#Guillaume Mahe

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Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

(more…)

[dailykhaleej]

Renault to cut 15,000 jobs in ‘vital’ cost-cutting plan

Renault employees collect in entrance of the Fonderie de Bretagne, a subsidiary of Groupe Renault, in Caudan, France, Could 28, 2020. Image taken Could 28, 2020. DailyKhaleej/Stephane?Mahe Picture Credit score: DailyKhaleej

PARIS: Carmaker Renault mentioned on Friday that it could cut practically 15,000 jobs, together with 4,600 at its core French operations, because it seeks to steer out of a money crunch exacerbated by the coronavirus disaster.

The corporate will goal financial savings of greater than two billion euros (Dh8.1 billion, $2.2 billion) over three years and switch its focus to electrical automobiles because it seeks to restore competitiveness in a market reeling from slumping gross sales, after the Covid-19 pandemic pressured hundreds of thousands of individuals into residence confinement for weeks on finish.

Renault had been navigating turbulent waters even earlier than the well being disaster, beginning with the shock arrest of its former boss Carlos Ghosn on monetary misconduct expenses in 2018, which led to deep rifts in its alliance with Japanese companions Nissan and Mitsubishi.

“The difficulties encountered by the group, the major crisis facing the automotive industry and the urgency of the ecological transition are all imperatives that are driving the company to accelerate its transformation,” it mentioned in a press release.

In February, Renault introduced it had suffered its first internet loss in a decade final 12 months, adopted rapidly by the 2020 well being disaster that noticed new automobile registrations in the European Union plunge 76.Three per cent year-on-year in April.

In an “adjustment” plan introduced to unions which AFP reported on Thursday, Renault mentioned practically 4,600 jobs can be cut out of 48,000 in France, and greater than 10,000 in the remainder of the world — some eight per cent of the corporate’s world workforce.

It will entail retraining, inside mobility and voluntary departures, unfold out over three years, with no outright dismissals envisioned for now.

Growth plans in Morocco and Romania have been halted, and are underneath assessment in Russia.

‘We don’t perceive’

4 manufacturing websites in France could possibly be closed or restructured, the automaker mentioned, and its hulking manufacturing unit at Flins northwest of Paris will cease making the Zoe electrical hatchback from 2024.

General, manufacturing capability shall be cut to 3.Three million by 2024 from 4 million automobiles at the moment.

“We want to generate economies of scale to restore our overall profitability and ensure our development in France and internationally,” Delbos mentioned.

The information got here as a bombshell in Choisy, south of Paris, the place a couple of hundred employees and native representatives gathered at a Renault plant on Friday morning.

It employs some 260 folks and is alone amongst 14 French manufacturing websites earmarked for closure by 2022 underneath the plan, in accordance to its chairman Jean-Dominique Senard.

“First we hear the news about Renault’s difficulties in the media, then they tell us we will close to go to Flins. It’s a shock … We don’t understand how it’s possible,” mentioned Antonio Perez, 52, who has labored on the Choisy website for over 20 years.

Added his colleague Farid, 43: “Now we know, we know that we have no future … They just drop us in the middle of a pandemic, they throw us out on the street.”

Future ‘likely to be harsh’

The mayor of Choisy, Didier Guillaume, additionally expressed his issues.

“Our region has already been marked by the deindustrialisation of the 1980s. What is hard to understand is that we are an exemplary site, engaged in a sustainable development approach,” he mentioned.

“It is the last remaining production plant in the inner ring (bordering on the Ile-de-France region of Paris) and the second private employer of the municipality. The future is likely to be harsh.”

On Tuesday, whereas asserting an eight-billion-euro rescue plan for France’s automobile trade, which has seen gross sales and income slashed by some 80 per cent, President Emmanuel Macron mentioned he wished no manufacturing of any automobile mannequin made in France to transfer elsewhere.

Macron’s plan is closely targeted on bolstering France’s electrical automobile trade, and he mentioned Renault had agreed to be part of a Franco-German venture to produce electrical batteries.

This had been a situation for Renault to obtain a five-billion-euro authorities rescue mortgage, together with ensures from the corporate over the way forward for employees at crops in Maubeuge and Douai in northern France.

The French authorities holds a 15 per cent stake in Renault.

On Wednesday, alliance companions Renault, Nissan and Mitsubishi unveiled a plan to deepen an alliance that simply months in the past appeared on the verge of breaking apart.

Yesterday, Nissan reported a $6.2 billion annual internet loss and mentioned it could shut its Barcelona plant and slash manufacturing.

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[olko71]

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New Post has been published on http://yaroreviews.info/2020/04/individual-ashtrays-hourly-disinfection-french-carmakers-eye-production-restart

Individual ashtrays, hourly disinfection: French carmakers eye production restart

PARIS (Reuters) – Peugeot-owner PSA and Renault are planning new safety measures in a push by France’s major industrial groups for a breakthrough with workers to reopen some factories before the government lifts its lockdown from mid-May, unions said.

FILE PHOTO: The logo of Renault carmaker is pictured at a dealership in Nantes, France, February 19, 2020. REUTERS/Stephane Mahe

Japanese carmaker Toyota Motor Corp. (7203.T) on Wednesday became the first auto company with a plant in France to agree with unions a gradual restart of production from April 21 at its factory in northern France, where it makes the Yaris model.

The ramp-up comes as auto rivals elsewhere look to resume manufacturing from next week, including in Germany where some restrictions to contain the new coronavirus outbreak will be eased shortly.

In France, negotiations with labour unions have been tough, however. PSA (PEUP.PA) and Renault (RENA.PA) told Reuters they were preparing for a restart of operations, but no date had officially been set yet.

At PSA’s gearbox factory in Valenciennes, where a first plan to resume production on a voluntary basis was rejected by unions in March, management and workers’ representatives are to hold fresh talks on Friday.

New safety protocols are being developed by the carmakers, union members said.

These could include wearing masks, giving out individual ashtrays so that smokers do not gather in one area, and keeping the doors open to avoid contact with the handles.

They would also entail disinfecting tools and work surfaces every 60 minutes and doubling the number of buses that pick up workers.

ENCOURAGEMENT

The French government has encouraged companies to resume production, mindful of a major hit to the economy, already expected to contract 8% this year.

“I believe that there is a way to do it: it is not about choosing either the resumption of activity, or the health of the employees, it is both at the same time, it is doable,” French labour minister Muriel Penicaud told LCI radio on Thursday, citing Toyota as a potential model.

Restrictions on movement in France will not be eased until at least May 11, starting with the reopening of some stores and schools.

French train maker Alstom (ALSO.PA) told Reuters on Thursday it had been progressively ramping up its activities since the beginning of April at its plants in France.

The hard-left CGT union, however, has said it still considers it premature for carmakers to resume production in late April or early May, arguing that masks are still reserved as a priority for the health workers and may not be available.

The country’s metals lobby said on Sunday that French companies in the automotive, aerospace and steel sectors were ready to return to work and assure “impeccable, sanitary conditions”.

Renault already restarted production in Portugal and Russia on Monday.

Reporting by Gilles Guillaume; Additional reporting and writing by Maya Nikolaeva, Editing by Sarah White and Emelia Sithole-Matarise

Our Standards:The Thomson Reuters Trust Principles.

[baclofenwiki-blog]

Pharmakokinetische Daten zur Verabreichung von hochdosiertem Baclofen bei alkoholabhängigen Patienten auf der Intensivstation (Data in Brief, 2019)

Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU (Data in Brief, 2019) Autoren: Mickael Vourc’h, Eric Dailly, Yannick Hourmant, Ronan Bellouard, Pierre-Joachim Mahe, Guillaume Deslandes, Matthieu Grégoire & Karim Asehnoune (pp, 11.01.2020)

Abstract im englischen Original

In the intensive care unit, alcohol intake above the NIAAA recommendations regardless of the existence of an Alcohol Use Disorder (AUD), was associated with an increased risk of death and longer time on ventilator. This rises the hypothesis that unhealthy alcohol use may lead to specific issues when weaning the mechanical ventilation (i.e. agitation or its related complications) regardless of AUD or withdrawal syndrome. Thus, we proposed to use baclofen off-label to avoid agitation. The data presented in this article is related to the research article entitled: „Pharmacokinetics and toxicity of high-dose baclofen in ICU patients“ Vourc’h et al., 2019 Data provided in this submission includes 1) the detailed methods for baclofen assay by mass spectrometric detection, 2) the supplementary population pharmacokinetic analysis presenting observed concentration vs. population or individual predicted concentration (raw data of the latter is also available), and 3) the algorithm for the adaptation of baclofen daily doses according of the renal clearance to assess the risk of toxicity in critically ill patients.

Link zum englischen Abstract Volltext auf Anfrage

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 jQuery('#synved-social-grey-script-marker-4').siblings('a.synved-social-grey').mouseover(function () { try { Pixastic.revert(jQuery(this).find('.synved-social-image').get(0)); } catch (ex) { } }).mouseleave(function () { try { jQuery(this).find('.synved-social-image').pixastic("desaturate"); } catch (ex) { } }).find('.synved-social-image').one('load', function() { try { jQuery(this).pixastic("desaturate"); } catch (ex) { } }).each(function() { if(this.complete) jQuery(this).load(); });

[eclecticstarlightblogger]

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

(more…)

[thoughtfullyblogger]

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

(more…)

[greekblogs]

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Τα επιδόματα θέσης ευθύνης των στελεχών της ΠΕ και ΔΕ

(more…)

[skandaladiaplokidiafthora]

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους (more…)

[baclofenwiki-blog]

Pharmakokinetik und Toxizität von hochdosiertem Baclofen bei Patienten auf der Intensivstation (Progress in Neuropsychopharmacology & Biological Psychiatry, 2019)

Pharmacokinetics and toxicity of high-dose baclofen in ICU patients (Progress in Neuropsychopharmacology & Biological Psychiatry, 2019) Autoren: Mickael Vourc’h, Eric Dailly, Yannick Hourmant, Ronan Bellouard, Pierre-Joachim Mahe, Guillaume Deslandes, Matthieu Grégoire, Karim Asehnoune (pp, 12.01.2020)

Struktur des Inhalts

1 Abstract im englischen Original

1.0.1 BACKGROUND:

1.0.2 MATERIALS AND METHODS:

1.0.3 RESULTS:

1.0.4 CONCLUSIONS:

Abstract im englischen Original

BACKGROUND:

High-dose baclofen could prove beneficial in patients with unhealthy alcohol use in intensive care units (ICU). However, the pharmacokinetic properties of baclofen are unknown in this population. Our objectives were to investigate the pharmacokinetics of baclofen and the relationship between baclofen exposure and its toxicity in the ICU.

MATERIALS AND METHODS:

As part of a healthcare quality improvement project, we conducted a prospective, single-center study in a surgical intensive care unit at Nantes University Hospital in order to assess our local protocol of sedation in patients with consumption of alcohol above the recommended limits by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Baclofen pharmacokinetics were investigated by a non-compartment analysis and a population approach in 20 patients under mechanical ventilation. After a baclofen loading dose on day 1, daily doses were divided into 3 intakes adapted to glomerular filtration rate (GFR) and blood samples were withdrawn on day 3 for pharmacokinetic analysis. Baclofen was administered until extubation or tracheostomy and agitation-related events as well as the potential side effects of baclofen were noted.

RESULTS:

In this population, pharmacokinetic parameters [absorption latency time = 0.37 h, absorption constant rate = 2.2 h-1, apparent volume of distribution = 105 L, apparent clearance (l/h) = 13.5 × (GFR/103)0.839] were characterized by modified absorption and the influence of renal function: renal failure significantly increased baclofen exposure (p = .007) and significantly decreased baclofen clearance (p = .007) compared with patients without renal failure. When comparing patients with or without possible signs of baclofen toxicity, no difference was found regarding baclofen exposure (p = .34) and plasma peak concentration (p = .26).

CONCLUSIONS:

The a priori planned algorithm for dose adaptation according to renal clearance appeared to be suitable in our population. Daily administration of 150 mg of baclofen in ICU patients with preserved renal function did not lead to toxic concentrations in the plasma. A dose reduction of approximately 40%, 60% and 70% in patients with mild, moderate and severe renal failure could be suggested.

Link zum englischen Abstract Volltext auf Anfrage

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 jQuery('#synved-social-grey-script-marker-4').siblings('a.synved-social-grey').mouseover(function () { try { Pixastic.revert(jQuery(this).find('.synved-social-image').get(0)); } catch (ex) { } }).mouseleave(function () { try { jQuery(this).find('.synved-social-image').pixastic("desaturate"); } catch (ex) { } }).find('.synved-social-image').one('load', function() { try { jQuery(this).pixastic("desaturate"); } catch (ex) { } }).each(function() { if(this.complete) jQuery(this).load(); });

[eclecticstarlightblogger]

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους (more…)

[thoughtfullyblogger]

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους (more…)

[greekblogs]

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους

Migrants play soccer on the basketball court at the Guillaume-Bude secondary school, on which is painted in French “Solidarity with refugees” in Paris, France, August 2, 2015. REUTERS/Stephane Mahe

Στέγη και σίτιση σε δασκάλους, καθηγητές και πανεπιστημιακούς από τους Δήμους (more…)