#(anyway that's unrelated. enjoy the bmc stuff)
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5, 8, 18 for the ask game
5. first sentence of the fifth paragraph of an unpublished WIP
Jenna: “It’s free therapy.”
from the bapo au
8. if you had to write a sequel to a fic, you’d write one for…
not so much a sequel, but i've had this idea of turning im so obsessed with your ex into a chlodeline series based on more of olivia rodrigo's music but we'll see
in terms of sequel, i think one for "she's the sweet to your savoury." it would either be similar premise but with chloe helping jake out with an anniversary thing or we switch perspectives and go to rich and brooke
18. if you keep them, share a deleted sentence or paragraph from a published fic
i don't have any deleted snippets from any fics. i was going to share some from my graphic novel wip but those are. not good. so here's the link to my BMC Fic Scraps doc again
#lohst.txt#ask tag#h0n3yk1tt3n#ask game#recollections i love you but my writing has gotten much better than when i first started working on you#or. i like the way i write now so much better#(but if mutuals want to read any of the stuff i have written for this project i will share the google drive with it all)#(i like to talk about it but have no one to talk to about it)#(anyway that's unrelated. enjoy the bmc stuff)
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To Do List:
What's up, my Herd of Nerds?
Anyway, as you can tell, tomorrow is AU Sunday. But, because it's one after a 'my input' one, it's a follower input AU day! Yay!
So, send me your AUs and I'll put all of em in a hat to pick one randomly. The winner is picked and posted and we'll all try and make headcanons about your AU.
Done:
Zombie Apocalypse AU :: (https://hermitcraftheadcanons.tumblr.com/post/618314308275863552/zombie-apocalypse-au-masterpost)
Pirate AU ::
Currently In The Raffle:
-Toy Story AU.
-Ever After High/Descendants/Vaguely 'nex gen priness' AU.
-Eldritch Horror AU :: Or if that's a bit too out there, a more normal Monster AU. I don't care, but in my heart, I know Cleo is some kind of eldritch horror. Zombie is far too easy.
-Eldritch Monster AU! Hermits are all Lovecraftian horrors who all individually decided that they wanted to pretend to be normal and are all trying to hide their otherworldliness. I also feel like Mumbo or X or someone as the one actually "normal" player on the server would work well. Most hermits don't know that everyone else isn't normal either, but some find out about friends maybe.
-Rabid Debate Club AU :: Random weird au idea where it's basic hs/uni au but like two of them try to start a debate club, then invite some friends just so there's enough people; cut to like two months later, it's all the hermits just fighting over whether or not pineapple should go on pizza or not lol it isn't very good i'm sorry but ya know rabid debate club AU.
-Animal/shapeshifting AU :: (Suggested Twice.) Every hermit can shapeshift into one token animal. (If it's something like "dog," they can only turn into one breed and color of dog, EXAMPLE: doc can shift into a black sable belgian malinois, but not anything else.)
-Wedding Planners AU :: Hermits work in various unrelated businesses such as a bakery, flower shop, etc., but see each other semi-often bc they're semi-often called upon to work together by another hermit's wedding planning business (obvs if you couldn't tell i know absolutely nothing abt wedding planning & businesses n shit lol but it's the /concept/ of it yannknow)
-Avatar: The Last Air Bender AU. (Suggested Thrice.)
-Fusion AU :: (Also suggested by Anon.) (Suggested Twice.) What if Hermits could fuse with each other? (Viva and Jumbo fused into MumboJumbo.)
-SCP AU :: The hermits have spooky powers and are kept locked up bc of it (or they have to keep the world safe from monsters and cursed objects!)
-RPG AU :: I feel like someone already thought of that but I am just wondering about it lately :p -🍋
-Adventure Time AU :: The hermits live in a post-apocalyptic world and the Lich (bad guy) is making everything decay. They need to gather all the gems (belt colours) to unlock the Enchiridion (a book) and have one wish each granted from Prismo (multiverse wish granting dude) before the Lich does. Only 4 elements can enter the multiverse: Slime (The Lich & Jevin), Redstone (Tango or Mumbo?), Ice (Stress), and Dirt (Grian, much to his dismay). Only the elementals can see the book. Grian's the protagonist with his sidekick Scar. He originally started collecting the belts because they were shiny but eventually decided to read the book and find out what they were for when Scar said he didn't see it. Doc, False, and Iskall are major obstacles because they don't believe the book exists.</p>
-Total Drama Island AU.
-Magical Girl AU :: Zedaph's the lead magical girl and rounds up a bunch of other magical girl hermits.
-Pokeman AU :: What are the Hermit's roles in this world? Who's the Champion, Elite Four. Are they scientists? Trainers? Do they compete in competitions, do they specialize in types? Who's everyone's starter? Has anyone encountered any legendaries?
-College AU
-High School AU
-Wizard101 AU :: I (🦊) recently got this AU idea and recently started going off somewhere with it in terms of writing, but, like, Hermitcraft meets Wizard101. Tons and tons of magical shenanigans, monster hunting, and idk what else.
-Magic AU
-My Hero Academia AU :: Headcanons can be about which hermits would have what quirks and occupations based on them.
-So I'm writing an AU where there's a second game of Demise but 5 years later. So far the first 2 hermits (Joe and Xisuma) have died, and their dead forms are cracked with an arrow in his chest (Xisuma) and cyborg (Joe). So since it's Saturday, I'm looking for what some skins would look for.
-City AU :: I mean this is really just a normal everyday AU.
-School AU.
-Terraria-Minecraft Fusion AU :: Who chooses what class? what events do each hermit prefer? how to they deal with the world infections? preferred biomes? Favourite NPCS? It has potentiallllll.
-70s/80s Teen Horror AU :: (like Stranger Things, Carreie, The Lost Boys, Halloween, etc.) -🦇
-Demi-God AU :: Sort of like percy jackson (everyone being the children of different gods from all different cultures.)
-Supernatural AU
-Marching Band AU :: Xisuma is the band major and all the show music is the remixes. I need to come up with some ideas for uniforms. Outfits and flags for the colorguard too.
-Different Eras AU :: (Suggested Twice.) All the hermits are from different time periods or eras. Like Wels is from the mediveal/dark era, Mumbo is from 1890-1920's, Iskall is from 2030, TFC is from 2020(?), Cleo is from 2130, etc!!! Like the mobs/animals became feused with humans, is when the mob players came from.
-Star Trek AU :: Like maybe they could be on one ship and each have different roles like engineers or doctors? I don’t know if this has been suggested but hope you enjoy! - 🐦
-House Mates AU :: ApartmentAU but scaled down?
-Atlantis AU :: (Could be merged with Mermaid AU???)
-Fighting Game AU :: Some influences would be Street Fighter, Mortal Kombat, and Ultra Instinct, that kind of stuff.
-Time loop AU :: The hermits each have to deal with their own time loop.
(All those above in red are from our community's lovely Anons!)
-Superhero/superpower AU :: They each have a unique power/powerset that is in some way connected to their personality. (ie Mumbo *could* control electricity because of his love of redstone) Some Hermits may even choose to be "villains" and prank their other servermates. If you need power ideas, I've got a couple. (12u3ie)
-Daycare AU :: The recap peeps are the caretakers :P (-@tikauniverse.)
-Incredibly Long Cross Country Train Ride AU :: they all are in the same train car, telling stories of where they’re going, backstories.)
-Stuck In An Airport AU :: pretty similar to train au but they can be going diff places.
-Doctors AU :: they’re all doctors working at the same hospital.)
-Circus AU (Also suggested by an Anon.) (Suggested Twice.)
-Spy AU (Also suggested by @shadeswiftdraws.) (Suggested Twice.)
-Runaways AU :: The hermits are all teenagers who have run away from home, they all live on the streets until TFC takes them in. Head canons can be about backstories, living on the streets, or when they’re with TFC.
-Criminals and Police Officers AU
(-@lookitsspacekween)
-Dancer AU :: I mean, I already got a list kind of planned out, but headcanons for why specific styles are chosen would be appreciated! :) (usedtobelucythefallenangel)
-Broadway/Musicals Hermits AU :: The hermits are all casts of various musicals and when this newly-built theater opens up they all fight for which musical gets to play in it first (they have a riff-off maybe?) musicals mainly included are Hamilton, BMC, DEH, SiX, Beetlejuice, etc (feel free to add more!) (-@heyitsroby.)
-DnD AU (Also suggested by Anon.) (Suggested twice.)
-Mermaid AU :: In honor of the end of Mermay
-Space exploration AU :: There could be different ships, command centers, aliens.... Maybe someone could even get stranded/crash on a new planet? Who knows, could be fun.
-Paranormal/ghost hunter AU :: A couple Hermits could be the ghost hunters going to haunted locations to prove/disprove their hauntedness, others could be camera crew, owners of haunted buildings, or even the ghosts themselves.
-Camping/Vacation AU.
-Summer Cottage AU :: They all spend summers/weekends along the same shoreline and do different summer activities together. Outdoor fun and shenanigans!
-Space AU :: like star trek or similar.
-I would say evil clone au but I think that's pretty much the entire Hermitcraft tumblr right now lol. (Suggested twice.)
(-@shadeswiftdraws.)
-Magic AU :: Magic exists and all the hermits have powers. They can also summon a weapon but what that weapon is depends on the hermit. I'm thinking it'll take place in a sort-of Demise 2 in S7 with a big war. So far I've got: Grian - Cloning himself to his different personas (each has a different power). Xisuma - Making barriers, teleporting, and transforming into different mobs. Scar - Making mutant plants & boosting other hermits' attack & health. (-@datsaltyperson.)
-Demon AU :: Something enters the overworld and turns into a supernatural style-demon through Dimentional Distortion. Who gets posessed first, who goes crazy, and who actually kills it? Honestly I think that, if anything, Tango would know how to gank it, for obvious reasons. (-@fireflower-dusk.)
-High Street AU :: Everyone owns a different shop on the same street or some run a shop together (-@violets-arepurple.)
-Cat AU :: Either they're were always cats, or Hels turned everyone, including himself, into a cat, and they have to survive and overcome challenges in the Season 7 world. An example of a challenge would be Cub's a Sand Cat(the cats that always look like kittens no matter how old they are and live in deserts), and everyone's not sure if he can actually swim, so they have to find a way for him to get around without involving water. (-@scp10000.)
-How about a secret AU.. Every hermit has their big secrets and when Grian joined. He doesn't really know anything about those secrets even till season 7. Not many hermits talked to him in S6 anyway.. Mumbo was the closest to him so they would have regular chats For Iskall is mostly business related things Grian wants to know why so he set out on a quest to force the others to at least talk to him so he wouldn't be lonely. (-@babylightstudentbiscuit.)
-Hermit Family AU :: Xisuma is very busy dad but when he isnt busy the kids and younger hermits annoying the hell out of him. Grian once asked to use Xisuma's computer and crashed the whole thing trying to download illegal gamesites and get money off the internet. Mumbo and his trains run through the entire house and Xisuma trips on them daily. (-@gamerutx.)
-College AU!! But they are not students. THEY ARE THE TEACHERS (-@ivi-prism.)
Ones I planned to do anyway but Hermitblr Hivemind and all that:
Battle of The Bands AU: i believe u once mentioned a bands/ battle of the bands au... thats my jam... (Anon.)
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Hey, so, I know you're not in the BMC fandom anymore but are you still interested in the dynamics between Jeremy and the SQUIP you've discussed (like Carnival Ride)? I'm not asking you to write more, because I know you aren't really writing BMC stuff any more. But if you still hve any interest in that dynamic I have a video I'd like to share with you. (If you aren't that's fine I know it's been awhile since you've been really into BMC)
Hey anon,
This answer got a bit long, and I want to preface it with the qualification that in the third paragraph and onward, I’m speaking generally about BMC fandom, and not about you specifically. I have no way of knowing your intentions here, and don’t want it to sound like I’m accusing you of anything! This ask just seemed like a good jumping off point to talk about some common behaviors in the fandom that bothered me when I was in it.
I’ve been going back and forth about whether to answer this question. It’s very thoughtful that you want to share a vid about one of my former interests with me and I appreciate that, but the truth is, I’m just not interested in BMC anymore. I sat on this ask because it seemed unnecessary and a little mean to answer it just to say, “No I don’t want to see your fanvid/animatic”, but I didn’t want to keep you hanging either.
The other thing is, I’m leery of answering asks to this effect because I’ve had multiple negative experiences in BMC fandom with people who would begin conversations with “I want to show you a thing!” and attempt to end them with, “Anyway, will you give me feedback on my [fic/fanart/fanvid]” after I agreed. Whether they were just socially oblivious or attempting to corner me into being their beta because they knew I’d feel rude about saying no at that point, I don’t know. But there were multiple people who attempted to pressure me into this multiple times, and there was at least one person who, after I told them no, would make future attempts like this on anon, which was difficult for me not to interpret as an attempt to trick me into giving them feedback. Sometimes they’d send me innocuous anon messages about unrelated things just to check if I was online, and once I’d respond, would immediately message me again on their handle with these kinds of requests. Sometimes they deliberately varied their speech patterns on anon so I’d have a more difficult time telling it was them. This left a bad taste in my mouth and put me off answering a lot of anon messages.
I’m glad people in BMC fandom enjoyed my fic and valued my input on their own creative work. That was immensely flattering and gratifying. But creators don’t owe you (general you) their time or attention, and fandom creators being more accessible doesn’t make you any more entitled to either. I only give feedback on stuff my friends make because a) I am constantly time-poor and if I’m not selective about where I invest it I will run out of hours in the day, b) it’s awkward giving potentially less-than-positive feedback to people who you don’t know well who might take it the wrong way (another thing that happened in BMC fandom, after the person assured me they wanted my honest feedback).
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Does Red Meat Give You Colon Cancer?
Have you heard? There’s a new “red meat will kill you” study. This time, it’s colorectal cancer.
Here’s the press release.
Here’s the full study.
I covered this a couple Sundays ago in “Sunday with Sisson.” If you haven’t signed up for that, I’d recommend it. SWS is where I delve into my habits, practices, and observations, health-related and health-unrelated—stuff you won’t find on the blog. Anyway, I thought I’d expand on my response to that study here today.
How the Study Was Conducted
It’s the basic story you see with most of these observational studies. Around 175,000 or so people were asked to recall what they ate on a regular basis—a food frequency questionnaire. This is the exact questionnaire, in fact. The research team took the answers, measured some baseline characteristics of all the subjects—socioeconomic status, exercise levels, whether they smoked, education level, occupation, family history of colorectal cancer, and a few others—and then followed up with participants an average of 5.7 years later to see how many had developed colorectal cancer.
What the Study “Showed���
Those who had moderate amounts of red meat had a 20% higher chance of getting cancer.
And in the end, the increased risk was a relative risk. It wasn’t a 20% absolute increase in risk. It was a relative increase in risk. The subjects started with a 0.5% risk of getting bowel cancer. In those who ate the most processed meat and red meat, that risk increased 20%—to 0.6%!
From 0.5 to 0.6%. Sure, that’s an increase, but is it something to overhaul your entire diet for? To give up the best sources of zinc, iron, B vitamins, protein, carnosine, creatine? All that for a measly 0.1% that hasn’t even been established as causal?
Study Findings Most News Outlets Won’t Include
One head scratcher that leaps out: the link between unprocessed red meat and colon cancer was not actually statistically significant. Only processed meat was significantly linked to colon cancer.
Another head scratcher: red meat, whether processed or unprocessed, had no significant association with colorectal cancer in women. Why didn’t they highlight the fact that in women, eating red meat was completely unrelated? That’s half the world’s population. That’s you or your mom, your daughter, your grandmother, your girlfriend. And unless they were to look at the full study and read the fine print, they’d never know that red meat actually had the opposite relationship. You’d think the authors would want to mention that in the abstract or see that the press releases and media treatments highlighted that fact.
It’s probably because mentioning that red meat was neutral in women and had no statistically significant link to colon cancer in men and women would have destroyed their case for red meat as an independent carcinogen. See, carcinogens are supposed to be carcinogens. There are many meaningful differences between men and women, but a poison is a poison.
What’s the proposed mechanism for red meat triggering colon cancer in men but not in women? If they didn’t have one (and I imagine they wouldn’t have mentioned it if they did), then there’s probably something else going on.
Besides, the literature is far from unequivocal.
What Other Research Says About Red Meat and Bowel Cancer
In analyses that include consideration of cooking methods and other mitigating factors, red meat has no relationship with colon cancer.
Or what about this study, where colon cancer patients were more likely to eat red meat, but less likely to have type 2 diabetes? Should people avoid red meat and work toward getting diagnosed with type 2 diabetes?
Or how about this study, which found no difference in colorectal cancer rates between people who ate red meat-free diets and people who ate diets containing red meat? Shouldn’t the diet without any red meat at all have some effect?
Or this classic study, where rats on a bacon-based diet had the lowest rates of colon cancer. In fact, bacon protected them from colon cancer after they were dosed with a colon cancer promoter, while rats on normal “healthy” chow were not.
The Blind Spot In Red Meat Research
I don’t need to go into all the confounding factors that might predispose conventional red meat lovers to bowel cancer. Nor will I mention that it’s impossible to fully control for variables like the buns and bread and fries you eat the red meat with and the industrial seed oils it’s cooked in.
That last bit is crucial: the seed oils. It’s what nearly every cancer researcher misses. It’s not just a minor variable; it’s quite possibly the most important determinant of whether meat is carcinogenic in the colon or not. Heme iron—the compound unique to red meat that usually gets the blame for any increase in cancer—is most carcinogenic in the presence of the omega-6 fatty acid linoleic acid.
In one study, feeding heme iron to rats promoted colon cancer only when fed alongside high-linoleic acid safflower oil. Feeding MUFA-rich and far more oxidatively-stable olive oil alongside the heme prevented the colon carcinogenesis.
Another study had similar results, finding that meats containing medium to high amounts of heme—beef and beef blood sausage—promoted carcinogenic conditions in the colon when the fat sources were linoleic acid-rich corn and soybean oil.
And most recently is this paper. Mice were split into three groups. One group got heme iron plus omega-6 PUFA (from safflower oil). One group got heme iron plus omega-3 PUFA (from fish oil). The third group got heme iron plus saturated fat (from fully hydrogenated coconut oil, which contains zero PUFA). To determine the carcinogenicity of each feeding regimen, the researchers analyzed the effect the animals’ fecal water (which is exactly what it sounds like) had on colon cells. The fecal water of both PUFA groups was full of carcinogenic indicators and lipid oxidation byproducts, and exposing colonic epithelial cells to fecal water from PUFA-fed mice was toxic. The coconut oil-derived fecal water had no markers of toxicity or lipid oxidation.
I never see these (animal) studies cited in observational studies of meat and colon cancer. I think that’s a huge blindspot, and it’s one of the reasons I rarely put any stock in these scary-sounding studies.
That’s it for today, folks. Thanks for reading. Now go enjoy a steak.
I just might do that myself—my favorite grass-fed steak actually. Check out Butcher Box if you’re looking for cooking inspiration—and an excellent source for healthier, grass-fed, pastured and heritage breed meats. Full disclosure: I’m an affiliate—but also a long-time happy customer. Thanks again, everybody.
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window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '74506' });}
References:
Bylsma LC, Alexander DD. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015;14:125.
Alsheridah N, Akhtar S. Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study. BMC Cancer. 2018;18(1):1227.
Rada-fernandez de jauregui D, Evans CEL, Jones P, Greenwood DC, Hancock N, Cade JE. Common dietary patterns and risk of cancers of the colon and rectum: Analysis from the United Kingdom Women’s Cohort Study (UKWCS). Int J Cancer. 2018;143(4):773-781.
The post Does Red Meat Give You Colon Cancer? appeared first on Mark's Daily Apple.
Does Red Meat Give You Colon Cancer? published first on https://drugaddictionsrehab.tumblr.com/
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Text
Does Red Meat Give You Colon Cancer?
Have you heard? There’s a new “red meat will kill you” study. This time, it’s colorectal cancer.
Here’s the press release.
Here’s the full study.
I covered this a couple Sundays ago in “Sunday with Sisson.” If you haven’t signed up for that, I’d recommend it. SWS is where I delve into my habits, practices, and observations, health-related and health-unrelated—stuff you won’t find on the blog. Anyway, I thought I’d expand on my response to that study here today.
How the Study Was Conducted
It’s the basic story you see with most of these observational studies. Around 175,000 or so people were asked to recall what they ate on a regular basis—a food frequency questionnaire. This is the exact questionnaire, in fact. The research team took the answers, measured some baseline characteristics of all the subjects—socioeconomic status, exercise levels, whether they smoked, education level, occupation, family history of colorectal cancer, and a few others—and then followed up with participants an average of 5.7 years later to see how many had developed colorectal cancer.
What the Study “Showed”
Those who had moderate amounts of red meat had a 20% higher chance of getting cancer.
And in the end, the increased risk was a relative risk. It wasn’t a 20% absolute increase in risk. It was a relative increase in risk. The subjects started with a 0.5% risk of getting bowel cancer. In those who ate the most processed meat and red meat, that risk increased 20%—to 0.6%!
From 0.5 to 0.6%. Sure, that’s an increase, but is it something to overhaul your entire diet for? To give up the best sources of zinc, iron, B vitamins, protein, carnosine, creatine? All that for a measly 0.1% that hasn’t even been established as causal?
Study Findings Most News Outlets Won’t Include
One head scratcher that leaps out: the link between unprocessed red meat and colon cancer was not actually statistically significant. Only processed meat was significantly linked to colon cancer.
Another head scratcher: red meat, whether processed or unprocessed, had no significant association with colorectal cancer in women. Why didn’t they highlight the fact that in women, eating red meat was completely unrelated? That’s half the world’s population. That’s you or your mom, your daughter, your grandmother, your girlfriend. And unless they were to look at the full study and read the fine print, they’d never know that red meat actually had the opposite relationship. You’d think the authors would want to mention that in the abstract or see that the press releases and media treatments highlighted that fact.
It’s probably because mentioning that red meat was neutral in women and had no statistically significant link to colon cancer in men and women would have destroyed their case for red meat as an independent carcinogen. See, carcinogens are supposed to be carcinogens. There are many meaningful differences between men and women, but a poison is a poison.
What’s the proposed mechanism for red meat triggering colon cancer in men but not in women? If they didn’t have one (and I imagine they wouldn’t have mentioned it if they did), then there’s probably something else going on.
Besides, the literature is far from unequivocal.
What Other Research Says About Red Meat and Bowel Cancer
In analyses that include consideration of cooking methods and other mitigating factors, red meat has no relationship with colon cancer.
Or what about this study, where colon cancer patients were more likely to eat red meat, but less likely to have type 2 diabetes? Should people avoid red meat and work toward getting diagnosed with type 2 diabetes?
Or how about this study, which found no difference in colorectal cancer rates between people who ate red meat-free diets and people who ate diets containing red meat? Shouldn’t the diet without any red meat at all have some effect?
Or this classic study, where rats on a bacon-based diet had the lowest rates of colon cancer. In fact, bacon protected them from colon cancer after they were dosed with a colon cancer promoter, while rats on normal “healthy” chow were not.
The Blind Spot In Red Meat Research
I don’t need to go into all the confounding factors that might predispose conventional red meat lovers to bowel cancer. Nor will I mention that it’s impossible to fully control for variables like the buns and bread and fries you eat the red meat with and the industrial seed oils it’s cooked in.
That last bit is crucial: the seed oils. It’s what nearly every cancer researcher misses. It’s not just a minor variable; it’s quite possibly the most important determinant of whether meat is carcinogenic in the colon or not. Heme iron—the compound unique to red meat that usually gets the blame for any increase in cancer—is most carcinogenic in the presence of the omega-6 fatty acid linoleic acid.
In one study, feeding heme iron to rats promoted colon cancer only when fed alongside high-linoleic acid safflower oil. Feeding MUFA-rich and far more oxidatively-stable olive oil alongside the heme prevented the colon carcinogenesis.
Another study had similar results, finding that meats containing medium to high amounts of heme—beef and beef blood sausage—promoted carcinogenic conditions in the colon when the fat sources were linoleic acid-rich corn and soybean oil.
And most recently is this paper. Mice were split into three groups. One group got heme iron plus omega-6 PUFA (from safflower oil). One group got heme iron plus omega-3 PUFA (from fish oil). The third group got heme iron plus saturated fat (from fully hydrogenated coconut oil, which contains zero PUFA). To determine the carcinogenicity of each feeding regimen, the researchers analyzed the effect the animals’ fecal water (which is exactly what it sounds like) had on colon cells. The fecal water of both PUFA groups was full of carcinogenic indicators and lipid oxidation byproducts, and exposing colonic epithelial cells to fecal water from PUFA-fed mice was toxic. The coconut oil-derived fecal water had no markers of toxicity or lipid oxidation.
I never see these (animal) studies cited in observational studies of meat and colon cancer. I think that’s a huge blindspot, and it’s one of the reasons I rarely put any stock in these scary-sounding studies.
That’s it for today, folks. Thanks for reading. Now go enjoy a steak.
(function($) { $("#dfGNJIv").load("https://www.marksdailyapple.com/wp-admin/admin-ajax.php?action=dfads_ajax_load_ads&groups=674&limit=1&orderby=random&order=ASC&container_id=&container_html=none&container_class=&ad_html=div&ad_class=&callback_function=&return_javascript=0&_block_id=dfGNJIv" ); })( jQuery );
window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '84166' });}
References:
Bylsma LC, Alexander DD. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015;14:125.
Alsheridah N, Akhtar S. Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study. BMC Cancer. 2018;18(1):1227.
Rada-fernandez de jauregui D, Evans CEL, Jones P, Greenwood DC, Hancock N, Cade JE. Common dietary patterns and risk of cancers of the colon and rectum: Analysis from the United Kingdom Women’s Cohort Study (UKWCS). Int J Cancer. 2018;143(4):773-781.
The post Does Red Meat Give You Colon Cancer? appeared first on Mark's Daily Apple.
Does Red Meat Give You Colon Cancer? published first on https://venabeahan.tumblr.com
0 notes
Text
Does Red Meat Give You Colon Cancer?
Have you heard? There’s a new “red meat will kill you” study. This time, it’s colorectal cancer.
Here’s the press release.
Here’s the full study.
I covered this a couple Sundays ago in “Sunday with Sisson.” If you haven’t signed up for that, I’d recommend it. SWS is where I delve into my habits, practices, and observations, health-related and health-unrelated—stuff you won’t find on the blog. Anyway, I thought I’d expand on my response to that study here today.
How the Study Was Conducted
It’s the basic story you see with most of these observational studies. Around 175,000 or so people were asked to recall what they ate on a regular basis—a food frequency questionnaire. This is the exact questionnaire, in fact. The research team took the answers, measured some baseline characteristics of all the subjects—socioeconomic status, exercise levels, whether they smoked, education level, occupation, family history of colorectal cancer, and a few others—and then followed up with participants an average of 5.7 years later to see how many had developed colorectal cancer.
What the Study “Showed”
Those who had moderate amounts of red meat had a 20% higher chance of getting cancer.
And in the end, the increased risk was a relative risk. It wasn’t a 20% absolute increase in risk. It was a relative increase in risk. The subjects started with a 0.5% risk of getting bowel cancer. In those who ate the most processed meat and red meat, that risk increased 20%—to 0.6%!
From 0.5 to 0.6%. Sure, that’s an increase, but is it something to overhaul your entire diet for? To give up the best sources of zinc, iron, B vitamins, protein, carnosine, creatine? All that for a measly 0.1% that hasn’t even been established as causal?
Study Findings Most News Outlets Won’t Include
One head scratcher that leaps out: the link between unprocessed red meat and colon cancer was not actually statistically significant. Only processed meat was significantly linked to colon cancer.
Another head scratcher: red meat, whether processed or unprocessed, had no significant association with colorectal cancer in women. Why didn’t they highlight the fact that in women, eating red meat was completely unrelated? That’s half the world’s population. That’s you or your mom, your daughter, your grandmother, your girlfriend. And unless they were to look at the full study and read the fine print, they’d never know that red meat actually had the opposite relationship. You’d think the authors would want to mention that in the abstract or see that the press releases and media treatments highlighted that fact.
It’s probably because mentioning that red meat was neutral in women and had no statistically significant link to colon cancer in men and women would have destroyed their case for red meat as an independent carcinogen. See, carcinogens are supposed to be carcinogens. There are many meaningful differences between men and women, but a poison is a poison.
What’s the proposed mechanism for red meat triggering colon cancer in men but not in women? If they didn’t have one (and I imagine they wouldn’t have mentioned it if they did), then there’s probably something else going on.
Besides, the literature is far from unequivocal.
What Other Research Says About Red Meat and Bowel Cancer
In analyses that include consideration of cooking methods and other mitigating factors, red meat has no relationship with colon cancer.
Or what about this study, where colon cancer patients were more likely to eat red meat, but less likely to have type 2 diabetes? Should people avoid red meat and work toward getting diagnosed with type 2 diabetes?
Or how about this study, which found no difference in colorectal cancer rates between people who ate red meat-free diets and people who ate diets containing red meat? Shouldn’t the diet without any red meat at all have some effect?
Or this classic study, where rats on a bacon-based diet had the lowest rates of colon cancer. In fact, bacon protected them from colon cancer after they were dosed with a colon cancer promoter, while rats on normal “healthy” chow were not.
The Blind Spot In Red Meat Research
I don’t need to go into all the confounding factors that might predispose conventional red meat lovers to bowel cancer. Nor will I mention that it’s impossible to fully control for variables like the buns and bread and fries you eat the red meat with and the industrial seed oils it’s cooked in.
That last bit is crucial: the seed oils. It’s what nearly every cancer researcher misses. It’s not just a minor variable; it’s quite possibly the most important determinant of whether meat is carcinogenic in the colon or not. Heme iron—the compound unique to red meat that usually gets the blame for any increase in cancer—is most carcinogenic in the presence of the omega-6 fatty acid linoleic acid.
In one study, feeding heme iron to rats promoted colon cancer only when fed alongside high-linoleic acid safflower oil. Feeding MUFA-rich and far more oxidatively-stable olive oil alongside the heme prevented the colon carcinogenesis.
Another study had similar results, finding that meats containing medium to high amounts of heme—beef and beef blood sausage—promoted carcinogenic conditions in the colon when the fat sources were linoleic acid-rich corn and soybean oil.
And most recently is this paper. Mice were split into three groups. One group got heme iron plus omega-6 PUFA (from safflower oil). One group got heme iron plus omega-3 PUFA (from fish oil). The third group got heme iron plus saturated fat (from fully hydrogenated coconut oil, which contains zero PUFA). To determine the carcinogenicity of each feeding regimen, the researchers analyzed the effect the animals’ fecal water (which is exactly what it sounds like) had on colon cells. The fecal water of both PUFA groups was full of carcinogenic indicators and lipid oxidation byproducts, and exposing colonic epithelial cells to fecal water from PUFA-fed mice was toxic. The coconut oil-derived fecal water had no markers of toxicity or lipid oxidation.
I never see these (animal) studies cited in observational studies of meat and colon cancer. I think that’s a huge blindspot, and it’s one of the reasons I rarely put any stock in these scary-sounding studies.
That’s it for today, folks. Thanks for reading. Now go enjoy a steak.
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window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '84166' });}
References:
Bylsma LC, Alexander DD. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015;14:125.
Alsheridah N, Akhtar S. Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study. BMC Cancer. 2018;18(1):1227.
Rada-fernandez de jauregui D, Evans CEL, Jones P, Greenwood DC, Hancock N, Cade JE. Common dietary patterns and risk of cancers of the colon and rectum: Analysis from the United Kingdom Women’s Cohort Study (UKWCS). Int J Cancer. 2018;143(4):773-781.
The post Does Red Meat Give You Colon Cancer? appeared first on Mark's Daily Apple.
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Does Red Meat Give You Colon Cancer?
Have you heard? There’s a new “red meat will kill you” study. This time, it’s colorectal cancer.
Here’s the press release.
Here’s the full study.
I covered this a couple Sundays ago in “Sunday with Sisson.” If you haven’t signed up for that, I’d recommend it. SWS is where I delve into my habits, practices, and observations, health-related and health-unrelated—stuff you won’t find on the blog. Anyway, I thought I’d expand on my response to that study here today.
How the Study Was Conducted
It’s the basic story you see with most of these observational studies. Around 175,000 or so people were asked to recall what they ate on a regular basis—a food frequency questionnaire. This is the exact questionnaire, in fact. The research team took the answers, measured some baseline characteristics of all the subjects—socioeconomic status, exercise levels, whether they smoked, education level, occupation, family history of colorectal cancer, and a few others—and then followed up with participants an average of 5.7 years later to see how many had developed colorectal cancer.
What the Study “Showed”
Those who had moderate amounts of red meat had a 20% higher chance of getting cancer.
And in the end, the increased risk was a relative risk. It wasn’t a 20% absolute increase in risk. It was a relative increase in risk. The subjects started with a 0.5% risk of getting bowel cancer. In those who ate the most processed meat and red meat, that risk increased 20%—to 0.6%!
From 0.5 to 0.6%. Sure, that’s an increase, but is it something to overhaul your entire diet for? To give up the best sources of zinc, iron, B vitamins, protein, carnosine, creatine? All that for a measly 0.1% that hasn’t even been established as causal?
Study Findings Most News Outlets Won’t Include
One head scratcher that leaps out: the link between unprocessed red meat and colon cancer was not actually statistically significant. Only processed meat was significantly linked to colon cancer.
Another head scratcher: red meat, whether processed or unprocessed, had no significant association with colorectal cancer in women. Why didn’t they highlight the fact that in women, eating red meat was completely unrelated? That’s half the world’s population. That’s you or your mom, your daughter, your grandmother, your girlfriend. And unless they were to look at the full study and read the fine print, they’d never know that red meat actually had the opposite relationship. You’d think the authors would want to mention that in the abstract or see that the press releases and media treatments highlighted that fact.
It’s probably because mentioning that red meat was neutral in women and had no statistically significant link to colon cancer in men and women would have destroyed their case for red meat as an independent carcinogen. See, carcinogens are supposed to be carcinogens. There are many meaningful differences between men and women, but a poison is a poison.
What’s the proposed mechanism for red meat triggering colon cancer in men but not in women? If they didn’t have one (and I imagine they wouldn’t have mentioned it if they did), then there’s probably something else going on.
Besides, the literature is far from unequivocal.
What Other Research Says About Red Meat and Bowel Cancer
In analyses that include consideration of cooking methods and other mitigating factors, red meat has no relationship with colon cancer.
Or what about this study, where colon cancer patients were more likely to eat red meat, but less likely to have type 2 diabetes? Should people avoid red meat and work toward getting diagnosed with type 2 diabetes?
Or how about this study, which found no difference in colorectal cancer rates between people who ate red meat-free diets and people who ate diets containing red meat? Shouldn’t the diet without any red meat at all have some effect?
Or this classic study, where rats on a bacon-based diet had the lowest rates of colon cancer. In fact, bacon protected them from colon cancer after they were dosed with a colon cancer promoter, while rats on normal “healthy” chow were not.
The Blind Spot In Red Meat Research
I don’t need to go into all the confounding factors that might predispose conventional red meat lovers to bowel cancer. Nor will I mention that it’s impossible to fully control for variables like the buns and bread and fries you eat the red meat with and the industrial seed oils it’s cooked in.
That last bit is crucial: the seed oils. It’s what nearly every cancer researcher misses. It’s not just a minor variable; it’s quite possibly the most important determinant of whether meat is carcinogenic in the colon or not. Heme iron—the compound unique to red meat that usually gets the blame for any increase in cancer—is most carcinogenic in the presence of the omega-6 fatty acid linoleic acid.
In one study, feeding heme iron to rats promoted colon cancer only when fed alongside high-linoleic acid safflower oil. Feeding MUFA-rich and far more oxidatively-stable olive oil alongside the heme prevented the colon carcinogenesis.
Another study had similar results, finding that meats containing medium to high amounts of heme—beef and beef blood sausage—promoted carcinogenic conditions in the colon when the fat sources were linoleic acid-rich corn and soybean oil.
And most recently is this paper. Mice were split into three groups. One group got heme iron plus omega-6 PUFA (from safflower oil). One group got heme iron plus omega-3 PUFA (from fish oil). The third group got heme iron plus saturated fat (from fully hydrogenated coconut oil, which contains zero PUFA). To determine the carcinogenicity of each feeding regimen, the researchers analyzed the effect the animals’ fecal water (which is exactly what it sounds like) had on colon cells. The fecal water of both PUFA groups was full of carcinogenic indicators and lipid oxidation byproducts, and exposing colonic epithelial cells to fecal water from PUFA-fed mice was toxic. The coconut oil-derived fecal water had no markers of toxicity or lipid oxidation.
I never see these (animal) studies cited in observational studies of meat and colon cancer. I think that’s a huge blindspot, and it’s one of the reasons I rarely put any stock in these scary-sounding studies.
That’s it for today, folks. Thanks for reading. Now go enjoy a steak.
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window.onload=function(){ga('send', { hitType: 'event', eventCategory: 'Ad Impression', eventAction: '67624' });}
References:
Bylsma LC, Alexander DD. A review and meta-analysis of prospective studies of red and processed meat, meat cooking methods, heme iron, heterocyclic amines and prostate cancer. Nutr J. 2015;14:125.
Alsheridah N, Akhtar S. Diet, obesity and colorectal carcinoma risk: results from a national cancer registry-based middle-eastern study. BMC Cancer. 2018;18(1):1227.
Rada-fernandez de jauregui D, Evans CEL, Jones P, Greenwood DC, Hancock N, Cade JE. Common dietary patterns and risk of cancers of the colon and rectum: Analysis from the United Kingdom Women’s Cohort Study (UKWCS). Int J Cancer. 2018;143(4):773-781.
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