#DNA Synthesizer Market

[health-views-updates]

Industry Analysis: DNA Synthesizer Market Size & Growth Forecast to 2032

The DNA Synthesizer Market, valued at USD 270.40 million in 2023, is on a robust growth trajectory and is anticipated to reach an impressive USD 922.11 million by 2032, with a remarkable CAGR of 14.62% during the forecast period from 2024 to 2032. The increasing demand for synthetic DNA across diverse industries, including biotechnology, pharmaceuticals, and diagnostics, is a key driver of this growth.

DNA Synthesizer Market Revenue has surged due to the rising adoption of synthetic biology for applications like genome engineering, personalized medicine, and vaccine development. Enhanced advancements in DNA synthesizer technologies have further fueled market demand by enabling faster, more accurate, and cost-efficient production of custom DNA sequences.

The market is witnessing significant innovation, with manufacturers introducing high-throughput and automated synthesizers to cater to the growing demand. As research institutions and biotechnology companies invest heavily in DNA synthesis for various R&D activities, the market’s future holds immense potential for growth. The expanding scope of DNA synthesizers in agriculture and food industries for genetic modification of crops is yet another factor propelling the market forward.

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Key Trends Shaping the DNA Synthesizer Market

Technological Innovations: The integration of advanced software tools in DNA synthesizers allows for high-precision sequence design, streamlining the synthesis process. AI-driven platforms are also paving the way for breakthroughs in synthetic biology.

Expanding Applications: Beyond healthcare, DNA synthesizers are finding use in environmental monitoring, biofuel production, and bio-remediation, significantly diversifying their application portfolio.

Rising Government Investments: Increased funding for synthetic biology research by governments worldwide has fostered the development and accessibility of cutting-edge DNA synthesis tools.

Regional Growth Opportunities: North America leads the market due to its established biotech ecosystem, while the Asia-Pacific region is witnessing exponential growth driven by increasing biotechnology investments and a burgeoning healthcare infrastructure.

Market Challenges

Despite the promising growth prospects, the DNA synthesizer market faces challenges, such as high initial costs and ethical concerns surrounding synthetic biology applications. Addressing these issues will be vital for sustained growth and broader acceptance of DNA synthesizers across industries.

Competitive Landscape

The DNA synthesizer market is highly competitive, with key players focusing on R&D to innovate their product offerings. Collaborations, mergers, and acquisitions are common strategies to strengthen market presence. Industry leaders are also prioritizing user-friendly systems and scalable solutions to cater to a wider customer base.

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[veliterbio]

What Is DNA Oligo Synthesis and Why Is It Important in Research?

DNA Oligo Synthesis is a laboratory technique of synthesis of small segments of DNA molecules known as oligonucleotides. These synthetic strands are important instruments for scientists working on matter the genetic makeup, molecular biology and new medications. The ability to design and produce these DNA fragments has done nothing short of revolutionizing science. It enables researchers to try and error with particular segments of the human genomic equation to analyze illnesses, design novel treatments, and potentially fashion individual treatments.

How DNA Oligo Synthesis Works

The process of DNA Oligosynthesis involves the synthesis of DNA molecules from nucleotides in a nucleotide-by-nucleotide manner. Cytosine is added after adenine, thymine is added next, then cytosine and guanine are added afterward. This synthesis occurs in small specialized facilities or oligo manufacturing plants, as they are commonly referred to. It is more efficient with input from the user and automated; the researchers input their timescales and receive the sequences they desire from the program.

The beauty of DNA oligo synthesis is its precision. Scientists are able to build the exact sequences related to any region of interest in the genome. It is for this reason that the tool can be regarded as incredibly useful in any research activity. Furthermore, to accomplish this process, an oligo analyzer can be used to examine the purity and accuracy of these sequence elements, fulfilling the needed norms.

Role of DNA Oligo Synthesis in the Research.

DNA oligo synthesis is the focal point of many studies. Researchers apply these synthetic oligonucleotides to gene editing, sequencing, and diagnostics. For example, custom oligos can be used in genetics to help researchers understand mutations and their impact on the body. In drug discovery, it is oligos that identify certain genes that cause certain diseases in the body.

This is quite significant for oligonucleotide drug development, especially those drugs that are made from synthesized oligonucleotides such as DNA and RNA and are designed to handle diseases such as cancer and other inherited disorders. The choice of the DNA sequence is the decisive factor, and that is where the synthesis process is so important. Without these tools, it becomes rather difficult to work on and deliver gene therapies and personalized medicine.

Applications in Biotechnology and Drug Development

In addition to research, DNA oligo synthesis is of great importance in the biotechnology and pharmaceutical industries. Large companies use it to develop diagnostic tools, work on vaccines, and even create oligonucleotide drugs. Oligonucleotides are also used in the pharmaceutical world to create quality patented drugs to target specific disease-causing genes.

This process is backed with oligonucleotide manufacturing companies that produce oligonucleotides in a large scale. These organizations are typically engaged in outsourced CDMO drug development services and provide development services to other companies to launch new therapies to markets.

Conclusion

DNA Oligo Synthesis is one of the most important tools for research work and biotechnology. From exploring the basis of hereditary to facilitating the creation of new treatment methods, this technology is in the heart of many scientific discoveries. Veliter Bio offers a comprehensive range of synthesized oligonucleotides at competitively low prices for research and pharmaceutical industries. For both small research projects that require oligo synthesis in small quantities or commercial scale projects that require large scale oligo synthesiss, we have got you covered.

[surbhijamdade]

Revenue Forecast and Competitive Landscape for the Oligonucleotide Synthesis Market

The Oligonucleotide Synthesis Market Report for 2024 provides a comprehensive overview of the Oligonucleotide Synthesis Market industry, presenting crucial data and insights into market dynamics, including growth drivers, challenges, and future potential. The report evaluates the Oligonucleotide Synthesis Market Components, focusing on significant opportunities and trends that could shape the industry's trajectory.

According to Straits Research, the global Oligonucleotide Synthesis Market market size was valued at USD 7.74 billion in 2023. It is projected to reach from USD 8.84 billion in 2024 to USD 25.57 billion by 2032, growing at a CAGR of 14.2% during the forecast period (2024–2032).

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Top Key Players of Oligonucleotide Synthesis Market :

Agilent Technologies, Inc.

ATDBio Ltd.

TriLink BioTechnologies LLC

Thermo Fisher Scientific

Nitto Denko Corporation

Merck KGaA

LGC Biosearch Technologies

Integrated DNA Technologies, Inc.

GenScript

GE Healthcare

Eurogentec

Eurofins

and more....

Key Insights from the Oligonucleotide Synthesis Market Report

Market Size Overview: The report provides comprehensive estimates of the Oligonucleotide Synthesis Marketsize, including value and sales volume, for the period.

Market Trends and Dynamics: An analysis of the key drivers, opportunities, challenges, and risks shaping the Oligonucleotide Synthesis Market.

Global Economic and Regional Impact: Evaluation of the effects of global inflation and the Russia-Ukraine conflict on the Oligonucleotide Synthesis Market.

Trade Flow Analysis: Detailed examination of import and export volumes of Oligonucleotide Synthesis Marketacross major regions.

Industry Value Chain: Insight into the Oligonucleotide Synthesis Marketvalue chain, covering raw materials, suppliers, manufacturing processes, distributors, and downstream customers.

Industry News, Policies, and Regulations: Coverage of the latest developments, policies, and regulations impacting the Oligonucleotide Synthesis Market.

Regional Analysis for Oligonucleotide Synthesis Market:

The regional analysis section of the report offers a thorough examination of the global Oligonucleotide Synthesis Market market, detailing the sales growth of various regional and country-level markets. It includes precise volume analysis by country and market size analysis by region for both past and future periods. The report provides an in-depth evaluation of the growth trends and other factors impacting the Oligonucleotide Synthesis Market market in key countries, such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia, Italy, China, Japan, Korea, India, Southeast Asia, Australia, Brazil, and Saudi Arabia. Moreover, it explores the progress of significant regional markets, including North America, Europe, Asia-Pacific, South America, and the Middle East & Africa.

Oligonucleotide Synthesis Market Segmentations:

By Product Type

Synthesized Oligonucleotide Product

Reagents

Equipment

By Applications

Research

PCR

Sequencing

Gene Synthesis

Diagnostics

Therapeutics

RNAi

Nucleic Acid Aptamers

Others

By End-User

Academic Research Institutes

Pharmaceutical and Biotechnology Companies

Diagnostic Laboratories

Others

Get Detail Market Segmentation :https://straitsresearch.com/report/oligonucleotide-synthesis-market/segmentation

Unit Economics must be known by C-suite professionals:

Cost of Goods Sold (COGS): Includes material, labor, and overhead costs in manufacturing.

R&D Costs: Investment in innovation and compliance with regulations.

Engineering and Design Costs: Resources for design, prototyping, and meeting technical standards.

Production Costs: Specialized manufacturing and quality control expenses.

Supply Chain Costs: Managing procurement and logistics for specialized components.

Testing and Quality Assurance: Costs for ensuring product safety and reliability.

SG&A Costs: Marketing, sales, and administrative expenses.

Revenue per Unit: Income from contracts, services, and licensing.

Gross Margin: Revenue minus COGS, showing unit profitability.

Break-even Analysis: Units or contracts needed to cover total costs.

Customer Acquisition Cost (CAC): Costs to secure new contracts.

Lifetime Value (LTV): Total revenue from a customer over time.

Capital Expenditure (CapEx): Investments in facilities and technology.

Economies of Scale: Cost reductions in larger production runs.

Profit Margin: Final profit after all expenses.

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Access to Comprehensive Insights: Gain access to extensive analysis, research, and data that are often challenging to gather independently. This report provides valuable information, saving you significant time and effort.

Support for Informed Decisions: Enhance your decision-making process with in-depth insights into market trends, consumer behavior, and key industry factors. This report is essential for strategic planning, including investments, product development, and marketing strategies.

Gain a Competitive Edge: Stay competitive by understanding market dynamics and competitor strategies. The report provides detailed insights into competitor performance and market trends, helping you craft effective business strategies.

Cost-Effective Research Solution: Save on research costs by investing in this report, which offers a detailed and comprehensive analysis of the market. This cost-effective option eliminates the need for extensive independent research.

COVID-19 Aftermath and Geopolitical Influences: Russia-Ukraine Conflict and Middle East Crisis

The report explores the multifaceted impact of COVID-19 on the Oligonucleotide Synthesis Market market, covering both direct and indirect effects across global and local levels. It discusses market size, trends, and growth trajectories in the Oligonucleotide Synthesis Market , classified by type, application, and customer sector. Additionally, it provides a detailed evaluation of market development components before and after the pandemic, supported by a PESTEL analysis to assess key influencers and barriers to market entry. We offer the flexibility to customize the report based on specific regions, applications, or any other statistical details. Our goal is to align our analysis with your specific needs, ensuring a more complete market study. The final report will also examine the impact of the Russia-Ukraine War on the Oligonucleotide Synthesis Market market, assessing how these geopolitical events are influencing current market conditions and future opportunities.

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[insightfulblogz]

DNA Synthesis Market Demand, Revenue, and Forecast to 2032

DNA synthesis is a pivotal process in modern genetic research, enabling scientists to create customized DNA sequences in the laboratory. Through synthetic biology and molecular biology techniques, DNA synthesis plays an essential role in advancing fields such as gene therapy, vaccine development, and personalized medicine. By synthesizing DNA, researchers can explore gene function, design novel genetic circuits, and develop new therapies for genetic disorders. As synthetic DNA becomes more accessible, the ability to tailor DNA sequences to specific applications has driven groundbreaking research in biotechnology, pharmaceuticals, and agriculture.

The DNA Synthesis Market size was estimated at USD 3.08 billion in 2023 and is expected to reach USD 11.22 billion by 2032 with a growing CAGR of 15.45% during the forecast period of 2024-2032.

Future Scope

The future of DNA synthesis holds promising potential, with innovations expected to increase speed, efficiency, and accessibility for researchers and industries alike. Advancements in automation and AI-driven design tools are anticipated to make DNA synthesis faster and more accurate, enabling scientists to synthesize longer DNA sequences and more complex constructs. Additionally, improvements in error-checking and purification processes are projected to enhance reliability, making synthesized DNA increasingly viable for therapeutic applications. Furthermore, with the rise of fields like synthetic biology and gene editing, DNA synthesis will continue to play a vital role in developing sustainable solutions, from bioengineered crops to next-generation biofuels.

Trends

Several trends are shaping the field of DNA synthesis, notably the growing integration of digital tools and automation in synthesis processes. Digital DNA design platforms, powered by AI and machine learning, are helping researchers streamline sequence optimization, making it easier to design sequences tailored to specific functional outcomes. Another trend is the miniaturization and portability of DNA synthesis devices, making on-site synthesis feasible in labs and even in remote locations. Additionally, there is an increasing interest in eco-friendly synthesis approaches, including enzymatic synthesis methods that reduce chemical waste and energy usage, aligning with global sustainability goals.

Applications

DNA synthesis has a wide range of applications across the life sciences. In biotechnology, synthetic DNA is instrumental in developing genetically modified organisms (GMOs) and bioengineered microbes for industrial purposes, such as biofuel production and waste treatment. In healthcare, DNA synthesis is used to develop gene therapies and precision medicines by creating DNA constructs that can replace or repair faulty genes, paving the way for treatments of genetic disorders. DNA synthesis also plays a crucial role in vaccine development, enabling the design of DNA-based vaccines that prompt the immune system to recognize and combat pathogens. Additionally, synthetic DNA is vital in diagnostics, aiding in the development of highly sensitive tests that can detect minute traces of genetic material.

Key Points

DNA synthesis enables the creation of custom DNA sequences for research and therapeutic applications.

Automation and AI integration are making DNA synthesis faster, more accurate, and accessible.

Digital DNA design platforms streamline sequence optimization for specific applications.

Eco-friendly synthesis methods, such as enzymatic synthesis, are gaining traction.

Applications include gene therapy, vaccine development, industrial biotechnology, and diagnostics.

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Conclusion

DNA synthesis continues to drive innovation across numerous sectors, enabling researchers to push the boundaries of genetic science and unlock new applications in biotechnology, healthcare, and agriculture. With advancements in automation, digital tools, and sustainable practices, DNA synthesis is poised to become even more efficient, versatile, and accessible to researchers and industries worldwide. As the field progresses, DNA synthesis will play an increasingly critical role in solving global challenges, from healthcare to environmental sustainability, establishing itself as a cornerstone of modern scientific advancement.

[viewzen]

Diamond: Understanding the King of Gems #2

Diamonds mined from nature and composed of pure carbon are the hardest minerals known and classified as diamonds. Their price is determined by the 4Cs: Cut, Carat, Color, and Clarity. Currently, several certification bodies issue reports, including the GIA in the U.S. and IGI and HRD in Belgium, as well as EGL and AGS. In Canada, reports from GemScan have credibility, similar to those from Korean organizations like Hyundai and Wooshin.

Lab-grown Diamonds

Lab-grown diamonds share the same chemical, optical, and physical DNA as naturally mined diamonds. These diamonds are created in a lab that replicates the long process of natural diamond formation by growing diamond seeds using methods like CVD (Chemical Vapor Deposition, which involves growing diamonds as a thin film from seeds) and HPHT (High Pressure High Temperature) over a period of 6 to 10 weeks. They can be selected in good grades at prices comparable to lower-end natural diamonds, and they are considered more environmentally friendly since they do not involve mining exploitation or environmental pollution.

Moissanite

Initially discovered as small mineral particles in nature, moissanite was first synthesized by Henri Moissan, which is how it got its name. It is a lab-created substitute for diamonds, developed to replicate the physical properties of natural diamonds. Moissanite has high hardness, a high refractive index, and dispersion, resulting in remarkable brilliance and fire. The price is about one-third that of diamonds, but availability is limited, and the resale market is not yet well established. Viewzen Diamonds & Jewellery offers lab-grown diamonds, created through advanced technology to match the beauty and durability of natural diamonds. Ethically sourced and environmentally friendly, these diamonds provide a sustainable, high-quality alternative for luxury diamonds jewellery at competitive prices.

[chemanalystdata]

Vitamin B4 Prices | Pricing | Trend | News | Database | Chart | Forecast

Vitamin B4, also known as adenine, is a component of the B-vitamin complex, though it's no longer officially recognized as a vitamin. Historically, it was considered essential for cellular functions, especially as a component of nucleic acids like DNA and RNA. Despite its reclassification, many still refer to it as Vitamin B4 in supplement industries. The pricing of Vitamin B4 supplements can vary greatly depending on several factors, including the source of the supplement, market demand, the production process, and geographical location. Understanding these factors can provide insights into why the prices fluctuate and how consumers can find affordable options.

The cost of Vitamin B4 supplements is influenced largely by the raw materials used in its production. Adenine is a compound that can be synthesized or extracted from natural sources. Synthetic production is often cheaper than extracting the compound from food sources, but there are consumers who prefer natural, organic supplements. Organic or plant-based Vitamin B4 supplements tend to be priced higher due to the complexity of the extraction process, the resources needed for organic farming, and the certifications required to market these supplements as organic. The additional costs incurred by manufacturers are passed on to consumers, leading to a higher price point.

Get Real Time Prices for Vitamin B4: https://www.chemanalyst.com/Pricing-data/vitamin-b4-1118Market demand is another major determinant of Vitamin B4 prices. As more consumers become aware of the health benefits associated with B-vitamins, there is a growing demand for B4 supplements, particularly among those who seek to improve their energy levels, cognitive function, and overall well-being. This heightened demand can drive up prices, especially when the supply of high-quality raw materials is limited. However, in markets where there is less awareness or competition from other supplements, the price of Vitamin B4 might remain relatively low. The balance between supply and demand is always shifting, making it important for consumers to stay informed about market trends.

The production process also plays a significant role in determining the price of Vitamin B4 supplements. Some manufacturers invest heavily in research and development to ensure that their products are not only effective but also safe for long-term use. They may employ advanced technologies to improve the bioavailability of adenine, making it easier for the body to absorb and utilize the compound. These added measures often come with a higher production cost, which results in a more expensive end product. Conversely, some producers may cut corners to offer cheaper alternatives, but these may not always provide the same level of efficacy, leading to variations in price based on quality.

Geographical location is another factor that can affect Vitamin B4 prices. In countries where there is a strong focus on natural health products and supplements, prices may be higher due to stringent regulatory standards, higher wages, and the cost of living. For instance, supplements manufactured in the United States, Canada, or Europe may come with a premium price compared to those produced in regions with lower production costs, such as parts of Asia. However, cheaper does not always mean better. Consumers should be cautious when purchasing from markets with less stringent safety standards, as lower prices might also indicate lower product quality.

Another critical aspect to consider when evaluating Vitamin B4 prices is the presence of additives, fillers, or other ingredients. Some manufacturers add these to reduce production costs, but they may compromise the purity and effectiveness of the supplement. While these products may be cheaper upfront, they might not provide the desired health benefits, leading consumers to spend more in the long run as they search for more effective alternatives. Transparent labeling and third-party testing are essential for ensuring that consumers are getting a high-quality product that justifies its price.

When shopping for Vitamin B4, consumers should also take into account the form in which the supplement is offered. Vitamin B4 can be found in tablets, capsules, powders, or liquid forms. Each form has its pros and cons, and prices can vary accordingly. Tablets and capsules are typically more affordable due to their longer shelf life and ease of production. Powders and liquids, on the other hand, might be more expensive as they require more careful storage and packaging to maintain their potency over time. The form that a consumer chooses may depend on their personal preferences, lifestyle, and how quickly they want the supplement to take effect. Liquids, for instance, are often absorbed more quickly by the body but may come at a higher price due to the specialized packaging.

Brand reputation is also a key factor in the pricing of Vitamin B4. Well-known brands that have established themselves as trusted providers of supplements may charge more for their products due to their reputation for quality and safety. These brands often invest more in sourcing high-quality raw materials, conducting rigorous testing, and adhering to stringent regulatory standards. In contrast, lesser-known or generic brands may offer cheaper alternatives, but they may not always undergo the same level of scrutiny. Consumers may be willing to pay more for a trusted brand, knowing that they are getting a product that meets high standards of quality and safety.

In conclusion, the price of Vitamin B4 supplements is shaped by a variety of factors, including the source of the raw materials, market demand, production processes, geographical location, product form, brand reputation, and global supply chain conditions. Consumers looking to purchase Vitamin B4 should consider these factors when evaluating the price of a supplement to ensure they are getting a product that meets their needs and offers good value for money. By staying informed about the factors that influence pricing, consumers can make better purchasing decisions and find high-quality Vitamin B4 supplements at a price that fits their budget.

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[tamanna31]

mRNA Synthesis Raw Materials Market Size, Share, Growth, Analysis Forecast to 2030

mRNA Synthesis Raw Materials Industry Overview

The global mRNA synthesis raw materials market size was estimated at USD 1.72 billion in 2023 and is anticipated to grow at a CAGR of 2.85% from 2024 to 2030.

mRNA is synthesized by the process of transcription in the nucleus by using a template made up of a DNA nucleotide sequence. It includes various steps such as initiation, elongation, editing, and termination. mRNA synthesis has a broad range of applications in drug discovery, vaccine development, and the manufacturing of therapeutics. RNA-based vaccines have better immunogenicity, higher efficiency, and require short production time. The key factors driving the market growth include the growing academic and industrial interest in mRNA technology, the advantages of mRNA vaccines, and increasing funding for research.

Gather more insights about the market drivers, restrains and growth of the mRNA Synthesis Raw Materials Market

The COVID-19 pandemic created new opportunities for mRNA technology platforms with the introduction and widespread use of vaccines. Government agencies from several nations, research institutions, and numerous biotech and pharmaceutical companies are focusing on efficient and quick methods for the rapid detection of COVID-19. mRNA vaccines are a safe and efficient method for preventing COVID-19. In addition, the advantages associated with the mRNA-based COVID-19 vaccines have sparked the attention of pharmaceutical businesses in delivering vaccines swiftly across the globe.

The National Institute of Allergy & Infectious Diseases and Moderna, Inc. mutually developed the mRNA-1273 (NIAID) in March 2020. It shows 94.1% efficacy in symptomatic prevention from COVID-19 and in December 2020, received emergency use authorization from the US Food & Drug Administration (US FDA) for widespread immunization of people. As a result, the usage of mRNA vaccines increased exponentially during the COVID-19 pandemic.

Recently, RNA centers have been established at numerous institutions to promote therapeutic uses of RNA, particularly in vitro transcribed (IVT) mRNA. These facilities include the Yale Center for RNA Science and Medicine, the RNA Institute at the University of Albany, the State University of New York, and the RNA Therapeutic Institute at the University of Massachusetts in the United States. Additionally, university spin-off businesses funded by significant venture capital infusions such as Argos Medicines, Factor Bioscience, CureVac, Ethris, BioNTech, Moderna, eTheRNA, and Onkaido have advanced the preclinical and clinical development of mRNA-based therapeutics. Hence, growing academic and industrial interest in mRNA technology is anticipated to increase the need for mRNA synthesis raw materials, thereby boosting market growth.

Furthermore, the simplicity to manufacture the mRNA vaccine is a key reason for the development of these vaccines. For instance, it is essential for DNA to enter the nucleus, and then it can be transcribed into mRNA. However, mRNA does not need to enter the nucleus to function as it initiates protein translation in the cytoplasm. Hence, this process makes the mRNA vaccine more efficient and simple to manufacture. In contrast to viral vectors and DNA, mRNAs do not insert into the genome but express the encoded protein instantaneously. Typical cellular processes can eliminate the mRNA since it doesn’t integrate into the host genome, thus eliminating any chance of infection or insertion mutation. In addition, the In Vitro Transcription (IVT) process readily synthesizes mRNA. The process is relatively inexpensive and can be quickly applied to a variety of therapies. Such advantages of mRNA vaccines are anticipated to drive the market during the study period.

Moreover, several operating players in the market and various research institutes are receiving funding for the development of novel mRNA therapeutics. For instance, in October 2022, the University of Columbia received USD 11.1 million in funding from the government of Canada to advance the mRNA vaccine technology. This funding aims to improve their efficacy, reduce the potential side effects of vaccines, and allow for a smaller vaccine dosage. Similarly, in December 2022, ExPLoRNA Therapeutics received USD 813,578 in funding from the Bill & Melinda Gates Foundation to further develop its mRNA technology. Therefore, rising funding for research is expected to increase the need for mRNA synthesis raw materials and fuel the market growth during the forecast period.

Additionally, the growing prevalence of chronic and infectious diseases is increasing the therapeutic application of mRNA technology. For instance, according to WHO, cancer is one of the leading causes of death worldwide, causing almost one in six deaths, while cardiovascular diseases lead to an estimated 17.9 million deaths each year. In addition, according to WHO, about 10 million people worldwide contracted tuberculosis in 2020 (1.1 million children, 5.6 million men, & 3.3 million women). Hence, scientists in industries and universities worldwide are finding novel and innovative ways to develop therapeutics using mRNA technology to prevent and treat disease. For instance, researchers at Penn Medicine are using the mRNA platform to create vaccines for several conditions such as cancer, treatment for food and environmental allergies, genetic diseases, and heart attack and stroke, among others.

Browse through Grand View Research's Biotechnology Industry Research Reports.

• The global recombinant DNA technology market size was valued at USD 728.9 billion in 2023 and is projected to grow at a CAGR of 5.4% from 2024 to 2030.

• The global DNA diagnostics market size was estimated at USD 10.64 billion in 2023 and is projected to grow at a CAGR of 4.51% from 2024 to 2030.

Key mRNA Synthesis Raw Materials Company Insights

The market players operating in the mRNA synthesis raw materials market are adopting product approval to increase the reach of their products in the market and improve the availability of their products in diverse geographical areas, along with expansion as a strategy to enhance production/research activities. In addition, several market players are acquiring smaller players to strengthen their market position. This strategy enables companies to increase their capabilities, expand their product portfolios, and improve their competencies.

Key mRNA Synthesis Raw Materials Companies:

The following are the leading companies in the mRNA synthesis raw materials market. These companies collectively hold the largest market share and dictate industry trends

F. Hoffmann-La Roche Ltd.

Jena Bioscience GmbH

Merck KGaA

Yeasen Biotechnology (Shanghai) Co., Ltd.

BOC Sciences

Thermo Fisher Scientific, Inc.

Maravai LifeSciences

New England Biolabs

Creative Biogene

HONGENE

Recent Developments

In April 2024, Telesis Bio Inc. announced its refocusing strategy to promote its innovative Gibson SOLA platform, targeting DNA and mRNA drug discovery. The company will also concentrate on enhancing its BioXp platform for mRNA synthesis, leveraging its distinct competitive advantage.

In February 2023, Life Edit Therapeutics Inc. and Moderna Inc. signed a collaboration agreement to discover and develop mRNA gene-editing therapies.

In January 2023, BioNTech and the UK Government signed a Strategic Partnership Agreement to help patients by advancing clinical trials for targeted mRNA immune therapies. To provide targeted cancer therapies to up to 10,000 patients by the end of 2030, through clinical trials or as approved treatments

Order a free sample PDF of the MRNA Synthesis Raw Materials Market Intelligence Study, published by Grand View Research.

[industrynewsupdates]

Oligonucleotide Synthesis Market Analysis And Segment Forecast 2024-2030

The global oligonucleotide synthesis market size was estimated at USD 3.68 billion in 2023 and is projected to grow at a compound annual growth rate (CAGR) of 13.21% from 2024 to 2030. 

The decreasing prices of sequencing have led to increasing demand for custom-made nucleotides for applications across genetic testing, research, forensics applications, and drug development. This has further boosted the demand for oligonucleotide synthesis. The COVID-19 pandemic has affected every market globally and there has been a surge in the demand for efficient treatment against COVID-19.

Gather more insights about the market drivers, restrains and growth of the Oligonucleotide Synthesis Market

Oligonucleotide therapeutics hold immense potential for treating chronic conditions such as cardiovascular diseases, cancers, and retinal disorders. Emerging new applications of oligo sequences in multiple fields of biotechnology are expected to increase market growth. Demand for molecular diagnostics in precision care is an important emerging application field for oligonucleotide synthesis.

The introduction of advanced techniques such as CRISPR and high-throughput sequencing for gene expression analysis has simplified the genetic screening and modification of genomes. Such innovations are observed to influence the demand for oligonucleotide synthesis. Manufacturers invest in technology development to enable the production of long Oligonucleotides with higher precision and better yield to cater to the growing need for custom oligos.

The availability of a regulatory environment that supports the progress of genomics is the key factor contributing to the market growth. Changes in the regulatory policies to provide a well-framed environment for advanced biological research and application in human use are expected to influence demand for oligonucleotide synthesis significantly. Stem cells, regenerative medicine, genetic engineering, and synthetic biology are the prominent fields identified with high potential in healthcare. For instance, the International Society for Stem Cell Research (ISSCR) ethics and public policy committee aims to recognize and resolve issues by conducting open discussions. The committee includes experts in ethics, law, and social policy worldwide.

Oligonucleotide Synthesis Market Segmentation

Grand View Research has segmented the global oligonucleotide synthesis market report based on product & service, application, and region:

Product & Service Outlook (Revenue, USD Million, 2018 - 2030)

• Oligonucleotides

o DNA

o Column-based

o Array-based

o RNA

o By Technology

o Column-based

o Array-based

o By Type

o Short RNA Oligos (<65 nt)

o Long RNA Oligos (>65 nt)

o CRISPR (sgRNA)

• Equipment/Synthesizer

• Reagents

• Services

o DNA

o Custom Oligo Synthesis Services

o 25 nmol

o 50 nmol

o 200 nmol

o 1000 nmol

o 10000 nmol

o Modification Services

o Purification Services

o RNA

o Custom Oligo Synthesis Services

o 25 nmol

o 100 nmol

o 1000 nmol

o 10000 nmol

o Modification Services

o Purification Services

Application Outlook (Revenue, USD Million, 2018 - 2030)

• PCR Primers

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• PCR Assays & Panels

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• Sequencing

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• DNA Microarrays

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• Fluorescence In Situ Hybridization (FISH)

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• Antisense Oligonucleotides

o Academic Research Institutes

o Diagnostic Laboratories

o Pharmaceutical - Biotechnology Companies

• Other Applications

Regional Outlook (Revenue, USD Million, 2018 - 2030)

• North America

o U.S.

o Canada

• Europe

o Germany

o U.K.

o France

o Spain

o Italy

o Denmark

o Sweden

o Norway

• Asia Pacific

o China

o Japan

o India

o South Korea

o Australia

o Thailand

• Latin America

o Brazil

o Mexico

o Argentina

• Middle East and Africa (MEA)

o South Africa

o Saudi Arabia

o UAE

o Kuwait

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• The global optical genome mapping market size was valued at USD 104.1 million in 2023 and is expected to grow at a CAGR of 26.76% from 2024 to 2030. 

• The global therapeutic drug monitoring market size was valued USD 1.80 billion in 2023 and is projected to grow at a CAGR of 3.8% from 2024 to 2030. 

Key Companies & Market Share Insights

Some of the key players operating in the market include Merck KGaA, Thermo Fisher Scientific, Inc., and Agilent Technologies. These players focus on business strategies such as partnerships/collaborations, product launches, and expansion. Twist Bioscience, Biolegio, and LGC Biosearch Technologies are some of the emerging market participants in the oligonucleotide market. These players primarily focus on expansion and partnerships to strengthen their position in the market.

Key Oligonucleotide Synthesis Companies:

• Thermo Fisher Scientific, Inc.

• Merck KGaA

• Danaher Corporation

• Dharmacon Inc.

• Agilent Technologies

• Bio-synthesis

• Kaneka Eurogentec S.A

• LGC Biosearch Technologies

• Biolegio

• Twist Bioscience

Recent Developments

• In October 2023, IDT inaugurated a new therapeutic manufacturing facility to meet the increasing demand in genomic medicine. The new facility is equipped to support the production of therapeutic oligonucleotides, catering to the expanding needs in the field of genomics and personalized medicine.

• In September 2023, Danaher Corporation (Integrated DNA Technologies) introduced a range of xGen NGS products tailored for the Ultima Genomics UG 100TM platform. The suite includes adapters, primers, and universal blockers, catering to various applications such as DNA, RNA, & methylation sequencing workflows. This offering is complemented by IDT's proven hybridization capture chemistry, enhancing versatility for researchers.

• In July 2023, Analytix introduced two new instruments designed for organic synthesis, including wavePREP, tailored for oligonucleotide synthesis, and Xelsius, a workstation for multireaction synthesis.

• In May 2023, GenScript expanded its life sciences facility in Zhenjiang, Jiangsu, China, to offer a rapid, high-purity oligonucleotide and peptide synthesis service tailored for research & development as well as preclinical applications.

• In May 2023, Twist Bioscience and CeGaT GmbH launched the Twist Alliance CeGaT RNA Fusion Panel. This collaborative effort aims to provide a specialized tool for oncology research, facilitating the detection of RNA fusions and enabling transcript variant analysis. RNA fusions, a result of chromosomal arrangements often seen in cancers, can now be efficiently studied using this newly introduced panel.

• In February 2023, Fluor Corp. and Agilent Technologies, Inc. collaborated to enhance its oligonucleotide therapeutics manufacturing facility in Frederick, Colorado. Under this collaboration, Fluor is expected to support the project's engineering and procurement. The total value of the project is evaluated at USD 725 million.

Order a free sample PDF of the Oligonucleotide Synthesis Market Intelligence Study, published by Grand View Research.

[health-views-updates]

DNA Synthesizer Market Forecast: Key Insights for Investors

The DNA synthesizer market is on the cusp of a significant expansion, with the market size estimated at USD 260.94 million in 2023. Driven by advancements in genomics and growing demand across various industries, the market is expected to experience a compound annual growth rate (CAGR) of 14.45% over the forecast period of 2024 to 2032, reaching an estimated valuation of USD 879.21 million by 2032.

This growth trajectory underscores the increasing reliance on DNA synthesis technologies for applications in genetic research, synthetic biology, pharmaceuticals, and biotechnology.

Key Market Drivers and Growth Factors

The accelerating growth of the DNA synthesizer market is primarily attributed to key developments in genetic research, personalized medicine, and synthetic biology. DNA synthesizers, which enable the automated assembly of DNA molecules, are integral tools for various applications, from gene synthesis and genome editing to drug discovery.

Advancements in Genomics and Synthetic Biology: With the ongoing advancements in CRISPR-Cas9 and other gene-editing technologies, there is a heightened demand for high-precision DNA synthesizers. Researchers and biotechnology firms are utilizing these machines to create customized DNA sequences, facilitating rapid progress in genetic research, including disease modeling, gene therapy, and agricultural biotechnology.

Rising Demand for Personalized Medicine: The global shift towards personalized medicine, which aims to develop patient-specific treatments based on genetic information, has created substantial demand for DNA synthesis technologies. These technologies enable the design of targeted therapies, ensuring more effective and tailored treatments for diseases such as cancer, genetic disorders, and autoimmune diseases.

Growth in Biopharmaceutical and Biotechnology Industries: The expanding biopharmaceutical industry is heavily reliant on DNA synthesis for drug development, especially in areas such as monoclonal antibodies, vaccines, and gene therapy. The production of synthetic genes and customized DNA strands is a critical aspect of developing novel therapeutics. Additionally, biotechnology companies are using DNA synthesizers to explore innovative solutions in fields such as bioengineering, environmental biotechnology, and industrial applications.

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Market Segmentation and Applications

The DNA synthesizer market is segmented based on type, application, end-user, and geography. DNA synthesizers can be classified into benchtop synthesizers, column-based synthesizers, and others, each catering to different levels of automation and scale.

In terms of application, the major segments include gene synthesis, diagnostics, drug discovery, and synthetic biology. Gene synthesis represents the largest application area, with synthetic biology emerging as a rapidly growing field. Researchers are increasingly relying on synthetic DNA sequences for bioengineering projects, including the creation of synthetic organisms, the development of biofuels, and the production of industrial chemicals.

End-users of DNA synthesizers include academic research institutions, biopharmaceutical companies, clinical laboratories, and synthetic biology firms. The biopharmaceutical sector is expected to remain the dominant end-user, driven by the need for precise gene synthesis in drug discovery and development. However, academic and research institutions are also playing a significant role, as governments worldwide continue to invest in genomics research, supporting both basic and applied genetic research.

Regional Insights

The DNA synthesizer market is experiencing substantial growth across North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa. North America, led by the United States, holds the largest share of the market, driven by the presence of leading biotechnology companies, advanced research infrastructure, and significant government funding for life sciences.

Europe is also a major market, with countries like Germany, the UK, and France at the forefront of synthetic biology and genetic research. European initiatives focusing on genomics research, healthcare innovation, and industrial biotechnology are contributing to the demand for DNA synthesizers.

Asia-Pacific is projected to witness the highest growth during the forecast period, driven by the increasing focus on biopharmaceutical production, rising healthcare investments, and government initiatives aimed at strengthening biotechnology capabilities. China, India, and Japan are particularly noteworthy markets, with China emerging as a global leader in gene therapy research and biopharmaceutical manufacturing.

Challenges and Opportunities

While the DNA synthesizer market is on a fast growth trajectory, it is not without challenges. High costs associated with DNA synthesizers, complex regulatory environments, and ethical concerns surrounding genetic manipulation are some of the factors that could limit market expansion.

Nevertheless, opportunities abound for companies that invest in cost-effective, high-throughput DNA synthesis technologies and focus on innovations that address the regulatory and ethical challenges. The integration of artificial intelligence (AI) and automation into DNA synthesis processes is expected to revolutionize the market, offering more efficient, scalable, and precise DNA synthesis.

Furthermore, the growing interest in environmental and industrial biotechnology, where synthetic DNA is being used to engineer microorganisms for environmental clean-up and sustainable chemical production, is likely to open up new avenues for market growth.

Conclusion

The DNA synthesizer market is set to experience significant growth over the next decade, with the market projected to reach USD 879.21 million by 2032, growing at a CAGR of 14.45%. The rise of genetic research, synthetic biology, and personalized medicine is fueling demand for advanced DNA synthesis technologies, making this market a cornerstone of modern biotechnology and life sciences.

As technological advancements continue to shape the future of DNA synthesis, companies that prioritize innovation and regulatory compliance are well-positioned to capitalize on the tremendous growth opportunities that lie ahead.

[veliterbio]

The Fate of Oligonucleotide Medications

Oligonucleotide drugs are rapidly gaining a central place in todayÕs pharmaceutical industry. These synthetic molecules of DNA or RNA are meant for selective action on definite genes associated with diseases. This makes oligonucleotide drugs development different from most other drugs, which target proteins or enzymes, because, in principle, one could design drugs that alter genetic activity. This indicates that there can be fresh approaches for managing many disorders, including inherited disorders, cancer, and diabetes.

Advancements in Oligonucleotide Manufacturing

The biggest issue in the oligonucleotide drug development process has been synthesis. The synthesis of good quality oligonucleotides is a process that needs special attention and skill. However, these challenges are being witnessed in the oligonucleotide manufacturing and are deformities, advanced in the synthesis of oligonucleotide have been enabling. The availability of sophisticated instruments enables many oligonucleotide manufacturing companies to be established in the market.

Notably, recent advances in large-scale oligo synthesis make these drugs more readily available to patients. This is a big leap towards increasing the ability to manufacture oligonucleotide drugs at an industrial scale in various parts of the world.

Personalized Medicine and Custom Oligos

Another interesting option for oligonucleotide drugs is individual production of custom oligonucleotide synthesis. This means that therapies can be made according to the patient's genetic structure. HSOs can be synthesized specifically to hit one gene behind a given disease, and this application cannot be had with other drugs.

This ability to develop personalized medicine could, therefore, transform the management of rare genetic ailments among patient populations. As oligo synthesis companies refine their technique, they will develop more targeted treatment services and, therefore, make personalized medicine a possibility.

The Role of Oligo CDMO in Drug Development

Oligo CDMO is a key enabler of these therapies with Contract Development and Manufacturing Organizations. These organizations focus on both the synthesis and production of oligonucleotide drugs, and guide pharmaceutical firms on the challenges of oligonucleotide manufacturing process.

CDMOs contribute to the acceleration of drug development through offering production know-how, quality control and regulatory knowledge. As the consumption of oligonucleotide drugs increases, oligoCDMOs will play an increasingly significant part.

The Future of RNA Oligo Synthesis

Another area of RNA oligo synthesis that we are likely to see much further development is RNA targets. These targets are discussed for potential treatment of cancer, viral disorders, and autoimmune responses. RNA oligonucleotides' effectiveness increases as RNA production advances, and there is hope for treatments as it creates more chances.

As it stands, Rna Synthesis Company are making formidable research efforts toward novel treatment regimens, and the perspective for RNA-based therapies is optimistic. The ability to change RNA directly and regulate the messages converting to proteins can be a good pharmaceutical prospect.

Conclusion

The future for oligonucleotide drugs is bright as we look forward to the future of this platform. As oligo manufacturing has progressed and Oligo CDMOs have entered the scene, these drugs are more available and functional. As the dream of personalized medicine comes to pass, PNA synthesis will provide a molecule that can be adapted to the genetically oriented ailment. Here at Veliter Bio, we are on the cutting edge of this rapidly growing fieldÑoffering the best oligo solutions that will drive the advancement of medicine.

[ps1396262]

DNA Data Storage Market Size, Revenue Analysis, Opportunities, Trends, Product Launch, 2024–2030

The DNA Data Storage Market was valued at USD 357 million in 2023-e and will surpass USD 3,100 million by 2030; growing at a CAGR of 89.3% during 2024 - 2030. one of the most fascinating and promising technologies on the horizon is DNA data storage. Imagine storing the entire contents of the Library of Congress in a space no bigger than a sugar cube.

This is not science fiction; it’s the potential of DNA data storage. As the volume of digital data continues to explode, traditional storage mediums like magnetic tapes and hard drives are struggling to keep up. Enter DNA, the blueprint of life, which offers a revolutionary way to store vast amounts of information in an incredibly compact form.

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What is DNA Data Storage?

DNA data storage refers to the process of encoding binary data (the 1s and 0s that make up digital files) into the four-letter nucleotide code of DNA (A, T, C, G). This is done by converting binary data into a sequence of DNA nucleotides, which are then synthesized into actual DNA molecules. These molecules can be read back and decoded into the original binary data, making DNA an incredibly dense and durable medium for storing digital information.

Why DNA?

DNA has several unique properties that make it an attractive option for data storage:

Density: DNA is incredibly dense; a single gram of DNA can theoretically store up to 215 petabytes (215 million gigabytes) of data.

Longevity: Unlike traditional storage mediums that degrade over time, DNA can remain stable for thousands of years under the right conditions, ensuring long-term data preservation.

Sustainability: With the growing environmental concerns surrounding data centers and their energy consumption, DNA offers a sustainable alternative, as it requires no power for storage.

The Growing Market for DNA Data Storage

The potential of DNA data storage is attracting significant interest from various industries, including technology, healthcare, and finance. As the demand for data storage continues to surge, companies are exploring DNA as a long-term solution to meet the world’s growing data needs.

Market Trends

Rising Data Generation: The exponential increase in data generation, driven by the Internet of Things (IoT), big data analytics, and artificial intelligence, is one of the primary drivers of the DNA data storage market.

Investment in Research and Development: Companies and research institutions are investing heavily in R&D to overcome the current challenges of DNA data storage, such as the high cost of DNA synthesis and sequencing. Advances in these areas are crucial for making DNA data storage commercially viable.

Collaborations and Partnerships: There has been a rise in collaborations between tech giants, biotech companies, and academic institutions aimed at accelerating the development and commercialization of DNA data storage technology.

Government Initiatives: Governments worldwide are recognizing the strategic importance of advanced data storage technologies and are supporting research initiatives that focus on DNA data storage.

Challenges to Overcome

Despite its enormous potential, DNA data storage faces several challenges that must be addressed before it can become a mainstream technology:

Cost: Currently, the cost of synthesizing and sequencing DNA is prohibitively high. However, as technology advances, these costs are expected to decrease significantly.

Speed: Writing and reading data in DNA is slower than in traditional storage systems. Improving the speed of data retrieval and encoding is a critical area of research.

Error Rates: DNA synthesis and sequencing processes can introduce errors. Developing more accurate and reliable methods is essential for the technology’s success.

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The Road Ahead

The DNA data storage market is still in its infancy, but its future is bright. As technological barriers are overcome, DNA has the potential to revolutionize the way we think about data storage. In the next decade, we can expect to see significant advancements in this field, with DNA storage emerging as a viable solution for archiving vast amounts of data.

The integration of DNA data storage into mainstream technology will likely occur gradually, starting with applications where long-term data preservation is critical, such as in historical archives, government records, and large-scale data centers. As the technology matures, it could eventually become a standard for data storage, offering an efficient, sustainable, and durable solution for the digital age.

Conclusion

The DNA data storage market represents a fascinating intersection of biology and technology, with the potential to transform the future of information storage. As we continue to generate data at an unprecedented rate, DNA may provide the key to unlocking a new era of data management, one where the limits of current storage technologies are surpassed, and the full potential of our digital world is realized.

[insightfulblogz]

Oligonucleotide Synthesis Market Future Growth, Scope, Price, and Forecast 2032

Oligonucleotide synthesis has emerged as a crucial component in modern biotechnology, enabling precise manipulation of genetic material for applications ranging from medical diagnostics to therapeutics. These short DNA or RNA molecules, commonly synthesized in laboratories, are instrumental in gene editing, polymerase chain reactions (PCR), molecular cloning, and various other research methods. With advances in synthetic biology, oligonucleotides have become fundamental tools for developing targeted therapies, especially for genetic disorders and cancer treatments. The field has seen remarkable growth as researchers and clinicians leverage these synthesized sequences to enhance accuracy and efficiency in gene-targeting techniques.

The synthesis of oligonucleotides requires highly specialized equipment and meticulous methodologies to ensure the precision of each nucleotide sequence. Leading techniques, such as solid-phase synthesis, phosphoramidite chemistry, and enzymatic synthesis, have contributed to achieving high-fidelity results, ensuring the effectiveness of synthesized oligonucleotides in clinical and research applications. As demand continues to grow for gene-based therapies, diagnostics, and advanced research applications, the market for oligonucleotide synthesis is projected to witness significant expansion in the coming years.

The Oligonucleotide Synthesis Market size was estimated at USD 3.67 billion in 2023 and is expected to reach USD 11.21 billion by 2032 at a CAGR of 13.22% during the forecast period of 2024-2032.

Future Growth

The future growth of the oligonucleotide synthesis market is anticipated to be driven by the increasing interest in gene-based therapies and personalized medicine. Advances in genomic research are revealing new pathways and genetic markers that can be targeted with precision therapies, propelling the demand for custom-synthesized oligonucleotides. Additionally, expanding applications in gene silencing, antisense oligonucleotides, and CRISPR technology are catalyzing a rise in demand for oligonucleotide synthesis as a tool for genetic intervention and cellular engineering.

Global investments in biotechnology research and development are further strengthening the market outlook. Governments and private institutions are increasingly funding initiatives aimed at discovering new genetic therapies and diagnostic tools, fueling the demand for oligonucleotide synthesis services. The field is also expected to benefit from innovations in synthesis processes, such as automation and miniaturization, which improve efficiency, reduce costs, and enable high-throughput applications in large-scale research studies and clinical applications.

Drivers

The rising prevalence of genetic disorders and chronic diseases is a major driver of the oligonucleotide synthesis market. As gene therapy and molecular diagnostics gain traction in healthcare, oligonucleotide synthesis has become an essential process in developing effective treatments and accurate diagnostic tests. Additionally, the ongoing evolution of biotechnology, characterized by advancements in genome editing tools such as CRISPR-Cas9, continues to drive demand for oligonucleotide synthesis. Researchers rely on synthesized oligonucleotides to design CRISPR guides, primers, and probes, highlighting their value in groundbreaking genetic interventions.

Another significant driver is the growth in pharmaceutical and biotechnological research aimed at creating personalized treatments tailored to an individual’s genetic makeup. As precision medicine gains momentum, the role of synthesized oligonucleotides becomes increasingly central in designing therapies that specifically target the genetic origins of diseases. The demand for high-throughput synthesis is also bolstered by academic and research institutions focusing on genomics, proteomics, and metabolomics, further stimulating the market’s expansion.

Key Takeaways

The oligonucleotide synthesis market is crucial to advancements in biotechnology, particularly in gene-based therapies and molecular diagnostics.

Future growth is expected to be driven by the rise in personalized medicine, genomic research, and innovative genome editing tools.

Major companies such as Integrated DNA Technologies and Thermo Fisher Scientific are pivotal players, investing in advanced synthesis techniques.

The demand is propelled by the rising incidence of genetic disorders and the need for precision medicine solutions.

Technological advancements in synthesis processes, including automation and miniaturization, are set to optimize production efficiency and accuracy.

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Conclusion

In conclusion, oligonucleotide synthesis stands at the forefront of biotechnology, empowering researchers, clinicians, and pharmaceutical developers to innovate with precision and specificity. The market is poised for substantial growth, fueled by expanding applications in gene-based research and treatment approaches. As the demand for personalized medicine and targeted therapies rises, synthesized oligonucleotides are expected to play an increasingly important role in diagnosing and treating complex genetic diseases. With continued investment in technological advancements, the future of oligonucleotide synthesis holds promising potential for furthering scientific understanding and improving patient outcomes in healthcare.

[axelknaus]

A full-size, high-density RNA microchip is about the size of a fingernail and can contain up to 780,000 unique RNA sequences, each covering an area of about 14 x 14 μm².

Tadika Kekić

The next generation of RNA chips

Research team achieves breakthrough: chemical synthesis of high-density RNA microarrays now faster and more efficient

An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and light sensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical production of these chips is now twice as fast and seven times more efficient. The results of the research work were recently published in the renowned journal Science Advances.

The emergence and market approval of RNA-based medical products, such as mRNA vaccines during the COVID-19 pandemic, has also brought the RNA molecule into the public eye. RNA (ribonucleic acid) is an information-carrying polymer - a chemical compound made up of similar subunits - but with a far greater structural and functional diversity than DNA. About 40 years ago, a method for the chemical synthesis of DNA and RNA was developed in which any sequence can be assembled from DNA or RNA building blocks using phosphoramidite chemistry. A nucleic acid chain is built up step by step using these special chemical building blocks (phosphoramidites). Each building block carries chemical "protective groups" that prevent unwanted reactions and ensure the formation of a natural link in the nucleic acid chain.

Mastering challenges

This chemical method is also used in the production of microchips ("microarrays"), where millions of unique sequences can be synthesized and analyzed simultaneously on a solid surface the size of a fingernail. While DNA microarrays are already widely used, adapting the technology to RNA microarrays has proven difficult due to the lower stability of RNA.

Back in 2018, the University of Vienna demonstrated how high-density RNA chips can be produced using photolithography: By precisely positioning a beam of light, areas on the surface can be prepared for the attachment of the next building block through a photochemical reaction. Although this first report was a world first and remains unchallenged to this day, the method suffered from its long production time, low yield and low stability. Now this approach has been massively improved.

Development of a new generation of RNA building blocks

A team from the Institute of Inorganic Chemistry at the University of Vienna, in collaboration with the Max Mousseron Institute for Biomolecules at the University of Montpellier (France), has now developed a new version of RNA building blocks with higher chemical reactivity and light sensitivity. This advance significantly shortens the production time of RNA chips and makes synthesis twice as fast and seven times more efficient. The innovative RNA chips are capable of screening millions of RNA candidates for valuable sequences for a wide range of applications.

"The production of RNA microarrays with functional RNA molecules was simply out of reach with our previous setup. With the improved method using the propionyloxymethyl (PrOM) group as a protecting group, it is now possible," says Jory Lietard, Assistant Professor at the Institute of Inorganic Chemistry.

As a direct application of these improved RNA chips, the publication includes a study of RNA aptamers, small oligonucleotides that bind specifically to a target molecule. Two "glowing" aptamers were selected that produce fluorescence when binding to a dye, and thousands of variants of these aptamers were synthesized on the chip. A single binding experiment is sufficient to obtain data on all variants simultaneously, paving the way for the identification of improved aptamers with better diagnostic properties.

"High-quality RNA chips could be particularly valuable in the rapidly growing field of non-invasive molecular diagnostics. New and improved RNA aptamers are desperately sought, e.g. those that can track hormone levels in real time or monitor other biological markers directly from sweat or saliva," says Tadija Kekić, PhD student in Jory Lietard's group.

This work was financially supported by a joint grant from the Agence Nationale pour la Recherche/Austrian Science Fund (FWF Individual Project International I4923).

Original publication:

Publication in "Science Advances" T. Kekić, N. Milisavljević, J. Troussier, A. Tahir, F. Debart and J. Lietard: Accelerated, high quality photolithographic synthesis of RNA microarrays in situ https://www.science.org/doi/10.1126/sciadv.ado6762 doi: 10.1126/sciadv.ado6762