#structure of dna

[er-cryptid]

[in-sightjournal]

Ask A Genius 1017: The Steven Stutts Session

Rick Rosner, American Comedy Writer, www.rickrosner.org Scott Douglas Jacobsen, Independent Journalist, www.in-sightpublishing.com Scott Douglas Jacobsen: Steven Stutts asks, “What do you think of the relationship between intelligence and awareness?” Rick Rosner: In fiction, I’m thinking of Sherlock Holmes, the genius who notices patterns in the world and details that people of regular…

[njere]

"You risked your own life to protect so much.

I couldn't bear to let that go to waste."

[twentyeightsuns]

something that always helps me whenever i am feeling unmotivated or resentful towards my studies (mostly because of the toxicity surrounding the competitive nature of the exams i am preparing for) is pausing for a sec and wondering how exactly the particular concept came to be in front of me. how many nights did the Curies spend awake discussing the whys and hows of radioactivity? how exactly did Henry and Raoult think of solvents exerting pressure differently in different cases? did Franklin have to worry about fighting patriarchy besides working on her discovery? did Stefan/Boltzmann ever know we'd be able to calculate the temperature of the Sun? did they know their passion and their love for their respective subjects would be influencing millions of lives down the road? did they? and so i take another breath, mutter a thank you w my head up and continue.

[deebrisbyfish]

Soooo, I generally DON'T get political or divisive in the strip... buuuuttt... it's PRIDE and, like with last week’s strip, I am kinda burnt out with seeing the same asinine arguments online over and over. Why do I have to defend my legal right to exist with people who learned biology from "Kindergarten Cop"?

[nocontextonepiece]

s hawk five minutes after being born

[monards]

rip rhinedottir taking middle school biology probably could’ve saved you

[febos]

Happy to share, ARTEMIS is now published at NAR!

https://doi.org/10.1093/nar/gkae758

ARTEMIS is a new tool for RNA/DNA 3D structure superposition and structure-based sequence alignment. Our benchmarks show that it outperforms the existing tools for both sequentially-ordered and topology-independent alignment.

ARTEMIS allowed us to identify an intriguing structural similarity between Lysine and M-box riboswitches (see the figure) and to describe the minor-groove/minor-groove helical packing motif. ARTEMIS is the first tool able to report several alternative superpositions, which makes it suitable for structural motif identification tasks.

ARTEMIS is available at GitHub: https://github.com/david-bogdan-r/ARTEMIS

Thanks to Davyd Bohdan, Janusz Bujnicki, & International Institute of Molecular and Cell Biology in Warsaw!

[theriancultureis]

Red panda (or rlly any cold weather creature) therian culture is not being able to STAND the cold, even despite the habitat of your kintype :((

yeah I cant handle anything that isn't 70 fahrenheight

cant handle the cold

cant handle the heat

[putting-ragatha-in-places]

put her in a dna structure

ragatha in a dna structure

[cbirt]

Scientists from Georgia State University, The University of Texas, and Lawrence Berkeley National Laboratory, USA, built models of transcription factor IIH (TFIIH) using cryo-electron microscopy (cryo-EM) to comprehend how it smoothly transitions between performing two vital yet vastly different functions, transcription initiation and nucleotide excision repair (NER). They employed simulations and graph-theoretical analysis and found that its two subunits, XPB and XPD, mediate conformational changes in TFIIH, enabling it to switch between transcription initiation and NER while ensuring that it performs only one function at a time. Another key observation they made was that diseases caused by TFIIH mutations can be grouped into distinct classes based on the interfaces of the constituents of TFIIH they affect.

The Fascinating Dynamism of TFIIH

TFIIH is a large and dynamic horse-shoe-shaped protein assembly consisting of ten subunits. The subunits include seven core ones (XPB, XPD, p62, p52, p44, p34, p8) and three CDK-activating kinase subunits (CDK7, Cyclin-H, MAT1). TFIIH is imperative to both transcription (enzymatic synthesis of RNAs from DNA templates), preinitiation complex (PIC), and nucleotide excision repair (removal of wide arrays of DNA lesions occurring due to UV radiation, reactive oxygen species, environmental and chemical mutagens), also called NER.

In transcription, TFIIH is a part of the assembly responsible for unwinding the DNA duplex and pushing it toward the RNA polymerase active site. TFIIH is basically the centerpiece of NER, as it assembles, coordinates, and regulates the NER machinery. And defects in NER are strongly associated with human genetic diseases such as Cockayne Syndrome, Xeroderma Pigmentosum, etc.

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[apatheticlexicographer]

okay but real talk

if m!leven was really, genuinely, unquestionably endgame then there would not be this much doubt and disbelief about it. there would be some, sure, but it would just be a tiny vocal minority like the byler community was before s4. somebody always wants to be contradictory. hundreds of thousands of people don't invest themselves heavily in that contradiction. millions don't feel casually favourable toward it.

it's an undeniable fact that the way season 4 was structured, on many levels, caused a large (large!!!) amount of people to doubt the stability of m!leven. for SO many people to switch over the course of just a month from either favourable to or actively shipping mike and el, to at the very least disliking their relationship and in many cases actively supporting the idea of mike and will instead??? that doesn't happen. it just. doesn't.

it's also an undeniable fact that, having been given an unfavourable perspective on m!leven's relationship by s4, many people have looked back on the previous seasons and noticed in retrospect how both the flaws of their relationship and the strengths of mike and will's have been present since the beginning. s4 didn't change the core of either relationship. all it did was finally strip back the layers that had always been a little transparent and put those cores on full display.

if m!leven was truly engame that wouldn't just mean that s4 was bad and it did such an inadequate job of making people root for its ship that it turned them away; it would mean that the entire show has been terribly written from the beginning concerning only these specific relationships.

it truly baffles me that so many diehard m!leven supporters (or at least, diehard byler antis, and we all know what that's code for😒😒) will happily take that as an explanation. they WANT their show to be badly written, because if it's well written then it's all too clear that the narrative is no longer in their favour. more than that: it never really was.

think about all the other relationships in the show, that fandom and GA alike concur are well written and compelling. think about jonathan and nancy, how the tension between them was evident from the beginning, but nancy was stuck in an increasingly unhappy relationship with steve. think about joyce and hopper, who have had painfully obvious chemistry for the whole show but took until well into the penultimate season to kiss. think about lucas and max, about the growing pains their relationship has gone through and how they only served to strengthen their connection. lumax in particular is the ultimate anti-m!leven, going through the same motions but with a natural chemistry and genuine connection that mike and el have never quite made believable. both the contrast between all three of these relationships and m!leven and the similarities they share with byler have been painfully clear for at least two seasons, and the elements that clash have been built since s1.

all of these relationships have had broad arcs that span across the seasons, and the dynamics have shifted accordingly every time. but mike and el??? their dynamic is the same as it was in s1, on the surface at least. and that's not cute or romantic, as much as the shippers would like to think it is. that's bad for them on an in-universe level and on a writing level as well. a static relationship is never compelling. the writers know this. they have demonstrated their ability to develop relationship arcs in new directions, that are predictable not because they're badly written and trite, but because they're well written and have been foreshadowed and eased into by the narrative whole seasons ahead of time.

if mike and el were truly meant to be, there wouldn't be this clash between them and every other pairing in the show. if mike and el were truly meant to be, their predictability would be like that of jancy, or jopper, or lumax. we know they'll work it out, we know they'll get together in the end, we know they'll grow closer as they grow up.

but, they don't. they don't work out the issues in their relationship. they argue about them, and then they ignore each other, and then they ignore the problems, and then they argue again. and again. and again. they don't get together in the end. if you count their first kiss as the unofficial beginning of their relationship, then they've been together in some capacity since s1. that's a whole season longer than any other endgame couple in the show. they don't grow up together. they grow up separated while el is hidden away, and then separated by tension from their breakup, and then separated by states' worth of distance and all the lies they build up between each other to lengthen it.

if they were "true love" then not only would these issues be either addressed and resolved in a satisfying manner or clearly primed for resolution in the next season, as is the case with the other ships, they wouldn't have been included in the first place. they wouldn't have been strewn throughout the early seasons for later consideration. they wouldn't have been overwhelmingly present in s3, but brushed off as comedy. they wouldn't have been put on full blast in s4 and shown for just what they truly are.

but coming up to s5, the show truly is reaching its climax. none of the relationships have been fully resolved yet. jonathan still needs to come clean to nancy, and nancy needs to let steve down. joyce and hopper still need to have their date at enzo's, and properly establish their relationship. max still needs to wake up, and i'm sure lucas will be responsible in some way for finding her. all of these relationships, however, have mirrored the main plot in their progression toward a climax. they're on the tipping point. if mike's monologue is to be taken at face value and the tension that follows it for the remaining runtime is ignored, el and mike have already reached the climax of their arc. never mind that their problems only continue to fester, unaddressed. never mind that mike and will sit on the same tipping point as the rest: half-addressed, with will's confession hidden in plain sight in the same way his feelings have been all along.

the last points to resolve in both relationships are obvious to us, not because we are "geniuses" for noticing them, but because they should be obvious, just like they are with every other relationship. not now in s4, when they aren't the focus and frankly shouldn't be, when the writers want to preserve one last layer of transparent mystery for the sake of an unbeatable talking point. it will be obvious in s5, when your dad and screenrant and the myriad reaction youtubers will all see as much as they always do: the surface level. and then they'll think back, remember the scenes that flashed by in the season recap. they won't feel decieved then, or even particularly subverted. they'll just see the story that has been told since the beginning. they'll feel satisfied, and if they don't then it has nothing to do with the quality of the writing and everything to do with their own prejudice.

[moldwood]

ok i've got a really cool idea for an ireena piece that will have to wait till after commissions because it's complex. i did the rough sketch but it's too rough to share. so instead i'll share this

[hadesknockedupintheunderworld]

Random funny thing to me is when people insist that two characters are basically siblings to each other and it's so weird to ship them (because they're connected in some way through a member of their family)

And the truth is that yes they can technically be considered family (in the nuclear family way) if you want them to be, but not because they're siblings. You actually have at least a miniscule argument here and yet you've lost arguing that they're basically siblings😂

[cherry-jamx]

Life is full of horrors, but I'll never be 26 again on a late August summer night, wandering through a Greek city in the pouring rain, wearing my most colorful sundress and holding hands with my close friends.

[kyngsnake]

question. would anyone be interested in reading my original universe content? hosted by local protagonist Avery Moreno as you might imagine. I've been considering sharing it because it's a solid 75% of what I've been putting my time into lately.