#Blueprint Medicines Corp

[blueprint90]

Healthcare is rapidly evolving, thanks to technology. One exciting development is remote work in medicine.

[b360news]

Marvell Technology is ‘Mr. 5G’ Raytheon: "I think it's a terrific combination and it should be bought." Crown Castle: "That is a castle keeper.

[shmothman]

THIS POST CONTAINS MAJOR SPOILERS FOR POKEMON: LEGENDS ARCEUS

slight AU, reader insert, post game, fixing Volo, + romance  

Judgement | Forgiveness

Part 4

Part One / Part Two / Part Three

AO3 Link

In the following weeks, you do your best not to think too much about Volo. It’s a losing battle, frustratingly, but you really are trying. Luckily, you have plenty of other things to think about: working on the Pokedex, for one; and adventuring with Giratina, for another. It wanted to see Hisui, after seeing in your heart how much you care for it, and, in its own way, you think it wants to apologize for the way it (and Volo) caused trouble. Whether or not what Volo said about Giratina being Arceus’s “unwanted child” was true, it seems the pokemon has had a change of heart, and you’re glad to take it with you for now. You’ve taken it to meet the Clans, the Nobles and Wardens, and it even let Professor Laventon study it a bit, though you had to do it away from Jubilife, so as not to scare the villagers. It can even “speak” with you, in your mind, though it’s less speaking and more... raw emotion sharing.

When you finally come home one night to a Togekiss perched on your rooftop, the emotion you feel first is relief. You bring her inside, and you curse yourself for not thinking to bring Volo a pen and paper, because figuring out what he needs from Togekiss’s gesturing is nearly an impossible task. But you eventually figure it out. When you go to him the next morning, you also bring more clothes, and extra blankets.

It’s almost as much of a shock to see him this time as the last—though it seems he’s been sleeping a bit better, at least—and again you say little. It isn’t as if you don’t want to talk to him; you want to ask him how he’s been spending his days, and you want to tell him of the progress you’ve made with Giratina. You know he would be interested to know of some things you found at Sendoff Spring... or at least, these are all things you wish you could talk to the old Volo about. The Volo that may or may not have been a facade. 

It would be so much easier if you could see no trace of his former self, if he had abandoned that piece of himself entirely—but that old smile is just below the surface of every nervous twitch of his lips, that spark of curiosity still in his eye, even if he no longer asks you the questions he wants to. You suppose he probably thinks you’ll be angry with him if he does.

You don’t know if you’d be angry or not.

Regardless, you’re rather impressed at the way he’s built up his little lean-to in the past few weeks: you might even call it more of a hut now, and it insulates from the chill of the mountain just a bit more. You think that maybe you can find some blueprints for him, some instructions to build an indoor stove that vents to the outside...

But your visit doesn’t last long, and once again, you awkwardly take your leave.

Though, you can’t help the way you look at every item in the shops with him in mind, now. Could Volo use this? Could the construction corps spare a copy of their blueprints?

It’s difficult to remind yourself that you’re keeping this secret for a reason. Most of the people of Jubilife would not be happy with you if they knew you were helping him—the whole point of banishment is that he receives no aid. That’s why it’s the harshest punishment available: humans are social creatures. He’s meant to be alone.

---

You visit him twice more in the coming weeks, bringing things he requests: seeds for growing sand radishes and medicinal leeks, and small tools—though reading his terrible handwriting is just as difficult as trying to interpret from Togekiss.

And each time, Volo’s hut has gotten larger, his pokemon always out and about, helping him to survive the frigid nights.

And each time, though you keep your distance, your heart aches.

---

It’s only been five days since the last time you brought him Volo supplies, and the sun is hanging low over the fieldlands as you make the return hike to Jubilife Village. You often forgo the help of the security corps entirely, these days—everyone already knows that you can handle yourself—but this evening, you’re thankful for the company of Laventon and the corps members. Since your closing the space-time rift, no one has dared to call you an outsider again... but now many of them have taken to calling you Hero, and the strange pedestal they’ve put you on leaves a sour taste in your mouth. Fitting in was never going to be easy, and you certainly don’t regret helping the people of Hisui... but it would be nice if everyone could just treat you like a normal person.

Even if, to them, you aren’t.

You have to admit, despite the fact that you’re surrounded by people, you’ve felt awfully lonely since you came to this world.

A guard rushes toward your group as you approach the gates. 

“Ress!” Laventon exclaims. “Is something wrong?”

Ress looks to you. “There’s a pokemon in town causing havoc. We think it’s looking for you.”

Immediately, you’re on high alert, and a sensation of dread crawls up your spine. Without waiting for the others, you sprint ahead, through the gate and onto Floaro Street. Your house isn’t far from the main gate, but you still hear Togekiss’s piercing cry before you see it.

It’s unmistakable.

The ice in your veins spurs you onward as you approach, finding Togekiss flying circles around your roof, screeching her strange fairy cry. Below are gathered many of the residents of Jubilife, pointing and muttering worriedly, and a couple of the security corps members are attempting to keep everyone back.

“You’re here!” Tsumigi calls you over, and the crowd parts easily around you. “It’s been here for a couple hours, just flying circles around your house and screaming like that. Do you know this pokemon?”

And Togekiss spots you, diving to the ground and bowling you over entirely. The crowd gasps, and you see Tsumigi grab for the pokeball at her belt. Wincing from the fall, you push yourself back up and thrust out your hand toward Tsumigi. 

“Stop!” You tell her, and she lowers the pokeball in uncertainty.

Your heart is pounding. If Togekiss is here, (so soon, so aggravated,) it can only mean one thing: Volo is in trouble. 

You don’t have time for explanation, and you can’t tell them the truth anyway, but Togekiss remains in your space, crying and screeching. So you take her face in your hands, and you say “okay, girl. It’s okay. I’m coming,” and whirl around to face the anxious villagers.

“This Togekiss is a friend of mine.” Not technically a lie. “She needs help, and she knew where to find me.”

Muttering to one another, the villagers slowly disperse, and you turn to Tsumigi. “I’m going to follow her, probably back to her nest. There’s probably an injured member of her flock. I’ll be gone a few days.”

Tsumigi looks concerned. “Is there anything I can do? Someone can come with you—”

“That’s okay,” you cut her off with what you hope comes off as a confident smile, though the ice creeping through your veins is making it hard to breathe. “I just need to fly there. I won’t be in any danger.”

“If you say so,” Tsumigi concedes. “Let us know if there’s anything we can do!”

Finally, she leaves you, headed back to her post at the gate. Togekiss gives an impatient trill, and you drop the smile immediately. “Let me gather my supplies,” you tell her. “I’ll be right back.”

Braviary doesn’t fly as fast as Togekiss—mostly because of the human on its back, you think—and Togekiss spends the entire way to the Alabaster Icelands looking behind herself and waiting for you to catch up. It’s frustrating, especially because you can see the fear in Togekiss’s eyes, but it isn’t that Braviary doesn’t understand the urgency; it’s just already flying at its limit. Not to mention the lowered visibility at night, coupled with the snowstorm you fly into immediately after passing the Coronet Highlands. You almost lose Togekiss in the storm a couple of times, but Braviary’s psychic abilities allow it to get you back on track.

Even at top speed, Braviary will take a few hours to cross Hisui, and that leaves you with far too much time to think.

Togekiss arrived from the Icelands a couple hours before sunset, which means that she probably left in the mid afternoon—and you won’t be able to get there until nearly ten. If Volo is truly hurt, you could be arriving too late. Was he hurt by a pokemon? Another person? Is he stranded in the snow? Does he have the rest of his pokemon with him?

Round and round your thoughts spin, fear after fear, as Braviary follows Togekiss through the night sky, as stars turn to clouds turn to snow and ice, and as you finally see the peak of the mountain beneath which Volo has set up camp, you grip Braviary’s feathers tight, willing it onward.

Togekiss clears the peak and dives, and Braviary follows, your stomach dropping out from under you as you hang on for dear life, cliffs and outcroppings flying past you at breakneck pace. You can’t see the ground for all the snow around you, but you trust in Togekiss to navigate, and in Braviary to be able to follow.

You feel Braviary level out, gliding more gently down the slopes, then nearly over level ground. Ahead of you, you catch sight of Togekiss in the brightness of the snowy night. She dives. 

Braviary flaps its wings wildly to come to an abrupt stop, and you realize that just ahead of you is a hole in the ice—an entrance to the sprawling system of caves beneath the Icelands. Stomach turning with fear, you urge Braviary downward, following Togekiss. 

And as you clear the opening, you can see Arcanine at the bottom, curled protectively around an unmoving form.

[ustribunenews-blog]

Lowering The 52 Week Low, Blueprint Medicines Corp (Nasdaq:BPMC) Closing Trading At $45.57

Lowering The 52 Week Low, Blueprint Medicines Corp (Nasdaq:BPMC) Closing Trading At $45.57

Blueprint Medicines Corp (Nasdaq:BPMC)

December 22nd, 2018 Amidst falling markets Blueprint Medicines Corp fell $4.26 Friday which equals a 8.55% decline, closing at $45.57. As well as the drop in value, Blueprint Medicines Corp hit a new 52 week low of $45.52, breaking the previous low of $49.75 from earlier this month. (more…)

[healthcaremrr]

Pain and Fever Relief Drugs Market 2022 by Top Key Players, Types, Applications and Future Forecast to 2030

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Global Pain and Fever Relief Drugs Market: By Type Aspirin Paracetamol Naproxen Ibuprofen Diclofenic Acid Metamizole Sodium

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Global Pain and Fever Relief Drugs Market:key players AstraZeneca Roche Lion Corp Calpol HEXAL Reckitt Benckiser Johnson and johnson

The global healthcare industry has been growing at a CAGR of around 5% and is expected to deliver even more in the future. The healthcare business is expanding at a steady rate and is expected to move up the growth scale in the future. The healthcare business is comprised of several main areas, including healthcare services and facilities, hospital supplies, medical equipment, pharmaceuticals, and drugs, and we provide comprehensive information on these sectors with the highest precision.

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[schaeffersresearch]

Earnings expected from Starbucks, Airbnb, AMD, PayPal, BP, JetBlue, Electronic Arts, Molson Coors, Caesars Entertainment, and Uber

[ramshariraut]

Activin Receptor Type 1  Market: Industry Growth Analysis, Global Trends, Insight, New Development And Forecast To 2028

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[pavanghage]

Activin Receptor Type 1 Market Size, Share, Value, And Competitive Landscape 2021-2027

"

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By Market Players: Blueprint Medicines Corp Oncodesign SA Daiichi Sankyo Company Ltd La Jolla Pharmaceutical Company Tolero Pharmaceuticals Inc By Type LJPC-6417 TP-0184 Dipyridamole Others By Application Alport Syndrome Chronic Kidney Disease Kidney Fibrosis Obesity Others

A detailed outline of the Global Activin Receptor Type 1 Market includes a comprehensive analysis of different verticals of businesses. North America, Latin America, Asia-Pacific, Africa, and Europe have been considered for the studies on the basis of several terminologies.

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Table of Contents:

Global Activin Receptor Type 1 Market Overview

Economic Impact on Industry

Market Competition by Manufacturers

Production, Revenue (Value) by Region

Production, Revenue (Value), Price Trend by Type

Market Analysis by Application

Cost Analysis

Industrial Chain, Sourcing Strategy and Downstream Buyers

Marketing Strategy Analysis, Distributors/Traders

Market Effect Factors Analysis

Global Activin Receptor Type 1 Market Forecast

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Axel Reports has the most comprehensive collection of market research products and services available on the web. We deliver reports from virtually all major publications and refresh our list regularly to provide you with immediate online access to the world’s most extensive and up-to-date archive of professional insights into global markets, companies, goods, and patterns.

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"

[researchkraft19]

Bile Duct Cancer Drug Market for the forecast period, 2020-2027

The Global Bile Duct Cancer Drug Market has enlisted a noteworthy CAGR during the most recent decade. It is relied upon to arrive at higher yearly development in the imminent years. Strength, hearty monetary framework, crude material opulence, taking off worldwide Bile Duct Cancer Drug request are boosting market advancement. So also, mechanical headways, advancements, expanding industrialization, and urbanization in the creating and created areas are probably going to maintain the Bile Duct Cancer Drug market income during forecast 2020-2027

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The most significant players coated in global Bile Duct Cancer Drug market report:

Ariad Pharmaceuticals Inc. , ArQule Inc. , Array BioPharma Inc. , Arrien Pharmaceuticals LLC , Aslan Pharmaceuticals Pte. Ltd. , Bavarian Nordic A/S , Bayer AG , Blueprint Medicines Corporation , Boehringer Ingelheim GmbH , Boston Biomedical Inc. , Bristol-Myers Squibb Company , Celgene Corporation , CellAct Pharma GmbH , Cellceutix Corporation , Cellular Biomedicine Group Inc. , Concordia Healthcare Corp

Types is divided into:

Cabozantinib S-malate

Elpamotide

Exatecan Mesylate

LY-2801653

NUC-1031

Others

Applications is divided into:

Hospital

Clinic

Others

Global Bile Duct Cancer Drug Market Regional Segmentation:

North America (U.S., Canada, Mexico) Europe (Germany, U.K., France, Italy, Russia, Spain, etc.) Asia-Pacific (China, India, Japan, Southeast Asia, etc.) South America (Brazil, Argentina, etc.) Middle East & Africa (South Africa, Saudi Arabia, etc.)

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[b360news]

I think Roku is good Roku: "I think Roku's good. ... it's got that cord-cutting feel that I like, so I'm going to say 'okay.'"

[kunalcmi]

CANCER DIAGNOSTICS MARKET ANALYSIS (2020-2027)

Tumor biomarkers tests use in diagnosis of cancer include, prostate specific antigen (PSA), circulating tumor cells (CTC), Alfa-fetoprotein test (AFP), CA-19 test for pancreatic cancer, HER-2 test, BRCA test, ALK test for lung cancer, carcioembryonic test (CEA), EGFR mutation test, and RAS mutation test.

The global cancer diagnostics market is estimated to account for US$ 45,106.5 Mn in terms of value and is expected to reach US$ 83,641.9 Mn by the end of 2027.

 Global Cancer Diagnostics Market: Drivers

Increasing prevalence of cancer is expected to propel growth of the global cancer diagnostics market over the forecast period. For instance, according to the American Cancer Society, in 2019, there will be an estimated 1,762,450 new cancer cases diagnosed and 606,880 cancer deaths in the U.S.

Moreover, R&D in cancer diagnostics is also expected to aid in growth of the market. For instance, in January 2020, researchers from Universidade do Porto, Portugal, reported assessment of the role of O-glycosylation using glycoengineered gastric cancer models in the detection of CD44v9 – a major protein splice variant isoforms expressed in human gastrointestinal cancer cells—by monoclonal antibodies. 

Biopsy held dominant position in the global cancer diagnostics market in 2019, accounting for 35.1% share in terms of value, followed by Imaging and Tumor Biomarkers Tests, respectively.

 Figure 1. Global Cancer Diagnostics Market Share (%), by Value, by Test Type, 2019

Global Cancer Diagnostics Market: Restraints

Inadequate reimbursement policies are expected to hinder growth of the market. There have been various advancements in radiology with regard to imaging equipment in the recent past. However, most medical insurance companies do not offer reimbursement for procedures using Computer-aided Detection (CAD). As a result, people tend to choose conventional methods for diagnosis such as biopsy, pathological test or conventional imaging methods such as mammography, and MRI procedures.

Moreover, high price of cancer detection software is also expected to hamper growth of the market. Computer-aided Detection (CAD) software is available with a one-year license and hospitals have to renew it each year. Moreover, some insurance providers are opting out of the CAD procedure reimbursement as it is deemed extravagant and not preferred by senior radiologists

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 Global Cancer Diagnostics Market: Opportunities 

Development of biopsy platforms for companion animal cancers is expected to offer lucrative growth opportunities for players in the global cancer diagnostics market. For instance, in January 2020, Zomedica Pharmaceuticals Corp., a veterinary diagnostic and pharmaceutical company, announced completing the development and manufacturing of its reference lab cancer liquid biopsy platform for canine cancers.

Moreover, use of AI in early detection of cancer is also expected to aid in growth of the market. For instance, Freenome, an AI genomics company based in the U.S., is focused on developing blood tests to detect the body’s early-warning signs of cancer, using AI. In October 2018, the company presented early data in R&D for using machine learning to detect colorectal cancer at its earliest stages.

The global cancer diagnostics market was valued at US$ 41,542.4 Mn in 2019 and is forecast to reach a value of US$ 83,641.9 Mn by 2027 at a CAGR of 9.2% between 2020 and 2027.

Figure 2. Global Cancer Diagnostics Market Value (US$ Mn), and Y-o-Y Growth (%), 2019-2027

Market Trends/Key Takeaways

Major players in the market are focused on adopting partnership strategies to enhance their market share. For instance, in February 2020, Foundation Medicine, Inc. and Chugai Pharmaceutical, Ltd. collaborated with National Cancer Center (NCC) for the use of FoundationOneLiquid, Foundation Medicine’s laboratory-developed liquid biopsy test, in the third stage of SCRUM-Japan, a cancer genomic screening consortium in Japan.

Major players in the market are also focused on adopting M&A strategies to expand their product portfolio. For instance, in January 2020, Quest Diagnostics acquired Blueprint Genetics to expand its product portfolio in genetic and rare diseases.

Global Cancer Diagnostics Market: Competitive Landscape

Major players operating in the global cancer diagnostics market include, Abbott Laboratories, F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc., Siemens AG, Bio Rad Laboratories Inc., GE Healthcare, Illumina, Inc., Koninklijke Philips N.V., Toshiba Medical Systems Corporation, Agilent Technologies, Inc., Aurora Imaging Technologies, Inc., Quest Diagnostics

Global Cancer Diagnostics Market: Key Developments

Major players in the market are focused on approval and launch of new products to expand their product portfolio. For instance, in May 2020, Myriad Genetics, Inc. received the U.S. Food and Drug Administration (FDA) approval for its BRACAnalysis CDx test as a CDx for Lynparza in homologous recombination repair-mutated metastatic castration-resistant prostate cancer.

Major players in the market are also focused on adopting partnership strategies to expand their product portfolio. For instance, in October 2019, Illumina, Inc. partnered with QIAGEN N.V. to broaden the availability and use of NGS-based in-vitro diagnostic kits, including companion diagnostics, for patient management.

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Source: https://www.coherentmarketinsights.com/market-insight/cancer-diagnostics-market-4029

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Motley Fool: Blueprint Medicines (BPMC) Q2 2019 Earnings Call Transcript

Motley Fool: Blueprint Medicines (BPMC) Q2 2019 Earnings Call Transcript

Image source: The Motley Fool.

Blueprint Medicines (NASDAQ:BPMC) Q2 2019 Earnings Call Aug 01, 2019, 8:30 a.m. ET

Contents:

Prepared Remarks

Questions and Answers

Call Participants

Trending

Prepared Remarks:

Operator

Good day, ladies and gentlemen, and welcome to the Q2 2019 Blueprint Medicines Corp conference call. [Operator instructions] I would now like to introduce your host for today’s…

[phooll123]

Loxo Continues Battle in Targeted Cancer Drugs With Fresh Data

By 

Cristin Flanagan

2 June 2018, 13:52 GMT+1

Results from an early-stage study of Loxo Oncology Inc.’s targeted cancer therapy keep getting better, the company said at the American Society of Clinical Oncology meeting taking place this weekend in Chicago.

The shares had already gained 34 percent since an initial abstract of the data last month was cheered by analysts as giving Loxo a lead over competitor Blueprint Medicines Corp. The updated findings show Loxo’s drug has activity in heavily pre-treated patients with RET-altered cancers, including those whose tumors have spread to the brain.

Updated data from the Phase 1 study being presented Saturday show:

An overall response rate (ORR) of 77 percent in RET fusion-positive tumors; confirmed ORR of 74 percent; rates were same in subset of non-small cell lung cancer patients

For patients with RET-mutated medullary thyroid cancer, ORR was 45 percent and confirmed ORR was 33 percent

As of the data cutoff, all responding patients across all tumor types remained on therapy; longest responding patient was on treatment for more than 10 months

Two severe (grade 3) side effects were deemed related to LOXO-292, including one case of elevated liver enzymes. Other case was tumor lysis syndrome that was considered a dose-limiting toxicity at 240 milligram twice-daily dose

Ahead of Loxo’s presentation, Blueprint Chief Executive Officer Jeffrey W Albers said durability will be key to long-term success and he’s confident in his company’s treatment. With no approved therapies targeting RET-fusion tumors, Loxo CEO Joshua Bilenker said he sees room for more than one player “if drugs can be differentiated.”

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Casdin Capital, LLC Buys Magenta Therapeutics Inc, Foundation Medicine Inc, Blueprint Medicines Corp, Sells iShares Nasdaq Biotechnology Index Fund, Evolent Health Inc, Jounce Therapeutics Inc

Casdin Capital, LLC Buys Magenta Therapeutics Inc, Foundation Medicine Inc, Blueprint Medicines Corp, Sells iShares Nasdaq Biotechnology Index Fund, Evolent Health Inc, Jounce Therapeutics Inc

Investment company Casdin Capital, LLCbuys Magenta Therapeutics Inc, Foundation Medicine Inc, Blueprint Medicines Corp, BioLife Solutions Inc, MyoKardia Inc, bluebird bio Inc, OraSure Technologies Inc, CRISPR Therapeutics AG, Neon Therapeutics Inc, CareDx Inc, sells iShares Nasdaq Biotechnology Index Fund, Evolent Health Inc, Jounce Therapeutics Inc, Adverum Biotechnologies Inc during the…

[marketprdaily]

Blueprint prices new cancer drug at $32,000 per month

Blueprint prices new cancer drug at $32,000 per month

Shares of Blueprint Medicines Corp. gained 0.9% in premarket trading on Friday after the Food and Drug Administration on Thursday approved Ayvakit, the company’s precision therapy treating a mutation in patients with gastrointestinal stromal tumors. The drug was approved by the regulator a month earlier than expected. A Blueprint spokesperson said the monthly wholesale acquisition cost for the…

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I like Broadcom so much World Wrestling Entertainment: "No. I know they've cut costs a lot, but you know what let's stick with video games.