#Hereditary breast and ovarian cancer
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The common types of hereditary cancer syndromes include:
1. Inherited Breast and Ovarian Cancer Syndrome (HBOC): HBOC primarily stems from mutations within the BRCA1 and BRCA2 genes. Females carrying these genetic alterations face notably heightened risks of breast and ovarian malignancies. Furthermore, BRCA mutations correlate with elevated susceptibilities to other cancers, such as prostate, pancreatic, and male breast cancer.
2. Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer, HNPCC): Lynch syndrome arises from mutations affecting genes responsible for DNA mismatch repair, notably MLH1, MSH2, MSH6, and PMS2. Those with Lynch syndrome exhibit increased predispositions to colorectal cancer, alongside risks of endometrial, ovarian, gastric, and urinary tract cancers.
3. Familial Adenomatous Polyposis (FAP): FAP manifests with the proliferation of numerous polyps within the colon and rectum, which pose a cancer risk if untreated. Primarily linked to mutations in the APC gene, FAP substantially heightens the likelihood of early-onset colorectal cancer.
4. Li-Fraumeni Syndrome (LFS): LFS, a rare hereditary cancer syndrome, arises from mutations in the TP53 tumor suppressor gene. Individuals with LFS confront elevated lifetime risks of various cancers, including breast cancer, sarcomas, brain tumors, and adrenal gland tumors, often occurring at a young age.
5. Hereditary Diffuse Gastric Cancer (HDGC): HDGC entails an escalated susceptibility to diffuse gastric cancer, characterized by infiltration of the stomach wall. This predisposition predominantly results from mutations in the CDH1 gene, which encodes a protein crucial for cell adhesion.
6. Cowden Syndrome (CS): CS stems from mutations in the PTEN gene and is typified by multiple noncancerous hamartomas, alongside heightened risks of developing diverse cancers, such as breast, thyroid, and endometrial cancers.
7. Hereditary Retinoblastoma (RB1): Hereditary retinoblastoma arises from mutations in the RB1 gene, leading to the formation of cancerous tumors in the retina, typically emerging in early childhood.
8. Von Hippel-Lindau Syndrome (VHL): VHL arises from mutations in the VHL gene and is characterized by the development of tumors and cysts in various organs, including the kidneys, adrenal glands, pancreas, and central nervous system.
If you have a family history of cancer, you should undergo regular cancer screenings for the early detection and management of cancer. You can undergo a regular full body health checkup at Jaslok Hospital Mumbai, which is one of the best hospitals in Mumbai for cancer screening and treatment.
#cancer#hereditary cancer#hereditary cancer syndrome#Lynch syndrome#inherited breast and ovarian cancer syndrome#familial adenomatous polyposis#full body health checkup#regular health checkups#cancer screening#health checkup packages
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Gynecology: Understanding Women's Health
Gynecology is a branch of medicine that focuses on the health of the female reproductive system, encompassing the uterus, ovaries, fallopian tubes, and vagina. This field is integral to ensuring women's health and wellness across various stages of life, from adolescence to post-menopause.Looking for trusted gynecologists in Dallas, TX.Discover expert care for women's health, from routine check-ups to specialized treatments.
The Scope of Gynecology
Gynecologists are medical professionals who specialize in diagnosing, treating, and managing a wide range of conditions affecting the female reproductive system. These include:
Menstrual Disorders: Conditions such as irregular periods, heavy bleeding, or amenorrhea (absence of menstruation).
Hormonal Imbalances: Issues related to thyroid function, polycystic ovary syndrome (PCOS), or menopause.
Infections and STDs: Diagnosing and treating sexually transmitted diseases and infections such as yeast infections or bacterial vaginosis.
Fertility Issues: Addressing challenges related to conception and providing treatments like in-vitro fertilization (IVF).
Cancers: Screening for and treating cancers of the reproductive system, such as cervical, ovarian, and uterine cancers.
The Importance of Regular Check-ups
Regular gynecological check-ups are essential for early detection and prevention of potential health issues. Key components of a routine visit may include:
Pap Smear: A screening test for cervical cancer.
Pelvic Exam: To assess the health of reproductive organs.
Breast Exam: To detect any lumps or abnormalities.
Consultation: Discussing menstrual patterns, sexual health, and any other concerns.
Common Procedures in Gynecology
Gynecologists perform various procedures, both diagnostic and therapeutic, such as:
Ultrasound: To examine the uterus and ovaries.
Colposcopy: To closely inspect the cervix for abnormalities.
Laparoscopy: A minimally invasive surgery to diagnose and treat conditions like endometriosis.
Hysteroscopy: Used to view and treat the inside of the uterus.
Advances in Gynecology
Recent advancements in gynecology have revolutionized patient care. These include:
Robotic Surgery: Enhancing precision and reducing recovery time.
Hormonal Therapies: Improved treatments for menopause and PCOS.
Genetic Testing: For early detection of hereditary cancers.
Breaking the Stigma
Despite its importance, discussions about gynecology are often surrounded by stigma and misconceptions. Promoting education and awareness is crucial to empower women to seek timely medical care.
Conclusion
Gynecology plays a pivotal role in safeguarding women's health. Regular consultations, awareness of bodily changes, and access to advanced medical care ensure women can lead healthy, fulfilling lives. By prioritizing gynecological health, women can take proactive steps toward overall well-being.Explore top-rated gynecology services in Dallas, TX, offering comprehensive care for women's health, including exams, treatments, and advanced procedures.
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Advanced Cancer Screening: A New Era in Early Detection
Cancer continues to be a leading cause of death worldwide, but advancements in screening technologies are making early detection more accessible and accurate. From genomic profiling labs to hereditary cancer testing, let's dive into how advanced cancer screening is reshaping the fight against cancer.
The Importance of Early Detection
Detecting cancer early significantly improves treatment outcomes and survival rates. However, traditional screening methods often fail to identify at-risk individuals before symptoms appear. Advanced cancer screening technologies bridge this gap, identifying risks earlier than ever.
Genomic Profiling Labs
Genomic profiling is revolutionizing cancer screening by analyzing DNA to detect genetic mutations linked to cancer. Key advancements include:
Liquid Biopsies: Non-invasive tests that detect cancer markers in blood samples.
Personalized Screening: Tailored to an individual’s genetic profile, ensuring more accurate predictions of cancer risk.
Improved Monitoring: For patients in remission, genomic profiling offers better surveillance for potential recurrences.
Hereditary Cancer Testing
Some cancers, such as breast, ovarian, and colorectal cancer, have hereditary links. Advanced testing identifies mutations in genes like BRCA1 and BRCA2, allowing at-risk individuals to take preventive steps. Benefits include:
Preventive Strategies: Early identification leads to lifestyle changes, preventive surgeries, or increased surveillance.
Family Planning Guidance: Testing helps families understand and manage inherited risks.
Advances in Technology
AI-Driven Tools: Machine learning algorithms analyze large datasets to identify cancer patterns missed by traditional methods.
Multi-Cancer Early Detection (MCED): These tests detect multiple types of cancer from a single sample, often before symptoms occur.
Challenges
While these technologies hold promise, challenges such as affordability, accessibility, and false positives must be addressed. Governments, healthcare providers, and biotech companies are working together to bring these technologies to a broader audience.
Conclusion
Advanced cancer screening is more than a scientific breakthrough; it's a beacon of hope for millions. By investing in these technologies and increasing public awareness, we can make significant strides in reducing cancer-related deaths.
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The Role of Genetics in Breast Cancer: Should You Get Tested?
Breast cancer is influenced by many factors, including genetics. About 5-10% of breast cancer cases are hereditary, meaning they are caused by abnormal genes passed from parents to children. The most well-known genes linked to breast cancer are BRCA1 and BRCA2. Mutations in these genes can significantly increase the risk of developing breast cancer. If you have a family history of breast or ovarian cancer, it may be important to consider genetic testing.
Read more: https://bestradiationoncologistindelhincr.blogspot.com/2024/10/the-role-of-genetics-in-breast-cancer.html
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Breast Cancer Awareness Month: the public health case for BRCA testing
Angelina Jolie’s case is one of the most recognised in genomic medicine. With a strong family history of cancer, she was found to carry a mutation in the BRCA1, significantly elevating her risk for Hereditary Breast and Ovarian Cancer (HBOC). In 2013, she opted for a preventive mastectomy and in 2015 for a salpingo-oophorectomy to reduce her risk of cancer. Early detection allows patients and…
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Understanding BRACAnalysis®: Hereditary Cancer Testing
BRACAnalysis® is additionally an essential clinical genetic test that determines the presence of mutations in the high-risk BRCA1 and BRCA2 genes associated with hereditary breast and ovarian cancer syndrome. People with such mutations have up to 87 percent of chances of getting breast cancer and up to 44 percent for ovarian cancer before they are 70 years of age. This relatively simple test can be done by a blood sample, a saliva swab just as well. Gene knowledge can help both you and your doctor to create a healthy minimizing healthcare risks future in the future. When a mutation is identified, measures such as enhanced screening, chemoprevention, and in some cases preventive surgeries may also be useful in managing cancer risks optimally.More so, research in the field has focused on the possible use of preventive measures such as chemoprevention in the prevention of mutation related cancers.
Check out: Bracanalysis hereditary cancer testing
#BRACAnalysis#HereditaryCancer#GeneticTesting#BreastCancer#OvarianCancer#HealthAwareness#CancerPrevention#WomensHealth#Genetics#EmpowerYourself
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Holidays 9.29
Holidays
Amaranth Day (French Republic)
Babi Bar Massacre Anniversary Day
Battle of Boquerón Anniversary Day (a.k.a. Victory of Boquerón Day; Paraguay)
Broadway Musicals Day
Day of Machine-Building Industry Workers (Russia)
Devil Spits Day (UK)
Diplomatic Service Employees Day (Tajikistan)
Free Web Search Day
Halsey 929 Day
Han’gawi (North Korea)
Happy Goose Day
Hidden Heroes Day (UK)
International Adhesive & Sealant Day
International Day of Awareness of Food Loss and Waster (UN)
Inventor's Day (Argentina)
Jitiya Parwa (Nepal)
Labor Day (Kazakhstan)
Leif Erickson Day
MAGS (Memphis Archeological and Geological Society) Day
Make a List of the Top 10 Happiest Days in Your Life Day
Maneki Neko Day (Japan)
Manit Day (Culture Day; Marshall Islands)
Mechanical Engineer’s Day
Mid-Autumn Festival (Taiwan)
Mutation Day (TMNT)
National Attend Your Grandchild's Birth Day
National Bot Restock Day
National Brave Day
National Carson Day
National Day of Accountability
National Day of Belongingness
National Oxygen Day
National Police Remembrance Day (Australia)
National Silent Movie Day
929 Day
Otorhinolaryngologist Day (Russia)
Quick Draw McGraw Day
Shakira Day
Sibling Support Day
Urban National Wildlife Refuge Day
VFW Day
World Daddy Lumba Day (Ghana)
World Day of Primary Immune Thrombocytopenia
World Heart Day
World Retina Day
World Tacha Day (Nigeria)
Xenophobe Understanding Day
Food & Drink Celebrations
Biscotti Day
Blackberries Day
Budweiser National Happy Hour
Coffee Day (Sweden)
Gnocchi Day (Argentina)
Happy Goose Day
Michaelmas [traditional start of Bavarian lager brewing season]
National Coffee Day (a.k.a. Coffee Lovers Day)
National Dunkin’ Day
National Mocha Day
National Poisoned Blackberries Day (Scotland)
National Starbucks Day
Swedish Fish Day
Independence & Related Days
Constitution Day (Brunei)
Villa Alicia (Declared; 2014) [unrecognized]
5th & Last Sunday in September
Banned Book Week begins [Sunday of Last Week]
Clypping the Church Ceremony (Painswick, Gloucestershire, England) [Last Sunday]
Gold Star Mother's Day [Last Sunday]
International Day of the Deaf [Last Sunday]
National Blood Donor Day (Kyrgyzstan) [Last Sunday]
National Get Outside Day [Last Sunday]
National Hereditary Breast & Ovarian Cancer Day [Last Sunday]
Police & Peace Officers’ National Memorial Day (Canada) [Last Sunday]
Priesthood Sunday [Last Sunday]
Russian Tiger Day [Last Sunday]
Seven For Sunday [Every Sunday]
Social Justice Sunday (Australia) [Last Sunday]
Souper Sunday [Last Sunday of Each Month]
Sultry Sunday [Last Sunday of Each Month]
Sundae Sunday [Every Sunday]
Sunday Funday [Every Sunday]
Tap-Up Day (Guilford, UK) [Sunday before Oct. 2]
World Day of Migrants & Refugees [Last Sunday]
World Day of Retinitis Pigmentosa [Last Sunday]
World Deaf Day [Last Sunday]
World Heart Day [Last Sunday]
World Rivers Day [Last Sunday]
Weekly Holidays beginning September 29 (Last Week of September)
National Chimney Safety Week (thru 10.5)
Restaurant Week (Westport-Weston, Connecticut) [thru 10.13]
Shetland Wool Week (thru 10.5)
Festivals Beginning September 29, 2024
Atlantic Antic Street Festival (Brooklyn, New York)
Ballinasloe Horse Fair & Festival (Ballinasloe, Ireland) [thru 10.6]
Fryeburg Fair (Fryeburg, Maine) [thru 10.6]
NBWA Convention & Product Showcase (San Diego, California) [thru 10.2]
Unsound (Krakow, Poland) [thru 10.6]
Vermont Pumpkin Chuckin' Festival (Stowe, Vermont)
Feast Days
All Angels’ Day (Christian)
Antoine Coysevox (Artology)
Arturo Lindsay (Artology)
Caravaggio (Artology)
Carl Giles (Artology)
Colin Dexter (Writerism)
Confucius Day (Confucianism)
The Daily Double (Church of the SubGenius)
Day of Hestia Tamia (Pagan)
Double Entendre Day (Pastafarian)
Feast of the Dedication of the Basilica of St. Michael the Archangel (Roman Catholic)
Festival of Tezcatzonctl (Chief Aztec God of Intoxication)
Fielding (Positivist; Saint)
François Boucher (Artology)
Gwynn ap Nudd’s Fest (Celtic God of the Underworld)
Ian Fairweather (Artology)
Luther D. Bradley (Artology)
Michael, Gabriel, Raphael (Christian; Angels)
Jacopo Robusti Tintoretto (Artology)
Michaelmas [traditional start of Bavarian lager brewing season]
Miguel de Cervantes (Writerism)
Quarter Day (England, Ireland & Wales) [3 of 4]
Rhipsime (Christian; Saint)
Rhipsime, Gaiana and Their Companions (Christian; Martyrs & Virgins)
Riding the Stang (Celtic Book of Days)
Stan Berenstain (Artology)
Tales of Kelp-Kori’s Second Visit Again (Shamanism)
Telly Monster (Muppetism)
Theodota (Christian; Martyr)
Lucky & Unlucky Days
Butsumetsu (仏滅 Japan) [Unlucky all day.]
Lucky Day (Philippines) [53 of 71]
Premieres
Alice in Slumberland (Ub Iwerks Disney Cartoon; 1926)
All the World’s a Stage, by Rush (Live Album; 1976)
Baby Wants Spinach (Fleischer/Famous Popeye Cartoon; 1950)
Best in Show (Film; 2000)
The Bicentennial Man and Other Stories, by Isaac Asimov (Short Stories; 1976)
Big Mouth (Animated TV Series; 2017)
Black Coffee in Bed, by Squeeze (Song; 1982)
Clarinet Quintet in A, written by Wolfgang Amadeus Mozart (Quintet; 1789)
Core, by Stone Temple Pilots (Album; 1992)
The Creator (Film; 2023)
Death on the Nile (Film; 1978)
Deduce, You Say! (WB LT Cartoon; 1956)
Felicity (TV Series; 1998)
Hamlet (Film; 1948)
The Headless Horseman (ComiColor cartoon; 1934)
Inhumans (TV Series; 2017)
I Yam What I Yam (Fleischer Popeye Cartoon; 1933)
MacGyver (TV Series; 1985)
Masters of Sex (TV Series; 2013)
Mickey Plays Papa (Disney Cartoon; 1934)
Moonlight and Valentino (Film; 1995)
Okie from Muskogee, by Merle Haggard (Song; 1969)
The Old Pioneer (Happy Harmonies MGM Cartoon; 1934)
Open Season (Animated Film; 2006)
Painted from Memory, by Elvis Costello with Burt Bacharach (Album; 1998)
Permanent Wave (Oswald the Lucky Rabbit Cartoon; 1929)
The Prisoner (UK TV Series; 1967)
Remember the Titans (Film; 2000)
Sackett's Land, by Louis L'Amour (Novel; 1974)
Serenade in C (a.k.a. Ganz Kleine Nachtmusik), by Wolfgang Amadeus Mozart (String Trio; 2024)
Smells Like Teen Spirit, by Nirvana (Music Video; 1991)
A Spell for Chameleon, by Piers Anthony (Novel 1977) [Xanth #1]
A Star is Born (Musical Film; 1954)
The Stranger, by Billy Joel (Album; 1988)
Superman/Batman: Public Enemies (WB Animated Film; 2009)
Tall in the Saddle (Film; 1944)
To Die For (Film; 1995)
Tony Hawk’s Pro Skater (Video Game; 1999)
Uptown Girl, by Billy Joel (Song; 1983)
Urban Hymns, by The Verve (Album; 1997)
Today’s Name Days
Gabriel, Gabriela, Michael, Michaela, Rafael, Rafaela (Austria)
Gabrijel, Mihael, Rafael (Croatia)
Michal (Czech Republic)
Michael (Denmark)
Mihkel, Miikael, Mikk, Miko, Miku (Estonia)
Miika, Miikka, Mika, Mikael, Mikaela, Mikko, Miko, Miska (Finland)
Gabriel, Michel, Raphaël (France)
Gabriel, Michael, Raphael (Germany)
Kyriakos (Greece)
Mihály (Hungary)
Gabriele, Michele, Nicolò, Raffaele (Italy)
Ivonna, Mihails, Miķelis, Mikus (Latvia)
Gabrielius, Michalina, Mykolas, Mykolė, Rapolas (Lithuania)
Mikael, Mikal, Mikkel (Norway)
Dadźbog, Franciszek, Michalina (Poland)
Chiriac (Romania)
Ludmila (Russia)
Michaela, Michal (Slovakia)
Gabriel, Miguel, Rafael (Spain)
Mikael, Mikaela (Sweden)
Teofan (Ukraine)
Carmichael, Mia, Micaela, Micah, Michael, Michaela, Micheal, Michele, Micheline, Michelle, Mickey, Miguel, Mikaela, Mikala, Mikayla, Mike, Mikel, Mitch, Mitchel, Mitchell (USA)
Today is Also…
Day of Year: Day 273 of 2024; 93 days remaining in the year
ISO: Day 7 of Week 39 of 2024
Celtic Tree Calendar: Gort (Ivy) [Day 1 of 28]
Chinese: Month 8 (Guy-You), Day 27 (Bing-Shen)
Chinese Year of the: Dragon 4722 (until January 29, 2025) [Wu-Chen]
Hebrew: 26 Elul 5784
Islamic: 25 Rabi I 1446
J Cal: 3 Orange; Threesday [3 of 30]
Julian: 16 September 2024
Moon: 8%: Waning Crescent
Positivist: 21 Shakespeare (10th Month) [Moliere]
Runic Half Month: Gyfu (Gift) [Day 8 of 15]
Season: Autumn or Fall (Day 8 of 90)
Week: Last Week of September/1st Week of October
Zodiac: Libra (Day 7 of 30)
Calendar Changes
Gort (Ivy) [Celtic Tree Calendar; Month 10 of 13]
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Holidays 9.29
Holidays
Amaranth Day (French Republic)
Babi Bar Massacre Anniversary Day
Battle of Boquerón Anniversary Day (a.k.a. Victory of Boquerón Day; Paraguay)
Broadway Musicals Day
Day of Machine-Building Industry Workers (Russia)
Devil Spits Day (UK)
Diplomatic Service Employees Day (Tajikistan)
Free Web Search Day
Halsey 929 Day
Han’gawi (North Korea)
Happy Goose Day
Hidden Heroes Day (UK)
International Adhesive & Sealant Day
International Day of Awareness of Food Loss and Waster (UN)
Inventor's Day (Argentina)
Jitiya Parwa (Nepal)
Labor Day (Kazakhstan)
Leif Erickson Day
MAGS (Memphis Archeological and Geological Society) Day
Make a List of the Top 10 Happiest Days in Your Life Day
Maneki Neko Day (Japan)
Manit Day (Culture Day; Marshall Islands)
Mechanical Engineer’s Day
Mid-Autumn Festival (Taiwan)
Mutation Day (TMNT)
National Attend Your Grandchild's Birth Day
National Bot Restock Day
National Brave Day
National Carson Day
National Day of Accountability
National Day of Belongingness
National Oxygen Day
National Police Remembrance Day (Australia)
National Silent Movie Day
929 Day
Otorhinolaryngologist Day (Russia)
Quick Draw McGraw Day
Shakira Day
Sibling Support Day
Urban National Wildlife Refuge Day
VFW Day
World Daddy Lumba Day (Ghana)
World Day of Primary Immune Thrombocytopenia
World Heart Day
World Retina Day
World Tacha Day (Nigeria)
Xenophobe Understanding Day
Food & Drink Celebrations
Biscotti Day
Blackberries Day
Budweiser National Happy Hour
Coffee Day (Sweden)
Gnocchi Day (Argentina)
Happy Goose Day
Michaelmas [traditional start of Bavarian lager brewing season]
National Coffee Day (a.k.a. Coffee Lovers Day)
National Dunkin’ Day
National Mocha Day
National Poisoned Blackberries Day (Scotland)
National Starbucks Day
Swedish Fish Day
Independence & Related Days
Constitution Day (Brunei)
Villa Alicia (Declared; 2014) [unrecognized]
5th & Last Sunday in September
Banned Book Week begins [Sunday of Last Week]
Clypping the Church Ceremony (Painswick, Gloucestershire, England) [Last Sunday]
Gold Star Mother's Day [Last Sunday]
International Day of the Deaf [Last Sunday]
National Blood Donor Day (Kyrgyzstan) [Last Sunday]
National Get Outside Day [Last Sunday]
National Hereditary Breast & Ovarian Cancer Day [Last Sunday]
Police & Peace Officers’ National Memorial Day (Canada) [Last Sunday]
Priesthood Sunday [Last Sunday]
Russian Tiger Day [Last Sunday]
Seven For Sunday [Every Sunday]
Social Justice Sunday (Australia) [Last Sunday]
Souper Sunday [Last Sunday of Each Month]
Sultry Sunday [Last Sunday of Each Month]
Sundae Sunday [Every Sunday]
Sunday Funday [Every Sunday]
Tap-Up Day (Guilford, UK) [Sunday before Oct. 2]
World Day of Migrants & Refugees [Last Sunday]
World Day of Retinitis Pigmentosa [Last Sunday]
World Deaf Day [Last Sunday]
World Heart Day [Last Sunday]
World Rivers Day [Last Sunday]
Weekly Holidays beginning September 29 (Last Week of September)
National Chimney Safety Week (thru 10.5)
Restaurant Week (Westport-Weston, Connecticut) [thru 10.13]
Shetland Wool Week (thru 10.5)
Festivals Beginning September 29, 2024
Atlantic Antic Street Festival (Brooklyn, New York)
Ballinasloe Horse Fair & Festival (Ballinasloe, Ireland) [thru 10.6]
Fryeburg Fair (Fryeburg, Maine) [thru 10.6]
NBWA Convention & Product Showcase (San Diego, California) [thru 10.2]
Unsound (Krakow, Poland) [thru 10.6]
Vermont Pumpkin Chuckin' Festival (Stowe, Vermont)
Feast Days
All Angels’ Day (Christian)
Antoine Coysevox (Artology)
Arturo Lindsay (Artology)
Caravaggio (Artology)
Carl Giles (Artology)
Colin Dexter (Writerism)
Confucius Day (Confucianism)
The Daily Double (Church of the SubGenius)
Day of Hestia Tamia (Pagan)
Double Entendre Day (Pastafarian)
Feast of the Dedication of the Basilica of St. Michael the Archangel (Roman Catholic)
Festival of Tezcatzonctl (Chief Aztec God of Intoxication)
Fielding (Positivist; Saint)
François Boucher (Artology)
Gwynn ap Nudd’s Fest (Celtic God of the Underworld)
Ian Fairweather (Artology)
Luther D. Bradley (Artology)
Michael, Gabriel, Raphael (Christian; Angels)
Jacopo Robusti Tintoretto (Artology)
Michaelmas [traditional start of Bavarian lager brewing season]
Miguel de Cervantes (Writerism)
Quarter Day (England, Ireland & Wales) [3 of 4]
Rhipsime (Christian; Saint)
Rhipsime, Gaiana and Their Companions (Christian; Martyrs & Virgins)
Riding the Stang (Celtic Book of Days)
Stan Berenstain (Artology)
Tales of Kelp-Kori’s Second Visit Again (Shamanism)
Telly Monster (Muppetism)
Theodota (Christian; Martyr)
Lucky & Unlucky Days
Butsumetsu (仏滅 Japan) [Unlucky all day.]
Lucky Day (Philippines) [53 of 71]
Premieres
Alice in Slumberland (Ub Iwerks Disney Cartoon; 1926)
All the World’s a Stage, by Rush (Live Album; 1976)
Baby Wants Spinach (Fleischer/Famous Popeye Cartoon; 1950)
Best in Show (Film; 2000)
The Bicentennial Man and Other Stories, by Isaac Asimov (Short Stories; 1976)
Big Mouth (Animated TV Series; 2017)
Black Coffee in Bed, by Squeeze (Song; 1982)
Clarinet Quintet in A, written by Wolfgang Amadeus Mozart (Quintet; 1789)
Core, by Stone Temple Pilots (Album; 1992)
The Creator (Film; 2023)
Death on the Nile (Film; 1978)
Deduce, You Say! (WB LT Cartoon; 1956)
Felicity (TV Series; 1998)
Hamlet (Film; 1948)
The Headless Horseman (ComiColor cartoon; 1934)
Inhumans (TV Series; 2017)
I Yam What I Yam (Fleischer Popeye Cartoon; 1933)
MacGyver (TV Series; 1985)
Masters of Sex (TV Series; 2013)
Mickey Plays Papa (Disney Cartoon; 1934)
Moonlight and Valentino (Film; 1995)
Okie from Muskogee, by Merle Haggard (Song; 1969)
The Old Pioneer (Happy Harmonies MGM Cartoon; 1934)
Open Season (Animated Film; 2006)
Painted from Memory, by Elvis Costello with Burt Bacharach (Album; 1998)
Permanent Wave (Oswald the Lucky Rabbit Cartoon; 1929)
The Prisoner (UK TV Series; 1967)
Remember the Titans (Film; 2000)
Sackett's Land, by Louis L'Amour (Novel; 1974)
Serenade in C (a.k.a. Ganz Kleine Nachtmusik), by Wolfgang Amadeus Mozart (String Trio; 2024)
Smells Like Teen Spirit, by Nirvana (Music Video; 1991)
A Spell for Chameleon, by Piers Anthony (Novel 1977) [Xanth #1]
A Star is Born (Musical Film; 1954)
The Stranger, by Billy Joel (Album; 1988)
Superman/Batman: Public Enemies (WB Animated Film; 2009)
Tall in the Saddle (Film; 1944)
To Die For (Film; 1995)
Tony Hawk’s Pro Skater (Video Game; 1999)
Uptown Girl, by Billy Joel (Song; 1983)
Urban Hymns, by The Verve (Album; 1997)
Today’s Name Days
Gabriel, Gabriela, Michael, Michaela, Rafael, Rafaela (Austria)
Gabrijel, Mihael, Rafael (Croatia)
Michal (Czech Republic)
Michael (Denmark)
Mihkel, Miikael, Mikk, Miko, Miku (Estonia)
Miika, Miikka, Mika, Mikael, Mikaela, Mikko, Miko, Miska (Finland)
Gabriel, Michel, Raphaël (France)
Gabriel, Michael, Raphael (Germany)
Kyriakos (Greece)
Mihály (Hungary)
Gabriele, Michele, Nicolò, Raffaele (Italy)
Ivonna, Mihails, Miķelis, Mikus (Latvia)
Gabrielius, Michalina, Mykolas, Mykolė, Rapolas (Lithuania)
Mikael, Mikal, Mikkel (Norway)
Dadźbog, Franciszek, Michalina (Poland)
Chiriac (Romania)
Ludmila (Russia)
Michaela, Michal (Slovakia)
Gabriel, Miguel, Rafael (Spain)
Mikael, Mikaela (Sweden)
Teofan (Ukraine)
Carmichael, Mia, Micaela, Micah, Michael, Michaela, Micheal, Michele, Micheline, Michelle, Mickey, Miguel, Mikaela, Mikala, Mikayla, Mike, Mikel, Mitch, Mitchel, Mitchell (USA)
Today is Also…
Day of Year: Day 273 of 2024; 93 days remaining in the year
ISO: Day 7 of Week 39 of 2024
Celtic Tree Calendar: Gort (Ivy) [Day 1 of 28]
Chinese: Month 8 (Guy-You), Day 27 (Bing-Shen)
Chinese Year of the: Dragon 4722 (until January 29, 2025) [Wu-Chen]
Hebrew: 26 Elul 5784
Islamic: 25 Rabi I 1446
J Cal: 3 Orange; Threesday [3 of 30]
Julian: 16 September 2024
Moon: 8%: Waning Crescent
Positivist: 21 Shakespeare (10th Month) [Moliere]
Runic Half Month: Gyfu (Gift) [Day 8 of 15]
Season: Autumn or Fall (Day 8 of 90)
Week: Last Week of September/1st Week of October
Zodiac: Libra (Day 7 of 30)
Calendar Changes
Gort (Ivy) [Celtic Tree Calendar; Month 10 of 13]
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The Association for Molecular Pathology v. Myriad Genetics (2013)
Series of several lawsuits aimed at patents on naturally occurring gene sequences among which was two key genes BRCA1 and BRCA2 which are tumor suppressor genes which are normally expressed in breast tissue.
Reference: Nancie Petrucelli, MS, Mary B Daly, MD, PhD, and Tuya Pal, MD.. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer. GeneReviews, at National Center for Biotechnology Information. Initial Posting: September 4, 1998; Last Update: December 15, 2016.
A patent for these genes, as well as methods for diagnosing likelyhood of breast cancer based upon them was filed by University of Utah, NIEHS, and Myriad Genetics - and which were enforced against clinical diagnostic labs. Exclusive ownership of these patents (the genes were found with publicly funded research) allowed Myriad Genetics to grow immensely through exclusive right to offer diagnostic testing services for mutations in the BRCA genes - aggressively defending this exclusive right through cease and desist letters to other genetic diagnostic laboratories. This exclusivity was an issue due to the high prices of the diagnostic test and the lack of any ability to verify tests with alternative labs.
Myriad Genetics was ruled against finally in a supreme court decision that held no naturally occurring DNA sequences could be patented - though cDNA sequences could be (why, it is literally just the same dna sequence but with introns removed). Myriad Genetics retained 515 patent claims to naturally isolated DNA sequences (!!!) and 24 patents.
Australia, a clown country, upheld the validity of Myriad's patent in 2013 and only decided isolated nucleic acids are not 'patentable inventions' in 2015.
I think the first time you see a DNA patent, if you're a person of any conviction at all, it permanently warps your political leanings in much the same way a sledgehammer permanently warps a cheap car door
#How the fuck did the BRCA1 and BRCA2 patents not get thrown out right away#why are gene diagnostic tests patentable when other diagnostic tests are not?
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Genetic Screening for HBOC | Hereditary Breast & Ovarian Cancer
Hereditary Breast and Ovarian Cancer Syndrome (HBOC) raises breast and ovarian cancer risk due to BRCA1/BRCA2 mutations. Learn more about prevention.
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Some Risk Factors for Ovarian Cancer
Ovarian cancer is a type of cancer that develops in the cells of the ovaries, hence its name. While it is not as common as breast or uterine cancer, ovarian cancer is typically more severe. Certain factors can significantly increase one's risk of developing ovarian cancer. Following are three major risk factors for the disease.
One common risk factor for ovarian cancer is age. The risk increases with age, with women under 40 being less likely to develop the condition compared to older women. Most ovarian cancers occur after menopause, and more than 50 percent of diagnosed cases are in women over 63 years old.
Obesity is another common risk factor for ovarian cancer. Apart from ovarian cancer, obesity is linked to various other types of cancer. Women with a body mass index (BMI) over 30 are at a higher risk of ovarian cancer.
Additionally, ovarian cancer can be hereditary, meaning it can run in families. People with a family history of ovarian cancer are at an increased risk of developing the condition due to genetic mutations that can be passed from parent to child.
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What are the Most Common Genetic Cancer Syndromes?
Hereditary cancer syndromes like HBOC, Lynch Syndrome, FAP, LFS, and MEN1 result from genetic mutations, increasing cancer risks. HBOC (BRCA1/BRCA2) raises breast and ovarian cancer risks. Lynch Syndrome (MLH1, MSH2) heightens colorectal cancer risks. Additionally, we emphasize the importance of Consulting the Best Radiation Doctor in Delhi for expert Guidance and Personalized care.
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Family History and Genetic Testing Assist in Determining Cancer Risk
Family history and genetic testing play a major role in determining cancer risk. Yes! This may sound quite unusual at times as cancer can happen to anyone at any point in time due to the high prevalence of environmental factors. However, as per research, it has been confirmed that the genetic cause of cancer puts you under the high-risk category.
In this context, GS Cancer Hospital Ghaziabad, the best cancer hospital in Hapur aims to spread awareness amongst their patients about the importance of family history and genetic testing to assist in determining high-risk cancer cases. Apart from providing excellent care and medical services with a team of the best oncologists in Meerut, the hospital also offers preventive cancer care.
In this blog, we shall unleash the importance of family history and genetic testing to assist in determining cancer risk. Let’s begin
What is Genetic Testing for Cancer?
Gene mutations play an important role in determining high-risk cases of cancer. These gene mutations are changes in the DNA of the cells that occur during a person’s lifetime.
In simple words, many changes take place in the cellular cycle as every individual grows. Moreover, the majority of the genes are considered familial genes which are derived from either parents or ancestors. One such gene mutation that can be detected through DNA or genetic testing is the cancer gene.
If you have a family history of cancer, undergoing genetic testing can help to confirm inherited cancer genes. If genetic testing reveals a hereditary mutation of the cancer gene, you are at high risk of developing cancer. Positive genetic testing for cancer helps you to work on lifestyle modifications to reduce the risk of cancer in the future allowing you to stay healthy.
Before you plan to get genetic testing done for cancer, it is recommended to speak to your oncologist who will take a detailed case consultation to check for the need for genetic testing.
Importance of family history and genetic testing in cancer
Detailed case consultation for cancer analysis is a must with your doctor. Knowing about one’s family history helps to lower the risk and prevent cancer. Genetic testing for cancer is an essential tool that helps in detecting high-risk cancer cases.
Accordingly, diagnosis and management of cancer can be done with timely screenings, routine check-ups, and lifestyle modifications at an early age to prevent cancer. A genetic evaluation of cancer can be done through detailed family history, past medical history, and genetic testing.
Hereditary forms of cancers
Many cancers are caused by hereditary mutations which are as follows-
Breast cancer
Ovarian Cancer
Lung cancer
Uterine cancer
Colon cancer
Pancreatic cancer
Prostate cancer
Thyroid cancer
Stomach cancer
Kidney cancer
Well, it is important to know that not all cancers are hereditary. Many are also caused due to environmental factors that act as potential triggers for the recurrence of cancer.
When is genetic testing for cancer recommended?
Genetic testing for cancer is recommended mainly by your doctor based on his detailed case consultation. Here are some of the following recommendations for genetic testing of cancer-
Age - If you are diagnosed with cancer in the early stage of life or at a young age
Complications- If you have multiple types of cancers due to metastasis
Extent of cancer- If you have cancer in bilateral organs such as bilateral breast or kidney
Family history of cancer which includes biological parents and siblings
Ancestral history of cancer in multiple family members
Inherited cancer syndromes such as neurofibromatosis
These are certain factors for genetic testing to determine cancer. However, your oncologist is the best judge who will guide you for the genetic testing for cancer after determining your case history.
Types of genetic testing for cancer
Here are the different types of genetic tests for cancer as advised by your doctor.
Single mutation genetic testing
This test mainly involves looking out for certain changes in specific areas of a particular gene. It is done for multiple family members to check for high-risk specific cancer cases.
Single gene testing
This test involves the check on the entire DNA of the specific gene for cancer.
Panel genetic testing
This involves testing mutations in several genes.
Procedure for genetic testing
The procedure for genetic testing is as follows-
First step: A detailed case consultation with your doctor
Second step: Genetic counseling is a must before genetic testing trained genetic counselors will also guide you through the procedure.
These two initial steps are very important before you decide on genetic testing. It will help guide you through the following:
Appropriate genetic testing suggestive as per your case
A detailed explanation of specific genetic tests according to your case as per your doctor
The pros and cons of genetic testing
The importance of genetic testing in your case to avoid future complications
The positive impact of genetic testing on family members and children
Genetic test results and thorough guidance for prevention by your doctor.
Advantages of family history and genetic testing for cancer
The advantages of knowing family history and genetic testing for cancer are as follows-
To know about the high-risk category cancer cases and take adequate measures
To know about regular timely screening promptly with your doctor’s recommendation
Take considered medicines as per your doctor to lower the risk of cancer
To reduce the risk of chemotherapy, radiation therapy, and surgery in the future
Genetic testing helps protect family members to prevent cancer in future
Preventing complications of cancer in existing cases of cancer
Prevention of passing on hereditary mutation to their biological children by taking necessary steps.
Disadvantages of genetic testing
The disadvantages of the genetic testing are as follows-
Fear of developing cancer in the future
If the genetic testing is positive, it is important to inform your family members about the possibility of the presence of a cancer gene
Genetic tests may show variations of genes at some stages
The presence of inherited cancers may be worrisome affecting the quality of life
If you have been positive for genetic testing, then your doctor will provide you with the necessary cancer prevention-centric treatment with a personalized approach as per your case.
A Note of Care by GS Hospital
GS Hospital, the best cancer hospital in Ghaziabad believes in the mantra of “Prevention is better than cure.” Moreover, the hospital advocates the importance of detecting cancer at early stages for better prognosis and recovery. Along with this, the hospital has taken over an important mission for a cancer awareness program through family history and genetic testing which will help assist the oncology team to determine high-risk cases of cancer. This will help prevent and reduce the risk of causing cancer for a better future and maintain the good health of the patients. GS Hospital is known to be the best cancer specialist in Ghaziabad for its high-end expertise in cancer cases. The hospital takes forward the mission to eradicate cancer nationwide to live a happy, healthy, and beautiful life.
#FamilyHistory#GeneticTestingAssist#CancerRisk#GSCancerHospital#Ghaziabad#DelhiNCR#TopCancerHospital#UttarPradesh#India
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Ovarian Cancer: Quick Facts for Awareness
When it comes to ovarian cancer, all women face some risk, with about 1 in 70 developing the disease in their lifetime. While the exact cause of ovarian cancer isn't clear, certain factors can increase or decrease a woman's chances of getting it.
Around 10 to 15 percent of women with ovarian cancer have a genetic tendency for the disease. The most important risk factor here is an inherited mutation in one or both of the BRCA1 or BRCA2 genes, often known as breast cancer genes. These genes contribute to about 5 to 10 percent of all ovarian cancers. For those seeking the best doctor for ovarian cancer in Delhi, it's essential to find a specialist who understands these risk factors and can provide appropriate care and guidance. Look for doctors who have experience in managing hereditary ovarian cancer cases and who can offer personalized treatment options. Consulting with a specialist can help you understand your risk and receive the best possible care for ovarian cancer.
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What are the different types of cancer screening tests?
Comprehensive Guide to Cancer Screening Tests by Dr. Nisha Mangal: Best Gynecologist in Jaipur
As a leading gynecologist and laparoscopic surgeon in Jaipur, Dr. Nisha Mangal prioritizes comprehensive women’s health care, including cancer screenings. At the Fertility IUI Center in Malviya Nagar Jaipur, Dr. Nisha Mangal specializes in fertility treatments, high-risk pregnancies, and gynecological concerns. Understanding the importance of early detection, Dr. Nisha Mangal provides insights into the various types of cancer screening tests recommended for women in Jaipur.
1. Pap Smear: Pap smear, also known as Pap test, is a vital screening tool for cervical cancer. Dr. Nisha Mangal, as a dedicated gynecologist in Jaipur, emphasizes the significance of regular Pap smears for early detection and prevention of cervical cancer. Through this test, abnormalities or precancerous changes in cervical cells can be identified and addressed promptly.
2. Mammography: Mammography remains the primary screening method for breast cancer. Dr. Nisha Mangal, recognized as the best gynecologist in Jaipur, recommends mammograms for women, particularly those over 40 or with a family history of breast cancer. Early detection through mammography can significantly improve treatment outcomes and survival rates.
3. Colonoscopy: Colonoscopy is essential for colorectal cancer screening. Dr. Nisha Mangal, a laparoscopic gynecologist in Jaipur, stresses the importance of colonoscopies, especially for individuals over 50 or with a family history of colorectal cancer. Timely detection of polyps or abnormal growths in the colon can lead to early intervention and prevention of cancer development.
4. HPV Testing: Human papillomavirus (HPV) testing is often conducted alongside Pap smears to screen for cervical cancer. Dr. Nisha Mangal, a pregnancy and maternity specialist in Jaipur, recommends HPV testing for women aged 30 and older. This test helps identify high-risk HPV strains associated with cervical cancer, allowing for proactive management and follow-up care.
5. Genetic Testing: Genetic testing plays a crucial role in identifying inherited mutations predisposing individuals to certain cancers, such as breast and ovarian cancer. Dr. Nisha Mangal, an infertility specialist in Jaipur, may recommend genetic testing for individuals with a family history of hereditary cancer syndromes. Personalized risk assessment and preventive measures can be implemented based on genetic test results.
6. Prostate-Specific Antigen (PSA) Test: For men, the PSA test is used to screen for prostate cancer. Dr. Nisha Mangal, a renowned gynecologist in Jaipur, acknowledges the importance of prostate cancer screening, particularly for men over 50 or with risk factors such as family history. Early detection through PSA testing enables timely intervention and improved outcomes.
As the leading gynecologist in Malviya Nagar Jaipur, Dr. Nisha Mangal is committed to promoting women’s health and well-being. Whether it’s managing high-risk pregnancies, providing PCOD/PCOS treatment, or offering infertility solutions, Dr. Nisha Mangal delivers personalized care tailored to each patient’s needs. For comprehensive cancer screenings and expert gynecological care in Jaipur, trust Dr. Nisha Mangal and her dedicated team.
To schedule a consultation or learn more about cancer screening tests, contact Dr. Nisha Mangal, the best gynecologist and laparoscopic surgeon in Jaipur. Your health is our priority.
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