#insuline peak inducing

[jsms01]

Combining time-restricted eating + HIIT improves glucose control

Both time-restricted eating (TRE) and high-intensity interval training (HIIT) have been shown to improve cardiometabolic health in people who are overweight and at risk of serious disease. (Cardiometabolic risk factors affect both heart disease and metabolic disorders such as type 2 diabetes.) Now a new randomized controlled trial has tested whether combining these two approaches is more effective than either of them on their own. The results revealed that the combination improved long-term blood sugar control. It also led to a 2-fold greater body fat reduction compared with each intervention in isolation.

About the study

The trial, conducted by researchers from the Norwegian University of Science and Technology had four arms: HIT alone, TRE alone, the TRE-HIIT combination and a control group. A total of 131 women were enrolled. All of them had overweight or obesity and had risk factors for type 2 diabetes and/or cardiovascular disease. TRE was defined as consuming all daily calories within a 10-hour time window. HIIT was defined as exercise done at 90% of maximum heart rate for 35 minutes, three times per week. The exercise sessions were supervised by the investigators. The participants were also asked to log their first and last calories every day. The interventions lasted for 7 weeks. Participants' blood pressure, body mass index, body fat, blood cholesterol, blood glucose and insulin levels were measured before and after the study.

Improvements in HbA1c, body fat, visceral fat with TRE+HIIT

The researchers found that the participants who combined TRE and HIIT were able to improve their long-term glycemic control measured as hemoglobin A1c (HbA1c). They were also able to reduce body fat and visceral fat as well as increase their cardiorespiratory fitness measured as peak oxygen uptake. There were no differences in blood cholesterol, appetite hormones of blood pressure after any of the interventions compared with the control group. The researchers recommend this kind of program for people who want a relatively simple way of changing diet and exercise habits and improving their health. Moholdt says. TRE is a less tedious and time-efficient way to lose weight compared with daily calorie counting. HIIT is safe for previously sedentary individuals and can be completed within 30-40 minutes.

Limitations

A limitation of the study was that the intervention period was only 7 weeks; longer-term investigations are needed to determine effects and feasibility for longer periods of time. The study also took place during COVID-19 lockdowns, which affected the participants' lifestyles and could have influenced the results. The researchers are currently inviting the participants back for follow-up testing 2 years after they completed the study to find out if they have continued with the interventions. They also plan to determine whether the combination of TRE and HIT will induce the same health benefits and have equally good adherence rates in a completely home-based setting. That study will include both men and women. Source: Cell Metabolism, October 4, 2022. All research on this web site is the property of Leslie Beck Nutrition Consulting Inc. and is protected by copyright. Keep in mind that research on these matters continues daily and is subject to change. The information presented is not intended as a substitute for medical treatment. It is intended to provide ongoing support of your healthy lifestyle practices. Source link Read the full article

[juniperpublishers-crdoj]

Evaluation of Glycemic Control Obtained from NPH Insulin in Patients Experiencing Corticosteroid-Induced Hyperglycemia

Authored by Megan N Hodges

Abstract

Objective:To compare the safety and efficacy of neutral protamine Hagedorn (NPH) insulin to other antidiabetic regimens in the treatment of corticosteroid-induced hyperglycemia in non-critically ill; hospitalized patients.

Methods:This retrospective cohort included patients treated with methylprednisolone or prednisone concomitantly with NPH or other antidiabetic medications for at least two days. Patients were screened for inclusion in reverse chronological order and matched based on gender; age; body mass index; steroid dose; and history of diabetes. The primary objective was mean daily blood glucose (BG). Secondary outcomes included percentage of readings between 70mg/dL-180mg/dL; median daily BG; number of hypoglycemic events; daily steroid to NPH ratios; and mean weight-based dose of NPH for each 10mg increment of prednisone when BG readings were within goal.

Results:A total of 72 patients were included in each arm. The primary efficacy endpoint of mean daily BG ranged from 111-217mg/dL in the control group and 163-228mg/dL in the NPH arm; however; there were no statistically significant differences (p>0.05). Overall rates of hypoglycemia were slightly lower in the NPH group but with no statistically significant differences (0.61% vs. 1.12%; p = 0.51).

Conclusions:NPH; compared to other regimens; may not have an impact on achieving glycemic controlin corticosteroid-induced hyperglycemia.

Keywords: Diabetes mellitus; Corticosteroid; Hyperglycemia; Neutral protamine hagedorn

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Introduction

Systemic corticosteroids are commonly used for a wide variety of medical conditions on both an inpatient and outpatient basis for the treatment of inflammation and immune suppression. Acute asthma and chronic obstructive pulmonary disease (COPD) exacerbations, rheumatoid arthritis, and organ transplant comprise just a few of the many indications. Although corticosteroids are highly efficacious, its use is limited by many serious adverse effects during acute and chronic treatment [1-6]. During short-course therapy, patients commonly develop hyperglycemia. Several studies have reported odds ratios from 1.5 to 2.5 for the development of new-onset diabetes relating specifically to steroid utilization [2-5]. Corticosteroids also have the potential to significantly worsen hyperglycemia in patients with a history of diabetes mellitus [1,7] . This represents a substantial health risk to patients since studies have found a correlation between hyperglycemia and decreased wound healing, increased length of stay (LOS) and mortality in hospitalized patients [8].

Several studies have been undertaken to better understand the exact mechanism of steroid-induced hyperglycemia. In patients receiving short-term therapy, skeletal muscle and hepatic cells develop reduced insulin sensitivity leading to decreased glucose uptake. During the post-prandial phase in particular, blood glucose (BG) levels are further elevated by impaired suppression of glucose production secondary to hepatic insulin resistance [6].

Insulin acts on liver, adipose tissue, and skeletal muscle to regulate metabolism of carbohydrates, fat, and protein. A cross- sectional review of 66 patients suggested that patients receiving ≥10mg per day of prednisolone compared to those not receiving corticosteroids experience afternoon and evening hyperglycemia despite receiving basal-bolus insulin regimens [9]. Neutral protamine Hagedorn (NPH) is a crystalline suspension of human insulin with protamine and zinc, which makes it intermediate acting insulin. Neutral protamine Hagedorn insulin produces a peak effect four to eight hours after administration with a total duration of sixteen to eighteen hours. These kinetic properties closely mirror the action of prednisone. Methylprednisolone also has a similar duration of action with a shorter onset of one to two hours [10-12]. In theory, the pharmacokinetic principles of subcutaneous NPH make it a prime candidate for the treatment of glucocorticoid induced hyperglycemia. The objective of this study is to compare NPH to other antidiabetic agents in the treatment of steroid-induced hyperglycemia.

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Materials and Methods

Study design

This single-center retrospective cohort study evaluated patients at a 450-bed community hospital. The trial was approved by the hospital Institutional Review Board before data collection began. Due to the retrospective nature of the study, informed consent was not necessary. All data was obtained through electronic medical records.

Eligibility requirements included age ≥18 years, concurrent treatment with methylprednisolone or prednisone with NPH insulin or other antidiabetic medications for at least two days, and steroid doses ≥10mg prednisone equivalent on day one. Patients receiving NPH for the treatment of steroid-induced hyperglycemia were included in the treatment arm and patients being treated with any other combination of antidiabetic medications were evaluated in the control arm. Patients in the NPH arm with glargine insulin as a home medication were included in the study if the glargine titration was limited to± 20% during the hospitalization since a 20% reduction is recommended at admission to decrease risk of hypoglycemia and to limit confounding adjustments to the glargine during steroid titration [13]. Patients were not eligible for inclusion in the NPH treatment arm if they received any other antidiabetic medications in addition to NPH, rapid acting insulin, or glargine as described above. Oral antidiabetic agents were allowed in the control arm; however, per institutional protocols and American Diabetes Association (ADA) recommendations these agents are routinely discontinued upon admission to the hospital [14]. Patients admitted with a BG>400mg/dL, those in the intensive care unit, patients on insulin pumps, and pregnant patients were excluded. Patients were also excluded if they had less than two BG readings per day or no recorded weight.

Patient characteristics were identified through queries of the hospital electronic medical record. Starting October 2014 through October 2012, all patients receiving ≥10mg of prednisone equivalent of methylprednisolone or prednisone for at least one day were consecutively screened for inclusion in reverse chronological order. After patients were identified for analysis in the NPH arm, controls were then matched by manual chart review to the NPH patients based on age, gender, body mass index (BMI) classification, steroid dose on day one, and history of diabetes.

Study outcomes and definitions

The primary outcome was the mean daily BG. Secondary outcomes included the percent of BG readings within a preset goal of 70mg/dL to 180mg/dL. All BG readings were incorporated in the analysis regardless of the patients’ fasting state, thus a higher goal of <80mg/dL was established based on the ADA random BG recommendations for non-critically ill, hospitalized patients. The low end of this range was based on the ADA definition of hypoglycemia, which is BG<70mg/dL [14]. Other secondary objectives included median daily BG, number of hypoglycemic and severe hypoglycemic events with and without intervention. Intervention was defined as intake of juice, oral glucose tablets or administration of glucagon or dextrose 50% water. As defined by the ADA, BG<40mg/dL is considered severe hypoglycemia. [14] Daily steroid to NPH ratios and steroid to NPH ratios on the index day were also collected. The index day was defined as the last day of steroid therapy or the day of discharge if the patient continued steroids as an outpatient. Mean weight-based dose of NPH for each 10mg increment of prednisone equivalent (8mg methylprednisolone) was collected for days on which all BG readings were within the goal range with the intention of formulating a standardized NPH protocol. Two subgroup analyses were performed on mean blood glucose to compare NPH to sliding scale insulin alone and to compare NPH to other antidiabetic regimens in patients admitted with a documented history of diabetes.

Statistical analysis

The outcomes data was analyzed to determine the glycemic control achieved with each regimen by looking at all available BG readings throughout the patients’ hospitalizations excluding repeat readings within 10 minutes. Baseline characteristics and outcomes were reported using means, medians, and standard deviations for interval level data and percentages for nominal and ordinal level data. Baseline demographics and study outcomes were compared between groups using Student’s t-test for continuous data and Fisher’s exact or chi-square test for categorical data. A p value of <0.05 indicated statistical significance. All analyses were performed with IBM SPSS Statistics for Windows.

To the authors’ knowledge, the only other published trials addressing this treatment regimen included a maximum of 66 patients in each arm and did not find a statistically significant difference; therefore, power was not calculated [15-17]. Based on available information, 72 patients were included in each arm.

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Results

A total of 241 patients were identified through the pharmacy informatics system for potential inclusion in the NPH arm. Of these patients, 72 were eligible based on the inclusion and exclusion criteria. Patients were well matched in regards to baseline demographics (Table 1). The only significant difference between groups was total LOS, which was significantly higher in the NPH group (6.98days vs. 4.88days, p =0.003). However, no differences existed among indication for steroid utilization. Baseline glycemic control was similar between groups: mean BG of 186mg/dL in the NPH group and 177mg/dL in the control group at admission (p=0.492).

*There were no significant differences between the two groups except for LOS (p=0.003)

The primary efficacy endpoint of mean daily BG ranged from 111-217mg/dL in the control group and 164-228mg/dL in the NPH arm; however, no statistically significant differences were detected for any day (Figure 1) & (Table 2). The results on the index day (Table 3) showed numerically though not statistically improved glycemic control for the control group compared with the NPH arm with a mean BG of 195mg/dL for the NPH group and 179mg/dL for the control group (p =0.135).

In regards to efficacy, the only statistically significant difference found was in the percent of BG readings between 70- 180mg/dL for day 1 in favor of the control arm (41.9%vs.28.1%, p=0.01) (Table 4). No trends were observed for the steroid: NPH ratios or weight-based NPH doses. Consistent glycemic control was achieved faster in the control arm; mean daily BG readings were <180mg/dL starting on day 5 compared to day 10 in the NPH arm (Figure 1). In contrast to a previous study, the NPH arm received a significantly higher total daily insulin dose on the index day compared to the control arm (0.37unit/kg vs. 0.21unit/kg, p=0.002). However, these differing results are likely accounted for by the inclusion of glargine insulin in the NPH arm [15].

aData presented as mean ± standard deviation.

Glycemic control was similar in both subgroup analyses (patients with a history of diabetes and those receiving only slide scale insulin compared to NPH) (data not shown). In patients with a documented history of diabetes, the mean BG on the index day was 197mg/dL in the NPH arm compared to 185mg/dL in the control arm (p=0.313). When comparing NPH and sliding scale insulin versus sliding scale insulin alone, BG on the index day was 187mg/dL in the NPH group and 174mg/dL in the sliding scale insulin group (p=0.246).

Overall, the incidence of hypoglycemia was low in both arms, with more events occurring in the control arm (Figure 2). A total of 9(0.61%) hypoglycemic episodes occurred in the NPH arm and 15(1.12%) in the control arm (p=0.51). Only one episode of severe hypoglycemia was noted in the control arm.

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Discussion

When interpreting these results, it is important to note that the number of patients evaluated dropped considerably each consecutive day. By day eleven, only two patients remained in the NPH arm compared to one patient in the control arm. Although daily trends are important to consider, the results on the index day may provide the most insight on glycemic control.

Several limitations exist within this study. Due to the retrospective design, there is also potential for data extraction errors and chart documentation errors. Another limitation is the lack of standardized NPH dosing at this institution. The doses prescribed varied greatly between patients, and the majority of weight-based NPH doses were much lower than other institution protocol recommendations [1,8-15]. Overall glycemic control was also relatively poor in both groups compared to previous studies. This could be partly due to higher daily steroid doses and lack of Diabetes Management Services [15]. Lastly, patients in the NPH group had a significantly longer LOS compared to the control group, which could have resulted in worse overall BG control with increased time of steroid exposure. However, there were no measurements to determine severity of illness to help explain the extended LOS. Although this study was conducted at a single community hospital with a limited sample size, it is the largest study to evaluate this topic.

Despite a lack of evidence, several institutions have implemented protocols for the use of weight-based NPH dosing for hyperglycemic patients treated with steroids. The doses usually range from 0.1units/kg to 0.5units/kg depending on steroid doses [1,8-15]. One retrospective cohort of 120 patients found no difference between NPH versus glargine to control steroid-induced hyperglycemia in patients with type 2 diabetes [15]. A randomized control trial of 50 patients evaluated whether an NPH-based insulin regimen is safer and more effective than a glargine-based regimen in hospitalized adults with prednisolone-induced hyperglycemia. The initial daily insulin dose was 0.5units/kg or 130% of the current daily insulin dose. No differences in either outcome was observed [16]. Another randomized control trial of 53 patients examining glargine versus NPH in type II diabetics with respiratory disease and glucocorticoid induced hyperglycemia yielded similar results [17]. This current trial included patients regardless of their diabetes history or steroid indication. Despite the similarity in pharmacokinetic profiles between corticosteroids and NPH, this approach may not offer better glycemic coverage in steroidinduced hyperglycemia over other regimens as shown in this trial and in the studies by Dhital et al. [15], Ruiz de Adana et al. [17], & Radhakutty et al. [16]. Additional large, randomized-controlled trials are warranted to further help direct future evidence-based treatment strategies for steroid-induced hyperglycemia.

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Conclusion

Based on the results of this study, no conclusions can be determined about the efficacy of NPH insulin for corticosteroidinduced hyperglycemia. Patients receiving standard care (control group) appeared to have better glycemic control over patients in the NPH arm; however, the resulting differences were not statistically significant and hampered by small sample size.

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[justhewayfaringstranger]

Aesthetic cover by: @otellosdeath

-Disclaimer- Despite the biblical inspiration (as I am a Christian witch), I have tried to make the ritual as inclusive as possible, so that it can be used by anyone.

☼ Milk & Honey ☼

Milk and honey recalls the biblica image of a perfect land so fertile its green hills flow with honey dripping from its hives, like liquid gold in the sunlight. A spacious land covered with pink hawthorn, red cyclamen, and white rockrose. There are the flowers of its myriad wild fruits, and the warm valley air smelling of their nectar.

This ritual is therefore meant for: Peace, prosperity, success, fertility, thanksgiving.

Associations: It is a ritual linked to spring and the sun.

Colors: white, yellow, gold.

When: There is no fairer time than another to do it. Made in the hottest hours of the day, when the sun is at its peak it could be a little more powerful, but do it whenever you want or need it.

Ingredients:

2 tablespoons of honey (about 50g) - sweetness; representation of gold.

Half a cup of milk (about 125ml) - prosperity; success; protection; nourishment. If you don't like milk from an animal or are sensitive to dairy, you can use any other type of vegetable milk associated with your intentions (e.g. soy milk is great for job success).

Your favorite incense (if you do not have or cannot use incense, replace it with essential oil of your choice or olive oil).

A white candle on which you will engrave a symbol or seal that corresponds to your intentions.

A gold-colored candle (also yellow or white is fine) to clean the space, give more push and power.

How to cast:

After having dosed the two ingredients separately, mix them together in a container until a homogeneous mixture is obtained. If you prefer the mixture to remain denser, you can use yogurt.

When the mixture is ready, ignite the incense and pass the mixture into the smoke (if you don’t have or cannot use incense, pour three drops of essential oil of your choice or olive oil into the mixture).

Say: I make this offering to (the earth, your divinity, the universe, ancestors, etc.). As tank for the many blessing I have received and those I shall some day receive. I know mote it be.

Light the candles (if you are doing this spell for a particular reason (you want work or school success, because you need economic peace, you want to thank your divinity for something in particular etc.) you can write your intention on a sheet of paper and burn it in the candle flame. It isn’t necessary, but it can be useful to center your intentions).

Apply the compound obtained on the root and length of the hair accompanying the action with gentle massages. Continue to massage for a few minutes (the mask should be applied to dry hair before shampooing).

Leave on for about 15 minutes, covering your hair with a bathing cap or plastic bag.

While you wait, you can relax and meditate, write on your book of shadows, do other spells, sit in the sun, draw, or do your chores while listening to the music that you remember the spring / summer, the sun or your divinity etc. anything related to the sun, light or spring / summer is fine.

After the laying time, rinse the head thoroughly, taking care that all the product is removed, to avoid the appearance of unpleasant halos after drying. Then proceed to wash your hair with your usual shampoo.

When you are finished, blow out the candles and instead let the incense burn (let it consume itself).

WORNING!

If the scalp is irritated, avoid applying this hair mask by consulting a specialist doctor.

Check that you are not allergic to any of the ingredients (even if you use essential oils instead of incense).

If after applying the hair mask nourish a sense of irritation, rinse the head thoroughly and do the shampoo again.

OTHER USES: If you don't want to cast this spell / ritual as a hair mask, you can change the way you use it: you can then use it as a face / body mask or as a drink, keeping the rest of the ritual unchanged. Note: if you use it as a drink, don’t use essential oils or olive oil inside. As said before, if you don’t want or cannot use incense to purify the mixture, if you have to ingest it, use cinnamon or vanilla instead of incense.

If you use it for hair, know that:

Honey deeply moisturizes the hair, in fact it is the ideal ingredient for brittle and dry hair that needs nourishment from the roots to the ends, regaining softness and lightness even to the touch.

Honey strengthens the hair and thanks to its restorative properties it repairs the internal breakages of the hair. For this reason, the hair mask with honey and milk especially benefits hair that breaks, as it is weakened by the action of external agents such as the heat of the hair dryer and plates, the constant washing, the action of the sun.

In addition, honey restores the dull and dry hair to new shine and radiance, giving the face even more vigor.

Honey has a prolonged action over time so it is sufficient to apply this type of hair mask once a week.

If you use it as a face / body mask:

Both honey and milk possess antimicrobial and cleansing properties. These properties are enhanced when the two are taken together. Numerous cleansers are prepared using milk and honey, because the mixture gives the skin a healthy glow. One can also enjoy a milk and honey bath, by mixing them in equal quantities in the water. The combination is often used in popular spas throughout the world.

If you use it as a drink, know that:

Help the digestion

Honey has long been known as a source of prebiotics, which are nutrients that stimulate the growth and development of probiotics, which are beneficial bacteria that grow and develop in our intestines and digestive system.

Prebiotics have demonstrated a stimulatory effect on bifidobacteria, a type of probiotic that is found in milk. The carbohydrates and oligosaccharides in honey promote the healthy and proper function of these beneficial bacteria that are essential for the healthy maintenance and function of the GI tract. When the bacterial balance in the digestive tract is good, it eliminates a number of irritating conditions, including constipation, cramps, bloating, and it prevents the development of detrimental bacterial growth!

Help the resistance:

A glass of milk and honey every morning is known to improve a person’s stamina. While milk contains proteins, honey contains the necessary carbohydrates required for effective stimulus of the metabolism. Milk and honey provides a boost in strength to everyone, including children and the elderly. Animal proteins from milk are broken down by enzymes into their basic amino acids, and are then reformed to create usable proteins for humans. The excess material in this transformation is then oxidized as usable energy. Proteins are an essential part of the human diet, and honey helps to stimulate their metabolism!

Help  Bone Health:

As research on honey continues, it is gradually becoming clear that honey acts as a carrier and a transport of nutrients from food throughout the body. Specifically, honey has shown itself to be integral in the body’s uptake of calcium, of which milk is a rich source. Therefore, consuming honey and milk together will not only give your body the necessary nutrient (calcium) to benefit your bone health, but also the nutrient to maximize the absorption of it into your body. Proper calcium levels can prevent conditions like osteoporosis and inflammation of the joints as we age!

Help for Insomnia:

Honey and milk have both been traditionally used as remedies for insomnia and sleeplessness. Individually, they are both effective, but the effects are strengthened when taken together. Honey is one of the rare sugary foods that causes a controlled increase in the amount of insulin being secreted, which also promotes tryptophan to be released into the brain. Tryptophan is normally converted into serotonin, which induces a feeling of relaxation. Furthermore, serotonin is commonly converted to melatonin, a well-researched sleep aid. Through that rather confusing chemical pathway, honey and milk can be used to reduce sleeplessness!

Have Anti-Aging Properties:

The combination of milk and honey impacts not only the skin, but also the rest of the body, by making it agile and youthful. People in many ancient civilizations, including the Greeks, Romans, Egyptians and Indians, drank milk and honey to preserve their youth. Since milk and honey can help to ensure long life, the combination was known as “the elixir of life.”

The many antioxidant properties that occur when milk and honey are combined are the scientific explanation behind the anti-aging properties, because antioxidants attack the free radicals which so drastically affect the organ systems. They are also one of the primary causes behind skin degradation, wrinkles, blotches, and general failing health of your body’s largest organ, the skin!

It owns Antibacterial Properties:

Research has shown that milk and honey have a more pronounced effect on staphylococcus bacteria than milk or honey when taken alone. It is also believed that honey, added to warm milk, cures constipation, flatulence and intestine disorders. It is also good for treating respiratory disorders such as colds and coughs.

The benefits of honey and milk on the human body are so enormous that the phrase “land of milk and honey” meaning “a place which has plenty” is commonly used. Jerusalem is referred to as the land of milk and honey in the Old Testament, so they probably enjoyed a wealth of health benefits back then!

  For all those interested:

The phrase “a land flowing [or ‘that floweth’] with milk and honey” appears 20 times in our King James Bible—

Exodus 3:8, Exodus 3:17, Exodus 13:5, Exodus 33:3, Leviticus 20:24, Numbers 13:27, Numbers 14:8, Numbers 16:13, Numbers 16:14, Deuteronomy 6:3, Deuteronomy 11:9, Deuteronomy 26:9, Deuteronomy 26:15, Deuteronomy 27:3, Deuteronomy 31:20, Joshua 5:6, Jeremiah 11:5, Jeremiah 32:22, Ezekiel 20:6, and Ezekiel 20:15.

 Curiosity: X

Stay safe and follow your instincts!

Blessings !!

[falltennis87]

Sarms Advantages And Downsides.

Anabolic Steroid Side Effects: A Brief Summary

Content

Damaging Down Barriers To Physical Activity.

Peptides: Why Advancing Peptide Science And Also Modern Technology Must Be A Top Priority.

Lawful Use Declaration: Aqua Peptides.

Sarm Lgd.

Another one of Sarms advantages is that they have been shown to work with other types of anabolic steroids such as NGH or Luteinizing hormone. By working with these anabolic steroids the body is able to increase muscle tissue and reduce fat tissue. This type of effect has made sarms very popular among bodybuilders. In fact, nearly all bodybuilders use some type of anabolic steroid supplementation during their training. This means that sarms can really help bodybuilders who want to improve not only their physical appearance but their overall health as well.

SARM criticizes politicians for travelling abroad during pandemic - 620 CKRM.com

SARM criticizes politicians for travelling abroad during pandemic.

Posted: Thu, 07 Jan 2021 11:00:22 GMT [source]

Besides its ability to promote overall better health and wellness, Sarms also has a few additional perks. For instance, sarms has the ability to fool the brain into thinking that it is full when in reality it is not. This is because the brain uses the same pathways for regulating calories that anabolic steroids use. Another bonus of sarm as compared to anabolic steroids is that it has been shown to prevent the onset of osteoporosis and certain cancers of the reproductive system. Because of these benefits, sarm has been deemed to be one of the most powerful anabolic steroids on the market today.

Damaging Down Barriers To Physical Activity.

The next advantage of sarms is that they work by encouraging anabolic steroids to be released from your body. Steroids are a type of hormone, which work to help improve your muscle growth and repair the damage caused by injuries or certain illnesses. When you take anabolic androgenic steroids, you will be able to produce a higher amount of testosterone which means that you will be able to grow your muscles much faster. In fact, it has been proven that sarm can be extremely effective for a number of different sports. Below we will discuss how sarms work and whether they are good for you.

MK-677 is a development hormone secretagogue that resembles the task of Ghrelin.

In layman's terms it sets off the body to burn fat as fuel over sugar.

Contributed to this Cardarine has been revealed to enhance ATP efficiency and as a result boost endurance.

Cardarine captured the attention of the physical fitness community because of its benefits in energy metabolism, by reducing glucose utilisation and increasing fat oxidation.

MK-677 like Cardarine is not a SARM however is likewise commonly classified or organized with SARMs from a sales as well as advertising and marketing viewpoint.

In human studies it has been shown to considerably elevate lotion degrees of both GH and IGF-1 levels, rise fat totally free mass, energy expenditure, improve rest high quality and lower diet regimen induced assimilation.

Sarms advantages lie in the fact that sarms can be easily and rapidly digested by your body, even before they hit the blood stream. This is a very important advantage because it means that you can begin building muscles quickly and build them in a variety of different ways. Of course, with all kinds of supplements there are some risks, so it is best to consult a professional if you are considering taking a particular kind of muscle building supplement. However, if you are using a good brand like No Nonsense Muscle Building then you should have no worries.

Peptides: Why Progressing Peptide Science And Also Innovation Need To Be A Concern.

But there are some disadvantages associated with taking ostarine. First, and most importantly, ostarine cannot be taken by pregnant women due to the presence of bovine insulin-like growth factor in the milk in which the mother is lactating. Since the hormone stimulates the production of glycogen which is used to build up muscle mass and provide energy, this could spell disaster for a woman who is trying to get her body back into shape. Furthermore, for https://highgrade-labs.com/product/muscle-stack/ who is looking to lose a significant amount of weight, taking ostarine could prove to be detrimental. Ostarine can reduce the body's ability to absorb and utilize glycerol, one of the essential compounds that provide the body with fuel and energy during exercise.

Does MK 677 increase strength?

MK-677 did not affect strength and function, but insulin sensitivity declined and mean serum glucose levels increased 0.28 mmol/L (5 mg/dL).

In order to understand exactly how ostarine works it's important to look at how steroids function. Steroids are hormones that act on the body to cause changes in muscle development and behavior. These changes are commonly referred to as growth hormone (GH) or protein synthesis. In regards to arms, it has been found that it is much more potent than the other anabolic hormones such as testosterone, which in turn means that it can act much faster and have far more profound effects. Because of this it can encourage muscle growth, fat loss, and speed the healing of any injury without impacting one negatively on another. This is the main reason why sarms is often taken prior to, as well as following, any exercise regime.

Legal Usage Statement: Aqua Peptides.

number one solution of Sarms advantages is its ability to improve the functionality and longevity of the liver. The liver is responsible for cleaning up the acid levels in the body as well-being by producing and secreting bile. By improving the production and secreting of bile Sarms can potentially improve the health of your kidneys as well-being. In addition to improving kidney function Sarms can also improve weight loss. The combination of these benefits make ostarine an ideal supplement for athletes and people who wish to enjoy overall better health as well as a leaner body.

Are SARMs legal in Canada?

The purchase and use of Selective Androgen Receptor Modulators in Canada are legal for research purposes. However, the sale or distribution of SARMs is not generally approved by Health Canada and/or Canada Border Services Agency.

Arms should be considered as an alternative to androgenic and anabolic steroids and should be used under the guidance of a professional medical practitioner. If you're not sure whether or not you should use artificial hormones, you can visit your local pharmacy and ask for information on natural herbs with anabolic androgenic steroids and how to best make use of them to achieve your goals. Your local gym might also be able to recommend a good gym to help you along your way to better health. Remember, if you want to build up more muscle mass or develop better fitness, you should stay away from androids and choose something natural instead.

Sarm Lgd.

One of the main advantages of sarms is that they work by helping you break down ostarine. One of the things that you need for your body to produce ostarine is amino acids. Shop Uk sarms post cycle therapy supplement Sarms is actually what makes you stronger as you go about your everyday life. However, when you are trying to build up lean muscle tissue you will find that it can become hard to produce enough of the right amino acids. By taking an anabolic androgenic steroid like sarm you will be able to trigger the right processes in your body so that you can successfully produce the right amounts of ostarine.

Another advantage of sarm that is great for those who want to increase their lean muscle mass is that it can help you to burn off a lot of body fat. As you may already know, one of the biggest problems that people have with losing weight is that their bodies do not have a way of breaking down body fat. If you want to get rid of unwanted body fat, you will need to focus on finding a way to speed up your metabolism. And the best way to do this is through taking sarm.

Finally, sarm can only be purchased from a health food store in America because ostarine is manufactured in a lab. Since no dietary supplement exists that contains ostarine, the seller must resort to creating a synthetic version of it in his own lab. The result is a product called ligandrol. Although it resembles sarm completely, it does not contain the anabolic hormone in its composition, so it cannot be used by body builders who need oestrogen. Nevertheless, ligandrol has its own advantages and disadvantages, which the user should understand before buying.

If you are new to using synthetic HGH or human growth hormone supplements then there are several Sarms advantages to know. First and foremost, Sarms can bind with the human growth hormone receptors, which are found only in the central nervous system, or the pituitary gland. This means that Sarms can bind with a high concentration of HGH and deliver peak levels of the hormone to the body quickly. The reason this is possible is because human growth hormones, also called HGH, are released from the pituitary gland which remains tightly wrapped in the cerebrospinal fluid. When the fluid leaks or the gland closes off the hormone is released into the blood stream.

Another disadvantage of sarm is that it could prove to be toxic to the user if taken in high doses over a long period of time. This is largely due to the fact that the FDA only approves the sale of sarm when it contains at least twenty-five percent oestradiol, but since the price tag for sarm comes in different packages, ranging from one hundred dollars to four hundred dollars, the buyer has to choose his or her package based on price. Taking sarm in combination with other anabolic steroids could prove harmful. While there have been no reports of serious side effects from taking sarm, the user should always consult his doctor before taking it.

One of the main advantages of sarm supplements is that they will increase your testosterone level. Testosterone is an androgenic hormone, which means that it can convert into other types of hormones in the body. So when you take sarm supplements you will be increasing the amount of testosterone in your body. And this means that you will be able to build muscle tissue very quickly.

[wisdomrays]

TAFAKKUR: Part 86

Biorhythms and Time Management: Part 1

And We made your sleep to be rest (to you) and the night to be a covering. (Qur'an 78:9-10)

Most time management experts agree that the essence of time management is self-management. A successful time management strategy requires the setting of goals, and then assigning priorities and identifying important activities that help achieve these goals. People then will organize their time into a 'time map' (just like a floor map), writes Morgenstern, and place important activities in fixed blocks of time.

This general strategy, which has worked for many, requires strong willpower. According to Taylor, it is 'self-management with respect to time.' We can achieve more important goals by increasing the time we spend on them and/or by increasing our productivity. To use our mind and body in the most effective manner, we need to understand the psychological and physiological aspects of our selves and act accordingly. This article considers the relationship of hormones, our body's biorhythms, and self-management with respect to time.

Hormones

Hormones, which are produced in certain parts of the body, are chemical signaling molecules that travel to another site to have an effect. Many researchers believe that these messenger molecules are the basic channels of mind-body communication. The periodic release of messenger molecules regulates our mind-body activities, but this does not mean that we are controlled by our hormones. We know that our thoughts, attitudes, and emotions can influence the release and flow of these messenger molecules just as they can influence our thinking, feeling, and behavior. By focusing on positive thoughts, we can induce the secretion of hormones associated with calmness and serenity, and vice versa (the mind-body communication flows both ways). Let's examine several important hormones that regulate our energy, stress, activity, and rest.

Energy and stress hormones. Energy is crucial for performance. Two important hormones, among others, are secreted to provide a steady level of energy for the brain and other organs: insulin and glucagon. Insulin, released when the blood sugar level increases, helps various organs consume sugar and hence decreases the blood sugar level. Glucagon, the other pancreatic hormone, tends to raise the blood sugar level.

Both hormones work together to help maintain the blood's normal level of glucose so that this critical energy source's supply is always constant and even. While different bodily organs can use other forms of sugar for energy with the help of insulin, the brain's only energy source is glucose. Therefore, it is vital to maintain a steady level of glucose in the bloodstream for the brain's healthy functioning.

Insulin is important because its excessive release causes large fluctuations in the blood sugar level, which affects our mental performance. High glycemic index foods, such as high-carbohydrate and sugar-loaded processed foods (e.g., cookies, cakes, sweet carbonated drinks etc.) raise the blood sugar level too quickly when they are digested. The body responds by releasing insulin, which causes the blood sugar level to drop too much.

Normally, various bodily mechanisms collaborate to ensure that the glucose level remains within certain limits. But if the brain cannot get enough glucose, it first may reduce its activity in the form of sleepiness or unconsciousness. Continued deprivation may cause brain damage and even death. To achieve maximum mental performance, high glycemic index foods should be avoided, and steady blood sugar levels should be maintained.

The adrenals glands, located just above the kidneys, often are referred to as the stress glands, because we could not survive stress without them. Cortisol, DHEA, and adrenaline are the three adrenal stress hormones that raise blood pressure and heartbeat. Under their influence, glycogen is converted to glucose for additional energy. A normal adrenal rhythm will produce correct amounts of these adrenal stress hormones at appropriate times during the day.

Occasional surges of stress hormones temporarily raise the heart rate, blood pressure, and mental acuity so that the task at hand can be accomplished. They give us the energy to escape danger, fight (verbally, psychologically, or physically), and generally survive the pressures of our lives. The downside is that too much of this activity erodes our health in insidious but serious ways. An excess of stress hormones compromises health, from damaging blood vessels to weakening the immune system. Some physicians blame stress for most disease.

Stress hormones play an important role in time management. Natural stress hormone secretion is at its peak during the early morning so that it can awaken the body and prepare it for the day. Cortisol and insulin secretions reach their maximum around 6:00 am, and we awaken. Lubeck states that German researchers have discovered that two hormones, ACTH and cortisol, send a message that alerts the brain. Even the blood's contents are enriched to get ready for the day. The early morning increase in stress hormones is part of our circadian biorhythm, and we can take advantage of it by scheduling demanding activities at this time.

However, an artificial increase in stress hormones may sometimes hurt us. A frequent cause for excess stress is the use of such stimulants as cola drinks (e.g., Coca Cola and Pepsi) and coffee. When trying to focus on a task, mental clarity is very important. When we are under stress, we may find it hard to concentrate and thus spend a lot of time to achieve very little. Continued stress depletes our energy and prevents us from undertaking important tasks. An abnormal release of stress hormones also affects our REM sleep, which is very important for memory consolidation. People who find it hard to wake up in the morning may suffer from an abnormal stress hormone cycle.

Some neurohormones such as pinoline and DMT, which are linked to spiritual imagery, reflection, and out-of-body experiences, are secreted at their peak level around midnight. Early Islamic scholars, following Prophet Muhammad's tradition of night prayer, used to wake up at midnight for reflection, study, and prayer. The discovery of these hormones may explain why this time of day might be the best time for such activities.

The rest hormone. The pineal gland's cells secrete the hormone melatonin in a 24-hour (circadian) cycle. The amount remains low during the daylight hours but increases during the nighttime hours. Melatonin regulates the 24-hour circadian biorhythms, and its secretion is affected by light. As a biological timekeeper, melatonin is critically involved in synchronizing hormone secretion and is responsible for regulating many biorhythms, including the sleep-wake cycle.

Since it is the 'rest hormone,' it generally is more productive to rest when its secretion is high, namely, the dark hours. Trying to work or study with the help of caffeine and other stimulants despite increased melatonin levels is like fighting the body's natural rest and healing systems. Students sometimes cram on the night before the exam. While this strategy may work for short periods, continued disruption of the body's rest cycle may leave the person weak and susceptible to diseases. Melatonin secretion turns off around 8:00 am.

[supplier-of-peptidesz]

Dosage of HGH and Peptides

Some info for your reference:

IGF-1 lr3

Dosage: daily dose ranges from 20mcg to 150mcg a day Effects: reducing body fat (abdominal area) and muscle building combine with other products To reduce fat: combine with HGH Fragment 176, CJC-1295 DAC Cycle for muscle building: combine with GHRP2, GHRP6, CJC-1295 DAC, MGF

BPC 157

A typical dosage of BPC 157 is 10 mcg per KG of body weight, but the actual dosage will depend on injury type and severity.

TB500

The dosage depends on the purpose and severity of the injury/damage you are treating. People generally use between 4 to 8 mg of TB500 per week during the initial (loading) period of 4 to 6 weeks. Afterward, some opt to maintain the effects with a low 2 to 6 mg dose once every 2 weeks. The effects of TB-500 wear off within 2 - 3 weeks of injection.

HGH

HGH is measured in IU (International Units) and mg (milligrams).1 mg equals approximately 3 IU while 1 IU equals approximately 0.33 mg. Dosage:

People generally use 2 IU per day for anti-aging purposes, take 4 to 6 IU for bodybuilding, weight loss, and fitness while taking 8 to 16 IU for a short duration to treat severe burns or recover after injuries. Doses below 3IU per day usually bring no side effects while people can notice the improvement of their skin, better sleep, more energy, eating junk food without gaining weight, etc.

PEG-MGF

PEG-MGF Dosage 1: 200mcg (10 IU) of PEG-MGF split bilaterally between muscles just trained i.e. 100mcg left side, 100mcg right side PEG-MGF Dosage 2: 200mcg (10 IU) of PEG-MGF is to be injected into abdominal fat

CJC 1295 without DAC

Dose per injection: 100mcg Injections per vial: 20 x 100mcg dosages Amount to Inject: If you have used 1ml of water for mixing then a 100mcg dosage = 0.05ml (or 5 units on Insulin Syringe). If you have used 2ml of water for mixing then 100mcg = 0.10ml (or 10 units) and if you have used 3ml of water for mixing, then 100mcg = 0.15ml (or 15 units). Injection Frequency: 100mcg injected 1-3 times per day, preferably together with a GHRP Peptide at 100-200mcg.

CJC 1295 with DAC

600mcg taken once per week, at any time of day.

GHRP-6

Dosing will ordinarily be at least twice per day and preferably 3x/day for best effect, taken at least 30-60 minutes before a meal and at a time of non-elevated blood sugar (in other words, after blood sugar has had time to fall since the most recent meal.) The amount taken generally will be from 50-300 mcg at a time. When using a GHRH along with GHRP-6, dosing should be reduced to 50-100 mcg at a time.

For an increase in GH levels, higher doses within the suggested range definitely increase the effect. With regard to healing benefit, for example for tendonitis, the low end of the range is often entirely sufficient, and the noticeably greater effect is not necessarily seen with increased dose.

EPO

A starting dosage is typically 20 i.u. per kilogram body weight, 3 times/week. After two to four weeks, a maintenance dose of 20 i.u. /kg BW can be taken once a week.

MT-2

All peptides need to be reconstituted with bacteriostatic water or sodium chloride specifically used for injections. In order to use Melanotan II effectively, you need to understand your skin type. To keep things simple, we can go ahead and break skin types into three categories.

Skin Type 1: Very fair skin, never tans. Dosages: 50-60mgs or 5-6vials. Skin Type 2: Fair skin, burns but sometimes tans. Dosages: 30-40mgs or 3-4 vials. Skin Type 3: Medium skin, sometimes burns and always tans. Dosages: 20mgs or 2 vials. Beyond that, if your pigmentation is already naturally olive or darker, you will need to use less

Melanotan II for your tanning needs. The tan results coupled with exposure to sunlight and UV rays should last a user all summer or through a season.

Daily Dosages vary depending on your needs: For Erectile Dysfunction (ED): average dose is around 0.025 mgs/kg (1kg = 2.2 lbs) For Tanning (skin pigmentation): average dose is 0.025-0.030 mgs/kg (1kg = 2.2 lbs) Taking too much M2 can make you somewhat yellowish, so you need to start slowly with lower doses and move your way

GHRP-2

Normally, GHRP-2 will be used 2-3 times a day at around 100mcg-300mcg per injection. For example, I recommend taking it before breakfast and before bed for maximum benefits.

HGH Fragment 176-191 How much Human Growth Hormone (HGH) Fragment 176-191 should be used? In most studies, favorable results have been shown with dosages between 400-600mcg or 4-6mcg/kg split into multiple dosages per day.

How long should Human Growth Hormone (HGH) Fragment 176-191 be used? In most studies, no adverse side effects were reported with continuous use per the dosage limits in the above answer.

What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?

Studies have suggested the following:

A typical beginner protocol would be: 200mcg before breakfast 200mcg 30 minutes prior to training Approximately 5-7 days a week – subcutaneous injections

A typical intermediate protocol would be: 250mcg before breakfast 250mcg 30 minutes prior to training Approximately 5-7 days a week – subcutaneous injections

A typical advance protocol would be: 200mcg before breakfast 200mcg before lunch 200mcg 30 minutes prior to training 7 days a week – subcutaneous injections

When dosing multiple times a day at least 3 hours should separate the administrations.

What are some of the possible side effects with Human Growth Hormone (HGH) Fragment 176-191?

Reported side effects have included: hypersomnia (excessive sleeping), insomnia, burning feeling at injection spot (last 10-15 minutes). All side effects went away after 2-3 days of discontinuing use.

Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?

Studies have shown that the administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait at least 30 minutes to eat. At that point, the growth hormone pulse has reached its peak and you can eat what you want.

HCG Usual Adult Dose for Ovulation Induction Human Chorionic Gonadotropin (HCG): 5000 to 10,000 units IM once 1 day following the last dose of menotropins

Recombinant Chorionic Gonadotropin (r-HCG): 250 mcg subcutaneously once 1 day following the last dose of the follicle-stimulating agent

Comments: -Some experts recommended HCG doses of 10,000 units. -Patients should be appropriately pretreated with human menotropins. -r-HCG should not be given until adequate follicular development is indicated with serum estradiol and vaginal ultrasonography; treatment should be withheld in patients with the excessive ovarian response (e.g., significant ovarian enlargement, excessive estradiol production).

Uses:

-Induction of ovulation (OI) and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure

-Induction of final follicular maturation and early luteinization in infertile women who have undergone pituitary desensitization and who have been appropriately pretreated with follicle-stimulating hormones as part of an assisted reproductive technology (ART) program (e.g., in vitro fertilization, embryo transfer)

Usual Adult Dose for Hypogonadism - Male HCG: 500 to 1000 units IM 3 times a week for 3 weeks, then 500 to 1000 units IM 2 times a week for 3 weeks OR 4000 units IM 3 times a week for 6 to 9 months, then 2000 units IM 3 times a week for 3 months

Uses: -Selected cases of hypogonadotropic hypogonadism in males -Hypogonadism secondary to a pituitary deficient in males

Usual Pediatric Dose for Prepubertal Cryptorchidism HCG: 4 years and older: 4000 units IM 3 times a week for 3 weeks OR 5000 units IM every other day for 4 injections OR 500 to 1000 units IM for 15 injections over a period of 6 weeks OR 500 units IM 3 times a week for 4 to 6 weeks; if unsuccessful, patients should be given an additional series using 1000 units starting 1 month later.

Comments: -Treatment is believed to induce a temporary testicular descent response in patients who would have testicular descent during puberty but may produce a permanent response in some patients. -Treatment usually occurs between 4 and 9 years of age.

Hexarelin Typically, a dosage of around 200mg each day works best for therapeutic benefits but can be as much as 400mg each day. Data shows that there are no added benefits of using more than 200mg a day.

Ipamorelin For ranges of dosing, use 200-300mcg 2-3 times per day. If you want, you can combine it with other growth hormone-releasing hormones for a greater synergistic effect. 8-12 weeks of dosing is suitable, and it can be used indefinitely.

Sermorelin A dosage of 0.2 - 0.3 mcg once daily at bedtime by subcutaneous injection is recommended. It is also recommended that subcutaneous injection sites be periodically rotated.

HMG MENOTROPINS FOR INJECTION USP

Usual adult dose Induction of ovulation Intramuscular, 75 Units of FSH and 75 Units of LH activity once a day for usually seven or more days, followed by 5000 to 10,000 Units of chorionic gonadotropin one day after the last dose of menotropins. If necessary, the dose of menotropins may be increased by 75 to 150 Units FSH and 75 to 150 Units LH every four or five days. Up to 450 Units, FSH, and 450 Units LH a day may be required.

Assisted reproductive technologies Intramuscular, 150 Units of FSH and 150 Units of LH activity once a day for usually seven or more days, followed by 5000 to 10,000 Units of chorionic gonadotropin one day after the last dose of menotropins. If necessary, the dose of menotropins may be increased by 75 to 150 Units FSH and 75 to 150 Units LH every four or five days.

Note: The dosage regimen may vary according to physician preference or patient response. If the ovaries are abnormally enlarged or the serum estradiol concentration is excessively elevated on the last day of menotropins therapy, human chorionic gonadotropin should not be given for that cycle.

Male infertility (hypogonadotropic hypogonadism) Intramuscular, 75 Units of FSH and 75 Units of LH activity three times a week (plus chorionic gonadotropin 2000 Units twice a week) for at least four months following pretreatment with chorionic gonadotropin (5000 Units three times a week for up to four to six months) {10}. If an increase in spermatogenesis has not occurred after four months, the dose may be increased to 150 Units FSH and 150 Units LH three times a week (with no change in dose of chorionic gonadotropin).

MGF A typical protocol would be: 100-300mcg of MGF divided into 1-2 bilateral administrations into 2-5 different areas of the muscles approximately 5-7 days a week – intramuscular injections.

Example, if you want to administer 200mcg of MGF into the chest and biceps muscles 2 times a day and 3 different areas of the muscle then you would need to divide the dose as follows:

200mcg / 2 times per day = 100mcg per administration 100mcg per administration / 4 muscles (2 chest and 2 bicep muscles) = 25mcg per muscle 25mcg per muscle / 3 different locations on each muscle = 8.3mcg per injection

Theoretically, the more locations used to administer the MGF into the muscle the more places for muscle growth.

Studies have also suggested the following: The administration should not be given within 2 hours after training in order not to reduce natural IGF-1 production.

The administration should not be given within 2 hours before sleeping in order not to reduce natural growth hormone production.

After administering, adequate-protein needs to be ingested for MGF to be effective in building new muscle.

How to reconstitute MGF? MGF is typically manufactured in 2mg amounts and is reconstituted with sterile water. – If 2ml (2 full – 1 ml U-100 insulin syringe) of sterile water is added to the vial then each unit of the syringe will equal 10mcg. – If the syringe is filled up to 10 units (up to the number 10 on the syringe) it will equal 100mcg of MGF.

How long should MGF be used? In most studies on MGF, no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

Selank Selank products are normally available as a 0.15% spray, with 75 μg of Selank per spray. The recommended dosage is 2 or 3 sprays per dose with 3 doses per day (a max total of 675 μg per day) [R].

For an adult weighing 67.5 kg (about 149 lbs.), this translates to about 0.01 mg Selank/kg body weight. Rat studies normally used 0.3 mg Selank/kg body weight.

Gonadorelin Adults: 100 mcg dose, subcutaneously, or intravenously. In females for whom the phase of the menstrual cycle can be established, the test should be performed in the early follicular phase (Days 1-7).

Epitalon Epithalon dosage and course (cycle) duration

The dosage depends on the purpose and severity of the damage which is treated. Epitalon can be used orally (less effective and large dose) or injected intramuscularly or under the skin (more effective at much smaller dose).

1. Oral Epithalon use (least effective): duration: between 10 - 20 days dosage: between 400 - 600 mg of Epithalon per day daily frequency:200 mg per serving, between 2 - 3 servings per day (depending on the dosage)

2. Epithalon as nasal spray or drops (medium effectiveness): duration: between 10 - 20 days dosage: between 15 - 30 mg of Epithalon per day daily frequency: total daily dosage split into 3 servings throughout the day

3. Injectable Epithalon use (most effective): duration: 10 - 20 days dosage: between 5 - 10 mg per day (20 mg intravenous for terminal patients) frequency of injection:1 injection per day for low dose, 2 injections for higher dose (divided between morning and late afternoon injection)

Each 10 - 20 days course of Epithalamin is followed by 4-6 months pause before repeating the course again. Epitalon treatment can be repeated indefinitely.

Semax Because Semax is so potent, only small doses are needed to achieve the desired results. In most cases, 0.5-1.0 milligrams per day are all the average users will need. In most cases, this is equivalent to one or two sprays from the nasal applicator. Semax does not need to be taken with food, nor do you need to adjust the dosage to account for sex or size differences. What one will have to make note of, however, are the different variants of Semax concentration. The 0.1% concentrations are less powerful than the 1% solutions (which are normally reserved for stroke victims or individuals with serious medical conditions). For cognitive enhancement, the lowered concentrations should work adequately.

For more details,  pls feel free to text me!

Whatsapp: +86-15918445525

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[mmjjbbaannkkss]

2019 Dec 29 - 2020 Jan 4, Happy New Year

“The objective of cleaning is not just to clean, but to feel happiness living within that environment.” Marie Kondo

Week 4 (all slow)

Food requirements have changed, by muscle recruitment have exhausted myself. Friday was an insulin related shock, either physically induced or recovery insufficiencies. Or both. Having low-fat mornings is my way of trying to remove bloodfat before workouts, to avoid overheating, regulate body temperature, and focus/executive mental function. The low-carb evenings are a game of mental balance, which under two weeks became body shock. It’s similar to losing a minute of sleep per day, then the insomnia triggering paranoia, whereas night owls hit that wall decades sooner. So, before workout has become things like vegan chili, yams and fruits, greens ect, but forces a waiting window one hour, carbs can make me sleepy at the gym. Feeling better getting out of bed, but getting motivated could stand for a bit more coffee, or (ikno i’ve been hocking vit-b a lot) some pre-workout, just for ‘peak mornings’, but that could be a (dopamine) high expectations issue. Can’t be peeled everyday, just doing deep tissue or fascia work, in prep, to Work for results. The mirror is a reflection, depression is a projection, so be in charge of what you can control. And easy on the cologne, cubs. 

#19 Heavy Push /lbs -

Treadmill 10 > Shldr Press *6/103050 > Rot incl press *6/(2)203040 > Facepulls htl *6/2025303550~ > BB Flat Bench *6/100*3~ > Incl DB Bench *6/404550 > Pec Deck *8/!*6/85100115? > Dips *8/888- > Pullover/down *8/303550- > Tric Pushdown *8/355065- > Abs *8/rev row 60708090- > Stairs 10 (last min knees) > Treadmill 10 

Should I watch the new Rambo; this new active resistance workout is hard, why they mentioned long carbs well. Do not skip brekkie. 

#20 Slow/Light Pull +pos

Treadmill 0/ stairs 5 > Lat Pulldown *6/LR25404040 > Palms-In Pulldown *6/100*3,120- > 1-Arm Row *6/35505050 > Pullover/down *6/203040- > Row *6/low 100*3 > Smith Shrug *8/50,100*3 > Delt Deck *8/facepulls 20253035 > Straight Bar Curl *8/2030*3 > Preacher Curl *8/3045*3-! > Alt DB Hammer *8/202530- instant? > Treadmill ? Stairs mainstay.  

Boots, good. Make sup. 

/notes/ A diagram of stairs, to indicate plateau effect. Normalizing cardio and acclimation, when your body is used to cardio, small changes in diet have major metabolic effect. Any point or level of cardio from gym-goers, using carbs to fuel cardio, eventually dumping carbs into high intensity long distance constant speed cardio. Not having sufficient time for the body to convert fat to carbs, your body might use protein and convert it to the carbs’ purpose of energy. Slow cardio/resistance allows the body to burn fat and raise metabolism, but if you’re hungry after a walk, just like in childhood you’ll gain muscle endurance rather than size. A 30k runner is smaller than Mr Olympia, you do the math. Savory oatmeal? Watch what you eat, but don’t skip meals, if you’re bored of the same old same old, have fun snacks, cheat meals so small only cats would feel full, pretend you’re a giant at a tea party ffs. 

If your hobby isn’t real, you’re a fake. #antisocialmedia; does high row = chin-ups? The other day mentioned Wednesday, today reminiscent of the bear movie one; friends we look into their general direction, family we look in the eyes.

#21 Heavy/Slow Legs - Jan 1st, Enero 1ro. 

Treadmill    one set, make resolutions in new year, not before, only when ready, grasshopper. 

Stairs = 22 + 22; done, HNY’s. 

Paid as much was stolen, due and granted savings going forward, considering, sick a policy would be unhealthy if the next were to replace anyone dining out again. Need = rope hoist center mass. Peck kettlebell or plate pinch? 

Forgot closes at seven is five, boots truly helping ankle to rehab, likely by not letting heel roll in, ankle buckle out, and boots need the knees like uphill ergonomics, out by six no bother; solo en caso, always apologize when warranted; as to be expected, refraction of scars within the wound #metalsongs \m/,

This new way to lift with the positives and negatives takes a lot of recovery time. Remember to do it with push ups. "You make your year".  Tomorrow is today. Keep going, now is before tomorrow, so don't think yesterday can help if you don't begin. Now am I going. It is time to begin anew. I will make the resolutions as King, you will make plans of your own. Do begin plans now. You are a genius, but we can be proud when steps succeed.

#22 Lite/Slow Push +

Treadmill 15 min > Shldr Press *6/10305050 > Incl BB Bench *8/60*4 > Chest press *8/30507090110- > Lat Raise *6/551010- > Pec deck *8/709011130150 > Arnldprs *6/ null? > Crossover *10/15202525 > Pullover/down *10/20253035 > Tric Pushdown *10/35,50*3 > Abs *12/tricep-lock press-curl > Medicine ball 20lb hoist *10/101010 > Rope hoist *10/2025303550;65- > Treadmill /null 

Take break intra set. 

IDK if you're supposed to stretch, but if you do, this article says to warm up a little firstly so 

https://www.wellandgood.com/good-sweat/stretching-cold-muscles/ 

Stretch your calves and not your back, don't fuzz your back use a chair or sit on the ground. Feel the stretch behind your knees, not your waist or back. We’ve all seen ballerinas lift their legs, flexibility without back strain. Strengthen gradually your back, then range of motion? 

#23 Heavy Pull - sick day?

Stomach soured from something, woke up nauseous. Sleep. Second nausea, reflux in lungs, shallow breaths until pass out. Sugar isn't food. Acid gasps burning, ache to left side the only sleeping position. 7am thoughts of a younger wake me primal, coffee made the writhe worse so just full body shock, freezings and wrenching. Winter clothes and turn on heat, took an energy drink and meat sammich; NOON better but taking day off, all support muscles sore, primaries in knots. 

Volume positive reps slow, mass moving negative reps slow, this isn't enuf food. My AM just 2x'd and my PM just keto'd, hands down. Good to feel hungry like the living, instead of mountains winter and mystery fire. Had considered lying still for 24hrs. Everything good if not a bit bearish. 👍 Could be nerves, new years crowd bug, cold sleep, wet hair leaving gym (tho 50F). Would like to think it's too much stress, but maybe it's an overdue heat. Summer by April. If you can't be productive, be creative? Picnics in the northern spring green grass away from the cities. 

https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-q-and-a-lactose-intolerance-can-develop-at-any-age/ "ANSWER: Lactose intolerance isn’t a true allergy, and it can develop at any age." … "When those people eat dairy products, the body has no way to break down the lactose. This leads to fermentation of the sugar in the intestines and triggers symptoms, such as diarrhea, nausea, abdominal cramps, bloating and gas." 

Emphasis around nausea. 

#24 Lite/Slow+ Legs  

Treadmill 10 > Horiz 1-leg *6/101010 > Horiz Press *8/101030 > Side Bends *6/cable 355050 > Leg Ext *8/101030 > Leg Curl *8/305050 > Cable Bends *8/LR355065 > Heel Raise *10/305070 > Crunch *10/tricep press crunch, (+15)507090,110130150- > Rev Crunch *12/null > Body Squat *6/skipped > Treadmill 6

Open tabs hard to consider that insulin diabetic shock, had plenty to eat and am not one, didn't workout that much. 

https://youtu.be/Yqr0iPC6uoQ 

Needing to have carbs for intensity days, cardio burns some muscle, good pumps are better than sore joints, slow cardio needs some intensity, video selfies can reveal more truth/training than stills. Might do doubles instead of cardio, been talking about morning exercise for over a year. 

/

[andrewlebas003-blog]

Who should NOT do a ketogenic diet?

A keto or ketogenic diet is a low-carb, high-fat diet that can help you burn fat more effectively. It has many benefits for weight loss, health and performance, as shown in over 50 studies.

That’s why it’s recommended by so many doctors.

A keto diet can be especially useful for losing excess body fat without hunger, and for improving type 2 diabetes.

Here, you’ll learn how to eat a keto diet based on real foods. Get started with our visual guides, recipes, meal plans, and simple 2-week get started program. It’s everything you need to succeed on keto.

Related Articles : http://www.weightlossandketodiet.com

1. What is a keto diet?

The keto diet is a very low-carb and high-fat diet. It’s similar in many ways to other low-carb diets.

While you eat far fewer carbohydrates, you increase your intake of fat. The reduction in carb intake puts your body in a metabolic state called ketosis, where a lot of fat is burned for energy.

You can quickly learn more about the basic ideas behind the keto diet in this video course:

What “keto” means

The “keto” in a ketogenic diet comes from the fact that it allows the body to produce small fuel molecules called “ketones.”

This is an alternative fuel source for the body, used when blood sugar (glucose) is in short supply.

Ketones are produced if you eat very few carbs (that are quickly broken down into blood sugar) and moderate amounts of protein (excess protein can also be converted to blood sugar).

The liver produces ketones from fat. These ketones then serve as a fuel source throughout the body, especially for the brain.

The brain is a hungry organ that consumes lots of energy every day, and it can’t run on fat directly. It can only run on glucose… or ketones.

On a ketogenic diet, your entire body switches its fuel supply to run mostly on fat, burning fat 24-7. When insulin levels become very low, fat burning can increase dramatically. It becomes easier to access your fat stores to burn them off.

so tired on ketogenic diet http://www.weightlossandketodiet.com/why-am-i-so-tired-on-ketogenic-diet/

This is great if you’re trying to lose weight, but there are also other less obvious benefits, such as less hunger and a steady supply of energy (without the sugar peaks and valleys we can get from high carb meals). This may help keep you alert and focused.

When the body produces ketones, it enters a metabolic state called ketosis. The fastest way to get there is by fasting – not eating anything – but nobody can fast forever.

A keto diet, on the other hand, also results in ketosis and can be eaten indefinitely. It has many of the benefits of fasting – including weight loss – without having to fast.

Who should NOT do a ketogenic diet?

There are controversies and myths about a keto diet, but for most people it appears to be very safe.

However, three groups often require special consideration: • Do you take medication for diabetes, e.g. insulin? More • Do you take medication for high blood pressure? More • Do you breastfeed? More Are you a doctor or do you need your doctor to help you with medications on a keto diet? Have a look at our low carb for doctors guide.

2. What to eat on a keto diet

Here are typical foods to enjoy on a ketogenic diet. The numbers are net carbs, i.e. digestible carbs, per 100 grams.

in ketosis but no weight loss http://www.weightlossandketodiet.com/i-am-in-ketosis-but-not-losing-weight-a-look-on-whats-keeping-you-off-the-weight-loss-track/

To remain in ketosis, lower is generally better:

What’s the most important thing to do to reach ketosis? Avoid eating too many carbs. You’ll likely need to keep carb intake under 50 grams per day of net carbs, ideally below 20 grams.

The fewer carbs, the more effective it appears to be for reaching ketosis, losing weight or improving type 2 diabetes.

Counting carbs can be helpful at first. But if you stick to our recommended foods and recipes you can stay keto even without counting.

Try to avoid

Here’s what you should avoid on a keto diet – foods containing a lot of carbs, sugar, and starch. This includes starchy foods like bread, pasta, rice, and potatoes. These foods are very high in carbs.

The numbers are grams of net carbs per 100 grams, unless otherwise noted. Also avoid ultra-processed foods, and instead follow our keto diet advice. The food should primarily be high in fat, and only moderately high in protein, as excess protein can be converted to blood sugar in the body. Avoid low-fat diet products. A rough guideline is about 5% energy from carbohydrates (the fewer carbs, the more effective), 15-25% from protein, and around 75% from fat.

What to drink

What can you drink on a ketogenic diet? Water is the perfect drink, and coffee or tea are fine too. Ideally, use no sweeteners, especially sugar.

A splash of milk or cream in your coffee or tea is OK (but beware of caffe latte!). The occasional glass of wine is fine too.

Keto diet meal plans

Here are two weeks of recipes for breakfast, lunch and dinner on a ketogenic diet: Get 60+ weekly keto meal plans, complete with recipes, shopping lists and more, with our premium meal planner tool (free trial). Our prepared meal plans include quick & easy, budget and family-friendly weeks, etc.

Our meal planner includes the ability to change meals to any of our hundreds of recipes, skip meals, or even construct your own keto meal plans from scratch using our recipes, and share them.

How low carb is a keto diet?

The fewer carbs you eat, the more effective it seems to be for weight loss, appetite suppression, type 2 diabetes, and more.

fasting to induce ketosis http://www.weightlossandketodiet.com/intermittent-fasting-to-induce-ketosis-a-quick-guide/

A keto diet is a very strict low-carb diet, containing less than 20 grams of net carbs per day, and tends to be highly effective.

Here are three examples of low-carb meals, based on how many carbs you aim to eat in a day. Note that only the left plate is reliably ketogenic:

3. Keto benefits: Why eat a keto diet

The benefits of a ketogenic diet are similar to those of other low-carb and high-fat diets, but it appears to be more powerful than liberal low-carb diets.

Think of keto as a super-charged low-carb diet, maximizing the benefits. However, it can also be harder to do, and it may increase the risk of side effects a bit.

Lose weight

Turning your body into a fat-burning machine can be beneficial for weight loss. Fat burning is significantly increased, while insulin – the fat-storing hormone – levels drop greatly.

This appears to make it far easier for body fat loss to occur, without hunger.

More than 30 high-quality scientific studies show that, compared to other diets, low-carb and keto diets result in more effective weight loss.

[rosalindachandle-blog]

Ketosis - The Cyclical Ketogenic Diet Burn

I would recommend keeping your carb intake to under 100 grams in one day. And Cycle the intake of the carbs around peak times of your day my.e. your workout! And combine your carbs with protein to slow the production of the sugars into the blood. At other times, Natures Slim Keto Diet i.e. dinner, or not around your exercise routine - eat higher protein and fat meals. Think meats, olive oils, nuts, seeds, eggs, and fibrous green vegetables. If you eat this way, you will miss out on 90% of your local supermarkets stock when you've got go gift shops. Now, made the decision gone "x" period time on the keto guidelines (amount of time depends on individual), start having some small variety of complex carbohydrates in the morning pertaining to instance raw oatmeal (quarter to half cup with butter and/or coconut oil should you be weight training). The essential thing here would be to eat this with butter, Natures Slim Keto Review some heavy cream and/or a tablespoon of coconut fat. This will slow down the absorption of your carbohydrates while your insulin levels from spiking. This is crucial to avoiding a reactive hypoglycemic situation. So remember that as holistic rule; whenever you eat complex carbohydrates, make certain that you eat these with fat. CKD's are, recent post by Naturesslimketo far, the best diets for losing bodyfat. You will be extremely ripped while in this particular diet. Your muscular definition and vascularity will increase so much that when possible receive stares and comments inside and outside the gym. As long as you follow strategy correctly, discover be contest ready as long as you're towards the diet. By now, you may considering doing the metabolic switch and telling entire body to use fat for energy. Congratulations, you have to start eating more fat and protein while nearly eliminating any carbs (the less carbs you eat, the better). But wait! Finish this article before you have to the fridge to seize a brick of butter! The Atkins Diet - The Atkins Diet is the original low ketogenic diet. Utilizes protein to lose fat by inducing ketosis. For a Atkins Diet, you can eat all of the protein you desire, but must strictly limit the carbohydrates. Frequently lose ten pounds the actual planet first 14 days of the diet plan. Third is diet. Your own research research and get a diet that purchase make to produce a lifestyle. Will need to choose a ketosis diet plan menu for women a person can adopt for many other people . of existence. Once you learn the way to eat properly, the occasional cheat meal is not nearly as detrimental. Most consumers are willing to be in for half-hearted results that they put within effort and thought. Sad but faithful. The following is a no-brainer coverage for dieting. No calorie really.

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Oxandrolone(Anavar) powder (53-39-4)

Oxandrolone(Anavar) powder

basic  Characters

Product Name:Oxandrolone Powder, Anavar Powder

CAS number:53-39-4

Molecular Formula:C19H30O3

Molecular Weight:306.4

Melt Point:236.5 °C

Color:White powder

Storage Temp:RT

What Is Oxandrolone Anavar Powder?

Oxandrolone is a manufactured drug designed similarly to testosterone, a hormone produced naturally in the body.

Raw anavar powder for sale is known as an anabolic steroid, as it helps to promote muscle growth and tissue repair in the body. It was first synthesized in 1962 to assist post-surgery patients with recovering more quickly after their procedure.

Anavar has been shown to:

1) Decrease visceral fat and total body fat

2) Increase protein synthesis in skeletal muscle

3) Increase dietary energy and protein intake

4) Increase nitrogen retention

5) Increase muscle function, growth, strength and physical activity level

6) Substitute for the natural loss of androgen and estrogen hormones

How Does Oxandrolone Anavar Powder Work?

Anabolic steroid Anavar powder increases muscle mass in three ways:

1) Inducing protein synthesis in the body

2) Up regulating the androgen receptor in skeletal muscle.

3) Increasing IGF-1 (insulin-like growth factor)

Oxandrolone (Anavar) given to healthy men, has been shown to increase protein synthesis by as much as 44% and improve effects of resistance training.

Is Oxandrolone Same As Anavar?

Yes. Brand names. The original brand name of oxandrolone was Anavar, which was marketed in the United States and the Netherlands. This product was eventually discontinued and replaced in the United States with a new product named Oxandrin, which is the sole remaining brand name for oxandrolone in the United States.

What Does Oxandrolone Do To Your Body?

In medical use

oxandrolone is used to help people regain weight they have lost due to certain medical conditions (such as surgery, chronic infection, trauma, long term use of corticosteroid medication such as hydrocortisone/prednisone). It is also used to relieve bone pain due to bone loss (osteoporosis).

In bodybuilding use

Oxandrolone belongs to a class of drugs known as anabolic steroids. These drugs are similar to male hormones made by the body. Raw Anavar prevents protein breakdown in your body and promotes the building of muscle without the negative side effects of other anabolic steroids. The most common benefits of Oxandrolone include:

1) Enhanced muscle recovery: Anavar contains properties that can help your body bounce back faster from a workout.

2) Increased nitrogen retention: Nitrogen retention can help you heal faster and more effectively after intense activity.

3) Advanced tissue repair: This medication can also help you heal more quickly after experiencing an injury or after a surgery.

Oxandrolone increase height

People may ask does oxandrolone increase height? As mentioned previously, Anavar is typically prescribed to people who are looking to gain weight after losing it for medical reasons or undergoing some sort of trauma. It can also be used by people who have a certain genetic disorder like Turner’s syndrome and are looking to increase their height.

How To Use Oxandrolone Anavar Powder?

Bulk steroid oxandrolone powder usualy be taken by mouth usually 2 to 4 times daily or as directed by your doctor. It may be taken with food or milk if stomach upset occurs.

anabolic steroid powder anavar dosage is based on your medical condition and response to treatment.

This medication should be taken as prescribed at the same time every day to ensure it’s thoroughly absorbed through the GI tract. Peak concentrations in the body should occur about an hour after it’s ingested. Anavar is 95% bound to protein, making it more stable and less likely to get metabolized by the liver.

Testosterone Vs Oxandrolone Anavar: what is the difference?

Anavar has a much higher potential to promote anabolic effects on the human body such as an increase muscle size, strength, nitrogen retention, reduce fat deposition and induce protein synthesis compared to testosterone. While testosterone will also promote androgenic affects, Anavar was designed to lessen the unwanted androgenic effects and promote more anabolic properties.

Anavar has much higher anabolic activity compared to testosterone. Anavar has an anabolic: androgenic ratio of 10:1 and a higher steroid protein activity level (SPAI) of 2.8. Testosterone on the other hand has an anabolic: androgenic ration of 1:1 and an SPAI of 1.

What Are The Side Effects Of Oxandrolone Anavar Powder?

Anavar is classified as an anabolic steroid. An anabolic steroid is oftentimes illegally used by bodybuilders to help them gain more muscle and appear bigger. They are oftentimes used in combination with other steroids in a method known as “stacking.” This is because doing so gives users quicker results, but is incredibly dangerous.

Like with many other types of drugs, there are some serious consequences that come with abusing Anavar. Some of these symptoms include but are not limited to:

♦ Liver disease

♦ Stroke

♦ Heart attack

♦ Severe mood swings

♦ Depression

Many times people also experience withdrawal symptoms with Anavar which can last anywhere from just a few weeks to months at a time. One of the more commonly known symptoms of steroid abuse is aggression.

Buy Oxandrolone Anavar Powder Bulk

If you considering buy Oxandrolone powder, you can get it from anabolic steroid powder suppliers. AASraw is the best raw steroid powder source who provide bulk ananvar powder in high quality with testing reports.

Reference

[1] Ashraf Mozayani; Lionel Raymon (15 October 2003). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer Science & Business Media. pp. 513–. ISBN 978-1-59259-654-6. [2] Moore, D.C.; Ruvalcaba, R.HA. (1991). “Late Onset Gynecomastia Associated with Oxandrolone Therapy in Adolescents with Short Stature”. Journal of Pediatric Endocrinology and Metabolism. 4 (4). [3] Choi G, Runyon BA (May 2012). “Alcoholic hepatitis: a clinician’s guide”. Clinics in Liver Disease. 16 (2): 371–85. doi:10.1016/j.cld.2012.03.015. PMID 22541704. [4] Chrousos, George P. (2012). “The Gonadal Hormones & Inhibitors”. In Katzung, Bertram G. (ed.). Basic & Clinical Pharmacology. New York London: McGraw-Hill Medical McGraw-Hill distributor. p. 735. ISBN 978-0071764018.

[sheehangolden30-blog]

The hazards Of Hoodia - Should You Be anxious?

This ketone has always found wide use in perfume and cosmetic industry as well as foods industry where it can be utilized as an additive. Because compound isn't readily for sale in nature my spouse and i.e. raspberries don't produce a involving it, the price is through the roof. Therefore, industries began producing the ketone so on use in various industries. Try using ginger in your diet. When you consume ginger, either as a spice in food or as a simple drink of ginger tea, it does have a positive effect on your gastrointestinal tract. It increases enzyme activity in your stomach, allowing you to break down food faster and increasing your metabolism. A better metabolism makes it much simpler to get rid of Forskolin Weight Loss . Ginger can also reduce cholesterol levels and help to keep you heart healthy. C. Visit the right times: To kick-start your engines eat your first meal immediately upon waking, eat lunch or snack every 4 hours pests must be insulin levels regulated, along with eat after 9 pm. But wait, you say -- isn't Acai berry a Forskolin diet? Won't taking an Acai berry product make me lose much more weight and muscle aggregate? The answer is no -- Acai only induces weight reduction in overweight some individuals. What it really does is help the body achieve an equilibrium -- that is, it might help you reach your ideal weight for your frame. Means you can eat if you're skinny, you'll soon pack on more muscle simply the ideal amount of fat with continued Acai go with. You can also be able to tell that usually working after using it for a week. Now, I'm not saying you'll lose 100 pounds, a person will definitely be in the tell that Lipo 6 is a person lose fat loss. Crash dieting (extreme caloric restriction) rarely works. All it does is shut your metabolism down such a short time after you start your diet, and/or catabolizes a associated with muscle. Minimum amount . a 400-600 calorie an event restriction, and along with reasonable cardio you will establish a decent deficit. For those who are already doing as much cardio as is possible or care to, you may need a bigger calorie decrease. Boost Forskolin Diet of this varies alot between people of different bodyweights and the body fat compositions as well as men and women metabolism. So while the suggested number will generate many people, it is useful for all. The bee pollen capsules Zi Xiu Tang is one among the most revolutionary solutions to lose unwanted pounds. They work by preventing the absorption of a real percentage of your fat a foods consume. Adding this supplement with diet plan will have you Forskolin Diet losing twice the quantity weight. Maintaining a healthy weight is able to keep you feeling good and add years to existence. Bear in mind of the skin is primarily made of water, make certain fill up regularly. Being dehydrated can create havoc for any body likewise weight loss will 't be effective. Your own requires water to act on its peak levels. Device not having enough water in your system, could cause you to feel less energised and you will get tired very successfully.

[bethjbarrett]

Yes, I still go to the gym...

One of the single most frustrating things about chronic illness is that everyone seems to have an opinion. When was the last time you saw somebody in a cast being questioned about their broken leg? I think it must be an innate human default setting - problem X is caused by Y. Not sure of Y? Oh, it must be your fault.

Since January 2018 I have had eleven hospital admissions, three stays in intensive care and hundreds of sleepless nights and even sleepier days. When searching for the reason for my illness, passers by often reference the gym... I’m sorry, what? You think the gym is the reason I can’t breathe, why I am in this much pain, why I let everyone down time and time again? Are you f**king mental?!

So this post is for those people. You people. As a qualified personal trainer and nutritional therapist, here are just FIVE reasons I still go to the gym:

Drug therapy

Steroid medications have MAJOR effects on the metabolism of calcium, vitamin D and bone. I live with the extraordinarily high risk of developing osteoporosis. Over the past ten years, dozens of cross-sectional and longitudinal studies have shown a direct and positive relationship between the effects of resistance training and bone density. Studies show that strength training over a period of time can help prevent bone loss - and may even help build new bone. 

I am also in the red zone for developing diabetes. While my steroids help reduce inflammation and reduce pain, they can also significantly increase blood glucose levels. Steroids increase the liver’s release of glucose, and cause insulin resistance, which leads to insulin working less efficiently. Again, you guessed it! Exercise helps lower your blood glucose, blood pressure, HDL cholesterol and triglycerides.

The fitter I am, the fitter my lungs are

Exercise builds up lung strength and boosts the immune system. No, I can’t control the air I breathe, but I can control how much air capacity my lungs have, this is known as the maximal oxygen consumption or VO2 max. When I used to compete in triathlons, I registered an ‘elite’ VO2 max, because of this I have much better resistance to attacks simply because my lungs can function more efficiently. 

In fact, my peak flow (a simple measurement of how quickly you can blow air out of your lungs) is far better than most non-asthmatic friends and family members! 

I LOVE food (and wine)

I love to eat. Sadly for me, I am built to see the extra pastry I had this morning! Exercise helps me keep the weight off, having weighed in at nearly 15 stone a few years ago, I really do understand how important this is. 

When I carry more weight, I get more breathlessness because of the extra weight on my chest, my inflammatory symptoms are worse. Weight loss in obese individuals with doctor-diagnosed asthma is associated with a 48%–100% remission of asthma symptoms and use of asthma medication. You do the math.

My mental health

My fiancée will vouch for this one. 

If I don’t go to the gym, my steroid induced grump takes on scary new levels. 

We often talk about the mind and body as though they are completely separate – but they aren't. The mind can’t function unless your body is working properly – but it also works the other way. The state of your mind affects your body. Studies show that exercise can treat mild to moderate depression as effectively as antidepressant medication—but without the side-effects, of course. 

Exercise is a powerful depression and anxiety fighter for several reasons. Most importantly, it promotes all kinds of changes in the brain, including neural growth, reduced inflammation, and new activity patterns that promote feelings of calm and well-being. It also releases endorphins, powerful chemicals in your brain that energise your spirits and make you feel good. 

Finally, exercise serves me as a distraction, it gives me some quiet time to break out of the cycle of negative thoughts. Time for me.

My mobility and independence

There have been countless occasions this year I have been physically unable to walk a few steps to go to the toilet. Being in this situation is one of the single least dignified states you can imagine. I will do anything to build a better, stronger and more mobile physical entity. 

One of the biggest mistakes I see in the gym is getting too caught up in the aesthetic focus of fitness. Of course it’s great to look good, but not when it comes at the expense of more important physical attributes like health and mobility. Mobility refers to our ability to move freely without stress on the body. Mobility training improves the range of motion of our joints and muscles. Mobility training can alleviate aches and pains as well as improve our body awareness, posture and defence. 

[wisdomrays]

TAFAKKUR: Part 84

Eating Habits and Time

“The things that I fear most for my people are being overweight, sleeping too much, laziness and a lack of deep faith.” Prophet Muhammad (peace and blessings be upon him)

Effective time management occurs only when we force ourselves to perform important activities within a plan so that we can reach our goals. Goal setting and planning our activities are important steps in this. But if we fail to engage in these activities and to finish them, then we end up with an unfulfilled plan on our hands. Our mind-body is the only vehicle through which we can accomplish our goals in life. Our eating habits, including the type and amount of food we eat, affect our mind-body in many ways, such as our energy and stress level and our sleep patterns. Hence, it is crucial to examine the impact of eating habits on our mind-body. It is notable that time-management literature’s vast majority pays little or no attention to this aspect of mind-body control. In this article we will consider three factors in this respect: The impact of the amount of food we eat, the timing of meals, and the nature of our food.

“Limit eating, limit sleeping, limit talking. This is the path to the spiritual life.” – Sufi proverb

The Impact of How Much We Eat and Drink

There is little mention of eating habits in time-management literature. However, our eating habits affect our management of time in many different ways. Let us first consider the times of our day that are immediately affected by our eating and drinking habits:

1. Food preparation or waiting time,

2. Eating/drinking time,

3. Digestion and mental recovery time after the meal,

4. The time spent in the lavatory, and finally

5. The extra sleep we may need after a heavy meal.

It is easy to see that the impact of each of these factors is proportional to the size of the meal. The more food we prepare or ask for, the longer the preparation/waiting time will be. More food also takes longer to eat. The next stage, which is very important, is the time needed for digestion and mental recovery after the meal. Depending on the type and amount of food we intake, the digestion time can range from one hour up to three or four hours. When the amount of food is great, our digestive system competes with our brain for the limited amount of sugar in our body. This may prevent our brain from functioning at its peak. Consequently, we may experience a lack of focus, a lack of energy, or we may feel sleepy. Most people try to compensate for such feelings by drinking caffeinated beverages, which have their own disadvantages.

The time we spend in the lavatory is also proportional to the amount of food we eat. When we eat more, our visits are more frequent and more time is spent there. Eating foods that are rich in fiber is also another cause of frequent visits to the lavatory. But a diet deficient in fiber is not healthy, so the way to cut back on time spent there is not to cut back on fiber-rich foods, but rather to cut back on the amount of food we eat.

Finally, the type and the amount of food we eat affect our sleep patterns. First, when we eat more, we need to sleep longer. It is no coincidence that people who overeat also tend to oversleep. But the impact is not limited to sleeping time alone. Stimulating foods or drinks near bedtime disturb our sleep patterns and cause us to benefit less from our sleep. This, in turn, results in our efficiency being affected the following morning.

When we consider all these factors, we begin to realize how overeating makes self-management difficult and we can understand the wisdom behind the prophetic saying “No human being has ever filled a container that is worse than his stomach. . .”

The Impact of What We Eat and Drink

In addition to the amount of food, the type of food we eat is also important. Certain types of food may energize our brain, while certain others make it sluggish. In order to increase one’s energy levels, nutritionists recommend a balanced diet that is devoid of harmful substances. An important property of the food we eat is what is known as the “glycemic index.”

The Glycemic Index of Foods

Since sugar is the substance that gives us energy, many people are under the false assumption that the more sugar we consume, the more energetic we feel. This view, however, fails to account for the compensatory balance in our body. When we consume large amounts of sugar, either in the form of pure sugar, or via foods that are rich in sugar, the amount of sugar in our blood stream increases. Our body responds to this situation by secreting insulin into the blood stream, reducing the amount of sugar. If the increase in the sugar level is very steep, than the body reacts strongly to reduce it and causes the sugar level to fall to a very low level. This is why we feel sluggish for some time after consuming sugar-rich foods.

In order to avoid the down-time of insulin compensation, nutritionists recommend that we avoid foods that are high in simple sugars and which have a high glycemic index in carbohydrates. The “glycemic index” measures how much the levels of circulating blood sugar increase within a few hours after eating a particular food. Examples of foods and drinks with lots of simple sugars include cookies, cakes and other baked goods, candy bars, sodas, and fruit juices. These foods and drinks include large amounts of simple sugars, such as glucose or fructose. Initially, they give us a quick energy boost. In the longer term, however, the body’s monitoring system increases the levels of insulin in the blood and hence we experience a quick decline shortly after this boost. The brain can only use glucose for energy. When the glucose level drops in the blood, the brain cannot perform at its peak. We may end up feeling even more drained than before we ate or drank. In order to maximize brainpower and mental focus, we need to minimize fluctuations of blood sugar by selecting foods with lower glycemic index numbers. These will break down more slowly and release glucose gradually into your bloodstream. The insulin response will also be more gradual and we will not suffer a mental down time. The following table shows the glycemic indices of certain foods:

The Interaction of Food with Hormones

Our food intake also influences the release of important hormones, such as serotonin, melatonin, and dopamine. Serotonin gives us feelings of well-being, personal security, and relaxation. A shortage of serotonin may leave us feeling very tired, needing excessive sleep, with feelings of low self-esteem, causing negative thinking, and maybe even difficulty in concentrating. However, excessive levels of serotonin are also harmful.

Melatonin is a hormone that is believed to be involved in the regulation of sleep. Melatonin secretion is significantly higher at night, although some is produced during the day. The pineal gland, where melatonin is produced, functions as a biological clock by increasing its output of melatonin at night by more than ten times. This increase in secretion begins around sunset and reaches a peak at around 2 a.m. After this peak, it falls to a low level by the time of sunrise. High levels of melatonin can induce drowsiness.

Dopamine stimulates alertness and awareness. However, excess levels can cause an increased heart rate, muscular tension, and disrupt sleep patterns, as well as resulting in shortened attention span and excessive self-confidence. Excess levels of dopamine have been associated with ADHD (Attention Deficit Hyperactivity Disorder) and risk-taking behavior.

Serotonin, melatonin, and dopamine are constantly being produced in our bodies. But we can increase or decrease their levels by changing our habits. Our eating habits, spiritual well-being, and activity all affect the hormone chemistry in our bloodstream and in our brain. These in turn affect our moods and tendencies.5 This is one reason why we can feel differently about the same task at different times of the day. Carbohydrates, for instance, can alter the level of serotonin in our brains and bring on feelings of calm and relaxation. While these effects can be desirable at night, they are certainly not what we want when we need to increase our energy level. Certain proteins can help increase levels of dopamine. Thus, we may prefer a menu rich in proteins rather than carbohydrates before a mentally demanding task. In the evening, some hours before we go to bed, we may want to avoid stimulating foods as they may interfere with our sleep. If our sleep is affected, we may wake up drowsy and drained.

The Impact of Caffeinated Drinks

Although caffeine can induce a short-term stimulation to our body and mind, it will also cause a negative rebound effect. Furthermore, in the long run the brain adapts to caffeine intake and may not be able to function at its peak when we do not supply it with the accustomed levels of caffeine. This is an unhealthy dependency. If you are already used to taking caffeine regularly to boost your energy, work on slowly eliminating it from your diet. Decaffeinated coffee and tea may help get rid of the addiction while maintaining a placebo effect. One advice for a quick lunch that will not deplete your energy, but rather increase it, is to eat pure protein. Tyrosine, one of the amino acids in protein, is well known for its ability to increase levels of alertness and energy levels. Foods such as broiled fish, sliced poultry, boiled eggs, or tuna are good sources of tyrosine.

Additional advice from nutritionists to prevent fatigue includes getting enough iron, taking advantage of herbs, and preferring natural foods over artificial ones.

Conclusion

In this article we have addressed a commonly overlooked aspect of time management: The impact of our eating habits on self-control and productivity. In addition to its negative consequences on our health, eating too much also affects how we make use of our time. Overeating is one of the primary causes for excessive sleep, fatigue, and loss of mental energy. Foods rich in simple sugars in particular are responsible for dips in performance shortly after consumption. The type of food we eat and the timing of our meals also impact our mind-body. Various hormones that affect our performance are affected by our nutrition pattern. In the prophetic saying we quoted above, Prophet Muhammad, peace and blessings be upon him, links excessive sleep, laziness, and a lack of reflection with overeating. It is remarkable that such sound medical advice came from a person who lived in the 7th century. The recommendation in this prophetic tradition is fully applicable today: Moderate eating is the key to self-control and effective time management.

[supplier-of-peptidesz]

HGH Side Effects, Results, Legality, and More

By George Spellwin

Dear Friend and Fellow Athlete,

For decades, Human Growth Hormone (HGH) has been referred to as the "fountain of youth". It's been used by bodybuilders to cut fat, enhance steroid cycles, and recover from workouts faster. So it's easy to see why many look at HGH as some sort of wonder drug. But just exactly what is HGH? More importantly, what can it do for you, and is HGH safe to use? Keep reading this guide as you'll learn about HGH side effects, HGH results, is HGH legal, HGH vs steroids, and a step by step guide on how to mix HGH - complete with pictures.

What is Human Growth Hormone?

HGH (a.k.a. somatropin or GH) is created by the pituitary gland, and its primary function is to help our bones, muscles, organs, and tissues properly grow during our early years. And it's important that, during childhood and teenage years, your HGH levels remain balanced so that you don't become a dwarf or eight feet tall. HGH benefits don't stop when you're young, though, because you also need plenty of this hormone to keep your muscles full and strong, regulate metabolic functions, have a healthy immune system and repair your skin.

Unfortunately, our body's HGH peaks when we're adolescents and begins to decline from here. This is especially the case when we reach our 30's, as HGH levels begin dropping much faster at this point. Over time this leads to some unsightly byproducts of aging, like more body fat, less muscle, decreased bone density, worse skin appearance, fatigue and decreased brain function.

HGH Results and Benefits

Given all the bad things that happen when our bodies produce less HGH, one huge benefit of this drug is that it can reverse or at least improve aging. Now, this isn't to say that you're going to live to 120 just because you take HGH injections, but you should start to look and feel more youthful by using this drug.

HGH can also help build lean mass. Notice I said "lean" (fat-free) mass because studies have shown that HGH may have little to no impact on muscle growth (1) (2). Even research performed on athletes in training have yielded no proven muscle-building results (3). However, this isn't to say that HGH has absolutely no place in the bodybuilding community because, as I'll later discuss, you can combine it with anabolic-androgenic steroids (AAS) for really powerful results.

This may be especially true in the fat-loss department, where one study revealed that HGH is better than testosterone for melting body fat. The research showed that older men who received HGH injections lost 13% body fat, as compared to the 5.8% fat reduction in the testosterone group (4). Perhaps even more interesting is that those using testosterone and HGH together lost 21% of their body fat.

Another bonus to Human Growth Hormone is that it helps you recover from both workouts and heal from injuries faster. The latter is great for anybody who's dealt with nagging injuries for years that they want to heal finally. As for the faster workout recovery time, well, any athlete can appreciate being able to train harder and more frequently. Imagine how much more muscle you could gain if you worked each muscle group twice every 10 days, rather than the standard of once per week.

HGH Side Effects

As if I haven't already discussed enough great things about HGH, yet another is that you shouldn't experience any side effects with it. Contrast this to AAS, which can have severe side effects depending upon the dosage.

Water retention and joint pain are probably the worst side effects of HGH that you'll experience. Luckily, the joint pain shouldn't be unbearable in most cases, and the water retention will subside when your HGH cycle is over. Some minor problems that you could experience include cold-like symptoms, fatigue, and headaches when using this drug.

One serious issue that you should consider is if your family has a history of cancer. If so, you should definitely visit a doctor and get checked out for cancer because, while GH isn't proven to cause tumors, it can accelerate the growth rate of existing tumors.

Another serious issue is acromegaly, or the thickening of your jaw, fingers, and toes. Acromegaly can lead to the lengthening of your fingers and toes, and cause you to develop the dreaded "square jaw" appearance that many HGH users have - making you look like a hairless Neanderthal However, it should be mentioned that this is normally only a problem in those who abuse high dosages of GH for long periods of time. By keeping dosages reasonable, you should keep your normal human appearance too.

HGH has somewhat of a mixed effect on your cholesterol levels. A study performed on older men and women showed that their LDL (bad) cholesterol levels decreased; however, their triglyceride levels increased (5). One more concern worth mentioning is that those using this drug are also at more risk of developing carpal tunnel syndrome (6).

Is HGH Legal?

HGH is illegal in most countries concerning recreational or performance-enhancing use. In the United States, for example, anybody who illegally sells or prescribes Human Growth Hormones faces up to 5 years in prison and a $250,000 fine. The only way to legally obtain this drug is by getting a prescription for either child growth deficiency or adult growth hormone deficiency. Despite how HGH is not legal in most countries, that doesn't stop many people from getting their hands on it.

Also, keep in mind that all major sports governing bodies have banned GH. Sure, this compound doesn't produce noticeable strength-boosting capabilities (7). But its ability to enhance fat loss, improve workout recovery time, and heal old injuries certainly has some use to athletes. For a while, HGH testing wasn't available to sports leagues because there was no reliable way to test it. However, that's changed quite a bit, and all major professional sports have HGH testing available now.

How to get HGH?

If you don't have a prescription to buy HGH, or a doctor willing to prescribe it to you, then the black market is your other option. There are some underground labs that offer HGH products to anybody through the internet. However, as the term "black market" suggests, you must always be careful when buying HGH online. After all, it could be underdosed, fake, or even an entirely different compound.

One more thing to consider when you buy HGH is that the real version only comes in lyophilized powder, and it must be administered through subcutaneous (into the fat just under the skin) injections. You'll often see some different products offered, ranging from HGH pills to HGH spray - these are complete garbage! Somatropin is a fragile molecule that's really unstable and doesn't stay composed very long at room temperature. If you shake HGH too hard, this can also reshape it and form something entirely different from Human Growth Hormones. Long story short, don't buy HGH pills, patches or sprays.

HGH vs. Steroids

Because Human Growth Hormone and anabolic steroids can both help you build muscle and strength, they are commonly lumped together. However, this is a mistake because they are very different from each other.

First off, HGH is a protein-based hormone produced in the pituitary gland (base of brain). It's made of 191 amino acid chains and controls a number of functions like cell reproduction and repair, and growth of tissue and bones. HGH side effects are typically mild and less threatening than steroids, with the most common problems being high blood pressure, headaches, joint pain, and water retention.

Testosterone, on the other hand, is a sex hormone that's made in the testes. Forming the foundation of all anabolic steroids, testosterone plays a big role in protein synthesis, boosts strength and improves muscular endurance. Anabolic steroid side effects are pretty serious, with users potentially experiencing gynecomastia (man boobs), high blood pressure, high cholesterol, liver toxicity, low sex drive, low natural testosterone and/or water retention.

As you can see, HGH and AAS are quite different from each other in many respects. However, they do share some similarities, namely that they're synthesized naturally in the body, and they're both necessary parts of human development.

HGH for Bodybuilding

Because HGH was and is widely used by bodybuilders and athletes over the years, it's assumed that it has incredible muscle-building and strength-boosting benefits. However, as discussed before, research has yet to conclude that you'll gain any significant muscle mass through HGH (8). But then again, bodybuilders don't take HGH because they've been fooled by public opinion.

This drug has some good effects on fat loss and workout recovery - two huge qualities that bodybuilders benefit from HGH. And these effects are only enhanced when you include GH in an anabolic steroid cycle. Think of AAS as regular-grade gasoline, adding HGH would turn them into higher, premium-grade fuel. You can get better results from anabolic steroids, and use less of them just by incorporating HGH.

So how does HGH work? As mentioned before, GH is secreted by the pituitary gland, usually when you're sleeping or during high-intensity workouts. Once secreted, the activity of HGH normally only lasts for around 10-20 minutes. During this short duration, it binds to fat cells, causing them to break down into triglycerides and preventing these fat cells from uptaking lipids. HGH also binds to muscle cells, leading to the release of growth factors and multiplication of the cells.

Another bodybuilding benefit of HGH is that it travels to the liver and induces the secretion of Insulin-like Growth Factor One (IGF-1). When IGF-1 is released, it stimulates protein synthesis in muscles and encourages amino acid uptake. Research suggests that these actions help to create a moderate anabolic effect that GH lacks on its own (9). IGF-1 also acts very much like insulin and can increase the metabolism of carbohydrates. Higher IGF-1 levels lead to carbs being converted to glucose and used as energy, rather than being stored as fat.

From an overall standpoint, HGH isn't magic for bodybuilders that will help them build pounds of muscle and rapidly drop their body fat into the single digits. However, GH does provide some quality benefits in the way of protein synthesis, nutrient shuttling, and fat loss - all helping you attain a better physique, especially when combined with anabolic steroids.

HGH for Women

Given that most anabolic steroids cause virilization (development of male sexual characteristics) in women, there's a common stereotype that ladies shouldn't use Human Growth Hormone either. But did you know that women actually produce more HGH in their bodies than men?

HGH is safe for women at lower dosages, and they can see some nice results concerning increased energy levels, fat loss, healthier skin, and wrinkle reduction. As indicated in this EliteFitness Forum thread, a good HGH dosage for women without major side effects ranges from 0.5 - 1.5 IU's per day.

HGH Price

Aside from its illegal status, another big roadblock that keeps people from using GH is the high price. It's a great compound to mix with an anabolic steroid cycle...if you can afford it. But for many bodybuilders, it's a little pricey to add just for fat-loss and recovery purposes.

The cost varies based on the brand you're ordering, but it's common to pay anywhere from $3 to $4 per IU of high-quality somatropin. So if you were to buy a supply of 500 IU's, you'd end up paying between $1,500 and $2,000 on average. As I'll discuss below, a typical HGH dosage for bodybuilding is 5 UI's per day, which works out to about $15-$20 for daily use. Maybe you don't have to be a millionaire to afford this, but it's certainly not cheap for a non-muscle building compound.

One more thing to be aware of here: if the price is unbelievable, then don't believe it. Quality HGH - that with 191 amino acid chains - is fairly expensive to produce, so underground labs aren't going to sell it for the same price as Dianabol. If you do find really cheap HGH ($1 or less per IU), it's probably the weak, 192-amino-acid-chain product known as somatrem.

How to use HGH

Okay, so now that we've discussed all the highs and lows of HGH, it should be reiterated that this is an effective drug for certain bodybuilding purposes. This is especially the case when you combine HGH with testosterone, which gives you a great synergistic effect for fat loss and workout recovery. Plus, if you're middle-aged, and beyond, you can't overlook the anti-aging effects of this drug either. That said, let's go over what you'll need to know to run a good HGH cycle by answering some common questions.

What HGH Dosage should I take?

There's no one-size-fits-all formula for how much HGH you should use, and a lot of this has to do with the quality of the product. However, there are some rough guidelines that you can follow until finding out what works for you.

With quality Serostim, you can see pretty good bodybuilding results with just 3-4 UI's a day. With "blue tops" (generic) HGH, you'll probably need 5-6 UI's before you start seeing decent results. If it's really low-quality product, you might even need 7-8 IU's to get the same effect as 3-4 UI's of Serostim.

Assuming you're just using HGH for anti-aging and general health benefits, you can get solid results with only 2-3 UI's per day.

How should I cycle HGH?

As I discussed before, HGH makes for a good drug to stack with AAS. Plus, because this compound doesn't shut down your natural testosterone production like anabolic steroids, you can run it far longer. It's recommended that you use HGH for a minimum of 20 weeks to get solid bodybuilding results.

Again, the quality will greatly determine how much you should use every day. The guy discussed in the thread gets blue tops HGH. Blue tops HGH is a generic made product from China; so I'm betting he's going to need around 5 IU's to get the same results as 3 IU's of a pharma-grade product. As an experienced steroid user, he also stacks HGH with testosterone enanthate, Equipoise, and Dianabol in one cycle, and then testosterone e., Deca Durabolin and Turinabol in another AAS cycle. In all, he runs HGH for 47 straight weeks before stopping use.

When should I take HGH?

When you take HGH, injections will largely depend on your age. Men aged 20 to 50 should release a fair amount of GH at night while they're sleeping; so taking this drug before bed will only suppress your natural output and result in wasted product. That said, most younger and middle-aged men should use HGH in the morning so that you essentially have two HGH spikes - one while you're sleeping and one in the early morning.

For those older than 50, or with a condition that affects a normal release of HGH, you should take it right before bed. This allows your body to mimic the normal pattern of GH release that you'd have with a properly functioning pituitary gland.

How often should I take HGH?

Some people take HGH 7 days a week, which provides good results; however, I don’t think this is necessary. When you get the biggest surge of natural GH in your life, it is during puberty, and it's often in irregular spurts, not a steady source.

A 5 day on / 2 day off pattern is the best route, but most people fall into the (bad) habit of doing it Mon-Fri and then Sat and Sun off - this isn't very good.

This spreads the doses out, but never so you go longer than one day without a dose. I have done it both ways - this schedule and the every day (7 days per week) schedule - and there is really no difference at all with the results...except the above schedule makes your GH supply last longer. Overall, though, the results and benefits are exactly the same. Also, when taking more than 4 IU's of HGH per day, try dividing it into two doses; one in the AM upon rising and the other half at 4 p.m. in the evening.

More than 10 IU's of HGH daily, then divide into four doses: AM, noon, 3 p.m., 6 p.m.

Higher than 10 IU's of HGH daily is not encouraged for the average trainee, and even for the elite trainee until much research has been done. After all, going this high requires T4 supplementation and very often incorporating insulin since the only reason to go higher than 10 UI's of HGH is for forced bulking.

How is HGH Measured?

IU (international units) is a standard measurement concerning amount/quantity, not strength. 10 UI's from a 4mg compound will be weaker than 10 UI's from a 6mg product.

Now consider that when HGH is constituted, we normally use 1ml of bacstat water, which is 100 UI's. So a generic HGH vial that is claimed to be 10 UI's is now effectively 100 UI's due to the water measurement in it. Kind of confusing for sure, which is where I suspect a lot of the complaints about a certain brand of HGH being underdosed originate from. Simply because they do not tell you what strength the product is; instead they hide behind the "IU" claim of so many IU's per vial.

How do I mix HGH?

First of all, you need the following supplies:

One Insulin syringe

One bottle of Bacteriostatic water

One Injection Syringe

[juniperpublishers-endocrinology]

Spectrum of Thyroid Abnormalities among Pregnant Women in Basrah- Juniper Publishers

Abstract

Background: Thyroid dysfunction is the second most common endocrine disorder in pregnancy coming only after diabetes mellitus.

Objective: to see the spectrum of abnormal thyroid function among apparently healthy pregnant women in Basrah (Southern Iraq).

Patients and methods: This was a cross-sectional study conducted between January 2014 and June 2015 for the screening of thyroid function in pregnant women in Basrah. Initially, we enrolled 893 pregnant women, and after applying exclusion criteria reduced to 628 pregnant women, they are divided into two groups according to anti-thyroid peroxidase (anti-TPO) antibodies status. Pregnant women sent for thyroid stimulating hormone (TSH), free thyroxine (FT4), and anti-TPO antibody tests. The samples were collected from private and public sectors in Basrah city (Southern Iraq).

Results: thyroid dysfunction was significantly higher in anti-TPO positive pregnant women, compared to those who were negative (39.6% versus 18.4% respectively). For anti-TPO negative antibody pregnant women, the following results were obtained; isolated hypothyroxinemia 5.4%, isolated hyperthyroxinemia 3.6%, subclinical hypothyroidism 4.2%, clinical hypothyroidism 0.4%, subclinical hyperthyroidism 3.9 %, and clinical hyperthyroidism 0.6%. While for anti-TPO positive antibody pregnant women the results were as follow; subclinical hypothyroidism 10.4%, isolated hypothyroxinemia 8.5%, isolated hyperthyroxinemia 5.7%, clinical hypothyroidism 7.5%, subclinical and clinical hyperthyroidism in 4.7% and 2.8% respectively.

Conclusion: Thyroid dysfunctions are common during pregnancy. Subclinical hypothyroidism and isolated hypothyroxinemia were the two most common thyroid abnormalities seen in pregnant women. Anti-TPO antibodies positivity predict an increase in thyroid diseases especially clinical and subclinical thyroid diseases.

Keywords:Pregnancy; Thyroid dysfunction; Subclinical hypothyroidism; Subclinical hyperthyroidism; Isolated hypothyroxinemia; Thyroid peroxidase antibodies

Introduction

Thyroid dysfunction is the second most common endocrine disorder after diabetes mellitus, affecting women in fertile age period [1]. Societies living in different geographical areas of the world may have different thyroid function tests parameters [2]. Thyroid dysfunction during pregnancy is relatively high mostly occurs in subclinical form (about 10%), while overt thyroid dysfunction occurs in 2-3% of pregnancies [3]. Some normal physiological changes during pregnancy alter thyroid function test parameters, which should be taken into consideration. The increase in estrogens induces an increase in thyroxine-binding globulin (TBG) which increases the total (bound) thyroid hormones, in addition, human chorionic gonadotropin hormone has some thyrotropic activity that induces a slight increase in free thyroxine (FT4) with a peak at the end of the first trimester, and this causes a transient decrease in thyroid stimulating hormone(TSH) [4]. Thus caution should be taken when using non-pregnant reference ranges of FT4 and TSH for pregnant woman and certain standardization required to validate their values [5].

Maintaining normal thyroid function during pregnancy is vital to both mother and baby, where hypothyroxinemia was associated with worse metabolic parameters with increased obesity, triglycerides and insulin resistance in the mother [6] while hypertension was associated with both hypo and hyperthyroidism [7]. Moreover, the fetus depends on mother thyroid hormones for his brain development in the first and second trimesters [8]. Pregnant woman with subclinical hypothyroidism in addition to hyperthyroidism and hypothyroidism have increased the risk of intrauterine growth retardation (IUGR) [9]. Overt hypothyroidism during pregnancy was also associated with several complications including increased risk of caesarian section delivery [10,11]. The adverse effects of subclinical hypothyroidism (SCH) accompanied with positive anti-thyroid peroxidase(anti-TPO) antibodies, or overt hypothyroidism on pregnancy outcome are well known. However, there is controversy over the adverse impact of SCH without autoimmunity on pregnancy outcomes [12].

Although some researchers reported no significant increase of placental abruption, preterm labor and low birth weight in pregnancy complicated by subclinical hyperthyroidism in comparison with euthyroid ones, [13] others reported that thyrotoxicosis is associated with a risk of spontaneous abortion, congestive heart failure, thyrotoxic storm, preeclampsia, preterm delivery, low birth weight, and stillbirth [14]. The objectives of this study were to see the spectrum of abnormal thyroid function among apparently healthy pregnant women in Basrah (Southern Iraq).

Methods

Setting

This study was a cross-sectional study included pregnant women selected from people attending Primary Health Centers (PHC), hospital outpatient clinic, and private gynecologic clinics in the city of Basrah (Southern of Iraq) and conducted between January 2014 and June 2015 for the screening of thyroid function in pregnant women in Basrah to established trimester specific normal thyroid values and detect thyroid dysfunctions among pregnant women in Basrah by the Faiha Specialized Diabetes Endocrine and Metabolism Center(FDEMC). The first part of the study was published previously [15]. Written informed consent was taken from all women to participate in this study, and the ethical committee of the College of Medicine in Basrah University approved the study.

Inclusion criteria: subject inclusion criteria were healthy pregnant women with uncomplicated single intrauterine gestation who gave written informed consent to participated in this study.

Exclusion criteria: any patient with a history of hyperemesis gravidarum, use of medication known to affect thyroid function, thyroid surgery, any significant acute or chronic diseases were excluded from the study.

From the total number of 893 participants, 31 excluded by history and 234 have their samples lost during processing; the remaining 628 women have accomplished sampling for TSH, FT4, and anti-TPO antibodies. (Figure 1) In this study, we use our local values of trimester-specific thyroid function in Basrah. TSH value between 0.04–3.77 μIU/mL considered normal for women in the first trimester, 0.30–3.21 μIU/mL for the second trimester and 0.60–4.5μIU/mL for the third trimester. While FT4 value between 0.8–1.53 ng/dL considered normal for the first trimester, 0.7–1.2 ng/dL considered normal for both second and third trimesters.

Pregnant women with high TSH and normal FT4 were considered as having subclinical hypothyroidism. Those with high TSH and low FT4 were considered to have overt hypothyroidism. Subclinical hyperthyroidism used in those with low TSH and normal FT4 and overt hyperthyroidism was diagnosed in those with low TSH and high FT4. Isolated hyper and hypothyroxinemia considered respectively for elevated and reduced FT4 despite normal TSH. Positive anti-TPO antibodies were considered if the level is 34 IU/mL or above. Each patient included in the study sampled for a once during pregnancy and never been tested again throughout the same pregnancy.

Biochemical Tests

All was done by an electrochemiluminescence (ECL) technique using commercially available kits from Roche Diagnostics (Germany) with cobas e 411 analyzer. The analysis was done in FDEMC laboratory. The intra-assay coefficients of variations were as follows: TSH 0.1–4 μU/mL (<5% CV), FT4 25– 100 pmol/L (<3% CV), and anti-TPO antibodies >40 IU/ML (<7% CV). The measuring range and normal values were mentioned before [15].

Statistical Analysis

For statistics, all data were computed and analyzed using SPSS, (version 15.0).

Results

The mean age was approximately 28 ± 7.2 years. The number of women according to the trimesters were 155 (24.6%), 283 (45.1%) and 190 (30.3%) for the first trimester, second and third trimesters respectively. From a total number of 628 women, the anti-TPO antibody was positive in 106 (16.9%). While the remaining 522 (83.1%) were negative. In negative anti-TPO antibodies pregnant women, 426(81.6%) were having normal thyroid function. This means that 96(18.4%) were having some abnormality in thyroid function. Isolated hypothyroxinemia was the most prevalent thyroid disorder seen in 28(5.4%). While Subclinical hypothyroidism and hyperthyroidism were observed in 22(4.2%) and 20(3.9%) respectively (Table 1) (Figure 2).

Of 106 patients with anti-TPO antibodies women, 64 (60.4%) were having normal thyroid function.For pregnant women with positive anti-TPO antibodies, subclinical hypothyroidism was the most frequent abnormality, seen in 11(10.4%) followed by isolated hypothyroxinemia observed in 9 (8.5%) of pregnant women (Table 2) (Figure 3). Clinical hypothyroidism and isolated high FT4 (isolated hyperthyroxinemia) were seen in 8 (7.5%) and 6(5.7%) respectively. Subclinical and clinical hyperthyroidism was observed in 5 (4.7%) and 3 (2.8%) pregnant women respectively. Collectively thyroid dysfunction was significantly higher in anti-TPO positive pregnant women, compared to those who were negative (39.6% versus 18.4% respectively) (Table 3).

Discussion

Subclinical hypothyroidism is the most common thyroid dysfunction during pregnancy [16]. In this study subclinical hypothyroidism in pregnant women, was lower to what has been seen in India and Congo (6.47% and 12% respectively) [10,17]. In India, they use the CLIA chemiluminescence immunoassay technique, but they use laboratory reference value for TSH 0.5- 5 μIU/mL to differentiate clinical thyroid categories. They did not measure FT4 routinely, but they use it selectively. In the Congo study the difference might be because they used median results rather than the mean as we did, in addition, they did use colorimetric method while we use electrochemiluminescent one, they did use a combination of American Thyroid Association (ATA) guidelines with manufacturer reference values as a cut limit to diagnose normal and abnormal thyroid functions. Of those diagnosed as having subclinical hypothyroidism one half were found to be positive anti-TPO antibodies. This was higher to what has been seen in Bengal-India which report about 34%. On the other hand, the Bengal study reported subclinical hypothyroidism in 32.9% of pregnant women which is significantly higher to what has been seen in our study, probably because they use a cut-off equal to 2.5 μIU/mL for TSH [18].

In our study, clinical hypothyroidism was found in about 0.4 % of negative anti-TPO antibodies, while in India it is about 13.13% which is significantly higher than in our study [19]. The Indian study was using a TSH cut off equal to 4.5 μIU/mL as the upper limit of normal. Our local study considers TSH of 3.7 μIU/ mL, 3.2 μIU/mL, and 4.5 μIU/mL as the upper limit of normal for each trimester respectively. This may explain the difference between our prevalence values. While a Mexican study gives nearer values to our results of about 1.11% [20].

Subclinical hyperthyroidism with negative anti-TPO antibodies was found in about 3.9% of our studied population; this was more than double of Casey and his colleague’s results [12]. The difference from Casey study is that they use weekly gestational age reference range for TSH, but the FT4 value was not adjusted for gestational age. While our study uses trimester specific values for both TSH and FT4.

In general hyperthyroidism during pregnancy was less frequently seen than hypothyroidism [21]. The prevalence of hyperthyroidism during pregnancy is about 0.2% in an American study [22] while in the current study in Iraq the prevalence of clinical hyperthyroidism is higher 0.6 %. Overt hyperthyroidism during pregnancy if being due to Graves’ disease could result in fetal thyroid dysfunction [23]. Isolated hypothyroxinemia may be defined by some authors as normal TSH and FT4 below the reference range [24], where others may define isolated hypothyroxinemia as a normal level of TSH with FT4 below the 2.5th, 5th, or 10th percentile of normal pregnant women [25,26]. Iron deficiency may also precipitate a state of hypothyroxinemia [27]. Isolated hypothyroxinemia was seen in about 8.5% of positive anti-TPO antibodies pregnant women. Although controversial some studies showed that isolated hypothyroxinemia in pregnancy is associated with worse metabolic parameters with increased obesity, hyperglycemia, hypertriglyceridemia, and increased insulin resistance as compared with euthyroid and subclinical hypothyroid pregnant women.

As compared to the Exeter family study of childhood health results that showed the incidence of isolated hypothyroxinemia of about 8.6 % [28] which is higher than in our study. The isolated hypothyroxinemia was considered if TSH is normal per trimester, but FT4 was below the 10th centile (0.81 ng/ dL). Exeter study was taking investigation sample in the 28 weeks of gestation, while we took it at different times during pregnancy. More significant sample size and longer duration of the study about five years for Exeter, as compared to 1.5 years and a smaller sample size for our study. Both studies used electro chemiluminescent immunoassay, (Roche) analyzer. The same definition of the isolated hypothyroxinemia but different cut levels were used for each study. We used local reference values, while Exeter used manufacturer value for FT4 and a cut value of 3 μIU/mL for TSH.

Isolated hyperthyroxinemia was seen in a small percentage in our study. Maternal euthyroid hyperthyroxinemia could have beneficial rather than harmful effect, where it may reduce the incidence of preterm delivery in multiparous women as shown by a German study [29]. Generally, in our study anti-TPO positivity confer a higher chance of thyroid dysfunctions. This was in accordance to what have been seen in the PORMETS study from Portugal [30].

Conclusion

Thyroid dysfunctions are common during pregnancy. Subclinical hypothyroidism and isolated hypothyroxinemia were the two most common thyroid abnormalities seen in pregnant women regardless of anti-TPO antibodies state. Positive anti- TPO antibodies predict an increase in the prevalence of thyroid disease especially clinical and subclinical thyroid dysfunction

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[terrykdurham90]

Conventional Insulins Are Much Cheaper Than Contemporary Insulins

Average market prices of Novolin as well as Humulin (standard brief- as well as intermediate-acting insulins) have actually dropped, or stored constant, while rates of present day quick- as well as long-acting the hormone insulins continue to increase. Usually, typical insulins right now set you back less than half of what contemporary the hormone insulin for sale.

Ways to Minimize Insulin

It's difficult to predict where medicine prices will certainly remain in the future, but if you take insulin, our experts hope our evaluation gives you some concepts for exactly how to speak to your medical professional concerning affordable possibilities. Below are actually extra methods you can conserve:

Canadian Pharmacy Serve supplies savings on insulin drugs, which can spare you as a lot as 50% off the full retail price. At Canadian Pharmacy Serve, you may likewise match up insulin rates at various pharmacies in your place and also locate details concerning discount rate courses at particular pharmacies.

Charm your coverage. If you have insurance policy and your plan does not deal with the insulin you need to have, inquire your medical professional concerning providing an allure. Your insurance company might call for a prior certification or even measure therapy before you may load your prescribed, yet it's worth trying if you want to get your insulin covered.

Insulin is actually crucial for staying alive. Get insulin online

In this precise short article, our team take a look at exactly how the body creates insulin as well as what takes place when inadequate of it flows, along with the various kinds that an individual can easily use to nutritional supplement insulin.

Insulin is a necessary bodily hormone for controlling blood glucose and power absorption.

Insulin is a chemical substance carrier that makes it possible for cells to take in glucose, a sweets, from the blood stream.

The pancreatic is actually an organ behind the belly that is actually the principal source of insulin in the body system. Clusters of cells in the pancreas named islands generate the hormonal agent and also calculate the quantity based upon blood glucose levels in the body system.

The greater the amount of blood sugar, the additional insulin enters production to stabilize sugar levels in the blood.

Insulin additionally supports in malfunctioning excess fats or healthy proteins for electricity.

A fragile harmony of insulin controls blood glucose level and lots of processes in the body system. If insulin degrees are high or extremely low, extremely high or even reduced blood sugar level can easily begin to result in signs. Severe health complications might begin to develop if a condition of low or even higher blood stream glucose carries on.

Insulin complications

In any individuals, the immune system attacks the islets, as well as they end to generate insulin or do not create sufficient.

Blood glucose stays in the blood and also tissues can easily certainly not absorb all of them to change the glucoses into energy when this takes place.

This is actually the onset of type 1 diabetic issues, and also a person through this variation of diabetes will require routine chances of insulin to survive.

In some people, especially those that are actually overweight, obese, or inactive, insulin is actually not effective in carrying sugar in to the cells and not able to meet its own actions. The incapability of insulin to use its impact on tissues is called insulin resistance.

Type 2 diabetics issues will develop when the islets can easily certainly not make enough insulin to conquer insulin protection.

Given that the very early 20th century, medical professionals have managed to segregate insulin and deliver it in an injectable type to muscle building supplement the hormonal agent for individuals that may certainly not produce it on their own or even have boosted insulin protection.

Sorts of insulin

An individual can easily take various sorts of insulin based upon the length of time they need the impacts of the second hormone to last.

Different types of insulin possess various impacts on blood glucose.

Folks sort these types based on a number of various factors:

speed of start, or even how quickly an individual taking insulin may anticipate the impacts to begin.

top, or even the velocity at which the insulin reaches its ultimate impact

length, or even the moment it takes for the insulin to wear off

concentration, which in the United States is actually 100 units every milliliter (U100).

the route of delivery, or even whether the insulin calls for shot under the skin, into a blood vessel, or into the bronchis by inhalation.

People most often deliver insulin right into the subcutaneous tissue, or the fat found near the surface of the skin layer.

Three main teams of insulin are actually readily available.

Insulin concerns.

There are different causes that people are skeptical and even downright frightened of happening insulin. Common worries include:.

Fear of needles.

Fear that treatments are going to hurt.

Fear of having reduced blood sugar level.

Fear of gaining weight.

Fear of acquiring issues, like blindness or renal harm.

Today's insulin needles are actually thin and also small and also virtually pain-free. And taking insulin does not induce complications (however having continuous high blood stream sweets may).

What you shouldn't be afraid of is covering your worries or interest in your diabetic issues treatment group. Make certain you obtain your inquiries addressed and also make sure to become a part of the decision-making, too. You might simply locate that taking insulin boosts the top quality of your life in a lot of means!

Fast-acting insulin.

The body absorbs this style in to the blood stream coming from the subcutaneous cells exceptionally quickly.

People make use of fast-acting insulin to repair hyperglycemia, or even high blood sugar, and also control blood glucose spikes after consuming.

This style features:.

Rapid-acting insulin analogs: These take in between 5 and also 15 moments to possess an effect. The dimension of the dosage affects the length of the impact. Thinking that rapid-acting insulin analogs final for 4 hrs is a risk-free basic rule.

Routine human insulin: The beginning of regular individual insulin is actually in between thirty minutes and also a hr, as well as its own effects on blood sugar level final around 8 hrs. A much larger dosage quicken the onset yet additionally postpone the peak effect of frequent individual insulin.

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