#Immunopathology

[larstudy]

🩷 15.06.2025 // I studied with a 90/15 schedule today and I'm feeling wayyy better than yesterday :)))

I did some physics, chemical analysis, a lot of immunopathology and some pharmacology! I'm glad my bf is here to help me do the past papers because everytime I'm reading one I'm panicking ://

I "only" studied 8 hours today but first I slept in a bit so it was nearly impossible to study more ahah (tomorrow I hope that I'll wake up earlier tho)

Also, tell me if you want more pictures of my cat as she spend all day in my bedroom, sleeping on my bed ahah

[alkalinevegannews]

Follow @alkalineherbshop Are you ever stressed, uninspired, moody, or anxious? According to the American Heart Association (AHA), you can naturally alleviate all these feelings simply by going outside. ⠀ On their website, the AHA cites numerous studies showing the benefits of exposure to nature. This includes relief of depression, stress, anxiety, and repetitive negative thoughts (rumination), and improvements in mood, memory, creativity, problem-solving, and prosocial feelings like empathy and generosity. ⠀ In addition to energizing and boosting mental health, spending time in nature may also enhance physical well-being. One small study from the International Journal of Immunopathology and Pharmacology showed that walking in a forest was associated with enhanced immune function, including increased expression of natural killer cells and proteins that protect against cancer. ⠀ Scientific support for spending time in nature spans decades and shows up in cultures from around the world. In Japan, the ancient practice shinrin-yoku or "forest bathing" is considered a national pastime. Western civilizations would do well to follow their lead. According to research funded by the Environmental Protection Agency, the typical American spends a whopping 93 percent of their time indoors. ⠀ Sources: https://www.heart.org/en/healthy-living/healthy-lifestyle/stress-management/spend-time-in-nature-to-reduce-stress-and-anxiety https://www.nature.com/articles/7500165 https://time.com/5259602/japanese-forest-bathing/ https://pubmed.ncbi.nlm.nih.gov/17903349/ https://www.instagram.com/p/Cnx2yLruIjY/?igshid=NGJjMDIxMWI=

[supriyapuram]

Immunopathology Including Amyloidosis Question And Answers

[hccentral-jobs]

Senior Scientist Immunopathology

Senior Scientist Immunopathology Employment Type: Full Time, Permanent Classification: Health Professional level 3 (PN 26301) Salary: $ 105,900 – $ 119,774 (Plus 11.5% Super) Location: The Canberra Hospital, Garran Section: Immunopathology Closing Date: 30 September 2024 What can we offer you: • City living without the traffic – click here to see why you should live in Canberra. • Competitive pay…

[rnomics]

Viruses, Vol. 16, Pages 1327: Transcriptional Response to Tick-Borne Flavivirus Infection in Neurons, Astrocytes and Microglia In Vivo and In Vitro

Tick-borne encephalitis virus (TBEV) is a neurotropic member of the genus Orthoflavivirus (former Flavivirus) and is of significant health concern in Europe and Asia. TBEV pathogenesis may occur directly via virus-induced damage to neurons or through immunopathology due to excessive inflammation. While primary cells isolated from the host can be used to study the immune response to TBEV, it is still unclear how well these reflect the immune response elicited in vivo. Here, we compared the transcriptional response to TBEV and the less pathogenic tick-borne flavivirus, Langat virus (LGTV), in primary monocultures of neurons, astrocytes and microglia in vitro, with the transcriptional response in vivo captured by single-nuclei #RNA sequencing (sn#RNA-seq) of a whole mouse cortex. We detected similar transcriptional changes induced by both LGTV and TBEV infection in vitro, with the lower response to LGTV likely resulting from slower viral kinetics. Gene set enrichment analysis showed a stronger transcriptional response in vivo than in vitro for astrocytes and microglia, with a limited overlap mainly dominated by interferon signaling. Together, this adds to our understanding of neurotropic flavivirus pathogenesis and the strengths and limitations of available model systems. https://www.mdpi.com/1999-4915/16/8/1327?utm_source=dlvr.it&utm_medium=tumblr

[leedsomics]

Spatial transcriptomics unveils the in situ cellular and molecular hallmarks of the lung in fatal COVID-19

Severe Coronavirus disease 2019 (COVID-19) induces heterogeneous and progressive diffuse alveolar damage (DAD) highly disrupting lung tissue architecture and homeostasis, hampering disease management and leading to fatal outcomes. Characterizing DAD pathophysiology across disease progression is of ultimate importance to better understand the molecular and cellular features driving different DAD patterns and to optimize treatment strategies. To contextualize the interplay between cell types and assess their distribution, spatial transcriptomics (ST) techniques have emerged allowing unprecedented resolution to investigate spatial architecture of tissues. To this end, post-mortem lung tissue provides valuable insights into cellular composition and their spatial relationships at the time of death. Here, we have leveraged VisumST technology in post-mortem COVID-19 induced acute and proliferative DAD lungs including control samples with normal morphological appearance to unravel the immunopathological mechanisms underlying DAD providing novel insights into cellular and molecular communication events driving DAD progression in fatal COVID-19. We report a progressive loss of endothelial cell types, pneumocytes type I and natural killer cells coupled with a continuous increase of myeloid and stromal cells, mostly peribronchial fibroblasts, over disease progression. Spatial organization analysis identified variable cellular compartments, ranging from major compartments defined by cell type lineages in control lungs to increased and more specific compartmentalization including immune-specific clusters across DAD spectrum. Importantly, spatially informed ligand-receptor interaction (LRI) analysis revealed an intercellular communication signature defining COVID-19 induced DAD lungs. Transcription factor (TF) activity enrichment analysis identified TGF-B pathway as DAD driver, highlighting SMAD3 and SMAD7 TFs activity role during lung fibrosis. Integration of deregulated LRIs and TFs activity, allowed us to propose a downstream intracellular signaling pathway in peribronchial fibroblasts, suggesting potential novel therapeutic targets. Finally, spatio-temporal trajectories analysis provided insights into the alveolar epithelium regeneration program, characterizing markers of pneumocytes type II differentiation towards pneumocytes type I. In conclusion, we provide a spatial characterization of lung tissue architecture upon COVID-19 induced DAD progression, identifying molecular and cellular hallmarks that may help optimize treatment and patient management. http://dlvr.it/T9C2Pz

[indoorverticalfarmingnews]

Tonisity International Latest News: Peer-Reviewed Study Highlights Effectiveness of Tonisity Px Against Porcine Epidemic Diarrhea Virus

Key Takeaways: A recent study published in the Veterinary Immunology and Immunopathology journal has demonstrated the effectiveness of Tonisity Px, a product by Tonisity International Limited, in combating Porcine Epidemic Diarrhea Virus (PEDV). This marks the first reported use of a commercially available swine feed supplement to show a beneficial impact on PEDV. The product, designed as a…

[miraridoctor]

Vitiligo and halo nevi are two skin conditions that often co-occur due to shared autoimmune and genetic factors contributing to melanocyte destruction and skin depigmentation. Understanding this relationship is key for appropriate diagnosis, prognost... #Mirari #MirariDoctor #MirariColdPlasma #ColdPlasma

[evoldir]

Fwd: Postdoc: UExeter.EvolutionaryEcology

Begin forwarded message: > From: evoldir@evol.biology.mcmaster.ca > Subject: Postdoc: UExeter.EvolutionaryEcology > Date: 20 October 2023 at 07:19:13 BST > To: rdmpage@gmail.com > > > 3-year Postdoc position in Evolutionary Ecology, University of Exeter, UK > > We are seeking a Postdoctoral Research Fellow with experience in > evolutionary, behavioural or molecular ecology to participate in a > NERC-funded research project to investigate processes that contribute > to the maintenance of genetic variation in disease susceptibility in > natural populations. Using a wild rodent (Myodes glareolus) as a model, > the project investigates the importance of pathogen-specificity and > immunopathology in mediating costs of resistance, and tests if the fitness > consequences of balanced genetic polymorphisms are context-dependent. The > project combines monitoring and sampling of wild populations, with > experiments in outdoor enclosures and in captivity. It integrates a > range of -omics, ecophysiological, quantitative genetic and statistical > approaches and tools. The postdoc will be responsible for the planning > of the project, data collection and data analysis, with the support > of associated researchers and technicians. Specific activities will > include field data collection, bioinformatics analyses, statistical > analyses, assessing, interpreting and evaluating outcomes of research, > preparing manuscripts for publication, science communication and public > outreach. While the postholder is expected to already have some of the > skills required for the work, they will be able to obtain training in > areas where they lack experience.  The project team includes Dr Barbara > Tschirren (PI), Dr Xav Harrison, Prof Erik Postma (University of Exeter, > UK), Prof Lars Råberg (Lund University, Sweden), Prof Tapio Mappes and > Prof Phill Watts (University of Jyväskylä, Finland). Extended visits to > Scandinavian field sites are planned for data collection and engagement > with international collaborators. > > The successful applicant possesses a relevant PhD (or nearing > completion) or equivalent qualification/experience in evolutionary, > behavioural or molecular ecology or a related field. They are able > to work collaboratively, have excellent organisational ability, are > willing to supervise the work of others and act as team leader, and have > excellent quantitative skills and fieldwork experience.  The 3-year post > is available starting by 1st May 2024  in the in the Centre for Ecology > and Conservation at the University of Exeter’s Cornwall campus, United > Kingdom (https://ift.tt/HU58xdy), which provides an > environment that is outstanding on a world-scale for conducting research > in ecology and evolution (11th ranked ecology department globally, 2021 > Shanghai University Rankings) with exceptional strengths in evolutionary > biology, behavioural ecology and disease ecology.  The successful > applicant will have the opportunity to develop and enhance the skills > required for a successful research career. They will be encouraged to > take advantage of the many training courses available at Exeter in areas > such as research skills, project management and leadership. The starting > salary will be from £41,732, depending on qualifications and experience. > > The closing date for completed applications > is 20th November 2023. Applications should be submitted via > https://ift.tt/q0TKFar > Please ensure you read the full person specification for the role > (attachment JD89846.pdf on the left side of the job ad page). > > For further information please contact Dr Barbara Tschirren by e-mail > (b.tschirren@exeter.ac.uk). > > > "Tschirren, Barbara"

[kai958531911]

NRP-1はCOVID-19における多系統炎症亢進の神経免疫イニシエーターなのか？

-綿密な炎症研究にもかかわらず、COVID-19におけるサイトカインネットワーク活性化の主要なイニシエーターはまだ見つかっていない。

-NRP-1は炎症メディエーターであり、SARS-CoV2による細胞への直接的なウイルス侵入のための宿主侵入因子である。

-NRP-1はCOVID-19の中枢神経系と肺、および他の身体系の炎症性障害に関与している可能性がある。

-NRP-1の神経免疫学的相互作用はCOVID-19における薬物療法の標的として適している。

-臨床試験では癌における抗NRP1/VEGFが検討されているが、COVID-19における安全性と有用性についてはさらなる研究が必要である。

[instantebookmart]

Immunopathology in Toxicology and Drug Development Volume 2, ISBN-13: 978-3319473840 [PDF eBook eTextbook] Publisher: ‎ Springer; 1st ed. 2017 edition (April 26, 2017) Language: ‎ English 848 pages ISBN-10: ‎ 3319473840 ISBN-13: ‎ 978-3319473840 This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. What makes us different? • Instant Download • Always Competitive Pricing • 100% Privacy • FREE Sample Available • 24-7 LIVE Customer Support

[eduebookstore]

Immunopathology in Toxicology and Drug Development Volume 2, ISBN-13: 978-3319473840 [PDF eBook eTextbook] Publisher: ‎ Springer; 1st ed. 2017 edition (April 26, 2017) Language: ‎ English 848 pages ISBN-10: ‎ 3319473840 ISBN-13: ‎ 978-3319473840 This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. What makes us different? • Instant Download • Always Competitive Pricing • 100% Privacy • FREE Sample Available • 24-7 LIVE Customer Support

[greatebookstoreblog]

Immunopathology in Toxicology and Drug Development Volume 2, ISBN-13: 978-3319473840 [PDF eBook eTextbook] Publisher: ‎ Springer; 1st ed. 2017 edition (April 26, 2017) Language: ‎ English 848 pages ISBN-10: ‎ 3319473840 ISBN-13: ‎ 978-3319473840 This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system. What makes us different? • Instant Download • Always Competitive Pricing • 100% Privacy • FREE Sample Available • 24-7 LIVE Customer Support

[hccentral-jobs]

Medical Laboratory Scientist - Immunopathology and Infectious Immunoassay

Medical Laboratory Scientist – Immunopathology and Infectious Immunoassay Employment Type: Part Time (22.05 hrs), Temporary 24 months with possibility of extension and/or permanency Classification: Health Professional Level 2 (PN 66967) Salary: $85,893.00 – $103,039.00 (Plus 11.5% Super) Location: The Canberra Hospital, Garran Section: Immunopathology and Infectious Immunoassay Closing Date: 13th…

[rnomics]

IJMS, Vol. 25, Pages 7892: Robust CXCL10/IP-10 and CCL5/RANTES Production Induced by Tick-Borne Encephalitis Virus in Human Brain Pericytes Despite Weak Infection

Tick-borne encephalitis virus (TBEV) targets the central nervous system (CNS), leading to potentially severe neurological complications. The neurovascular unit plays a fundamental role in the CNS and in the neuroinvasion of TBEV. However, the role of human brain pericytes, a key component of the neurovascular unit, during TBEV infection has not yet been elucidated. In this study, TBEV infection of the primary human brain perivascular pericytes was investigated with highly virulent Hypr strain and mildly virulent Neudoerfl strain. We used Luminex assay to measure cytokines/chemokines and growth factors. Both viral strains showed comparable replication kinetics, peaking at 3 days post infection (dpi). Intracellular viral #RNA copies peaked at 6 dpi for Hypr and 3 dpi for Neudoerfl cultures. According to immunofluorescence staining, only small proportion of pericytes were infected (3% for Hypr and 2% for Neudoerfl), and no cytopathic effect was observed in the infected cells. In cell culture supernatants, IL-6 production was detected at 3 dpi, together with slight increases in IL-15 and IL-4, but IP-10, RANTES and MCP-1 were the main chemokines released after TBEV infection. These chemokines play key roles in both immune defense and immunopathology during TBE. This study suggests that pericytes are an important source of these signaling molecules during TBEV infection in the brain. https://www.mdpi.com/1422-0067/25/14/7892?utm_source=dlvr.it&utm_medium=tumblr