk. Anak yang telah diberikan minuman jahe madu oleh peneliti gejala keparahan batuk seperti batuk berdahak, pilek, rewel, tidak nafsu makan dan gejala lainnya menjadi berkurang.

2. Kunyit (Curcuma longa)

Kandungan kunyit adalah minyak atsiri, kurkumin, dimetoksin kurkumin, arbinosa, fruktosa, glukosa, pati, tannin, magnesium besi, kalsium, natrium, dan kalium. Berdasarkan kandungan tersebut maka kunyit memiliki efek herbal atau khasiat untuk menjaga stamina, hepatoprotektor, diuretic, antioksidan anti radang, immunomodulator, dan antikanker. Juga bersifat antiinflamasi, anti hiperkolesterolemia, antiproliferative, dan antitumor. Bubuk kunyit bisa mengobati hidung meler, sakit tenggorokan pada anak ketika balita batuk pilek.

3. Madu

Kandungan antimikrobanya membantu melawan virus penyebab flu, rasa manis pada madu membantu produk saliva yang bisa mengencerkan lendir sehingga mudah untuk dikeluarkan. Madu mempunyai efek antimikroba yang bertanggung jawab atas aktivitas antibakteri sehingga membantu melawan agen penyebab ISPA.

4. Kencur (Kaempferia galanga L.)

Kencur dimanfaatkan untuk menyembuhkan batuk, peluruh dahak atau pembersih tenggorokan, menghilangkan lendir yang menyumbat hidung, dan menghangatkan. badan.

5. Lemon (Citrus limon)

Lemon memiliki kandungan senyawa yang meningkatkan sistem kekebalan tubuh dalam melawan sakit dan radikal bebas di dalam tubuh. Perasan jeruk lemon dengan madu merupakan obat herbal untuk meredakan batuk pilek secara efektif.

6. Bawang Merah (Allium cepa)

Ekstrak bawang merah efektif terhadap bakteri yang terdapat di udara dan salah satu bakteri koinfeksi ISPA (Infeksi Saluran Pernapasan Atas) yang disebabkan oleh virus.

Bagaimana cara pengolahannya? Menurut buku Ensiklopedi Tanaman Obat Indonesia (Haryanto, 2012)

Salah satu cara membuat ramuan untuk salah satu penyakit ISPA (Infeksi Saluran Pernapasan Atas), yaitu dengan menyiapkan lengkuas; temulawak; halia; keningar; daun pecut kuda; daun iler; dan daun kayu manis secukupnya. Kemudian, semua bahan ditumbuk halus dan direbus dengan 3 gelas sampai air mendidih, dan diminum 2 kali sehari (pagi dan sore). Selain itu, pembuatan obat herbal untuk flu dengan bahan lemon; minyak kayu putih; dan kapur sirih. Lemon dipanggang dan diperas, dan dicampur dengan air dan bahan lainnya, kemudian diaduk sampai merata dan disaring. Cara lainnya yaitu dengan cara minum perasan air lemon dicampur dengan kecap dan garam secukupnya.

Dengan cara pengolahannya yang mudah diikuti di rumah dan bahan-bahan yang mudah dijangkau, kita bisa membuat obat herbal untuk meredakan ISPA.

Sekian, terima kasih!

Hana Izbiniyah - XI IPA 2

[cedarbeing]

Unconventional Plants and Herbs in Witchcraft:

Entry No. 3

Stinging nettle (Urtica diocia)

General Information and History:

General info:

Depending on the subspecies, Urtica diocia is either classed as native or exotic in British Columbia. However, in some places in North America it is classified as invasive. Nettle can also be found in north Africa, Asia, and Europe.

Readily found in disturbed habitats (roadsides, barnyards etc). Meadows, open forests. Always in rich moist soil.

The entire plant is edible after cooking or drying

The sting comes from the small needle like hairs on the plant, when they come into contact with skin, irritating chemicals are injected (such as formic acid).

History:

Nettles have been used for hundreds of years, not only as a food source and a medicinal, but for textiles and fibres as well. It is incredibly strong when used for fabrics and holds up to the test of time.

Medicinal Information:

Note: use at your own risk. If pregnant/nursing, taking medications, or have medical conditions, contact a physician prior to use. Please be aware that medicinal herbs are meant to be used in moderation. This is NOT a guide to usage.

Possible Properties: antiproliferative, anti-inflammatory, antioxidant, analgesic, antihistamine, hypotensive, diuretic, as well as the ability to prevent cardiovascular disease.

Methods of use: edible, tea, tincture, hair rinse, etc.

Used for: painful muscles and joints, eczema, arthritis, gout, anemia, allergies, hair growth…and more!

Usage in Witchcraft:

Now, compared to my other two entries, nettle is much more common compared to the others. However, I believe it is under utilized and under appreciated. So while it might not fit under the “unconventional” aspect of these posts, I decided to write on it anyways. Below lies the most common correspondences I found.

Common Correspondences: Protection, Purification, Healing, Binding, Banishing, Boundaries, Warding, Lust, return to sender.

Other very important information

Some information is derived or cross referenced from: PLANTS OF THE PACIFIC NORTHWEST COAST Washington, Oregon, British Columbia & Alaska. (Paul B. Alaback). This is a SUPERB field guide if you live in the area(s) mentioned and it carries a wealth of information. I HIGHLY recommend it!

In regards to foraging:

Be safe, sustainable, and ethical when foraging.  (Click the link)

ALWAYS positively identify before use. If you’re not 100% sure, don’t use it!

Be prepared for a possible negative reaction or allergy. When trying new things, try a small amount first.

Know the local area/the dangers (terrain, wild animals, incoming weather, etc) be prepared!

DO NOT take more than you need/can use. (This does not apply to invasive species)

Harvest from different locations if possible.

Do as little damage to the plant and grounds.

Use a mesh bag to collect in the case of mushrooms.

Make an effort to spread seeds from plants when harvesting if possible. (This does not apply to invasive species)

This post is not a comprehensive guide to stinging nettle and it’s usage, it is a brief and general overview of information that I have compiled, and not necessarily beginner friendly. Please treat it as such. Happy spell crafting! :)

[rnomics]

Genes, Vol. 15, Pages 1165: Schistosoma japonicum sja-let-7 Inhibits the Growth of Hepatocellular Carcinoma Cells via Cross-Species Regulation of Col1α2

Liver fibrosis, a critical precursor to hepatocellular carcinoma (HCC), results from chronic liver injury and significantly contributes to HCC progression. Schistosomiasis, a neglected tropical disease, is known to cause liver fibrosis; however, this process can be modulated by schistosome-derived #miRNAs. Previous studies from our laboratory have demonstrated that Schistosoma japonicum extracellular vesicles (EVs) deliver sja-let-7 to hepatic stellate cells, leading to the inhibition of Col1α2 expression and alleviation of liver fibrosis. Given the well-documented antifibrotic and antiproliferative properties of the let-7 #miRNA family, this study aims to preliminarily investigate the effects of the sja-let-7/Col1α2 axis on BALB/c mice and HCC cell line SNU387, providing a basis for the potential application of parasite-derived molecules in HCC therapy. In the present study, schistosome-induced fibrosis datasets were analyzed to identify the role of Col1α2 in extracellular matrix organization. Pan-#cancer analysis revealed that Col1α2 is upregulated in various #cancers, including HCC, with significant associations with immune cell infiltration and clinical parameters, highlighting its diagnostic importance. Functional assays demonstrated that transfection with sja-let-7 mimics significantly reduced Col1α2 expression, inhibited HCC cell proliferation, migration, and colony formation. These findings suggest that sja-let-7, by targeting Col1α2, has the potential to serve as a therapeutic agent in HCC treatment. This study indicates the pivotal role of Col1α2 in liver fibrosis and HCC, and the promising therapeutic application of helminth-derived #miRNAs. https://www.mdpi.com/2073-4425/15/9/1165?utm_source=dlvr.it&utm_medium=tumblr

[medicapharmabv]

Sirolimus: A Powerful Tool in Transplantation and Beyond

Sirolimus, also known as Rapamycin, is a potent immunosuppressive medication widely used in transplantation medicine to prevent organ rejection. With its unique mechanism of action and broad therapeutic potential, sirolimus is a crucial component in ensuring successful outcomes for transplant patients and offers promise in treating various other conditions.

Mechanism of Action

Sirolimus exerts its effects by inhibiting the mammalian target of rapamycin (mTOR) pathway, a critical regulator of cell growth, proliferation, and survival. By blocking this pathway, sirolimus interferes with the activation and proliferation of T-cells, which are responsible for mounting an immune response against transplanted organs. This suppression of the immune system helps to prevent organ rejection, making sirolimus an essential drug in the post-transplantation regimen. Moreover, sirolimus also exhibits antiproliferative properties by inhibiting the growth of smooth muscle cells, which is particularly beneficial in preventing restenosis in coronary artery stents.

Benefits and Advantages

Sirolimus offers several advantages that make it a preferred choice in clinical settings:

Preventing Organ Rejection: The primary use of sirolimus is in transplantation medicine, where its potent immunosuppressive effects are invaluable in preventing the rejection of transplanted organs. By suppressing the immune system, sirolimus helps to ensure that the body does not attack the new organ, leading to better graft survival and patient outcomes.

Reducing Restenosis Risk: Sirolimus is also used in cardiology to prevent the proliferation of smooth muscle cells in coronary artery stents. This antiproliferative effect reduces the risk of restenosis, a condition where the arteries narrow again after being treated with a stent.

Expanding Therapeutic Applications: Beyond its role in transplantation and cardiology, sirolimus shows potential in treating various cancers, autoimmune diseases, and vascular proliferative disorders. This versatility makes it a valuable drug in multiple therapeutic areas.

Side Effects and Risks

While sirolimus is highly effective, it is not without potential side effects:

Increased Risk of Infections: Due to its immunosuppressive effects, sirolimus can increase the risk of infections by hindering the body’s ability to fight off pathogens.

Metabolic Abnormalities: Patients on sirolimus may experience metabolic issues such as hyperlipidemia, hyperglycemia, and insulin resistance, which can contribute to cardiovascular complications and diabetes.

Renal Dysfunction: Prolonged use of sirolimus has been associated with renal dysfunction, including impaired kidney function and proteinuria. Close monitoring of renal parameters is necessary during treatment to prevent long-term damage.

Why Choose MedicaPharma?

When it comes to purchasing sirolimus, MedicaPharma is your trusted partner. We are committed to providing high-quality active pharmaceutical ingredients (APIs) that meet stringent Good Manufacturing Practice (GMP) standards. Our logistics operations are in full compliance with Good Distribution Practice (GDP) regulations, ensuring that you receive your medication in the best possible condition.

Request a Quote Today

If you’re considering sirolimus for transplantation or other therapeutic purposes, you can buy sirolimus from MedicaPharma with confidence. Contact us today to request a quote and learn more about how our products can support your medical needs.

Sirolimus is more than just a medication—it’s a key to better health and improved patient outcomes. Let MedicaPharma help you access the best in pharmaceutical care. Buy sirolimus from us and take the first step towards better health.

[twinkl22004]

“Breast Cancer”, Victor McKusick, ��Mendelian Inheritance in Man”, 1966.

ABOVE is the twenty-four (24) hour day of  CHROMOSOMIC CLOCK and this time is seventeen (#17). Here I present: “Breast Cancer”, Victor McKusick,  Mendelian Inheritance in Man’, 1966. INTRODUCTION. Prohibitin is a 30-kD intracellular, antiproliferative protein.  The prohibitin gene (PHB) located on the breast cancer type-A1 (BRCA1) chromosome region 17q21.33 was originally thought to be a negative…

[stubbornweightloss1]

stubborn weight loss

Meals: Increase your weight loss program with these powerhouse meals

Printed 12:00 am Thursday, Might 2, 2024These nutrient-rich meals could make nice additions to health-conscious people’ diets. — Metro Inventive Connection

Metro Inventive Connection

A nutritious weight loss program is a key element of a wholesome life-style. That’s an necessary factor to recollect for folks trying to flip over a more healthy leaf and attain their long-term wellness targets.

Avoiding sure substances, like saturated fat and added sugars, and selecting meals recognized for his or her dietary advantages is a method people can make the most of weight loss program to stay more healthy. Though such meals can not fully get rid of threat for sure ailments or make an individual invincible, consuming extra of them definitely can profit people’ general well being.

• Kale: Kale lengthy has had a spot on wholesome consuming lists. Kale is an efficient supply of nutritional vitamins A, C and Okay, and likewise accommodates alpha-linolenic acid, which is an omega-3 fatty acid. In accordance with Britannica, research present kale will help fight coronary heart illness and most cancers, and likewise increase eye well being by decreasing threat for cataracts and macular degeneration. Kale will not be the one darkish, leafy inexperienced vegetable that has earned celebrity standing. Swiss chard, spinach, collard greens, and turnip greens are equally useful.

• Berries: There’s robust antioxidant capability related to berries that helps cut back the danger of coronary heart illness and different inflammatory situations, says Healthline. That’s why blueberries, strawberries, blackberries, raspberries, and cranberries are so revered by nutritionists. They’re additionally nice sources of fiber, nutritional vitamins and minerals.

• Honey: This pure sweetener is a robust ally to animals and bugs. Honey is likely one of the most appreciated and valued pure merchandise, in response to the research “Honey and Well being: A Evaluation of Latest Medical Analysis,” printed in 2017. Since historical occasions, honey has been used therapeutically on account of its antioxidant, antimicrobial, anti-inflammatory, and antiproliferative results.

• Walnuts: Research have discovered that these with greater nut consumption have improved cardiovascular threat components and decrease charges of heart problems. Nuts are an necessary a part of the Mediterranean weight loss program, which has been discovered to be coronary heart wholesome as effectively, in response to Harvard Well being. Walnuts are a very good selection for decreasing LDL ldl cholesterol, triglycerides and apoprotein B (a protein linked to heart problems).

• Legumes: Legumes, also called pulses, embrace beans, lentils, peas, peanuts, and alfalfa. Legumes are filled with vitamins, like minerals, protein, fiber, and B nutritional vitamins. Healthline notes legumes additionally enhance emotions of fullness, which can assist folks eat much less at every meal.

• Teff: Not too many individuals have heard of teff, which is a really small grain that may be a dietary staple in components of jap Africa. Teff is excessive within the vitamins iron, magnesium, zinc, calcium, and vitamin C. Teff additionally accommodates ample protein and fiber. Teff is also gluten-free, so it may be ground and used instead of different flours in cooking, says Britannica.

• Kefir: Fermented meals and drinks have garnered elevated consideration just lately due to their impact on serving to preserve intestine well being. Kefir is loaded with nutritional vitamins, minerals and vitamins, says the Cleveland Clinic. It’s a fermented milk that boasts greater concentrations of probiotics than another fermented meals, like yogurt. Kefir has roughly 12 energetic probiotic strains.

[moleculardepot]

Human TAPA-1/CD81 Extracellular Domain

Human TAPA-1/CD81 Extracellular Domain Catalog number: B2016767 Lot number: Batch Dependent Expiration Date: Batch dependent Amount: 50 µg Molecular Weight or Concentration: 12.1 kDa Supplied as: Solution Applications: a molecular tool for various biochemical applications Storage: -80°C Keywords: CVID6.,TAPA-1, Target of Antiproliferative Antibody 1, TSPAN28 Grade: Biotechnology grade. All…

[seoexpert-123]

Palo Santo and Sage benefits

Benefits and uses of Palo Santo

healing & pain reliever

In-house, usage of palo santo extended from common colds, flu symptoms, headaches, asthma, stress and inflammation by smudging and making teas and tinctures from the wood and it’s essential oils. Rich source of phytochemicals and antioxidants known as terpenes, like limonene and α-terpineol. According to a study conducted by University of Havana, they state the following: “The chemical composition of the essential oil, determined by GC-MS, was complex and dominated by limonene (26.5%).” These results demonstrate that the essential oil from B. graveolens is a promissory antiproliferative product. While Bursera oil inhibited the growth of MCF-7 breast tumor cells.

[tishatcasida]

Health Benefits from Oregano - That's Natural Detox CBD

If you are looking for immune system support, in addition to helping your body detox from a variety of factors, one of the most important things to include in your repertoire is the Essential Oil of Oregano (EOO). Oregano’s properties have been known for centuries – this amazing herb is: antimicrobial, antifungal, bactericidal, antiviral, in addition to being an antioxidant, antiproliferative,…

[didanawisgi]

Abstract

Aging is characterized by a progressive inability to maintain homeostasis, self-repair, renewal, performance, and fitness of different tissues throughout the lifespan. Senescence is occurring following enormous intracellular or extracellular stress stimuli. Cellular senescence serves as an antiproliferative process that causes permanent cell cycle arrest and restricts the lifespan. Senescent cells are characterized by terminal cell cycle arrest, enlarged lysosome, and DNA double-strand breaks as well as lipofuscin granularity, senescence-associated heterochromatin foci, and activation of DNA damage response. Curcumin, a hydrophobic polyphenol, is a bioactive chemical constituent of the rhizomes of Curcuma longa Linn (turmeric), which has been extensively used for the alleviation of various human disorders. In addition to its pleiotropic effects, curcumin has been suggested to have antiaging features. In this review, we summarized the therapeutic potential of curcumin in the prevention and delaying of the aging process.

[cytgen]

Abstract Since the nanoscale in combination with luminescent properties and prospective applications in different fields of optoelectronics and biomedicine is stimulating a growing interest towards research in the area of cadmium telluride (CdTe) quantum dots (QDs), the method of “green” synthesis of CdTe QDs with the use of the Pleurotus ostreatus mycelium culture as a biological matrix has been developed. The study of their physical and chemical characteristics has shown that the synthesized CdTe QDs are characterized by a crystalline structure and a predominantly spherical morphology and are 3–8 nm in size with the luminescence maximum within the 340–370 nm range. The study of their effects on different types of mammalian cells has shown that CdTe QDs have dose-dependent effects on mouse endothelial cells and human and rat erythrocytes, T- and B-lymphocytes, colorectal cancer cells (Colo 205), and human breast cancer cells (MCF-7). In particular, suppression of proliferative indices of endotheliocytes and an increase in the count of dead cells were observed, which indicates the cytotoxic action of nanocrystalline CdTe and its antiproliferative effect on endothelial cells. At the 5 µM concentration, CdTe QDs exhibited hemolytic activity, due to their action on erythrocytes, and affected adhesive contacts and cancer cell survivability. At the same time, human breast cancer cells (MCF-7) were more sensitive to their action. The data obtained are exclusively important for the understanding of mechanisms underlying the toxicity of CdTe QDs and for their future application in biological and biomedical research.

[rnomics]

Biomedicines, Vol. 12, Pages 2001: Epigenetic Regulation of DNA Methylation and #RNA Interference in Gastric #cancer: A 2024 Update

Gastric #cancer (GC) remains a significant public health concern because of its lethality, underscoring the need for deeper insights into its molecular mechanisms. Recent studies have increasingly highlighted the role of epigenetic modifications as critical players in #cancer progression. Despite their importance, research specifically addressing epigenetic factors in GC is relatively scarce. This paper seeks to bridge that gap by examining recent literature that elucidates the epigenetic landscape associated with GC. The investigation of long noncoding #RNAs (l#ncRNAs) has revealed their substantial involvement in gene dysregulation and epigenetic alterations within GC tumors. Notably, l#ncRNAs such as LINC00853 and LINC01266 have been identified as significant contributors to the epigenetic modulation of gene expression. Furthermore, the overexpression of KAT5 and GPX4 has been shown to mitigate the antiproliferative effects resulting from the depletion of circRHOT1, suggesting a complex interplay between these molecules in GC pathophysiology. Another pivotal aspect of epigenetic regulation in GC involves modifications in N6-methyladenosine (m6A), which play crucial roles in #mRNA maturation processes such as splicing, export, degradation, and translation. m6A modifications are known for their influence on various #cancer-related pathways, thus presenting a potential avenue for targeted interventions. Our findings indicate that the most pronounced instances of epigenetic dysregulation in GC can be traced back to the effects of long l#ncRNAs and alterations in m6A modification patterns. This underscores the urgent need for comprehensive investigations into these epigenetic factors, as a deeper understanding could lead to enhanced diagnostic markers and innovative therapeutic strategies. The integration of genetic and epigenetic considerations is essential for advancing the field of GC research. This synthesis of recent findings concerning epigenetic regulation offers valuable insights that could inform future studies and therapeutic developments. There is a critical need for ongoing research to elucidate the complexities of epigenetic modifications in GC, ultimately improving patient outcomes through tailored interventions. https://www.mdpi.com/2227-9059/12/9/2001?utm_source=dlvr.it&utm_medium=tumblr

[tumimmtxpapers]

Investigation of in vitro antimicrobial, antioxidant and antiproliferative activities of Nostoc calcicola biosynthesized gold nanoparticles

The cyanobacteria are the promising candidate for synthesizing gold nanoparticles (AuNPs), due to their ability to accumulate heavy metals from the cellular environment and additionally contain varied bioactive compounds as reducing and stabilizing agents. This study describes the N(2)-fixing cyanobacterium Nostoc calcicola-mediated bioreduction of AuNPs and the inherent antimicrobial, antioxidant, and antiproliferative activities in vitro. Biosynthesized Nc-AuNPs were characterized by spectral... http://dlvr.it/SsLSLh