#LOOK AT THE GERMLIN

[etirabys]

abiogenesis & endosymbiosis timeline

I put this together after reading Nick Lane's The Vital Question. The proposed timeline:

3.8bya: The earliest evidence for life is isotopic fractionation. The carbon (and iron, sulfur, nitrogen) atoms in graphite in Greenland are non-randomly sorted, which indicates the presence of cells whose enzymes have a slight preference for the lighter forms of each. However, geological processes can also produce non-random sorting, so this evidence is ambiguous.

3.5bya: Less ambiguously, we have microfossils that look like cells, again with isotopic signatures.

We think bacteria and archaea split off really early, close to the beginning of life (abiogenesis) itself. This is because their cell walls and membranes are so different it's hard to see how one could have evolved from the other. They probably emerged in parallel when they became independent at all. (Quick sketch of abiogenesis, and bacteria/archaea divergences.)

3.2bya: We see bacterial activity in rust bands in rocks. When bacteria strip electrons from iron dissolved in the oceans, the oxidated iron precipitates out into rust and sinks down to the ocean floor.

All bacteria and archaea respire (strip electrons from a donor 'fuel' to generate ATP, which fuels cellular activity). Many donors are possible – common ones are Fe2+, H2S, or H2O (which respectively become Fe3+, S, and O2 after the electron is stripped). Water is the last to be cracked as a donor.

2.4bya: It's cracked now, by some bacteria (archaea never manage it), which leads to The Great Oxidation Event. The oxygen is first absorbed by the oceans, the seabed, and land surfaces. It'll take over a billion years before the oxygen 'sinks' are exhausted, and oxygen accumulates in the atmosphere for real.

1.8bya: A bacterium somehow ends up inside an archaeon cell, and somehow they don't die about it. The bacterium becomes a specialized energy-producing unit, allowing the host cell to grow larger and more complex. They become the first eukaryote, invent sex, and spawn all complex life. (You can read my RPF about it btw.)

1bya: This engulfment – endosymbiosis – happens one more time, to produce chloroplasts in plants.

0.5-6bya: Atmospheric oxygen levels are rising for real now. We see large complex eukaryotes for the first time. These creatures have specialized tissues whose failure threatens the entire organism, and it becomes advantageous to separate out the germline (the part of eukaryotes that divide forever, e.g. sperm and eggs) and make the rest of the body just durable enough to last as long as the most failure-prone tissues. Death by design has entered the world.

[florawrites-blog]

"You're perfect" - Mark lee

You’ve been feeling stressed for weeks, and it’s been showing up in the form of late-night snack binges. You can’t pinpoint why you’re binge eating and you keep promising yourself you will cut it out , but at a point it’s become a nightly ritual ever since your semster ended you told yourself its probably because your worried about your grades or it's probably your hormones playing a big role.

Tonight, Mark, your boyfriend who’s been away on tour, is finally back. It’s 1 AM, and you’ve both decided to order takeout. Sitting in front of the TV, wearing matching pajamas, you’re surrounded by your favorite snacks and takeout containers.

As you take a bite of your food, you suddenly start laughing. “Mark, I’ve been binge eating so much lately. I swear, at this rate, I might start eating people!”

Mark laughs, shaking his head. “Well, at least you’re eating. Better than skipping meals. Besides, I’m just glad you’re keeping yourself fed.”

You laugh along with him, but then, out of nowhere, tears start streaming down your cheeks. Overwhelmed, you throw your head onto the table in front of you.

Panic flashes across Mark’s face. “Yo, baby, are you good?” he asks, genuine fear in his eyes. “What’s wrong? Did I say something that hurt you?”

He quickly moves closer, gently fixing your posture by your shoulders. “Look at me, baby,” he says softly, his voice full of concern.

You lift your head, tears still flowing. “I AM SO FAT IF A TEENAGE BOY SAW ME HE WOULD PULL A YO MAMA SO FAT SHES SEEN FROM THE WORLD MAP JOKE ON ME UGHHHHHHHH IM ALMOST A GERMLIN"

Mark wraps his arms around you, pulling you into a comforting hug trying to hold his giggles after you dramatically nuzzled your head in his chest. “It’s okay bro, we’ll figure it out a way to stop your cravings together. You’re perfect the way you are fuck what these teenage boys might say they dont see you the way I do, Also even if you were a germlin you are my germlin mine mine mine all mine I would love you in any shape and form ” he whispers, gently rubbing your back. you sob harder almost choking on your tears as you managed to mutter out some words hoping they wont sound gibberish to your boyfriend “I love you loser" mark giggles to himself "yeah i know that dude and I love you even more"

Mark always found a way to make you feel loved. His words, always filled with love and reassurance, makesyou feel safe. In his embrace, the weight of your stress starts to decrease, replaced by the warmth of his support.

wrote this while inhaling a large bag of chips

Note: if you are dealing with any sort of problem please reach out to a person you might think that you are being a burden or that they might not help but its always worth a shot.

Please don't steal or copy , thank you

[thewritersaddictions]

Day Six: Geralt of Rivia + Germlins

What had been a planned trip away for the holidays had turned into precisely the opposite. While you were getting ready to go down to the local pub with Jaskier and Geralt, Geralt was nowhere to be found.

"Jaskier, where is Geralt?" You ask; he gives you that look, the one that tells you Jaskier knows where Geralt is and will probably say to you because he'd instead want Geralt's wrath than yours coming down on him.

"You better tell me where he is!" I wanted to let you know that you demand Jaskier. Fear streaks over his face, and he rambles to get his words out of his mouth. "He went to do a job; someone came looking for him, and I told them he was here." Your face drops, and you can't tell who you're more made at.

Jaskier had exposed to pretty much the whole little town that Geralt of Rivia was there and that he was open for work or that Geralt had taken the job in the first place, knowing that you were all there for a vacation away from monster hunting.

"Fine, we are going to get him back." You say with a serious face, "What do you mean?" Jaskier questions you, "We are going to get him back to celebrate and have fun before we have to return to Kaer Morhen." Jaskier nods, so the two of you get on to go find Geralt.

You'd think it would be harder to track him, but all you have to do is follow his name's snarls and groans when you get further out of the town. "Geralt!' Jaskier starts to shout his name out into the woods. You can practically hear his eye-rolling at Jaskier shouting his name.

"Geralt!?" Your voice echoes in the woods, "Y/n!" You can hear Geralt shouting your name. Playing a game of marco-polo, you find Geralt in a relatively tight situation. Caught between a rock and about twenty little dirty-looking monsters. "what the hell happened?" YOu shout to your boyfriend. Geralt groans. "I- I went to get gifts, and I was fucking ambushed by these things," Geralt calls back.

Your thoughts are taken over by the idea, and imagine Geralt carrying a handful of gifts for the bunch of you to celebrate a holiday, which you know he doesn't care for but will do anything to make you happy.

"Can you daydream later, honey, and help me the fuck out!" Geralt shouts. You roll your eyes and huff out a dramatic sigh, but you gather yourself and get to work slaying the little, cute-looking monsters surrounding Geralt. Once they have been taken care of and your hands are interlocked with Geralts, you ask him what he thinks they might have been after.

"To hell if I know what they wanted." Geralt murmurs, "They were kinda cute." You hear Jaskier comment as he trails behind the two of you. "Like fucking hell they were." Geralt counters, nearly snarling behind him. "And they fucking destroyed all the presents I had in my hands, so no, they were fucking assholes." He's not mad, just a little disappointed. "We can always get more before we travel to Kaer Morhen." With a warm smile, you add while staying stuck to Geralt's side like glue.

"Whatever you want, angel." He murmurs as he comes down to kiss you softly on your forehead. Your eyes light up, and Geralt almost backtracks on his words. "I don't want anything besides to have a good holiday with you." You reply, "Hey, what about me?" Jaskier shrieks from behind the two of you, "And you Jaskier."

Completed on: 11/20/23

Posted on: 12/06/23

The Heros-

The Witcher Master List // The Heros Master List // Christmas Stories Master List

[bpod-bpod]

Keeping Stem

Division of stem cells results in a daughter with the capacity to self-renew and one that goes on to become a maturing cell type. As a model of this asymmetric division, researchers look at female fruit fly germline stem cell development. This study discovers the importance of a protein called emerin in the preservation of stem cells during such division as it regulates a key structure of the division machinery, the centrosome

Read the published research article here

Image captured with Leica Microsystems microscopy

Image from work by Samuel D. Jones and colleagues

Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA

Image contributed by the authors under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence

Published in Development, November 2024

You can also follow BPoD on Instagram, Twitter, Facebook and Bluesky

[allthebrazilianpolitics]

Researchers map genetic variants associated with pancreatic cancer in Brazilian patients

The pioneering initiative by scientists at the University of São Paulo aimed to promote early diagnosis and improve treatment of the disease, which is relatively infrequent but one of the leading causes of death from cancer in Brazil.

Pancreatic cancer has recently been included in the list of diseases about which Brazil’s National Cancer Institute (INCA) periodically publishes statistics. Although it is not the most frequent type of cancer, its high lethality makes it one of the leading causes of death from cancer in Brazil, partly owing to late diagnosis. 

“It’s striking how little data on the disease is available in Brazil and indeed in Latin America as a whole. There are no studies on pancreatic cancer involving Brazilian patients because its incidence is low in this country compared with breast and lung cancer, for example. Yet it’s the type of cancer with the highest mortality rate – and it kills very quickly,” said Lívia Munhoz Rodrigues, a researcher at the São Paulo State Cancer Institute (ICESP) with a PhD in oncology from the University of São Paulo’s Medical School (FM-USP). 

Leading a team that included other researchers at ICESP, as well as collaborators at FM-USP’s Department of Legal Medicine, Bioethics, Occupational Medicine and Physical Medicine and Rehabilitation, and the D’Or Research and Education Institute (IDOR), Rodrigues conducted a pioneering study of 192 pancreatic ductal adenocarcinoma patients treated at ICESP between 2018 and 2022 at the expense of the SUS (Sistema Único de Saúde), Brazil’s public health network. Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer.

The scientists used genomic DNA sequencing to look for alterations to 113 oncogenes – genes that can cause cancer when they undergo mutation or are activated in an abnormal manner – in the shape of pathogenic germline variants (PGVs), which are hereditary mutations. 

Continue reading.

[kudiikis]

I want to tell y’all about the dynamic that was my husband and I because it makes me CACKLE

So my husband was a 6’2 Lithuanian man who was absolutely a product of his environment right he came here for school and he had this accent and very business casual every where we went very hot, very put together, very sexy

Then theres me his fucking 5’4 goth crossing dressing loud mouthed vulgar husband who either looked like a punk or a slut no in between.

Now of course i can shine up we’ve seen it but 99.9% of the time we looked a fucking sight and it makes me cackle everytime i look back on pictures bc theres him all clean and sharp, button up and slacks and next to him is this fucking germlin in ripped jeans and this jean jacket

I mean in all fairness when he met me i was dressed to the nines but our first date I wore my battle jacket and docs so like he could have backed out then but apparently he went yes “Yes. This one. This will be my husband.”

[science-lover33]

Revolutionizing Healthcare: The Marvels of Gene Therapy

Gene therapy, a cutting-edge medical technique, has emerged as a game-changer in the field of healthcare. This transformative approach involves the modification of a patient's genetic material to treat or prevent a range of diseases. Let's embark on an in-depth exploration of the technical intricacies of this revolutionary treatment, its historical evolution, and its profound implications for the future of medicine.

Gene Therapy in a Nutshell:

Gene therapy primarily operates by introducing, altering, or repairing specific genes within an individual's cells. By utilizing viral vectors, such as adeno-associated viruses (AAVs) or lentiviruses, scientists can deliver therapeutic genes into target cells with remarkable precision, thus opening up new avenues for combating previously untreatable conditions. This precision is akin to the delicate strokes of an artist's brush, where each modification holds the potential to transform lives.

Historical Evolution:

To truly appreciate the significance of gene therapy, it's essential to glance back at its historical evolution. The concept of manipulating genes to treat diseases has been a dream of scientists for decades. The initial steps in gene therapy research were taken in the 1970s and 1980s, but it wasn't until the 1990s that the first clinical trials began, marking a pivotal moment in medical history. Over the years, the field has witnessed remarkable advancements, from developing safer delivery mechanisms to expanding the range of treatable diseases. Today, we stand on the shoulders of these pioneers, poised to achieve what was once thought impossible.

Applications and Achievements:

Gene therapy has already demonstrated remarkable success in treating a wide array of genetic disorders. Conditions like spinal muscular atrophy (SMA), hemophilia, and inherited retinal diseases that were once considered incurable are now within the realm of possibility for effective treatment. Moreover, the revolutionary field of cancer immunotherapy, a subset of gene therapy, harnesses the immune system's power by genetically modifying T cells to specifically target and destroy cancer cells, offering renewed hope to cancer patients worldwide. Excitingly, ongoing research is exploring the potential of gene therapy to combat neurodegenerative diseases, including Alzheimer's and Parkinson's, promising a brighter future for those affected by these devastating conditions. The horizon of possibilities in gene therapy continues to expand, unveiling new hope for patients and their families.

Challenges and Ethical Considerations:

While gene therapy holds immense promise, it is not without its set of challenges and ethical dilemmas. Concerns about off-target effects and immune responses necessitate meticulous research and testing to ensure the safety and efficacy of gene therapies. Ethical discussions surrounding germline editing, the potential for unintended consequences, and the need for responsible genetic manipulation are ongoing, highlighting the importance of a balanced approach to this groundbreaking technology. These discussions underscore the critical need for transparent and collaborative decision-making as we tread carefully in this uncharted territory.

Gene therapy's potential to revolutionize medicine is undeniable. As research continues to advance and ethical considerations evolve, we find ourselves at the threshold of a new era in healthcare. Stay informed and engaged as we navigate this exciting frontier, where science fiction becomes science fact, and hope is restored for countless individuals and families around the world. The future of healthcare has never looked brighter, thanks to the marvels of gene therapy, and it's a future that holds the promise of healthier, happier lives for generations to come.

References:

Kaeppel, C., & Verma, I. M. (2018). Viral Vectors for Gene Therapies: The Road Ahead. Molecular Therapy, 26(3), 699-700. doi:10.1016/j.ymthe.2018.01.011

Rinaldi, C., & Wood, M. J. (2018). Antisense oligonucleotides: the next frontier for treatment of neurological disorders. Nature Reviews Neurology, 14(1), 9-21. doi:10.1038/nrneurol.2017.148

Cyranoski, D. (2019). The CRISPR-baby scandal: what’s next for human gene-editing. Nature, 566(7745), 440-442. doi:10.1038/d41586-019-00550-9

[gnusnoteunuchs]

a thought about tolkien orcs:

the basic story is that they were mutated from elves by melkor, right? it sort of comes across as just another atrocity, oh look, melkor killed/maimed/tormented more elves. crime against humanity #37 from Mister Crimes Against Humanity. and sure, it drills in just how much he doesn't care about hurting people, and how he needs to twist the world around him to his own ends since he can't actually create things. cool, great

i have seen some people try to turn this on its head, though. instead of the orcs-to-be being victims, people who got pulled into something horrible, never to return, they spin it instead as being a thing they were willing to do, something they agreed to. i think that's interesting! i think there's some untreaded ground there in "these people willingly agreed to something you consider an atrocity. what does that say about them? what does that say about your ability to discriminate right from wrong?"

but the thing is, somehow melkor would have had to make this worth their trouble, right? but "i'm gonna mutate you into orcs and then everyone will hate you forever and then one day legolas will look super awesome and badass riding your shield down some steps while killing your buddy" seems like a tough sell. so i was thinking, how can melkor make this attractive to an unbegotten or only-somewhat-begotten elf?

idea: what if he took the angle of "as elves you're immortal, but you can still die. you'll be changed forever by your painful long lives, you'll succumb to violence, to kinslaying, to the slow mutation of your morals and politics, and one day you won't be able to recognize who you used to be...if you haven't been murdered yet. would you like to be truly immortal? to know that who and what you are will always persist, replicated with exacting precision? would you like to be unkillable, safe against entropy?"

and, of course, what happens is that he would tweak a few genes, and germinate in these elves' bodies cancers they could never have imagined. he would make them biologically immortal, indestructible tumor-beings that replicate indefinitely, that have no need for pregnancy or sex or the hideous ravages of LACE because they can just keep cloning themselves. what if orcs are genetically identical to elves, they're just the same ten germlines mutating themselves over and over again down the centuries? like those immortal cancer cell cultures like HeLa, imagine one of those with just enough functionality persisting to still be recognizable as a person. i think this whips

but we can take it further.

an army of hideous cancer-beasts is limited, yeah? their bodies would be deformed and flawed. the uruk-hai, of course, are meant to fix this. they're said to be hybrids, right? between orcs and "goblin-men?"

what if to make the immortal orc tumor line stronger, they implant orc colonies into the bodies of willing human subjects, people who make the same deal those elves did all those ages ago, people who want to become unforgettable, indestructible, and totally powerful? what if "goblin" is simply a moral judgment, denoting those who accede to this deal? think of the canine transmissible venereal tumor, which used to be a dog once. what if the uruk-hai are men, but infected by orc cells? a sort of faustian microchimerism.

in retrospect i realize this is highly reminiscent of bits of the baru cormorant books. but those books ruled, so maybe i'm onto something here. maybe i'll write something about cancer orcs.

[madmanwonder]

Halloween Prompt: Pink Lemonade (Yang x Nora); Mad Scientist!Nora listening to Frankenstein Monster!Yang's heartbeat

Frankenstein Monster Yang: *Deadpan* Nora. What on name of logic and reason are you doing now? *Look at her short germlin lover with a bemused look*

Nora: *Head on Yang well-endowed chest* I am listenting to the sound of your heartbeat for SCIENCE! *Smiling in a mad scientist fashion enjoying the sound of the loud, powerful heartbeat with a crackle*

Frankenstein Monster Yang: Ah...Okay *Closed her eyes in resignation as she just let her crazy half-creator/half-lover indulged in her oddball behavior*

[fnaflover2024]

An au,where Mike wakes up as a thriteen self and has to survive a Megapizzaplex with a germlin that looks like his brother and a protective dad bear animatronic

[your-fav-smooth-criminal]

My friends keep making like amazing campaign and all my friends have amazing characters and then there's me look at this stinky little germlin I have sooo many character that are just like what went wrong

List of all my characters

• pat a human cleric that kept charging his party from him to heal them can and will be bribed has a gambling addiction dream is just leave the party

• merry a kender wizard who is just a chaos god in a very bad disguise is a famous bad luck charm party had to stop them from eating random stuff

• bandit a litertal child warlock who is stuck to never age in constant teenage angst and the Parton Is like a overbearing parent one of there flaws was that they could sleep anywhere absolutely anywhere fighting a horde of zombies oohh is that a nice bed of Moss and they were off in lala land

[kajalsawant434]

Gene Therapy Market Overview: Current Landscape and Future Projections

The Gene Therapy Market is rapidly transforming the healthcare industry, offering groundbreaking solutions to previously untreatable genetic disorders. Leveraging the ability to correct or replace faulty genes at the molecular level, gene therapy holds the promise of long-term cures rather than symptom management. As advancements in genomics, vector technology, and regulatory frameworks evolve, the global gene therapy market is poised for sustained growth and widespread adoption.

This article explores the current state of the gene therapy market, its key trends, drivers, challenges, and a forward-looking view of how this transformative field is expected to develop through 2030.

Current Market Landscape

The gene therapy market has transitioned from experimental research to clinical reality. Over the past decade, numerous gene therapies have received regulatory approvals for diseases such as spinal muscular atrophy (SMA), inherited retinal disorders, and hemophilia. These breakthroughs validate the potential of gene therapy and have increased investor confidence.

Key characteristics of the current market include:

Approved Therapies: A growing number of therapies have reached commercial markets, including Zolgensma, Luxturna, and Roctavian, establishing proof of concept.

Robust Pipeline: Hundreds of gene therapy candidates are in various stages of clinical trials targeting both rare and common conditions such as sickle cell disease, Duchenne muscular dystrophy, and certain cancers.

Technological Innovation: Improved delivery systems (like adeno-associated virus vectors and non-viral vectors), CRISPR gene editing, and synthetic biology are enhancing therapy safety and effectiveness.

Market Drivers

Several factors are fueling the rapid growth of the gene therapy market:

Unmet Medical Needs: Genetic disorders, many of which have limited treatment options, are driving demand for curative therapies.

Technological Advances: Next-generation sequencing, genome editing, and advanced vector design are accelerating development and improving outcomes.

Regulatory Support: Streamlined approval processes and special designations (e.g., orphan drug status, fast track) encourage innovation and market entry.

Investment Surge: Venture capital firms, biotech companies, and pharmaceutical giants are heavily investing in gene therapy startups and research collaborations.

Increasing Partnerships: Strategic alliances between academia, biotech firms, and large pharmaceutical companies are facilitating knowledge transfer and commercialization.

Challenges in the Market

Despite its promise, the gene therapy market faces several challenges:

High Costs: Treatments can cost millions per patient, limiting accessibility and posing reimbursement challenges.

Manufacturing Complexities: Production of gene therapies requires highly specialized facilities, stringent quality control, and scalability.

Long-Term Safety: Concerns around immune reactions, off-target effects, and durability of therapeutic effects persist.

Ethical and Regulatory Hurdles: Ethical debates about gene editing and long-term impact, particularly for germline modifications, remain unresolved.

Addressing these challenges will be key to ensuring long-term market success and wider patient access.

Future Projections and Trends

The global gene therapy market is projected to experience double-digit compound annual growth through 2030, with estimates placing its value well above USD 25 billion by the end of the decade.

Key future trends include:

Expansion Beyond Rare Diseases: Initially focused on rare monogenic disorders, gene therapy is now being explored for more prevalent conditions such as diabetes, cardiovascular disease, and neurodegenerative disorders.

In Vivo vs. Ex Vivo Therapies: Innovations in both approaches—direct delivery into the body (in vivo) and manipulation of cells outside the body before reinfusion (ex vivo)—will diversify treatment options.

CRISPR and Gene Editing Therapies: Precision editing tools like CRISPR-Cas9 are driving a new wave of highly targeted and potentially safer treatments.

Global Market Penetration: Increased investment in infrastructure and regulatory harmonization in Asia-Pacific, Latin America, and the Middle East will support market expansion beyond North America and Europe.

Digital Health Integration: AI, big data, and digital tools will aid in patient selection, outcome prediction, and post-therapy monitoring.

Conclusion

The Gene Therapy Market stands on the cusp of a healthcare revolution. With its potential to cure or significantly alter the course of genetic diseases, gene therapy is more than a treatment—it's a paradigm shift. While the market still faces scientific, economic, and ethical challenges, ongoing innovations and strategic investments are paving the way for broader clinical adoption and accessibility. As the industry matures, gene therapy is expected to become a cornerstone of precision medicine, offering hope to millions of patients worldwide.

[brocia]

What is Advanced Medical Wellness in NYC

Introduction What if you were able to combine the appealing aspects of old school medicine with breakthrough wellness treatments? That is what advanced medical wellness is about. New York City, a hub for healthcare and innovation, – is replete with medical practices that combine conventional treatments with more ‘wholesome’ health practices. In this guide, we are going to take a deeper look at the offerings and advantages of state of the art medical wellness centers in New York and how they can be beneficial to you on your journey to health. What is Advanced Medical Wellness Advanced medical wellness is the fusion of conventional medical practices with holistic therapies, aiming Advanced medical wellness is a combination of traditional Western medicine practices with alternative therapies in an effort to heal the body as a whole – mind, body and soul. Unlike the old wellness that focused on just fitness and lifestyle, the new wellness incorporates medical supervision, diagnostic metrics, and tailored health interventions. - Medical Care: Functional medicine, chronic disease management, germline genetic testing. - Wellness Therapies: Acupuncture, massage therapy, chiropractic care, mental health support, fitness programmes. - Technology interface: AI-driven diagnostics, biometric monitoring, wellness apps. This model of care offers customized health plans to the unique individual, focusing on total health rather than the treatment of illness. Services Provided in a Premier Medical Wellness Center in New York Manhattan has a number of advanced health promoting spas with a variety of services: 1. NYU Langone Health At NYU Langone, we also offer a full range of integrative health services. - Acupuncture: This addresses stress, anxiety, and chronic pain. - Massage Therapy: Therapeutic massage to ease muscle tension and induce relaxation. - Mind-Body Programs: Applications of guided imagery, yoga, and energy therapies for mood regulation. - Nutrition Counseling: Custom-made meal plans to help you achieve your health goals. The offerings are available in outpatient programs and intended as a complement to traditional medical treatment. Read more about NYU Langone’s wellness programs. 2. Soho Wellness Center They also have combination of classic and alternative healing treatmentsThis Soho Wellness Center offers mixture of conventional and alternative healing procedures such as: - Chiropractic Care: Concentrate on spinal health and regular nervous system performance. - Massage Types: Different types of massages to relieve stress and relax muscles. - Nutrition Consultation: Diet and lifestyle recommendations for maximizing health. Their whole-body philosophy attacks health problems at their source, supporting overall wellness. So on that note, please check out the services of Soho Wellness Center! 3. Advanced Medical Care Advanced Medical Care is a comprehensive wellness center that provides a variety of healthcare services: - Cardiology and Neurology: Complete care for the Heart and Mind. - Physical Therapy: The therapy to restore motion, strength and function. - Health & Long Life: Programs for preventive medicine and healthy aging. Their holistic approach means patients receive seamless care between different silos of health. Explore advmedny. Benefits of Advanced Medical Wellness There are many benefits to be had from practicing advanced medical health: - Prevention Better than Cure: Focus on preventive health to avoid chronic conditions. - Custom Health Programs: Programs specially designed to meet your personal health needs and goals. - A Wholistic Attitude: Attending to body/mind/emotion for a total and complete experience of being. - The Benefits Over Time: More energy, better sleep, mental clarity, and ability to handle stress. These advantages help improve your overall quality of life as well as long-term health and wellness. What makes���Advanced Medical Wellness Different than Traditional Wellness Programs? Wellness programs do, however, tend to make fitness or lifestyle changes a priority and do not always require medical supervision. Advanced medical wellness, however combines: - Medical Management: Physician participation in planning, monitoring and management of health care. - Diagnosis: Application of advanced diagnostics (e.g., genetic testing) for therapeutic decision-making. - Personalised Health Plans: Personalised plans according to your health assessments. This holistic strategy will see all areas of health addressed, resulting in more successful results. Cost and Insurance Information for Functional Medical Wellness in New York It is essential to know what it costs and what is covered by insurance: ServiceCostInsurance CoverageFinancial AidConsultations$100 to $300Many services covered by insurance (varies by provider)Some centers offer payment plans or sliding scale optionsAcupuncture & Massage$80 to $150 per sessionCoverage varies, check with your insurance providerSome centers provide financing or payment plan optionsOther Wellness TherapiesVaries by therapy (typically $80 to $200)Coverage may apply depending on the service and planPayment options may be available (sliding scale, financing) Do get in touch directly with the wellness center, though, if you want to hear about costs and insurance specifics. How to Select the Best Advanced Medical Wellness Center in New York Choosing the best Center to determine the best center for you, consider: - Reputation and Reviews: Seek out centers with happy patient reviews and known certifications. - Services Provided: Make certain that the center offers the services you need. - Location: Select a center which can be easily reached for regular visits. - Consultation: If the center offers a consultation, you can personally decide if its plan and goals fit with your own health objectives. High Quality Wellness Trends in New York Keep up with new trends: - AI and Health Tech: The increasingly personalization of health with AI used to provide health plans and diagnostics. - Mental Health Is Top Of Mind: Mental wellness taking its place on a par with physical treatments. - Luxury wellness: High-end treatments and retreats for elite treatment in the market. Such trends are indicative of the changing face of wellness, with technology and individualized care. FAQS Conclusion With advanced medical wellness in New York, you’re getting a full-spectrum perspective on health—medical care is combined with holistic therapies. The center that you select and the specific wellness plans you pursue are ways to take charge of your health and well-being. Read the full article

[thewritersaddictions]

Christmas Stories 2023 Master List

Welcome to the Christmas Stories 2023 Master List

A/n- There will be some fluff for and during the Christmas time. This is 24 days of fluff, with a mixture of Christmas-themed songs and movies. Yes 'the nightmare before Christmas' is a Christmas movie.

Word Count- 19,868k

Series Master List

Day 1- Solider Boy + Baby, it's cold outside.

Day 2- Billy Hargrove + National Lampoons Christmas Vacation.

Day 3- Karl Heisenberg + Violent Night

Day 4- Jim Hopper + Sleigh Ride

Day 5- Eddie Munson + Scrooged

Day 6- Geralt + Germlins

Day 7- Damon Salvatore + Grinch

Day 8- John Price + Here Comes Santa Claus

Day 9- Simon “Ghost” Riley + It's beginning to look a lot like Christmas

Day 10- Koing + Home Alone

Day 11- Steve Harrington + Mele Kalikimaka

Day 12- Luis Serra + Elf

Day 13- Klaus Mikealson + Die Hard

Day 14- Steve Rogers + Have yourself a merry little Christmas

Day 15- Aaron Hotchner + Frosty the snowman

Day 16- Jaskier + Santa Baby

Day 17- Alcina Dimitrescu + A Christmas Story

Day 18- Daryl Dixon + Home Alone 2 Lost in New York

Day 19- James 'Bucky' Barnes + Let it snow, let it snow, let it snow

Day 20- Joel Miller + Winter Wonderland

Day 21- Leon S. Kennedy + Holly Jolly Christmas

Day 22- Negan Smith + The Nightmare Before Christmas

Day 23- John “Soap” MacTavish + Feliz Navidad

Day 24- Rick Grimes + I Saw Mommy Kissing Santa Claus

Completed on: (12/24/23)

Posted on: (09/20/23) - (12/01/23)

Christmas Stories Tags- @dackwccgjd @alex000sstuff @elenaguarnieri @emilyrosetravis @magnificentalpacabird @crazybooklover33 @yourfavthiopoan @peachbunnieluv @jokenotfunny @pastanoodles11 @hyunjinbiased-blog @tuquoquebrute @kjah97 @is-being-ignored-a-hobby @kiwi-lanes @welcomethefears @elenenvy @multifandom456 @sweatshirtXO @g8sstuff @rottendorkmomo @emmasstuff2415

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Precision Oncology: Best Ovarian Cancer Treatment

Ovarian cancer is often called the "silent killer" because its symptoms can be subtle and hard to detect early. But today, a revolution is happening in the way this disease is treated. Precision oncology is changing lives—offering targeted, effective, and personalized care to women across the world. In cities like Chennai, this approach is reshaping how specialists deliver the best ovarian cancer treatment, offering real hope where once there was uncertainty.

Understanding Ovarian Cancer and Its Complexity

Ovarian cancer is not a one-size-fits-all condition. There are several subtypes, each with its own biological behavior. Understanding these differences is key to selecting the most effective treatment.

Traditional treatments often rely on a general approach—surgery, followed by chemotherapy. While this can be effective, it doesn’t account for the unique characteristics of each patient’s cancer. This is where precision oncology comes in: it brings the focus back to the individual.

What Is Precision Oncology?

Precision oncology is a treatment strategy that uses information about a person’s genes and the genetic profile of their tumor. This data helps doctors choose therapies that target the specific mutations driving cancer growth. Rather than treating all patients the same way, precision oncology delivers therapy that fits the unique blueprint of the disease.

By identifying biomarkers, doctors can determine which treatments are likely to work best. It minimizes trial and error, leading to faster, more effective results. This approach not only increases survival rates but also improves quality of life during treatment.

How It Works: The Precision Treatment Journey

The process begins with advanced diagnostic testing, including molecular profiling. This involves analyzing the patient’s tumor tissue to identify specific genetic mutations. These insights guide the selection of drugs or therapies most likely to be effective.

Patients may receive targeted therapy, which attacks cancer cells without harming healthy tissue. In some cases, immunotherapy is introduced to stimulate the body’s own immune system to fight the cancer. Hormone therapy, PARP inhibitors, and clinical trial options may also be considered.

Each treatment plan is uniquely tailored, evolving with the patient’s needs and response. This level of personalization is what defines the best ovarian cancer treatment in Chennai today. It’s not about doing more; it’s about doing what’s right for that particular patient.

Why Precision Oncology Is Changing Ovarian Cancer Outcomes

Precision oncology is delivering real, measurable benefits to patients. Targeted treatments reduce side effects, as they don’t harm healthy cells as much as chemotherapy. They also improve response rates, particularly in patients with advanced or recurrent disease.

For instance, patients with BRCA1 or BRCA2 mutations may benefit significantly from PARP inhibitors. These drugs are designed to block enzymes cancer cells need to repair themselves. By targeting this vulnerability, they help keep the cancer from growing or returning.

Women who previously had limited treatment options are now seeing new possibilities. These therapies extend survival and offer a better quality of life. It’s a promising direction for care, especially when supported by an expert medical team.

The Role of Genetic Testing in Personalized Care

Genetic testing is central to precision oncology. It provides the roadmap for treatment, highlighting mutations and changes that can be targeted. In ovarian cancer, this includes both inherited (germline) and acquired (somatic) mutations.

Germline testing looks for mutations passed down through families, such as BRCA1 and BRCA2. Somatic testing examines the tumor for new genetic changes that occurred during the cancer’s development. Both are essential for a comprehensive treatment approach.

The best ovarian cancer treatment in Chennai includes access to sophisticated testing facilities. When done early, this testing can help patients make informed decisions from the start. It also allows for participation in cutting-edge clinical trials that may offer additional options.

Holistic Support Alongside Medical Treatment

While precision oncology focuses on personalized medicine, holistic support remains essential. Patients benefit from a compassionate, multidisciplinary team—oncologists, nutritionists, counselors, and physiotherapists. This integrated care helps manage physical and emotional side effects.

Nutrition planning ensures the body remains strong during therapy. Mental health support helps patients cope with the anxiety and uncertainty of cancer. Rehabilitation and physiotherapy promote healing after surgery or long-term treatments.

This comprehensive care approach helps women feel empowered and supported. It recognizes that cancer treatment isn’t just about medicine—it’s about healing the whole person. That’s what makes a treatment plan truly effective and life-affirming.

Accessing the Best Ovarian Cancer Treatment in Chennai

Chennai is emerging as a hub for advanced cancer care, with facilities offering precision oncology at international standards. The city’s medical infrastructure, skilled professionals, and research-based practices make it a preferred destination. Patients from across India and abroad seek care here for its affordability and expertise.

The best ovarian cancer treatment in Chennai is not just about technology. It’s about the people—doctors who listen, staff who care, and institutions that believe in patient-centered care. Facilities offering precision oncology combine science with compassion, ensuring every woman is treated with dignity.

Awareness is growing, and more patients are choosing this path for its effectiveness and fewer side effects. As early detection and genetic screening become more accessible, precision medicine will become the norm. The future is hopeful, and it’s being built today—right here in Chennai.

Conclusion

Ovarian cancer is a challenging diagnosis, but the journey doesn’t have to be faced alone or without clarity. Precision oncology is lighting the way to safer, more effective treatments tailored to each woman’s unique cancer profile. It represents the best of what modern medicine can offer—hope, accuracy, and improved outcomes.

For those seeking the best ovarian cancer treatment in Chennai, ICCG India stands committed to delivering care that’s both advanced and deeply compassionate.

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Scaling and Root Planning: The First Step to Treating Gum Disease in Lomita

Gum disease is a serious oral health condition that, if left untreated, can lead to tooth loss and other complications. One of the most effective initial treatments for gum disease is scaling and root planning. If you’re looking for expert gum disease treatment in Lomita, understanding this procedure is crucial for restoring your oral health.

What is Scaling and Root Planning?

Scaling and root planning is a deep cleaning procedure designed to remove plaque, tartar, and bacteria from below the germline. Unlike a regular dental cleaning, which focuses on the surface of the teeth, this treatment targets the root surfaces and gum pockets to prevent infection from spreading.

Why is Scaling and Root Planning Important?

Scaling and root planning is the first line of defense against periodontal disease. This procedure helps:

Remove plaque and tartar buildup that contributes to gum inflammation.

Reduce gum pockets, preventing bacteria from accumulating.

Prevent gum recession and tooth loss caused by advanced gum disease.

Improve overall oral health, reducing the risk of systemic diseases linked to gum infections.

The Process of Scaling and Root Planning:

This procedure is typically performed by a periodontist or a dental hygienist in two steps:

1. Scaling

The dentist or hygienist uses ultrasonic tools and manual scalers to remove plaque and tartar from above and below the germline.

Special attention is given to deep gum pockets where bacteria thrive.

2. Root Planning

After scaling, the roots of the teeth are smoothed to prevent further bacterial attachment.

This process encourages the gums to reattach to the teeth, reducing pocket depth.

What to Expect After the Procedure:

Mild discomfort or sensitivity for a few days.

Gums may feel tender or slightly swollen.

Improved gum health as inflammation subsides.

Follow-up visits to monitor healing and ensure the treatment is effective.

How to Maintain Healthy Gums After Treatment:

To ensure the success of scaling and root planning, follow these steps:

Brush twice daily with a soft-bristle toothbrush.

Floss daily to remove debris from between teeth.

Use an antibacterial mouthwash to kill bacteria.

Avoid smoking, which can slow healing and worsen gum disease.

Schedule regular dental visits for professional cleanings and check-ups.

When to Seek Professional Gum Disease Treatment in Lomita:

If you experience symptoms like bleeding gums, persistent bad breath, gum recession, or tooth sensitivity, it's time to seek professional care. At Dr. Smile, we specialize in scaling and root planning as an effective treatment for gum disease in Lomita.

Why Choose Dr. Smile?

Expert periodontal care with advanced technology.

Comprehensive gum disease treatment plans tailored to your needs.

Comfort-focused approach to ensure a pain-free experience.

📍 Dr. Smile – Your Trusted Dental Care Provider in Lomita 📞 Call Now: (949) 541-6015 🌐 Visit Us: doctorsmileonline.com