#she was born in 2008. that is an infant

[chellsiememmel]

all I ask is for hezly to have a hit on bars I just want her to have a good day

[fangirl-dot-com]

Reader Lore - Born to Break Records

So this is a little filler for between now and the next chapter. This chapter might have triggers for death, abusive parents, and brief mentions of bullying. If these make you uncomfortable, then please feel free to skip this chapter. The synopsis is the reader’s life up until her first race win in F2. 

Welcome to Reader-Lore

2003

The cry of a baby filled the sterile walls of the delivery room. Pants filled in the quiet moments, but were mostly covered. The wailing baby was placed into the arms of the waiting mother, the father looking down on the two. 

“It’s a girl,” the nurse told them, writing something down in a book. 

The atmosphere suddenly changed. The once hopeful air was dampened with disappointment. The father sighed loudly, turning his head to look out the window. The mother, who had held her baby tight, loosened her grip. Her nose was now scrunched in borderline disgust. 

The nurse, feeling the off energy, offered to take the baby girl. She made some excuse about needing to weigh her and make sure that she was healthy, things that could have waited until after the parents bonded. 

The mother was quick to hand her over, waiving her hand as though it wasn’t a big deal. The father had now moved farther away from the hospital bed. 

The baby had started to wail once more after being taken from the arms of her mother. Arms that she thought were safe. Arms connected to the body that had cared for her for 9 months. Arms that suddenly did not hold her tight. Arms that willingly gave her away to some stranger. 

Once the nurse and frightened infant left the from, the mother and father looked at each other. 

“I wanted a boy,” the male murmured.

The female rolled her eyes, “I know. And so did I. But we don’t have a choice anymore.” 

“We do. Could always leave her here. A boy would be able to break records. A girl is useless.” 

“And be arrested? No thank you.” The mother rolled on her side, arms around her front. The father just huffed. 

“Everything we talked about, our future, is now a wasted memory.” 

The mother looked at the door with a sliver of hope, although, it was too small for anyone to see it. “Maybe she can do everything that you wanted a boy to do.” 

“We can just have another baby,” the father persisted. 

“You heard the doctor. It would be too dangerous for me to have another. What’s done is done. You can walk out now if you can’t commit.” The woman went to say something else, but was interrupted by whimpers. 

The nurse had walked back in, now with a swaddled baby. Begrudgingly, the mother held her hands out to take the bundle of blankets. She looked down at the brand new baby, but her heart didn’t swell with pride like she read about. Her heart filled with distain, as if the baby were a Christmas present that she didn't want. But this time, she couldn’t return the baby like she’d return a gift at whatever store it was bought from. 

The father had taken a few steps closer to the bed, but kept his distance. There wasn’t a bone in his body that actually wanted the child. 

“We still need a name for her,” the nurse stated, clicking her pen. 

The mother glanced to the father before saying, “Y/n. Her name is Y/n.” 

2008 – Five years old 

The air was stuffy, filled with the scent of petrol and burnt rubber. The quiet that could have been was broken by the rattles of engines and throttles. You wished for silence. 

You wanted nothing to do with this. But, you’d rather get in a kart then flinch at your father’s hand. You had been allowed to wander around the track. The big boys were driving now. And by big boys, you meant 11- and 10-year-olds. They were bigger than you and drove karts that were so much faster than the little one that you had. 

You looked around. There was definitely not a shortage of girls hanging around, but none were dressed like you. Most were the older or younger sisters of the drivers. Their pink tops, paired with shorts or skirts, flowed in the wind. None of them were wearing an old itchy race suit that was two sized too big. They were allowed to wear sandals, while you had to endure the tight racing shoes that your dad had definitely yanked on the laces too much. It wasn’t your fault that you hadn’t learn to tie them yet. 

You watched their hair bounce in the tall pony tails tied on the tops of their heads. They didn’t need their hair to be wrapped in a bun at the base of their necks so that it could fit into a helmet. 

You wished that your mom and dad would allow you to cut it off so that you could be the boy that they wanted. You knew that they didn’t want you, your little mind was able to catch on to things like that. 

You understood patterns. Patterns on the track helped you know what areas to avoid. Patters on the kart taught you where to put your feet and hands. Patterns told you that moms and dads should be happy for their children, and not yell at them. Patters revealed that children did not flinch when their parents patted their heads or caressed their cheeks. 

The wind blew loud as the kart race came to a close. You knew that you needed to get back quickly to where you parents were waiting, but you wanted to see the winners, wanted to see them taste a victory that you were so desperate for. 

You squeezed past the other boys and looked up at the three on the podium. The one on the lowest step wasn’t rememberable. His hair looked the same as others. His height wasn’t tall or small, just in the middle. 

But the boys on the other two steps were. The one on the second pedestal had a shaggy hair cut, with bangs that pointed down. You had seen him before, surrounded by his family. A little brother, a big brother, mom and dad, and then a man who looked at the boy with stars in his eyes. 

You wished someone looked at you like that. 

“And in second place, Charles Leclerc.” So that was his name. Sharl. His eyes were bright green and filled with light and hope. But a sadness still glazed them as he looked up at the boy on the top step. 

The boy who towered over the crowd had blond sandy hair. For a winner, he didn’t look happy. His blue eyes didn’t hold the same brightness that the green eyes had. 

“And our winner, Max Verstappen!” 

That was a nice name. Max. You wanted to look at the boy winner for a few more moments. Engrave his image into your mind. Because, you didn’t know when the next time you’d be able to do this. Your dad would probably ban you from such things, saying something like you didn’t need to look at something you’d never achieve.

But you were hungry. 

You were taken out of your watching by the announcement that your own race was going to start soon. And you weren’t in your kart. 

You rushed through the crowd, trying to put on your bright pink helmet on. You could put your gloves on while you got into your kart. 

By the time you got there, your dad was already looking at you with a disappointed look. Your mother was nowhere to be found. 

“Where have you been,” he hissed, hitting your helmet. 

“I wanted to see the podiums,” you muttered, getting your gloves on. 

Your dad shook his head. “What have I told you about that?” 

“That I shouldn’t look at things that I can’t get.” 

“Exactly. Now get in your kart.” 

You did as he said. You heart was pounding as you taxied the little thing onto the smaller track. You were able to be seen by everyone, your helmet acting as a little flag. It seemed to say “look at me! I’m the only girl trying to be on par with all these boys! Watch me fail!” 

But you were determined to prove them all wrong. 

By the last lap, you were right behind one more kart. One more pass and you could win. Prove your dad wrong. Prove everyone wrong. 

You watched as he broke your pattern. The pattern that would help you win. 

He made a mistake, and you welcomed it with glee. 

You passed over the finish line with a significant gap behind you and that boy. At the stopping point, you parked your kart and stepped out, exhaling sharply. 

You thought that people would cheer and shout, but the silence that you had wished for earlier had come to haunt you. 

You won and there was nothing to celebrate. 

2015 – Twelve years old 

Everyone thought he was crazy. There was no way that he was going to sponsor a 12 year old in karting, a female none the less. 

He wasn’t crazy. How could he not want to sponsor you, a consecutive race winner in your league. He constantly watched you drive circles around the boys who would berate you in their free time. He watched as you would let their words roll right off your back. You didn’t let their words get to you.

But, he was your godfather and he had a sense of responsibility for you. He watched as you climbed out of the kart, looking around trying to find a familiar face. 

He could see your eyebrows raise through the visor when you caught sight of him. 

“LoLo!” you yelled, quickly sprinting over to him. He was ready to catch you, but not expecting the hit with your helmet. 

He let out an oof as you knocked him slightly off balance. 

“Hey kid! You did good!” He rubbed your helmet as if it were hair. You quickly unbuckled the pink contraption and took it off, hair sticking to your forehead. 

You looked around before your shoulders slumped. You kicked a rock as you spoke, “They didn’t come.” 

Lorenzo had noticed a lack of your parents as soon as he arrived. He would have come earlier to help you with your kart if he had known that they weren’t here. He looked down at you with sad eyes, and that’s the last thing you wanted. 

You always wished for someone to look at you with so much love and affection that it poured out of their soul. But you only ever got looks of hatred and pity. 

He rubbed your shoulder, “It’s ok kid. But you wanna know something?” He crouched down to your level, pant legs getting damp with moisture. You nodded your head. “LoLo gets to sponsor you!” 

You gasped, eyes tearing. Even though you were twelve, you knew the weight of the situation. Your parents had told you that because you were winning, you were embarrassing them. And because you were embarrassing them, they wouldn’t pay any more years of karting after this one. You wailed when you told Lorenzo the next time you saw him. And he saw your heart break into itty bitty pieces while you did. 

When you left, he looked into every possibly way that he could keep you in karting. The only option was to sponsor you.

And sponsor you he did. He emailed, texted, and called multiple companies, trying to get their support. He would get sponsorship to put on your kart so that you could carry the logos proudly. He had your new one sitting in the back of his old truck, but that was a surprise. It was blue with two proud bulls on the very front. He had done it. He found you a sponsor that would keep you going for a couple of years. 

His thoughts were interrupted by you actually knocking him over. He knew his sweater was getting damp, but he didn’t care. He just wanted to see you smile for the rest of his life. 

You were too busy whispering thank you after thank you for you to notice the weird looks that you were getting. Looks from the boys that you had just beaten. Looks from the parents who didn’t know the worries of paying for karting. 

He quickly picked you up and took you back over to get your cart. He helped you load it on the mover and rolled it over to his truck. You wouldn’t be needing this kart that was almost falling apart. You had a new one, and you’d be all right. 

You talked the whole way home, animatedly moving your hands around as you described your latest win. Your hands rolled over the other as you showed him how you turned the wheel, barely clipping the front of the kart who wanted to push you off. 

Lorenzo only looked at you with pure adoration. A look that you wanted so much, but were too busy to see due to your explanations of your imaginations. 

Maybe he was crazy, but he didn’t think so. 

2019 – Sixteen years old (F3)

Your eyes were pricked with tears as you read the letter you received in the mail. The big letters of DISOWNMENT flashed in the reflections. They had done it weeks ago, according to the date on the top of the paper. By now, your things were probably thrown away or burned.   

You had just finished the F4 category and were making a name for yourself in F3. You couldn’t deal with this now. One of the management people came and knocked on your door, telling you that the race was about to start. 

You crumpled the paper up and threw it in the trash. If they didn’t need you, you didn’t need them. That was the lie you continually told yourself. Of course a girl needed her parents. They were the people who were supposed to nurture you and help you. 

But they never did that in the first place. At least you didn’t have to constantly buy drug store foundation and concealer and try to explain the black and blue around your eyes after it melted off during the race. No more flinching. No more hiding. 

Just no more. 

You would call Lorenzo and see if you could stay with him for a bit during the break. You would have to or you wouldn’t have a place to sleep. 

Your breath shuddered at the thought. 

You told yourself that you knew this was coming. They had cut all contact with you months ago and weren’t spotted when you went home during the last break. 

You allowed the tears to fall as you got your helmet on. No one would see the streams as you placed your visor down. You were now hidden away from the weird looks that everyone sent you. No girl had ever made it this far. 

Sure as you grew, there were girls in karting. That number seemed to increase in F4. Most of them were from the driver academies. You were still able to participate due to multiple sponsorships that Lorenzo had gotten you. 

But with increase, there has to be a decrease. You were currently the only female in F3 and were set to be the only female to make it to F2. Well, that’s what everyone told you. Your stats reflected your need to prove yourself. 

Race win after race win helped thrust you through the blockades built by men. They wouldn’t stop you, and you didn’t want to stop. Not now, not ever. 

Each race win fueled your hunger in this world. And it only grew and grew. 

Your tears were brushed away by the wind brushing through your car. At that moment, you told yourself that you wouldn’t cry over your parents ever again. They didn’t deserve them. 

You could cry about other things. Such as passing over the finish line, marking your first win in F3. 

You constantly showed the world that you could do it. You wanted to cry again as you listened to your anthem. You wanted to cry when the boys celebrated with each other, leaving you out. You wanted to cry as you walked back to your “motor home,” knowing that it was put up quickly for you. 

The time you finally let yourself cry was when you were talking with Lorenzo on the phone. Your eyes were tired and dehydrated by the time you quit. Lorenzo was able to calm you down. He told you that he would take care of everything, take care of you. 

You knew you wouldn’t be able to see him much though. The F3 calendar was far busier than the F4 one had. And you knew the moment you entered F2, time for relaxation would be far and few between. 

But you had Lorenzo to fall back on when the times got hard. You could always count on him. 

2020 – Seventeen years old (F2)

It was too soon. Too too soon. It wasn’t fair either. Your tears had not stopped streaming down your face since you arrived. The sterile smell itched your nose, but you needed to be here. For him. 

He had gotten paler in the few moments since you had been there. His breath rattled with each inhale and exhale. And each breath brought more tears. You didn’t want to let him go. 

“Please LoLo. I can’t do this without you,” you whispered, knowing that he probably would not hear you. The doctors told you that he was far too gone for that, but you liked to believe that he was still listening. “You can’t leave me like everyone has. I can’t be alone. I need you.” You put your face down in the blankets, squeezing his hand. 

The nurses stood in the door, with tears of their own. They were watching a child lose the only family that she had left. 

You inhaled sharply, wiping your tears away.

“You know I’m going to do it. For you. It’s only ever been you. You’ve been my best friend and I don’t know how I’m going to get through this scary world without you.” You hiccupped. “But, I know that you need to go. And I’m being selfish for keeping you here.” 

You stood and kissed his forehead. 

“Thank you LoLo, for everything. I love you.” 

His chest rose, fell, rose, and fell. 

But didn’t rise again. The multiple beeps from the different machines let you know that he was gone. And he wasn’t coming back. 

One of the nurses came and rubbed your back as you sobbed, not caring who heard you. Your tears did not stop. 

They didn’t stop on the plane to Bahrain. They refused to dry up during the practices as you set record times. They let up as you gave post-practice interviews, saving you from being embarrassed. 

You cried as you put your helmet on. Stickers had been placed on it the night before with Lorenzo’s name and dates of birth and death to commemorate his legacy that would continue through you. 

You knew this race was important. You heard that multiple F1 drivers were there to watch. And you’d give them a spectacle, before hiding away to burry your dead godfather. You hoped that the blond kid with blue eyes that had grown up by now was there. He didn’t need to know that you looked up to him. You just hoped that he’d be there. And possibly the green eyed Justin Bieber look-a-like as well, you had followed him too. 

You had managed to score a P5 starting on the grid and you knew it would be tough to fight for the front. But you had a feeling that you’d be just fine. 

And just fine you were. 

You all hauled your F2 car over that finish line, finishing with a gap of 10 seconds. Your crew was screaming in your ear through the radio and congratulations were being thrown everywhere. You pulled into the number 1 spot and climbed onto the nose. You put your finger on the big numbers on the nose of your car, kissed the finger that touched it, and raised it, pointing at the sky. You had changed your driver number to the permanent 89 this season, and for the rest of your career. 

One time, Lorenzo had showed you pictures of when he used to kart. The big 89 was visible through the old photographs. He had trophies upon trophies, but was never picked up by anyone. You told him that if he had raced these days, he’d be able to skip everything and would be put into an F1 car immediately. He had just laughed and told you to do it for him. 

So that’s what you were doing. After you commemoration, you scrambled down the car and jumped into the crews waiting arms. These days, you did not flinch when they hit your helmet. You knew that these were celebrations for racers and you were thankful to partake. Two boys followed you up and went before you. You didn’t remember their names, only the Australian accent and the odd American accent. But they would remember your name. 

You carried your flag high as you walked onto the stage. The anthem sounded much sweeter this time around. The trophy felt a little heavier this time though. You looked up to see those blue eyes that you saw many years ago. Max said a quick congratulations before you raised it as though to almost offer it to the open sky. This time, you let the tears go. You quicky wiped them away and picked up the giant bottle of champagne. You hauled it over your shoulder and sprayed the others, absolutely drenching them. 

This time, they did it to you as well.  

You knew you made it. 

I’ll do it for you, LoLo. 

December 2024 – Twenty-one years old 

Christian Horner sat in the folding chair, as he did year after year. A camera was right in front of him, with an interviewer to the side. 

“Please state your name for the camera.” He rolled his eyes. 

“My name is Christian Horner, and I am the Team Principal of the Oracle Red Bull Racing Formula 1 Team.” 

“Let’s talk about your driver, Y/n L/n.” 

The screen cuts to the pace of your car, passing multiple others in one clean sweep. 

“She’s one of the best talents I’ve seen in a while.” 

A scene of you holding a trophy, high in the sky. 

“What is one thing that you admire about your driver. She has said a lot about you.” Christian smiled. Of course you had. You told him that you saw him as the dad you never had. 

“Almost everything she touches, she turns it to gold.” 

The scene changes to your first win. The crowds of red cheered your name. Something you didn’t think was possible. You had taken that win from their favorites and you were being praised for it. Slow-motion splashes of champagne hit you from either side as you wiped your face. 

The scene returns, but Max is in Christian’s spot. 

“She’s different. She’s the epitome of what a rookie should be. I’m just thankful that she’s my teammate and not working against me.” 

The screen fades to two Red Bull cars with an Aston Martin in between them. 

“Y/n, Max is currently behind the Aston. Gap to you is 1.237 seconds,” Mitch’s voice is heard off screen through the radio. 

“Tell Maxie that it’s time to do the old switcharoo!” 

Your car suddenly slowed down just enough on the turn, and the crowd cheered as Max’s car went wide, putting him before you. You quickly got in his slip stream and the two of you sped off, leaving the green car in the dust. 

Another driver, with green eyes, is now in the seat, answering the same question. 

Charles looked up in thought while blowing some air out his lips. “She’s fearless. You normally don’t see that anywhere. Sure, everyone gets scared if they have an impact, especially as big as the one she had, but not her.” 

The camera cuts to the violent scene of your first DNF. Your car flipped, you were trapped. People’s faces were adorned with tears including Christian, no one had been able to contact you. Yet, the focus is now on you, wiggling out from beneath the wreckage. You, in spite of it all, raised your fist as though you were celebrating a first win. 

The scene cuts to an Australian with a straight smile. He looks semi-uncomfortable in the seat.  

“It looked like you and L/n had a tussle in the beginning. Is that true?” 

Oscar shook his head. “There was never a tussle. We both made mistakes, but that’s racing. Wheels touch all the time: it doesn’t mean that we have the urge to take each other out.” 

The interviewer continued, “But she did take you out.” 

The screen fades to a clip of two cars dangerously close together, one orange and one navy. 

David Croft’s voice could be heard, “And there goes the Red Bull of Y/n L/n and the McLaren of Oscar Piastri! They are close together around that corner and they aren’t backing down. Are they going to make contact! And they do! Off the track they go, debris is everywhere. And I don’t think they are going to be able to continue.” 

You knew that you should not have “never backed down never what-ed.” But Oscar was going for it and so were you. And you felt terrible. You quickly used the halo to climb out. Looking over, Oscar was doing the same thing. 

The camera followed you as you made your way through the swarming stewards. You just knew that you needed to check on the Aussie. 

The crowds could hear David speak again, “Oh no. Looks like L/n is mad. Does Red Bull have a thing for drivers with anger issues?” 

Oscar looked up and saw you storming towards him, batting away the stewards hands. He stiffened, ready for anything. But what he didn’t expect was a giant hug. He could feel you shaking and he quickly put his hands around you. 

“I’m ok.”  

The screen flashes back to Oscar. 

He huffed, “She did. But the moment she got out of the car, she came to check on me. She batted away the stewards who were desperate to make sure that she was fine, since she took the brunt of the hit. If that doesn’t convince you that Y/n is a great friend and better driver, then I don’t know what will.” The Aussie looked livid. 

The scene cuts to now a new face, your manager. 

The interviewer asks, “What is something that people might not know about Y/n.” Vito put his hand to his chin. You had already given him the permission to talk about what might be discussed. 

He inhaled, “She’s strong. Not just physically, but mentally and emotionally as well.” 

“Can you give us an example?” 

“The kid was disowned in 2019, right before her F3 debut. And you know what she did? She put that F3 car in the P1 spot. She never showed it though. She held her head high, and was squeezing into her place, that was waiting for her, in this sport.” 

A quick flash of 16 year old you, holding your first F3 trophy, was shown on screen. 

Vito kept talking as the scene changed to you walking around your motor home, greeting everyone who was there. They knew what had happened, and comforted you with words and hugs. You were thankful for them. 

“She also lost her godfather Lorenzo in January 2020. It was heartbreaking to hear her over the phone. Her debut in F2 was the next day. I told her that she didn’t have to, but she insisted that she needed to race, to win.” 

The camera followed 17 year old you, helmet on and visor down, as you walked to your F2 car, shining with your new number. 

“In less than 24 hours, she was back in the car.” 

Your car sped down the straight, over the finish line. 

“And she won.” 

The scene shifted to 23 year old Max Verstappen handing you the big F2 trophy. Tears could be seen in your eyes as you took the cup and thanked him. 

“Did you know?” 

Max looked at her in bewilderment. “I didn’t. And you would have never guessed it. Y/n has her heart on her sleeve, everywhere she goes, except when she races.” 

A quick cut now shows Christian back in the seat. 

“The last driver I saw with that mental strength was Charles Leclerc. He previously lost his godfather, and then lost his father. A few days later he won his race. Y/n lost the only family she had in less than a year.” Christian laughed. “These rookies are built different. You’d think they were made for the earlier days of racing, with how much they put into it. But Y/n, I don’t know. Her aura commands attention.” 

The scenes now shown are from multiple races. 

The camera followed you as you walked through the crowded paddock, trying to get back to hospitality. You thought that it would be different, that you’d have to squeeze through to get by. But with each step you took, the people parted like water. 

You flashed a smile at many fans who seemed awestruck to be in your presence. 

A new driver is now in the seat. 

“She’s almost like Charles, in a sense,” Lando said. “The two of them,” he looked around, “I don’t know. It’s hard to describe.” 

“Can you try?” Lando shot her a cheeky grin. “They are basically the F1 royalty. Any driver has a ‘celebrity image’ and people are excited to see us outside. They ask to take pictures, but they also do things against us.” 

The scene cuts to multiple instances of booing and pushing drivers. 

“And yet, Charles and Y/n bend them to their will almost. They listen to them. The King and Queen of Formula 1.” 

A video of you, Lando, Max, and Charles speaking before the Monaco Grand Prix plays. 

“Ah, Max. Did I tell you that we have to address them as your highness now?” 

Max looked up from his phone and followed Lando’s finger that was pointed at Charles and you, deep in conversation.

“No? Why?” Lando walked over and showed him the edit and comments on his phone. 

The caption read “Y/n L/n and Charles Leclerc are F1 royalty and we need to address them as such.” The video that played started with a clip of Charles in Monaco, with the grid and Monegasque royalty behind him. He looked so majestic. It switched over to you in your home country, with a crowd around your pedestal. You hadn’t even won yet, and they looked at you as though you hung the moon. You stretched out your arms and the crowd roared.

Max looked back at the two, who were ignorantly blissed. Max looked up at Lando. 

“You’re right.” 

The camera is back to Charles. 

His eyes were wide with eyebrows raised, “Lando really said that.” He smirked. Shuffling up to good posture he said, “I’m fine with that. Y/n has always been different, but in a good way. She knows what the people wants, but also doesn’t get caught up in all the PR. She’s herself.” 

A clip of you with fans plays. Your smile was mirrored with theirs. Everyone wanted to see you, hug you, feel you. And the waves that were emanating from you only made the crowd happier. 

Now, the seat is occupied by none other than Sir Lewis Hamilton. 

“What do I think about Y/n?” he questions back to himself. “I know that she is one of the best rookies to ever come across in the world of Formula 1. I’ve had the opportunity to share podiums with so many drivers, but her? There’s something different.”

The scene flashes to a podium shared with you, Lewis, and Max. Lewis had been able to take the win, leaving you on the third step. You had almost had the win, but a late safety car ruined it. Lewis looked over at you, expecting a disappointed face. But all he saw was a smile that rivaled the sun. 

“She never seems to be disappointed with anything. Even if she was to qualify in last place, she would still smile.” Lewis laughed. “And I think everyone loves her more than they realize.” 

A small clip of you and a bulldog flashes across the screen. Roscoe was licking all over your face. 

“Roscoe, stop!” But you were laughing, and the dog thought that he should continue. Lewis found the two of you in the middle of the floor in the Mercedes hospitality. A blanket was draped around your shoulders.  

“And what are you doing here kid?” Lewis put his hands on his sides. 

You shrugged. “Toto told me I could hang out here. Max is having one of those ‘adult meetings’ that Christian says my ears shouldn’t hear. I think they forget that I’m 21 now.” 

Lewis just laughed, thinking of how Toto must have let you in and had given you a blanket as well. He just ruffled your hair and sat on the ground with you.  

The scene changes one more time. You are now in the seat. 

The interviewer asks, “Please state your name and your occupation.” 

You smiled, “My name is Y/n L/n and I am a Formula 1 racer who drives for the Oracle Red Bull Racing Formula 1 Team. I also DJ,” you shot finger guns at the camera and clicked you mouth, “Thanks Lando.” 

“How was your first season in Formula 1. You obviously showed the world of what you could do.” 

You nodded before continuing, “The season went better than I expected. To place third in the driver’s championship as a rookie? Unheard of.” You smirked. “Until now.” 

The person behind the camera continued, “You were only 10 points away from Charles Leclerc. How does that make you feel?” 

You cocked your head. “It feels wonderful. Charles had a really good season.” You leaned in as though to tell a secret. “If anything, don’t tell Charles or Max I said this, but Max and I would rather lose to Charles than anyone else.” 

“And why is that?” 

You deadpanned. “Well Charles is Lightning McQueen incarnate and Max’s emotional support rival. Who else would we want?” People laughed in the background. 

“Now that you know you could win a championship…” 

You cut her off, “Oh I’ve always known I could win a championship. But I also know that I was born to break records. And right now, I’m on a path to help Max break the 7 streak.” 

“Ah yes, sorry. What would you do after winning a championship.” You hadn’t seen Max slip in. 

“I think I’d pull a Nico Rosenburg. Ya know? Retire while I’m ahead.” 

“You would not do that!” Max said behind the camera and you looked straight at him. 

“Yes I would.” 

“No you wouldn’t. Because you said you were born to break records. Well Kid, if I make a record championship, you need to be the one to break it.” 

Oh my gosh, I loved how this chapter turned out. And it is officially the longest chapter I have written so far – 6,077 words. Right now, I have to write the chapter for the last race of F2 and you readers have to pretend that it lands on a weekend that the F1 drivers can attend. 

Also! I am pleased to announce that the first few chapters of a new series will be out shortly! It is called “Besties for the Resties” and it’s how you got close with many of the drivers. Not all of them will have their own chapter and not all the drivers are being written about. So please be aware that this will not be going over 10 chapters! 

Thank you to all my readers and Happy Thanksgiving!  

Tag List : @awekbachira @lightdragonrayne @leilanixx @angsthology @digitalizeduniqueness @topguncultleader @landosgirlxoxo @gods-menace @itsjustkhaos @thefandomswhre @alwaysboredsworld @vellicora @bintuabbas @sam-is-lost @empress-kimiko @assholeinatrenchcoat @kagatinkita @glitterquadricorn @zyonsay @tsukishimawhore @treehouse-mouse @ashy-kit @agent-curt-mega @julesbabey @lydialawrence @stopeatread @claudia5912 @nichmeddar @blueberry64857959 @laura-naruto-fan1998 @leptitlu @alessioayla @badassturtle13 @kaaale @wcnorris @cool-ultra-nerd @hockeyboysarehot @agent-curt-mega @myxticmoon @cmleitora @sam-is-lost

[jcsmicasereports]

Trisomy 18 and Microdeletion 18p Mosaicism: A case report and literature review by Chao-Chun ZOU in Journal of Clinical Case Reports Medical Images and Health Sciences

ABSTRACT

The trisomy 18 syndrome is a common chromosomal disorder due to the presence of an extra chromosome 18, either complete, mosaic trisomy or partial trisomy 18q. The mosaic trisomy 18 patients’ phenotype was extremely variable, from the absence of dysmorphic features to complete trisomy 18 syndrome. The phenotype of 18p deletion syndrome is variable and almost all survived. A 2-year-old girl was referred to our hospital due to growth delay. Mild dysmorphy including thin hair, frontal bossing, low set ears, broad-flat nose, nostrils slightly upward, downturned corners of the mouth, dysplasia teeth, small hands and fingers bilaterally was observed. The karyotype of peripheral leukocyte showed 46,XX, psu idic (18)(p11.2)[55]/46,XX, del (18)(p11.2)[45]. We report this case to add to our knowledge of the trisomy 18 and microdeletion 18p mosaicism.

Keywords: Trisomy 18, mosaic;18p microdeletion; Psychomotor retardation; Karyotype

INTRODUCTION

The trisomy 18 syndrome was first reported by Edwards et al in 1960, also known as Edwards syndrome. It is the second most common autosomal chromosomal disorder after trisomy 21（Down’s syndrome）due to the presence of an extra chromosome 18, which has three basic types: complete, mosaic and partial type (Edwards et al., 1960, Cereda and Carey, 2012,Mudaliyar and Mudaliyar, 2017). The syndrome presents a recognizable pattern of major and minor anomalies, significant psychomotor and cognitive disability are associated with high neonatal and infant morbidity and mortality. The estimated overall prevalence of trisomy 18 in live born is approximately 1/6, 000 to 1/8, 000 while the incidence in fetus is much higher, the difference is caused by fetal loss and pregnancy termination after prenatal diagnosis (Cereda and Carey, 2012, Rasmussen et al., 2003). The mosaic trisomy 18 usually means having more than one cell line in the individual, and it occurs in approximately 5 percent in all trisomy 18 patients (Fitas et al., 2013). The phenotypic manifestations are highly variable, from the absence of dysmorphic features to the complete trisomy 18 syndrome (Tucker et al., 2007). Since the clinical outcomes of complete and mosaic trisomy 18 can be different, it is of vital importance to achieve a correct diagnosis because of implications in medical management and genetic counselling. 18p deletion was first described by de Grouchy and colleagues in 1963 and was estimated to occur in approximately 1/50, 000 live born, which results from deletion of a part or full of the short arm of chromosome 18(Turleau, 2008). The mostly reported clinical features include cognitive impairment, congenital heart defects, small stature, minor facial dysmorphy, and skeletal deformities(Turleau, 2008, Xiao et al., 2019, Hasi-Zogaj et al., 2015, Yi et al., 2014)

Typical facial features include hypertelorism, ptosis, strabismus, broad–flat nose, micrognathia, and low-set big ears. Holoprosencephaly may be seen in approximately 10–15% of patients(Turleau, 2008). In addition, speech and language difficulties, pituitary abnormalities, generalized seizures, dystonia, and autoimmune diseases have also been described(Turleau, 2008, Rao et al., 2001, Graziadio et al., 2009, McGoey et al., 2011). However, these non-specific features are easily overlooked clinically. The clinical phenotype severity is related to the size and location of deletion region. In this report, we present a 2-year-old girl of mosaic trisomy 18 and 18p microdeletion with mild psychomotor retardation, cognitive impairment and language developmental disability.

Clinical description

A 2-year-old female second child of non-consanguineous parents was admitted to our hospital due to growth delay. Her mother and father were 34 years old and 38 years old when giving birth to her. She was born at full-term with uncomplicated gestation, her birth weight was 3.35 kg and the length was about 50 cm. No feeding difficulty and complications were referred in the neonatal period. She had a motor retardation of autonomous walking until 22-months old and intelligence disability and language disability. She only knew a few simple words like ”mama“, not ”baba“, and she cannot communicate clearly with others though she was willing to speak to strangers. Gesell Developmental Schedules performed in local hospital indicated mental developmental delay in motor behavior, language behavior, adaptive behavior and personal-social behavior at age of one year and 8 months old. The height of her father, mother and 15

years old sister were 165cm, 161cm, and 155cm, respectively. No similar history was noted in her family.

On physical examination, she had a height of 81.4 cm below -3SD and a weigh of 11.6 kg below -1SD. Mild craniofacial dysmorphy was present, including thin hair, frontal bossing, low set ears, broad-flat nose, nostrils slightly upward, and downturned corners of the mouth while other craniofacial anomalies were not obvious (Fig.1A). Her hands were small especially her fingers, but the fingernails are normal (Fig.1B). Her teeth were dysplasia (Fig.1C). The echocardiography revealed patent foramen ovale (ϕ 2.96 mm) while no murmur was present. The muscle tension was normal and no other organ abnormality was detected in our patient.

Laboratory examinations (urine, liver, kidney, thyroid hormone, GS/MS and blood glucose analyses) were all normal. Insulin-like growth factor-1 was 72.5 ng/ml (normal range, 55-327 ng/ml).

Management and outcome

Ten months ago, the child was brought to a local hospital with developmental delay, the peripheral leukocyte karyotype was taken and revealed two abnormal cell lines, the result was 46,XX, psu idic (18)(p11.2)[55]/46, XX, del (18)(p11.2)[45] . She was then referred to another hospital to take the whole-exome sequencing demonstrating a deletion at 18p11.32-p11.22 (GRch37/hg19, chr18:158679 9708482del) and a duplication at

18p11.21-q23(GRch37/hg19, chr18:12012132 78005255dup). She was diagnosed mosaic trisomy 18 syndrome.

Discussion

The first reported patients with trisomy 18 syndrome were initially described by Edwards et al and Smith et al in 1960s, while the first case of mosaic trisomy 18 was reported in 1965. Less than 5% portion of patients have mosaicism of trisomy 18, and Banka et al reminded that routine karyotype from lymphocyte culture may not be sufficient to diagnose mosaicism if practitioners suspect a diagnosis of mosaic trisomy 18, karyotype from skin fibroblasts should be considered. Since then over 40 cases of mosaic trisomy 18 have been described, Tucker et al reviewed 33 reported individuals of mosaic trisomy 18 and added 2 more cases in 2007. Their clinical manifestations are extremely variable from complete trisomy 18 syndrome with early death to near totally normal. Some physical features are relatively more common and included brachydactyly, high arched palate, microcephaly, delayed bone age, frequent respiratory infections and otitis media, heart defect, 5th finger clinodactyly, micrognathia, and hypotonia. The most common heart defect is ventricular septal defect in mosaic trisomy 18. Our case has mild craniofacial dysmorphy and patent foramen ovale, and no other physical anomalies were observed.

Trisomy 18 mosaicism usually indicates the existence of more than one cell line in the individual. The peripheral leukocyte karyotype demonstrates pseudodicentric chromosome substituting a normal chromosome 18 in 55 cells and chromosome 18 missing the end of the short arm in 45 cells. The skin fibroblasts karyotype was not taken. Furthermore, there is no correlation between the physical and intellectual findings and the percentage of trisomy 18 cells in either peripheral leukocytes or skin fibroblasts. Besides, there is no correlation between the percentage of trisomic cells in peripheral leukocytes and brain, gonads, or other key organs. The variety of mosaic trisomy 18 may be related to the percentage of trisomic cells in different key organs of the body.

For complete trisomy 18 patients, approximately 50% of infants live longer than one week and about 5-10% of children survive beyond the first year. In overall, trisomy 18 mosaicism patients usually survive longer when compared to complete trisomy 18. This does not mean that all the mosaic trisomy 18 patients have a longer survival, some died a few hours after birth. For normal or mild phenotypical mosaic trisomy 18 cases, some were diagnosed due to recurrent miscarriages or giving birth to a child with trisomy 18 while others may never be identified. 18p deletion syndrome, also called monosomy 18p and De Grouchy syndrome type Ⅰ, which means a deletion of full short arm of chromosome 18 or a microdeletion of the short arm of chromosome 18. Some researches showed that nearly half of patients have breakpoints in the centromeric region and the rest scatter in the short arm, and approximately half of the deletions occur on the maternal chromosome 18 no matter where the breakpoint locations are. Our case’s breakpoint is at the 18p11.32-p11.22. Approximately two thirds of patients’18p deletion are de novo; the rest may be due to a de novo unbalanced translocation or malsegregation of parental chromosome rearrangement or a ring chromosome. The patient’s height and weight is 81.4 cm below -3SD, 11.6 kg below -1SD, respectively. It may be a prodrome of small stature, but her insulin-like growth factor-1 was normal. It also could be contributed to feeding problem. More follow-up work needs to be done to figure it out. Some reported cases show that growth hormone replacement treatment is efficient in growth hormone deficiency patients.

Our case has trisomy 18 and microdeletion 18p mosaicism simultaneously. The possibility of meiotic chromosomal nondisjunction of the ovogonia/spermatocyte was increased because of her parents’ advanced maternal age, some women may have higher a risk for nondisjunction. More possible mechanism may be a de novo unequal recombination occurring in early embryonic mitosis. Some deletions are from the parents, there is no way to figure her mutation mechanism out since we can not get her parents’ consent to analysis. The phenotype of our case combines two syndromes’ typical features, including common psychomotor retardation, cognitive impairment and congenital heart defect, characteristic small stature and language impairment of 18p deletion syndrome. Our case’s uncharacteristic craniofacial features also combine two syndromes.

In a conclusion, mosaic trisomy 18 and 18p deletion syndrome both are chromosomal disorders which has a variety of clinical manifestations. If an individual has untypical phenotypical anomalies and psychomotor and cognitive disability, chromosome disorder should be considered and cytogenic analysis is needed.

Acknowledgements: We thank the patient and his parents for permitting us to use the data.

[dramashutup]

I was telling my sister we should try listening to songs by groups debuting after or same time as txt, yknow just to know what my nephew is listening to

My sister searched for enhypen and boynextdoor and I feel like we're looking at crimes in real time

Why are these infants allowed onstage. I can't lmao. Why are they born in 2000s whyyyy

Jaehyun go back to school, why are you singing i need a girl

And no wonder there was such a ruckus with new jeans. The maknae was born 2006. She was 14 when they debuted

Meovv's maknae is 16. She was born in 2008. This feels so wrong

I mean ik being born in 2000s means they're basically in their early 20s but like,, .....show biz should only be for people older than that and the kpop scene with their lots of problematic sides, it's just.....CONCERNING

It has always been this way in the industry yh but now that I'm older and know more things it's like o H H NOO

It didn't feel this noticeable when i was stanning groups in my teenage years but now it's like pls take the mics from the children lol

[wtffundiefamilies]

When the topic of abortion came up during the first Republican primary presidential debate, Florida Gov. Ron DeSantis shared a perplexing anecdote about a woman he met who he said had survived the procedure. "I know a lady in Florida named Penny," DeSantis said. "She survived multiple abortion attempts. She was left discarded in a pan. Fortunately, her grandmother saved her and brought her to a different hospital." Some accused the governor of fabricating the story. "Let me see if I understand this correctly. Doctors tried to abort ‘Penny’ multiple times and discarded her in a pan, and then her grandmother took her to another hospital? DeSantis lies like a toddler," one person posted on X, formerly Twitter. Our research found that a woman named Penny, who tells an unusual birth story about an attempted abortion, does exist. We asked DeSantis’ campaign for evidence or more information. The campaign replied via email, sending only a link to a Daily Signal article that identified "Penny" by her full name and recounted her story.  The woman DeSantis referred to is Miriam "Penny" Hopper, an anti-abortion activist who said she survived an abortion attempt in Florida in 1955. Her claim, which is uncorroborated, has been featured online by Protect Life Michigan, an anti-abortion advocacy group.  In a video and in interviews, Hopper said she had been delivered around 23 weeks gestation after her mother went to a hospital in Wauchula, Florida, while experiencing bleeding. In a 2013 interview with radio station WFSU, Hopper said she believes an abortion had been attempted at home before her parents went to the hospital, which also could be why DeSantis referenced "multiple" abortion attempts.  Hopper said the doctor at the hospital induced labor, and she was born at 1 pound, 11 ounces and was left in a bedpan. She told WFSU her grandmother found her alive the next day and was enraged about her being abandoned. Then a nurse volunteered to transport Hopper to what was then Morell Memorial Hospital in Lakeland, Florida, now the site of Lakeland Regional Health Medical Center. That’s about 40 miles north of the hospital where Hopper says she was born.  Her story has been used to support "born alive" bills in state legislatures, which aim to protect infants that survive an abortion, even though there are federal laws for that purpose.  We were unable to gauge the accuracy of Hopper’s account. We couldn’t find records, such as news reports, dating to the 1950s, and people who could corroborate the story, such as her grandmother, are no longer living. Hopper did not respond to requests for comment.  Medically speaking, the scenario is dubious.  From the 1950s through 1980, "newborn death was virtually ensured" for infants born at or before 24 weeks of gestation, The American College of Obstetrics and Gynecology says on its website.  Recent studies have shown wide variation in modern-day survival rates for infants born around 23 weeks, partly because of improved hospital practices for resuscitation and active treatment. A 2022 University of Rochester Medical Center study found that babies born at 23 weeks — who were "actively treated" at academic medical centers in the National Institutes of Health-funded Neonatal Research Network —  had a 55% chance of survival. This is considerably higher than the 23-week survival rate at many other institutions, as well as a previous study conducted from 2008 to 2012 in the same network, which put the rate at 32%. (Lifesaving care for babies born at 22 and 23 weeks varies by hospital policy and physician opinion, according to a New York Times story.)  Before the 1970s, most babies born before 28 weeks gestation died because they lacked the ability to breathe on their own for more than a short time, and reliable mechanical ventilators for these infants did not yet exist. That also makes it improbable that Hopper could have survived overnight without medical intervention when born at 23 weeks in the 1950s.  PolitiFact researcher Caryn Baird contributed to this report.

[adultswim2021]

Moral Orel #41: “Sacrifice” | November 18, 2008 - 12:15AM | S03E11

Sacrifice is gonna be a little hard to talk about extensively because it’s not really joke-driven. It’s funny, and has jokes on it, but most of the episode is basically a one-act play taking place in Forghetty's pub. But before that, the episode actually opens with a little flashback to Numb, featuring Clay’s POV scene at the end. This time it’s not scored to Mountain Goats, and we just hear him muttering to himself. Then we join the church service at the end of the previous episode, Sundays. Reverend Putty’s sermon is about some Jesus story where a tomb or some shit gets opened and there’s nothing in it, and how nothingness can actually mean hope. 

Do you all like how I didn’t even bother to look up that Jesus stuff they referenced? Isn’t it weird that I’m ostensibly Catholic (not anymore I'm normal now! I'm Bahá’í!) and I don’t even seem to have a passing familiarity with Jesus’s greatest hits? Anyway, I had to work on my day off and I’m PISSED OFF so I’m taking out on this blog by doing a bad job. Sorry. 

Speaking of doing a bad job: I really can’t see myself going beat-by-beat for this episode, because it’s mostly dialogue. But here's the paragraph where I try and sum it up:

Various men in Moralton encounter each other in the bar and have it out with Clay, who rants and goads the others (Officer Papermouth, Reverend Putty, and Dr. Potterswheel). Clay declares that he can’t come into his stinking dead end job or else he’ll kill somebody, the drama queen! He winds up Reverend Putty and Officer Papermouth over their woes with, as it turns out, the same woman. And Clay says nasty stuff to the doctor because, as we see in Numb/the earlier scene rehashed from Numb, Clay discovered and currently possesses his handkerchief that Bloberta took out of his office.

This bar scene (which is the lion's share of the episode) ends with Clay practically begging for a pop to the face. The other men all decide against punching Clay, and simply walk out, paralleling his own father’s declaration of him not being “worth it”. 

The episode itself ends with Orel at home, calling the bar to try and reach his father. Bloberta is tearing the house apart looking for the handkerchief. Shapey actually says something eloquent (and sad!). The credits roll over footage of Clay returning to the nature reserve to retrieve the bear carcass he thinks he shot. 

This one’s a highlight for the season, just pure theater and great performances. That's episode 11 of 13! Two to go! Or three. Or… FOUR?

MAIL BAG

Normally at the end of these posts I do a 44 Nights of Orel wrap-up, but since they aired two premieres back to back, I don’t have any repeats to note. So, I’m doing a Mail Bag instead. Unfortunately that means I will not be needing the Dino and Scott picture to introduce it. Sorry.

*sung to the tune of the cartoon network ad where chicken of cow & chicken plays electric guitar on a stage* Robot Chicken yeah, Robot Chicken yeah, Robot Chicken yeAHHH

Um… link??

kevin smith looks like a fucking dog in cartoon form. they should give him a bone and let him run around the yard.

I wouldn’t leave him alone with your infant, movie tickets, or clit/brown/taint-area, that is for sure.

Hey fake woke Americans, guess who actually lives on stolen land? You do. Guess who actually lives on stolen land? You do. You do. You do. Me Jew. You do. Me Jew. You do. You live on stolen land. Anyway looking forward to your Eagleheart and Dinner in America writeups!

Hahah. Oh man. You ain’t kiddin’ brother.

My daughter turns 11 this month, I basically stopped watching adult swim not too long before she was born but I never missed a sunday before that. This has been a great look back and I'm excited to start seeing what I missed soon. 

Hey man, I know this message you’ve sent in isn’t actually finished yet, but this just meant so much to me that I had to stop reading it right here and respond immediately. I know, I’m breaking my own protocol, but it’s worth it for me to give you the extra attention. This is the stuff that’s truly important in life and it touches my heart and means the world to me. Cherish your little one, and maybe some day when she’s old enough she’ll even become a viewer and reader of this blog! I know, it seems a long ways away, but she’ll be a little adult swimmer before you know it, so cherish these moments, and know that I cherish you. Okay, onto the rest of your message:

Also, my daughters last birthday wish was a Dino and Scott banner, so could you make it happen?

No! 

Matt Christmas from cahpo

Very weird stuff you’re saying right now, but I heard he’s doing better. Isn’t that great? Surely you’re happy to hear this, and you’re not doing some tasteless bit where you’re pretending to be him right now. That would be UNTOWARD. 

me love the way you talk the way you move is so hot. now let me get you a shot of rum and then make you wanna come...with me to the ocean. that would be phat. you could be my bow cat. nice ital breeze, bring you to your knees. we jammin.

Stop doing this! I have to google it every time and pretend I already know it’s a Steven Segal song. Do you have any idea how sad it is to get weird words in the mail and then you google them and you have to look at a picture of Steven Segal. He is always giving "fuck me" eyes to the camera. This is practically assault, and I will have you removed.

I'm not the one sending you messages about the making the morel orel guys the banner but I do think it's a good idea.

It’s a good idea. It might be the idea the saves the world. But, I never buckle. The racist cartoon stays, and I will also keep being racist

Hey this is Paul McCartney of the Beatles and Wings. Happy Tasty Tuesday to all who celebrate it. Tell me about your pets.

Hi Paul. I like (not love) your rock and roll music and viral videos. I don’t have any pets they are all in hell right now. My roommate has two frisky cats and sometimes they come in here while I’m masturbating, just beh-ging for pets. Of course… I gotta hand it to ‘em. Both of them are nice. Thanks for writing in before you die next week

[influencermagazineuk]

Damian Musk: Know About Elon Musk's Son

Damian Musk is a well-known American celebrity kid born on January 1, 2006, in Los Angeles, California, United States of America. He is the son of Elon Musk, a business magnate and investor, and Canadian author Justine Wilson. Damian has two brothers named Saxon Musk and Kai Musk, and six siblings in total. Damian's first child was born in 2002, but unfortunately died of sudden infant death syndrome at the age of 10 weeks. Through in vitro fertilization, Justine gave birth to twins in 2004, and then the triplets, Damian, Saxon, and Kai, were born in 2006. As of 2023, Damian Musk is 17 years old, and his zodiac sign is Capricorn. The name Damian means "to tame, subdue" and is of Greek origin. It is derived from the Greek word "damazo," which means "to tame." Damian's grandfather is Errol Musk, and his grandmother is Maye Musk. Elon Musk, Damian's father, is the founder, CEO, and chief engineer of SpaceX; angel investor, CEO, and product architect of Tesla, Inc.; founder of The Boring Company; and co-founder of Neuralink and OpenAI. With an estimated net worth of around $238 billion as of September 26, 2022, Musk is the wealthiest person in the world, according to both the Bloomberg Billionaires Index and Forbes' real-time billionaires list. Damian's mother, Jennifer Justine Wilson, is a Canadian author. She wrote the contemporary fantasy novel BloodAngel, published in 2005 by the Roc Books imprint of Penguin Books. Her second book, Uninvited, was released in 2007 and is an unrelated work intended for young-adult readers. A sequel to BloodAngel, Lord of Bones, was released in 2008. In a 2007 interview, she identified Margaret Atwood, Joyce Carol Oates, Paul Theroux, George R.R. Martin, Guy Gavriel Kay, and Neil Gaiman as authors to whom she could relate her writings. Damian Musk has four half-siblings named X AE A-XII Musk, Exa Dark Sideræl Musk, and the Twins (names not revealed yet), and six siblings named Nevada Alexander Musk, Griffin Musk, Vivian Musk, Kai Musk, and Saxon Musk. His uncle and aunts are Kimbal Musk, Tosca Musk, Elliot Rush Musk, Asha Rose Musk, and Alexandra Musk. In conclusion, Damian Musk is a famous American celebrity kid, known for being the son of Elon Musk and Justine Wilson. He has six siblings and four half-siblings, and his father is the founder, CEO, and chief engineer of SpaceX; angel investor, CEO, and product architect of Tesla, Inc.; founder of The Boring Company; and co-founder of Neuralink and OpenAI. Damian's mother, Jennifer Justine Wilson, is a Canadian author. This article has aimed to provide readers with some valuable insights into Damian Musk's family background and his parents' career, and the keyword Damian Musk has been optimized throughout the article. Read the full article

[globalworship]

“St. Luke painting Madonna” Ukraine icon

Ivanka Demchuk was born in 1990, in Lviv, Ukraine. She graduated from the Lviv College of Decorative and Applied Art in 2008. She ontinued studies in the Sacred Art department in Lviv National Academy of Arts, receiving a masters degree with honors in 2014. Since 2008, she has participated in group exhibitions in Ukraine and Poland. https://iconart-gallery.com/en/artists/ivanka-demchuk/

Here is a recent beautiful painting she created, with some close-up views below it.

«Св. Лука малює Богородицю» “St. Luke painting Madonna” egg tempera and acrylic on chalk gesso

+++

The following close-up views show what an absolute masterpiece this painting is.

1 The counter and view outside the window

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2 Madonna and Infant Jesus

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3 St. Luke

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4 Madonna's skirt and the carpet

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5 Left half of the scene:

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6 Right side of the scene:

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At her website, the icon maker writes:

An important aspect of my works is the modern reflection of sacred art for the spiritual enrichment of a person, a new reflection of the religious essence, research into the principle of interpreting an icon or a work of religious art without losing its sacred meaning.

An icon can and should develop, change,and embody the best aesthetic achievements of its time, then it becomes closer to the perception of a modern person, who will have interest in it. At the same time, as a sacred work, it should preserve spirituality in each new appearance.

 Searching for the new means of expression in the process of work, I use both modern and ancient technologies to create interesting colour effects and textures, in particular chalk gesso and natural pigments, which perfectly approach for the experiments and researches. https://en.ivankademchuk.com/about

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See herr portfolio at https://en.ivankademchuk.com/ivankademchukportfolio and https://iconart-gallery.com/en/catalogue/#!/Ivanka-Demchuk/c/86065064

Follow herr art at https://www.facebook.com/ivanka.demchuk.3

Over a dozen of her icons have been made into wooden puzzles which you can order at https://www.etsy.com/shop/moderniconart/?etsrc=sdt

and you can order more tha 70 of her icons as perfect prints on canvas at https://www.etsy.com/shop/moderniconart/?etsrc=sdt§ion_id=40077887

She has sold more than 4,600 items so far through Etsy.

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Prints of a close-up of the Madonna and Child icon above are for sale at https://www.etsy.com/listing/1647846033/mary-with-the-child-original-print-on

You can purchase a print of the entire icon at https://www.etsy.com/listing/1780731674/st-luke-painting-madonna-original-print

+++

There is an ancient legend that St. Luke painted an icon of Mary holding infant Jesus, which was later carried to Constantinople. "It was said to have been brought back from the Holy Land by Eudocia, the wife of emperor Theodosius II (408–450), and to have been painted by Saint Luke the evangelist." https://en.wikipedia.org/wiki/Hodegetria

[jacobsullivan]

BASICS —

name: Jacob Michael Sullivan

nicknames: Jake, Jac, Jackie, Sulli

age / dob: 34 | November 11th, 1989

gender / pronouns: cismale / he & him

sexuality: bisexual

relationship status: single

species: Witch

affiliation: Coven Member

powers: aura reading, healing, teleportation, electrokinesis

hometown: Lunar Cove, Rhode Island

current residence: Sunny Harbor, Lunar Cove, Rhode Island

occupation: Architect

SUMMARY —

Jacob Sullivan (Jake) is a 34 year old witch who was born and raised in Lunar Cove.

He is a coven member, and his magical abilities are: aura reading, healing, teleporting, and electrokinesis.

TIMELINE —

1989 - Born on 11/11

2008 - Jake graduates highschool and starts college at the university of Rhode Island.

2012 - Jake moves to New York to get his masters at NYU.

2015 - Jake receives his masters and moves back home to Lunar Cove.

2024 - Jakes becomes an uncle.

HEADCANONS —

Jake has an orange cat named Sabrina.

Jake's sisters, Frankie, moved in with him at the end of May 2024.

Jake never got his driver's license but knows how to drive and does so for fun (illegally)

Jake enjoys fashion and self care. He blames it on having 3 sisters but really he just likes pampering himself ✨

Jake's favorite spot to hangout in town is on top of the water tower.

NOTABLE CONNECTIONS —

Family -

Mother: Emma Sullivan (deceased)

Father: John Bennett (biological), Phil Sullivan (adopted / step)

Sisters: Frankie Sullivan (29), + 2 more (wanted connections)

Niece: Emma Sullivan-Baker (infant)

Friends -

Altan Önder - childhood friends, Jake has been close to Altan all his life. They shared many nights together during their lost boy years. Jake counts Atlan one of his best friends.

Nico Castillo - brothers from other mothers, Jake met Nico in grade school and instantly began to idolize him. The big brother he never had, the role model he needed as a misunderstood little boy. Jake counts Nico as one of his best friends.

Poppy Reed - childhood friends, Jake met Poppy in grade school. Jake feels for Poppy's burden as supreme, and he does what he can to support her and the coven; even making her protection charms (shaped like pizza slices because he calls her the Supreme Pizza)

Linden Reed - childhood friends, Jake owes some of his wildest teenage wilds to the Reed boy. As debaucherous as him and even better at not getting caught, Jake counted Linden a best friend; even while growing up.

Prescott Reece -

Nate Windsor -

Song

Partners / Exes / Flings -

Elif Karadaş - a long time friend, a kismet connection, a spark shared between two flames; reignited multiple times over the years, across countries and continents and once more in Lunar Cove.

Rio Tavarez - current friend with benefits. Jake met Rio for the first time at the masquerade ball and began sleeping with her the week after she attended a party he threw for his friends', Poppy and Linden, birthday.

BIOGRAPHY —

Trigger Warnings:  Adoption, Teen Pregnancy, Miscarriage, Car Accident, Death, Child Death, Mental Health Struggles, Drug Use, Alcoholism, Overdose, Rehab, Cancer

On November 11th, 1989 Jacob Bennett was born to an unwed mother, the secretary of a wall street tycoon, legally renamed Jacob Sullivan two years after his birth when his mother returned to her hometown of Lunar Cove and married his stepfather; Phil Sullivan. Shortly after remarrying, Jake’s mother had three more children and he became a big brother to three little sisters. Phil adopted Jacob before his first sister was born and treated him just like his own child, though Jacob would continue to have a tumultuous relationship with his birth father.

Growing up, Jake was a rambunctious child. Sensitive and impulsive but deeply loved by his family. He was 10 years old when he came into his first power; Aura Reading. Then came the ability to heal, and in highschool Jake discovered he possessed the power of teleportation.

Senior year, Jacob got his highschool girlfriend pregnant and forewent attending college out of state to stay behind with her and raise their child. He began school at the University of Rhode Island in the fall of 2008.

A few months before her due date, Jacob’s girlfriend was hit by a drunk driver and died upon impact alongside their unborn child. Grief came like a tidal wave, drowning Jacob beneath its weight. A loss that forever changed him, but in the wake of the tragedy his family and coven surrounded him. There was no question after that, Jacob would join Lunar Cove’s coven and came into his fourth and final power; electrokinesis.

Devoted to his family and to the coven, yet still an avid wanderer; Jacob took every opportunity to travel. He used his gift of teleportation to explore the world during holidays from school. Which is what convinced him to leave his hometown when given the chance.

In 2012, Jacob graduated from the University of Rhode Island and accepted an offer from NYU to obtain his masters in architecture. An avid lover of the arts his whole life, Jake was excited to marry his passion and profession. It wasn’t his first time living in the city, either. Growing up, he often spent summers in New York, visiting his father.

During the three year program, Jacob gave himself permission to indulge in life. He eased his long held grief in the beds of women and men alike, drowning his remaining sorrows at the bottom of drink and pill bottles.

A wake up call came the night he and an ex overindulged themselves. He should’ve known better than to let his former partner  behind the wheel in the state they were in. No stranger to the deadly implications of driving under the influence, yet thoughtless to the ramifications of their actions until they collided with a light pole.  In a better state than his once boyfriend, Jake couldn’t watch him die and broke the rules to heal him, promising them both he’d get his head back on straight.

After a stint in self admitted rehab, Jake made peace with his past and became committed to sober living. He graduated with his masters in architecture and was set to take a job out in California when he was called home for an impromptu “family meeting”.

Gathered around his childhood’s kitchen table, his mother broke the news to Jake and his siblings that she had cancer. He didn’t hesitate to move home, turning down his job offer to take one in Lunar Cove.

It was hard for Jake to be back home. Every street corner held memories of his youth, of all that he had lost. He traveled as often as he could to keep his mind busy, using his gifts of teleportation once more to put distance between himself and what hurt. Always coming home after a few weeks, though, remaining a constant support in his family’s lives. During this time, Jake constructed his dream home in Sunny Harbor. A three story craftsman he spared no detail in designing. From an attic with no door, not a problem to a witch with the power of teleportation, where he practiced spells, to a backyard with a pool of his childhood dreams.

In 2022, his mother lost her battle to cancer and Jacob returned to a dark place again. Once more, drowning his grief in bottles and traveling. He spent more time away than before, but came home for good at the start of 2024 when the oldest of his three, little sisters had her first baby. Jake’s first niece, named after their mother, little Emma drowned out all the dark.

As madness descends across Lunar Cove, wreaking havoc in Jake’s once safe haven, he has committed himself to staying put and protecting those he loves. The years of Peter Pan have passed. No longer a lost boy, but a man who must resist the call of Never Never land or risk losing the only real home he’s ever known.

[the-active-news]

How Old Is Alabama Barker?And How She Became Reality TV Actress!

American actress, singer, and internet sensation Alabama Barker. Her role in the hit TV show Meet the Barkers catapulted her to fame. She also has a large number of devoted followers on Instagram and other social media sites. She has inherited her parents' fame, thus she is well-known as well. Alabama Barker is a well-known reality TV actress who shot to fame thanks to her appearances on Meet the Barkers. Alabama Luella Barker was born in 2005 in California to Travis Barker (the drummer for the band Blink-182) and Shanna Moakler, a former beauty queen.

Alabama Barker Biography, Age &Relationships

Landon Barker is the older brother in Alabama. Both kids have been on the show since they were infants. Alabama has been showing off her musical ability, and she has released her first single, "Our House," despite being only ten years old. For someone so young, Alabama Barker has a bright future ahead of her because of her positive attitude and laid-back demeanor. https://www.instagram.com/p/Cof-viYvXfI/?utm_source=ig_web_copy_link She gave the modeling industry a shot in the 2020s. On December 24, 2005, Alabama Barker entered this world. Alabama Barker is 17 years old at this time. There are 9 months and 26 days until Alabama Barker celebrates her next birthday. She started dating Travis Barker, the drummer for the band Blink-182, in the summer of 2002, and the couple had their son, Landon Barker, the following year. Alabama's birth would be included in the show's season finale, marking her first appearance on television. According to this thethings.com 

Alabama Barker Career

She shot to fame after making cameos on Teen Mom on MTV and Dog and Beth: On the Hunt on CMT. The famous country music duo of Travis Barker and Shanna Moakler have a daughter named Alabama. She's been a part of the show since she was a toddler, and her bold and confident character has made her a fan favorite. Alabama Barker, along with her parents and two older siblings, made her acting debut in the long-running sitcom Meet the Barkers. The act was mostly inspired by the routines of her parents and brothers. In 2017, she also released the hit singles Heartbreaker and the album Our Home.

What Happened Between Shanna Moakler And Her Daughter Alabama Barker?

In 2006, Travis filed for divorce, and after a brief reconciliation, the couple finally separated in 2008. Many people believe that the stress of trying to co-parent their children peacefully is what has driven a wedge between Shanna and Alabama for so long. https://youtu.be/cdVxge_WM_8 Although Shanna and Travis had a rocky start to their relationship, it appeared that they were getting along well with the actress's kids. She has said over the years that she and her ex-husband always wanted the best for their kids. Their attitudes towards their mother changed as news of her ex's romance with Kourtney Kardashian spread. In 2021, in response to a comment on TikTok, Landon explained that, unlike Barker, his mother isn't involved in his and his siblings' daily lives. Alabama then posted a similar message on Instagram, "My mother has never truly been a part of my life. Can you just stop making her out to be the perfect mother? On Mother's Day, my mother didn't make an effort to see me. Reality shows, I can no longer keep a secret."  some twitter posts are. EXPOSED: Travis Barker’s daughter Alabama exposes her mom with DM where her mom accuses Travis of being emotionally abusive and cheating on her with Kim Kardashian before moving to Kourtney. “My mom has never been completely in my life ... stop painting her out to be” amazing. pic.twitter.com/NWmUyCR1pk — Def Noodles (@defnoodles) May 16, 2021 To which Shanna responded, "utterly ludicrous." Her boyfriend, Matthew Rondeau, stepped up to defend her, saying that being a mother was just one of the many reasons he loved Shanna so much. Shanna's daughter Alabama had posted a photo of alleged infidelity on Instagram days previously, voicing the disapproval of the rest of the children. The mother and daughter were already estranged when the public acknowledgment of the rift drove a deeper wedge between them. Shanna and Matthew are still together, and Alabama stayed with her father, Travis. Similar Articles  - How Old Is John Larroquette: Is John Larroquette Still Alive? - Brandon Smiley Age: Is He Not In The World? Conclusion- Starring in Meet the Barkers catapulted Alabama Barker to popularity, and she has since starred in numerous other reality shows. In spite of the public feud between her parents, Travis Barker and Shanna Moakler, she has chosen to remain in her father's care. She is a model from the 2020s and has just released her debut single. Talented and ambitious, young Alabama Barker has a promising future. Read the full article

[knowworldnow112]

In the now-deleted Instagram article, Cuoco wrote which they were being “swimming and rockin out to 1 Way about the sound technique.” People today claimed that some company’ pics showed them sporting mermaid costumes. “Total working day of pleasurable during the Perample captioned her video. “Thanks @kaleycuoco for owning us celebrate.”

Her encounter with stunts and martial arts supplies her a distinct gain when performing in movies. She was qualified by black belt masters and has a all-natural expertise for executing feats.

may not be republished, copied, or redistributed, in whole or partly, with out acknowledgment or permission. This short article is for educational reasons only and the information talked about listed here may not be one hundred% suitable.

She recalled staying in Concentrate on when her agent named and questioned her a seemingly random question: “Athena, could you carry your leg up to the head?” She confirmed that she could, and, at her agent’s ask for, she sent him a photograph of herself demonstrating off her overall flexibility in The shop’s shoe Section. This is what served her protected the part.

Athena Peramble is really a passionate supporter of children’s education and learning. She has committed A great deal of her time and Electrical power towards the non-earnings organisation True Connection, a bunch devoted to encouraging young people to produce empathy and find progressive methods to worries on each a personal and world-wide scale.

, and he or she went on to deliver her dance moves on the NBA courtroom as a dancer for The l. a. Clippers. Because then, she has become a longtime actress and

Her paintings usually look at how conventional Western art kinds and new means of expressing Inventive flexibility in good shape with each other. Athena is likewise an creator. She has created two publications about how to paint. She likes to backyard garden, examine, and expend time with her household in her free time.

. But in that scenario, the infant was around the verge of becoming born, not gestating. In this universe, zombies – at least Alpha zombies; the smarter, a lot quicker types – might have little ones. In a way, that tracks with the strategy of development and evolution with the zombies; Zeus himself grew hair in enough time in between the First outbreak and when Military in the Useless’s primary story can take area, so It appears their cells usually are not dead. Whether they might age, however, is also unclear.

Childhood picture of Athena Perample with her mom She attended an area private college for her Key schooling. Later, she enrolled herself within an esteemed faculty for her graduation. She includes a eager fascination in dancing and modeling due to the fact childhood.

Yet another risk for your Zombie Queen currently being Expecting is that she was presently pregnant when she was became an Alpha zombie, just like the zombie baby which was born in Snyder’s initial film On this style,

Athena Perample is really a stunt Lady and play purpose in Army of Useless as zombie Queen. She began out her job in 2008 like a stunt girl for function films and tv demonstrates. In 2012, she auditioned for Army of Lifeless and was Solid as zombie queen.

When she entered the Film sector, her adore of dance led to even greater options. In her to start with Television set demonstrate, Glee, Athena had her individual portion as being a dancer. Next that, it was merely a make a difference of times just before she began to severely pursue components in other films and TV programs.

Athena Perample is surely Athena Perample an accomplished American stuntwoman and actress with around a dozen performing credits to her title. She can also be a Mother.

Athena Perample is often a very well-recognised Specialist dancer and actress from The usa who rose to fame soon after appearing as being a dancer within the strike Tv set demonstrate Glee.

Athena enjoys feeding on out with her household and hanging out with her buddies. She also uploads many pictures of her traveling together with her relatives.

[jcrmhscasereports]

Trisomy 18 and Microdeletion 18p Mosaicism: A case report and literature review by Chao-Chun ZOU in Journal of Clinical Case Reports Medical Images and Health Sciences

ABSTRACT

The trisomy 18 syndrome is a common chromosomal disorder due to the presence of an extra chromosome 18, either complete, mosaic trisomy or partial trisomy 18q. The mosaic trisomy 18 patients’ phenotype was extremely variable, from the absence of dysmorphic features to complete trisomy 18 syndrome. The phenotype of 18p deletion syndrome is variable and almost all survived. A 2-year-old girl was referred to our hospital due to growth delay. Mild dysmorphy including thin hair, frontal bossing, low set ears, broad-flat nose, nostrils slightly upward, downturned corners of the mouth, dysplasia teeth, small hands and fingers bilaterally was observed. The karyotype of peripheral leukocyte showed 46,XX, psu idic (18)(p11.2)[55]/46,XX, del (18)(p11.2)[45]. We report this case to add to our knowledge of the trisomy 18 and microdeletion 18p mosaicism.

Keywords: Trisomy 18, mosaic;18p microdeletion; Psychomotor retardation; Karyotype

INTRODUCTION

The trisomy 18 syndrome was first reported by Edwards et al in 1960, also known as Edwards syndrome. It is the second most common autosomal chromosomal disorder after trisomy 21（Down’s syndrome）due to the presence of an extra chromosome 18, which has three basic types: complete, mosaic and partial type (Edwards et al., 1960, Cereda and Carey, 2012,Mudaliyar and Mudaliyar, 2017). The syndrome presents a recognizable pattern of major and minor anomalies, significant psychomotor and cognitive disability are associated with high neonatal and infant morbidity and mortality. The estimated overall prevalence of trisomy 18 in live born is approximately 1/6, 000 to 1/8, 000 while the incidence in fetus is much higher, the difference is caused by fetal loss and pregnancy termination after prenatal diagnosis (Cereda and Carey, 2012, Rasmussen et al., 2003). The mosaic trisomy 18 usually means having more than one cell line in the individual, and it occurs in approximately 5 percent in all trisomy 18 patients (Fitas et al., 2013). The phenotypic manifestations are highly variable, from the absence of dysmorphic features to the complete trisomy 18 syndrome (Tucker et al., 2007). Since the clinical outcomes of complete and mosaic trisomy 18 can be different, it is of vital importance to achieve a correct diagnosis because of implications in medical management and genetic counselling. 18p deletion was first described by de Grouchy and colleagues in 1963 and was estimated to occur in approximately 1/50, 000 live born, which results from deletion of a part or full of the short arm of chromosome 18(Turleau, 2008). The mostly reported clinical features include cognitive impairment, congenital heart defects, small stature, minor facial dysmorphy, and skeletal deformities(Turleau, 2008, Xiao et al., 2019, Hasi-Zogaj et al., 2015, Yi et al., 2014)

Typical facial features include hypertelorism, ptosis, strabismus, broad–flat nose, micrognathia, and low-set big ears. Holoprosencephaly may be seen in approximately 10–15% of patients(Turleau, 2008). In addition, speech and language difficulties, pituitary abnormalities, generalized seizures, dystonia, and autoimmune diseases have also been described(Turleau, 2008, Rao et al., 2001, Graziadio et al., 2009, McGoey et al., 2011). However, these non-specific features are easily overlooked clinically. The clinical phenotype severity is related to the size and location of deletion region. In this report, we present a 2-year-old girl of mosaic trisomy 18 and 18p microdeletion with mild psychomotor retardation, cognitive impairment and language developmental disability.

CLINICAL DESCRIPTION

A 2-year-old female second child of non-consanguineous parents was admitted to our hospital due to growth delay. Her mother and father were 34 years old and 38 years old when giving birth to her. She was born at full-term with uncomplicated gestation, her birth weight was 3.35 kg and the length was about 50 cm. No feeding difficulty and complications were referred in the neonatal period. She had a motor retardation of autonomous walking until 22-months old and intelligence disability and language disability. She only knew a few simple words like ”mama“, not ”baba“, and she cannot communicate clearly with others though she was willing to speak to strangers. Gesell Developmental Schedules performed in local hospital indicated mental developmental delay in motor behavior, language behavior, adaptive behavior and personal-social behavior at age of one year and 8 months old. The height of her father, mother and 15

years old sister were 165cm, 161cm, and 155cm, respectively. No similar history was noted in her family.

On physical examination, she had a height of 81.4 cm below -3SD and a weigh of 11.6 kg below -1SD. Mild craniofacial dysmorphy was present, including thin hair, frontal bossing, low set ears, broad-flat nose, nostrils slightly upward, and downturned corners of the mouth while other craniofacial anomalies were not obvious (Fig.1A). Her hands were small especially her fingers, but the fingernails are normal (Fig.1B). Her teeth were dysplasia (Fig.1C). The echocardiography revealed patent foramen ovale (ϕ 2.96 mm) while no murmur was present. The muscle tension was normal and no other organ abnormality was detected in our patient.

Laboratory examinations (urine, liver, kidney, thyroid hormone, GS/MS and blood glucose analyses) were all normal. Insulin-like growth factor-1 was 72.5 ng/ml (normal range, 55-327 ng/ml).

MANAGEMENT AND OUTCOME

Ten months ago, the child was brought to a local hospital with developmental delay, the peripheral leukocyte karyotype was taken and revealed two abnormal cell lines, the result was 46,XX, psu idic (18)(p11.2)[55]/46, XX, del (18)(p11.2)[45] . She was then referred to another hospital to take the whole-exome sequencing demonstrating a deletion at 18p11.32-p11.22 (GRch37/hg19, chr18:158679 9708482del) and a duplication at

18p11.21-q23(GRch37/hg19, chr18:12012132 78005255dup). She was diagnosed mosaic trisomy 18 syndrome.

Figure 1: Clinical manifestation and karyotype of our patient. (A and B) thin hair, frontal bossing, low set ears, broad-flat nose, nostrils slightly upward, downturned corners of the mouth, small hands and fingers bilaterally; C) dysplasia teeth; (D) Karyotype shows 46,XX, psu idic (18)(p11.2)[55]/46,XX, del (18)(p11.2)[45]

DISCUSSION

The first reported patients with trisomy 18 syndrome were initially described by Edwards et al and Smith et al in 1960s, while the first case of mosaic trisomy 18 was reported in 1965. Less than 5% portion of patients have mosaicism of trisomy 18, and Banka et al reminded that routine karyotype from lymphocyte culture may not be sufficient to diagnose mosaicism if practitioners suspect a diagnosis of mosaic trisomy 18, karyotype from skin fibroblasts should be considered. Since then over 40 cases of mosaic trisomy 18 have been described, Tucker et al reviewed 33 reported individuals of mosaic trisomy 18 and added 2 more cases in 2007. Their clinical manifestations are extremely variable from complete trisomy 18 syndrome with early death to near totally normal. Some physical features are relatively more common and included brachydactyly, high arched palate, microcephaly, delayed bone age, frequent respiratory infections and otitis media, heart defect, 5th finger clinodactyly, micrognathia, and hypotonia. The most common heart defect is ventricular septal defect in mosaic trisomy 18. Our case has mild craniofacial dysmorphy and patent foramen ovale, and no other physical anomalies were observed.

Trisomy 18 mosaicism usually indicates the existence of more than one cell line in the individual. The peripheral leukocyte karyotype demonstrates pseudodicentric chromosome substituting a normal chromosome 18 in 55 cells and chromosome 18 missing the end of the short arm in 45 cells. The skin fibroblasts karyotype was not taken. Furthermore, there is no correlation between the physical and intellectual findings and the percentage of trisomy 18 cells in either peripheral leukocytes or skin fibroblasts. Besides, there is no correlation between the percentage of trisomic cells in peripheral leukocytes and brain, gonads, or other key organs. The variety of mosaic trisomy 18 may be related to the percentage of trisomic cells in different key organs of the body.

For complete trisomy 18 patients, approximately 50% of infants live longer than one week and about 5-10% of children survive beyond the first year. In overall, trisomy 18 mosaicism patients usually survive longer when compared to complete trisomy 18. This does not mean that all the mosaic trisomy 18 patients have a longer survival, some died a few hours after birth. For normal or mild phenotypical mosaic trisomy 18 cases, some were diagnosed due to recurrent miscarriages or giving birth to a child with trisomy 18 while others may never be identified. 18p deletion syndrome, also called monosomy 18p and De Grouchy syndrome type Ⅰ, which means a deletion of full short arm of chromosome 18 or a microdeletion of the short arm of chromosome 18. Some researches showed that nearly half of patients have breakpoints in the centromeric region and the rest scatter in the short arm, and approximately half of the deletions occur on the maternal chromosome 18 no matter where the breakpoint locations are. Our case’s breakpoint is at the 18p11.32-p11.22. Approximately two thirds of patients’18p deletion are de novo; the rest may be due to a de novo unbalanced translocation or malsegregation of parental chromosome rearrangement or a ring chromosome. The patient’s height and weight is 81.4 cm below -3SD, 11.6 kg below -1SD, respectively. It may be a prodrome of small stature, but her insulin-like growth factor-1 was normal. It also could be contributed to feeding problem. More follow-up work needs to be done to figure it out. Some reported cases show that growth hormone replacement treatment is efficient in growth hormone deficiency patients.

Our case has trisomy 18 and microdeletion 18p mosaicism simultaneously. The possibility of meiotic chromosomal nondisjunction of the ovogonia/spermatocyte was increased because of her parents’ advanced maternal age, some women may have higher a risk for nondisjunction. More possible mechanism may be a de novo unequal recombination occurring in early embryonic mitosis. Some deletions are from the parents, there is no way to figure her mutation mechanism out since we can not get her parents’ consent to analysis. The phenotype of our case combines two syndromes’ typical features, including common psychomotor retardation, cognitive impairment and congenital heart defect, characteristic small stature and language impairment of 18p deletion syndrome. Our case’s uncharacteristic craniofacial features also combine two syndromes.

In a conclusion, mosaic trisomy 18 and 18p deletion syndrome both are chromosomal disorders which has a variety of clinical manifestations. If an individual has untypical phenotypical anomalies and psychomotor and cognitive disability, chromosome disorder should be considered and cytogenic analysis is needed.

Acknowledgements: We thank the patient and his parents for permitting us to use the data.

For more information: https://jmedcasereportsimages.org/about-us/

For more submission : https://jmedcasereportsimages.org/

[lilalbatross]

god, nothing makes you feel decrepit quite like the birth years of rookie kpop idols

[smiliegurl92]

Flynn’s house/family is a mixture of the mom’s house from Yours, Mine & Ours, the Fosters (from the tv shows Fosters and Good Trouble), as well as the real life Braniff family (on YouTube as This Gathered Nest, and Angela Braniff).

Sarah (Sadie) Thomas was born in 1968, and works as a biomedical engineer. Aulii Kim was born in 1970, and works as an actuary. Aulii grew up in Hawaii, Sadie grew up in Michigan. They met in university, and moved to LA. They officially got married in 2008 before the whole Proposition 8 bs started, although they had been living as common-law spouses since 1991.

Flynn is the youngest of 5, all adopted by her 2 moms. There were also a large number of foster kids in and out of the house throughout the years, many of whom stay connected to the Thomases even after they return to their birth parents, or move on to wherever they are going next.

1.    Arlo (1994)

2.    Harper (1997)

3.    Daisy (2000)

4.    Jack (2002)

5.    Flynn (2005)

Arlo was a domestic infant adoption, but their birth family chose a closed/private adoption.

Harper was a domestic infant adoption, and it was an open adoption so her birth mother is involved with the family (somewhat; she lives in New York).

Daisy was adopted from foster care.

Jack and Flynn are biological siblings (adopted from foster care).

[girlactionfigure]

Only when he got older he realized just how fortunate he and his family were to be alive.

“The extermination of most of his relatives and millions of other Jews by the Nazis; the intrusive, unemployed immigrants who survived and crowded his parents’ small apartment; his sickly childhood; his mother’s dark moods; his own ever-present depression” - all of this, he survived, according to Patricia Cohen of The New York Times.

He was born in Brooklyn to Polish-Jewish immigrant parents on June 10, 1928.

One of his earliest photographs (attached to this story) shows him as an infant - “a plump, round-faced, slanting-eyed, droopy-lidded, arching-browed creature” held by his mother, with his older siblings, according to writer Margalit Fox.

Growing up, Murray as he was then known “har­bored ongo­ing fear of the per­ils that might lurk out­side of his home and neigh­bor­hood” and remembered how he cel­e­brat­ed his bar mitz­vah, according to writer Stephen Whit­field. 

That's when his father discovered that much of his extended family had died in concentration camps. The young boy thought he had "done something very bad, that I had made him suffer more than he had to."

“The death of members of his extended family during the Holocaust . . . exposed him at a young age to the concept of mortality,” according to NPR.

“As he got old­er, he was con­stant­ly aware of his mar­gin­al­i­ty and dif­fer­ence,” wrote Whit­field.

He seemed to be always sick, but when he was well, he could be naughty. He remembered his mother often called him “vilde chaya”, which in Yiddish meant "wild animal".

“His view of the outside world was often limited. . . and the little that he could see from his window,” according to PBS. “It was during this time that he began to draw and to allow his imagination to run free.”

He made a name for himself as an illustrator. When he received an opportunity to write his first book, he used the title "Where the Wild Horses Are" - unfortunately, he realized he couldn't draw horses, so he told his editor. His editor would respond, "Well, what can you draw?"

He would answer "Things."

He would become “the most important children’s book artist of the 20th century, who wrenched the picture book out of the safe, sanitized world of the nursery and plunged it into the dark, terrifying and hauntingly beautiful recesses of the human psyche,” according to the New York Times.

He remembers receiving a letter from one fan:

In an interview with NPR, he is quoted as saying, “A little boy sent me a charming card with a little drawing on it. I loved it. I answer all my children's letters – sometimes very hastily – but this one I lingered over . . . I wrote, 'Dear Jim: I loved your card.' Then I got a letter back from his mother and she said: 'Jim loved your card so much he ate it.' That to me was one of the highest compliments I've ever received . . . He saw it, he loved it, he ate it.”

~~~~~

“Maurice Sendak has been one of the most consistently inventive and challenging voices in children’s literature,” according to PBS. “His books and productions are among the best-loved imaginative works of their time. Like the Grimm brothers before him, Sendak has created a body of work both entertaining and educational, which will continue to be popular for generations.”

“Roundly praised, intermittently censored and occasionally eaten, Mr. Sendak’s books were essential ingredients of childhood for the generation born after 1960 or thereabouts, and in turn for their children,” wrote Fox. “He was known in particular for more than a dozen picture books he wrote and illustrated himself, most famously ‘Where the Wild Things Are,’ which was simultaneously genre-breaking and career-making when it was published by Harper & Row in 1963.”

He brought “to life a world of fantasy and imagination,” according to PBS. “His unique vision is loved around the globe by both young and old.”

When he died in 2012, the Washington Post wrote:

“They say that a creative adult is simply a child who has survived. Sendak survived a great deal, losing relatives in the Holocaust and struggling through a childhood that he remembered as “a very passionate, upsetting, silly, comic business.”

“And his books captured this — never talking down, yet always reassuring.

“The best writers are the ones who trust their audiences. Sendak did. And we trusted him right back.

“Sendak did not lie to children. He did not attempt to say that the world was more or less difficult than it was.”

~~~~~

In 2008 in the New York Times, Sendak revealed that he was gay and had lived with his partner, psychoanalyst Eugene Glynn (February 25, 1926 – May 15, 2007), for 50 years before Glynn's death in May 2007.

In that article, Sendak said he never told his parents: "All I wanted was to be straight so my parents could be happy," he recalled. "They never, never, never knew."

In a 2011 interview with NPR host Terry Gross, Mr. Sendak said "finding out that I was gay when I was older was a shock and a disappointment. I did not want to be gay. It meant a whole different thing to me — which is really hard to recover now because that's many years ago. I always objected to it because there is a part of me that is solid Brooklyn and solid conventional and I know that. I can't escape that. It's my genetic makeup. It's who I am."

Elisabeth Hoffman of the Baltimore Sun wrote, “Why do we pass laws that isolate, demean and shame people for something so utterly personal? It's no surprise that gay teens are bullied. No surprise that Maurice Sendak had to hide part of his identity from his parents — and from his readers.”

“In that often emotional NPR interview, Sendak also said: "I have nothing now but praise for my life. I'm not unhappy. I cry a lot because I miss people. They die and I can't stop them. They leave me and I love them more. What I dread is the isolation. There are so many beautiful things in the world which I will have to leave when I die. But I'm ready, I'm ready, I'm ready."

~~~~~

“His work . . . did not seek to for­get the emo­tion­al threats that scarred his life,” wrote Whit­field. “Sendak’s rec­ol­lec­tions of dread and dan­ger instead became the source of a painstak­ing cre­ativ­i­ty that [Golan Y.] Moskowitz [author of “Wild Vision­ary: Mau­rice Sendak in Queer Jew­ish Context”] read­i­ly calls illus­tra­tions of ​“genius.” Sendak believed that his fan­tasies must instill truths, rather than con­firm the con­ven­tions of inno­cence, and this think­ing rev­o­lu­tion­ized the way that young peo­ple were under­stood and addressed.”

In that last interview with NPR, “the beloved children’s writer and illustrator was 83 years old and in declining health. He was feeling the loss of people close to him who had died in recent years. Inevitably, the discussion turned to issues of mortality … By the time it was over there were teary-eyed people in cars all across North America. One listener, Brent Eades, left a message on the NPR Web site: “I happened to be listening to this extraordinary interview while on the early-morning commute from my small Ontario town to Ottawa. I was entirely absorbed in it; and the final couple of minutes left me with tears streaming down my face, which I’m sure nonplussed my fellow commuters.”

~~~~~

In “Where the Wild Things Are”, Sendak wrote:

“ . . . the wild things cried, “Oh please don’t go we’ll eat you up-we love you so!”

And Max said, “No!”

The wild things roared their terrible roars and gnashed their terrible teeth

and rolled their terrible eyes and showed their terrible claws

but Max stepped into his private boat and waved good-bye

and sailed back over a year

and in and out of weeks

and through a day

and into the night of his very own room

where he found his supper waiting for him.”

~ jsr

The Jon S. Randal Peace Page

[criminol]

The Fritzl Case

The Fritzl cases refers to a woman named Elisabeth Fritzl, who was held captive by her father, Josef Fritzl, for 24 years in their family home.

On 28th August 1984, after Elisabeth turned 18, Fritzl lured her to the basement of the family home. He then knocked Elisabeth out and sealed her in a chamber he had built for that purpose. A missing person case was opened and Elisabeth was forced to write letters to her family, which were to be given to the police, saying that she had run away and not to look for her. Fritzl claimed Elisabeth had joined a cult.

Over the next 24 years, Fritzl visited Elisabeth almost every day bringing her food and supplies but also repeatedly raping her. Elisabeth gave birth to seven children during her captivity- one died shortly after birth and three were removed from the cellar and lived with Fritzl and his wife as foster parents. Fritzl claimed the infants had been left on his doorstep by Elisabeth and authorities allowed him to care for them with no suspicions.

When Elisabeth's next child was born Fritzl expanded the prison, forcing Elisabeth and her children to dig the soil with their bare hands. At times he turned off their lights or did not give them food to punish them. Fritzl told Elisabeth and the three children who stayed with her that they would be gassed if they tried to escape.

In April 2008, Fritzl agreed to seek medical attention when the eldest of Elisabeth's daughters living in the basement fell unconscious. Elisabeth helped carry her daughter out of the prison and the daughter was taken to hospital and found to have life-threatening kidney failure. Fritzl later arrived at the hospital claiming to have a letter written by the girl's mother. Medical staff grew suspicious of his story and sent out an alert for the missing mother to provide information about her sick daughter's medical history. The police reopened the missing person's case for Elisabeth. Experts noticed Elisabeth's letters seemed oddly written and dictated.

Elisabeth pleaded to be taken to the hospital to see her unwell daughter, eventually her father agreed. Following a tip-off, police were alerted that Elisabeth and Fritzl were at the hospital and detained the pair.

Elisabeth would only provide details to police when they assured her she would never have to see her father again. During a two-hour testimony, she told a horrific story. Elisabeth told police that Fritzl had raped her and forced her to watch pornographic videos and re-enact them in front of her children. Josef Fritzl, aged 73, was arrested and Elisabeth and her children were taken into care. DNA later confirmed him to be the biological father of all of Elisabeth's children.

Josef Fritzl was sentenced to life imprisonment where he remains.