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Men's health and sexual activity remain some of the most discussed topics, raising numerous questions and myths. It is believed that a man's ability to maintain an erection can persist throughout his lifetime. If there are issues, it’s important to explore the causes. The author reviewed a one-hour interview with a renowned urology specialist and prepared a summary of the most relevant points for you. Key Insights into Men’s Health:

1. Testosterone: The Key Role in the Male Body

Testosterone is a hormone that defines men’s health in many areas. It impacts sexual desire, muscle mass, bone density, energy levels, and emotional stability. Its active form, dihydrotestosterone, is essential for maintaining erections and libido.

Belly fat is testosterone's enemy. Fat tissue produces an enzyme called aromatase, which converts testosterone into estrogen. This creates a vicious cycle: more fat – less testosterone – poorer metabolism.

Age-related changes. After age 35, testosterone levels naturally decline by 1-2% annually. Some men experience this process gradually, while others notice significant changes that may require medical attention.

2. How to Check Testosterone Levels

Accurate testing methods are essential for understanding testosterone levels:

The most accurate method – gas chromatography or mass spectrometry, though these options can be expensive.

Accessible option – saliva steroid profiling provides reliable insights into hormonal balance without complicated procedures.

Timing matters. Testosterone levels peak in the morning, making morning tests more accurate. For a comprehensive view, follow-up tests in the afternoon may be recommended.

3. Erection as a Health Marker

An erection is more than just a sexual function; it’s a window into vascular health. Disruptions may indicate blood flow problems or underlying health concerns.

Morning erection as a key indicator. The presence of regular morning erections is a strong marker of hormonal and vascular health. Its absence could signal issues with testosterone levels or blood circulation.

A warning for heart health. Impairment in the dorsal artery of the penis (approximately 1-2 mm in diameter) might signal issues with larger blood vessels.

Act promptly. If erections suddenly disappear without an apparent reason, consult a specialist immediately.

A warning for heart health. Impairment in the dorsal artery of the penis (approximately 1-2 mm in diameter) might signal issues with larger blood vessels.

Act promptly. If erections suddenly disappear without an apparent reason, consult a specialist immediately.

4. Insulin Resistance – The Silent Enemy

Insulin resistance occurs when cells lose sensitivity to insulin, leading to elevated blood sugar levels. This condition is linked to fatigue, weight gain, and reduced libido.

Recognizing early signs: fatigue, "brain fog," drowsiness, and declining productivity.

Preventive measures: cutting back on sugar and fast carbs, staying physically active, and monitoring blood sugar levels regularly.

5. Hormone Therapy: Myths and Realities

Modern hormone replacement therapies offer safe ways to manage testosterone levels:

Depot injections. These ensure steady testosterone levels for three months with a single dose.

Tadalafil-based medications (Viagra analogs) enhance blood flow and support vascular health, offering benefits beyond improving erections.

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6. Depression and Libido

Mental health has a significant impact on sexual function. Depression, low dopamine levels, and chronic fatigue can suppress sexual desire and performance.

Effective solutions: a combination of psychotherapy and medication can help restore libido and overall well-being.

7. Preventive Measures: Enhancing Men’s Health

Physical activity. Regular exercise promotes better blood circulation and hormonal balance.

Monitor your weight. Men with a waist circumference over 94 cm are more prone to hormonal imbalances.

Prioritize sleep. Testosterone production primarily occurs during sleep, making restful nights essential for maintaining hormonal levels.

Conclusion

Men’s health isn’t just about testosterone. A holistic approach that includes proper nutrition, regular physical activity, mental well-being, and routine health check-ups is crucial. Monitoring hormone levels and making lifestyle adjustments can help preserve not only sexual function but also overall quality of life.

Balancing hormones, managing weight, adopting healthy eating habits, and staying active are the cornerstones of long-lasting health and vitality. Embrace these steps to live a fulfilling and energetic life.

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Benign Prostatic Hyperplasia Market expected to rise | Companies- Dongkook Pharmaceutical, Urovant Sciences, Ausio Pharmaceuticals, GlaxoSmithKline, RECORDATI GROUP, Astellas Pharma Inc, Eli Lilly and Company, Sophiris Bio Corp, Bayer, Warner Chilcott, Materia Medica Holding, Ausio Pharmaceuticals, LLC, Nymox Corporation, Olympus Medical, Butterfly Medical, SRS Medical, Teleflex Interventional Urology, Urotronic, Zenflow, ProArc Medical, Medion Biodesign, expected to drive market

The Benign Prostatic Hyperplasia market growth is driven by factors like increase in the prevalence of Benign Prostatic Hyperplasia, investments in research and development, entry of emerging therapies during the study period 2019-2032.

The Benign Prostatic Hyperplasia market report also offers comprehensive insights into the Benign Prostatic Hyperplasia market size, share, Benign Prostatic Hyperplasia epidemiology, emerging therapies, market drivers and barriers, ongoing clinical trials, key collaboration in the space, market uptake by key therapies and companies actively pushing Benign Prostatic Hyperplasia market size growth forward. 

Some of the key highlights from the Benign Prostatic Hyperplasia Market Insights Report:

Several key pharmaceutical companies, including Dongkook Pharmaceutical, Urovant Sciences, Ausio Pharmaceuticals, GlaxoSmithKline, RECORDATI GROUP, Astellas Pharma Inc, Eli Lilly and Company, Sophiris Bio Corp, Bayer, Warner Chilcott, Materia Medica Holding, Ausio Pharmaceuticals, LLC, Nymox Corporation, Olympus Medical, Butterfly Medical, SRS Medical, Teleflex Interventional Urology, Urotronic, Zenflow, ProArc Medical, Medion Biodesign, and others, are developing novel products to improve the Benign Prostatic Hyperplasia treatment outlook. 

Promosing therapies in the Benign Prostatic Hyperplasia market are DKF0313, Vibegron, AUS-131 (S-equo), GI198745, DKF-313, Silodosin, ASP4901, Tadalafil, PRX302, Levitra (Vardenafil, BAY38-9456), WC3055, Afalaza, S-equol, NX-1207, Tamsulosin, and others.

The total Benign Prostatic Hyperplasia market size will include the market size of the potential upcoming therapies and current treatment regimens in the seven major markets.

As per DelveInsight analysis, the Benign Prostatic Hyperplasia market is anticipated to witness growth at a considerable CAGR

Among the 7MM, the most prevalent cases of Benign Prostatic Hyperplasia (BPH) were recorded in the United States.

As per a study conducted by Lim et al. (2017), the histological prevalence of Benign Prostatic Hyperplasia was observed as 8%, 50%, and 80% in the 4th, 6th, and 9th decades of life, respectively.

A study conducted by Lee et al. (2017), titled “The global burden of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: A systematic review and meta-analysis,” showed that the median point prevalence of BPH was 25.2%.

According to the study by Lee et al., BPH is more common in older males as compared to those below 40 years. 

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Benign Prostatic Hyperplasia Overview 

Benign Prostatic Hyperplasia (BPH) refers to an enlargement of the prostate gland, while the symptoms associated with BPH are commonly known as lower urinary tract symptoms (LUTS). LUTS can manifest as irritative symptoms, obstructive symptoms, or a combination of both. Some men with BPH may not experience any symptoms, while others may find relief through lifestyle modifications, while some may require medical or surgical interventions. Symptoms of BPH typically become more prevalent as men age. These symptoms include feeling of incomplete bladder emptying, difficulty initiating urination, urinary hesitancy, weak urine flow, painful urination, frequent nighttime urination (nocturia), increased urinary frequency, and urgent need to urinate.

To diagnose BPH, the medical history of the patient is assessed, along with a physical examination that may include a digital rectal examination (DRE) and urinalysis. Additional tests such as uroflowmetry (measuring urine flow rate) and post-void residual (PVR) volume measurement may be conducted to confirm the presence of obstructive symptoms associated with BPH. There are two main classes of medications commonly used for the treatment of BPH: alpha-adrenergic blockers and 5-alpha reductase inhibitors.

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Benign Prostatic Hyperplasia Epidemiology Segmentation 

DelveInsight’s Benign Prostatic Hyperplasia market report is prepared on the basis of epidemiology model. It offers comprehensive insights to the Benign Prostatic Hyperplasia historical patient pools and forecasted Benign Prostatic Hyperplasia patients. The report provides in-depth data of various subtypes and for the same epidemiology is segmented further. The Benign Prostatic Hyperplasia Market report proffers epidemiological analysis for the study period 2019-32 in the 7MM segmented into:

Benign Prostatic Hyperplasia Prevalence 

Age-Specific Benign Prostatic Hyperplasia Prevalence 

Gender-Specific Benign Prostatic Hyperplasia Prevalence 

Diagnosed and Treatable Cases of Benign Prostatic Hyperplasia

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Recent Breakthroughs in the Benign Prostatic Hyperplasia Market:

Medeon Biodesign Inc., the manufacturer of the XFLO minimally invasive therapy device for Benign Prostatic Hyperplasia, announced positive results from clinical trials on January 27, 2021. The interim findings from the EXPANDER-1 clinical study were promising, and the company's upcoming product launches are expected to contribute to market expansion.

Olympus Corporation acquired Medi Tale Ltd., an Israeli company that produces non-surgical devices for treating Benign Prostatic Hyperplasia, on February 26, 2021. This acquisition positions Olympus as the market leader and allows the company to broaden its product range.

Benign Prostatic Hyperplasia Treatment Market 

The Benign Prostatic Hyperplasia market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Benign Prostatic Hyperplasia market trends by analyzing the impact of current Benign Prostatic Hyperplasia therapies on the market, unmet needs, drivers and barriers, and demand for better technology.

This segment gives a thorough detail of Benign Prostatic Hyperplasia market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Benign Prostatic Hyperplasia market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the Benign Prostatic Hyperplasia market in 7MM is expected to witness a major change in the study period 2019-2032.

Benign Prostatic Hyperplasia Therapy Assessment

Fexapotide: Nymox Pharmaceutical

Fexapotide (NX-1207) is a pro-apoptotic injectable protein and is in development for the treatment of benign prostatic hyperplasia. In February 2023, Nymox Pharmaceutical Corporation announced that the Company's recent submission of Fexapotide Triflutate for the treatment of symptoms of benign prostate enlargement (benign prostatic hyperplasia, referred to as BPH) has been validated by the Denmark authorities, and the formal review process has now started. The trademarked name for the new product is NYMOZARFEX (TM). The Marketing Authorization Application (MAA) was submitted at the beginning of December 2022. The Company will continue to provide further information, including other expected submissions, when the information becomes available.

AIV007: AiViva BioPharma

AIV007 is a novel formulation using company’s JEL Technology designed for prolonged drug release. AIV007 targets multiple pathways including VEGFR, PDGFR, and FGFR to address neovascularization and fibrosis, and it also modulates TGFβ1 mRNA expression and TGFβ1 levels to prevent and inhibit cell proliferation. AIV007 is currently in clinical studies for neovascular macular degeneration (nAMD) treatment and in preclinical studies for Benign Prostatic Hyperplasia (BPH) (BPH), and certain solid tumors.

Benign Prostatic Hyperplasia Key Companies

Dongkook Pharmaceutical

Urovant Sciences

Ausio Pharmaceuticals

GlaxoSmithKline

RECORDATI GROUP

Astellas Pharma Inc

Eli Lilly and Company

Sophiris Bio Corp

Bayer, Warner Chilcott

Materia Medica Holding

Ausio Pharmaceuticals

Nymox Corporation

Olympus Medical

Butterfly Medical

SRS Medical

Teleflex Interventional Urology

Urotronic

Zenflow

ProArc Medical

Medion Biodesign

Benign Prostatic Hyperplasia Therapies

DKF0313

Vibegron

AUS-131 (S-equo)

GI198745

DKF-313

Silodosin

ASP4901

Tadalafil

PRX302

Levitra (Vardenafil, BAY38-9456)

WC3055

Afalaza

S-equol

NX-1207

Tamsulosin

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Tadalista, a medication containing Tadalafil, is widely known for its effectiveness in treating conditions like erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). While it offers relief for these conditions, its interaction with medications commonly prescribed for heart disease requires careful consideration.

Understanding Heart Disease and Common Medications

Heart disease encompasses a range of conditions affecting the heart and blood vessels, including hypertension (high blood pressure), coronary artery disease, and more. The medications used to manage these conditions aim to regulate blood pressure, improve heart function, and reduce the risk of complications such as heart attacks and strokes. Common classes of medications include ACE inhibitors, beta-blockers, calcium channel blockers, and nitrates.

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Tadalista works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which leads to increased blood flow to the penis, helping men achieve and maintain erections. In the case of PAH, Tadalista dilates pulmonary arteries, reducing pulmonary vascular resistance and improving exercise capacity.

Potential Interactions Between Tadalista and Heart Medications

One of the most critical interactions involves nitrates, which are commonly prescribed for chest pain (angina) in heart disease. Nitrates work by dilating blood vessels to improve blood flow to the heart. Tadalista, similarly, dilates blood vessels but to a greater extent. When used together, there is a risk of severe hypotension (dangerously low blood pressure), which can lead to dizziness, fainting, and even heart attack in severe cases. Therefore, Tadalista should never be taken with nitrates.

Other cardiovascular medications like ACE inhibitors, beta-blockers, and calcium channel blockers may also interact with Tadalista. These medications can lower blood pressure and combining them with Tadalista may potentiate this effect, potentially causing symptomatic hypotension. Healthcare providers must assess the risks and benefits before co-prescribing these medications.

Precautions and Considerations

Patients must inform their healthcare providers about all medications they are taking, including over-the-counter drugs and supplements. This information helps in assessing the risk of drug interactions and determining the safest treatment options. Before prescribing Tadalista, healthcare providers should conduct a thorough medical history review, especially focusing on cardiovascular health.

Guidance for Healthcare Providers

Healthcare providers should exercise caution when prescribing Tadalafil to patients with underlying cardiovascular conditions. They should screen for cardiovascular risk factors and consider alternative treatment options if there is a high risk of adverse interactions. Regular monitoring of blood pressure and symptoms is crucial during treatment to detect any potential complications early.

Conclusion: Safety and Awareness

While Tadalista is effective in treating ED and PAH, its interaction with medications commonly used for heart disease necessitates careful management. Patients should prioritize open communication with their healthcare providers to ensure safe and effective treatment. By understanding these interactions and following medical guidance, patients can minimize risks and maximize the benefits of Tadalista therapy.

In conclusion, while Tadalista offers significant therapeutic benefits, particularly for ED and PAH, its potential interactions with cardiovascular medications require vigilance and informed medical supervision. This approach ensures that patients receive optimal care while minimizing the risk of adverse effects.

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