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Rhinovirus Infection Therapeutics to Witness Significant Growth due to Positive Results in the Coming Years

Rhinovirus infections, caused by rhinoviruses, occurs in the upper or lower respiratory tracts. The occurrence frequency of the infection is a year-around, but most often in spring and fall seasons. The infections are mostly acknowledged as ‘common cold’, but the infection can also lead to lesser degree pneumonia, sore throats, sinus infections, ear infections, and bronchiolitis. In children, around 8-10 course of occurrence have been observed during the first two-years. The symptoms manifest after the incubation period of viruses (12-24 hours) and last till 7-11 days. The signs and symptoms of the infection include nasal irritation or dryness, headache, less sense of smell and taste, hoarseness, cough, and fever.

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According to the research findings, most of the drug candidates are being developed as vaccine and administered by the intramuscular and intranasal route. The major advantage of vaccines includes they generate acquired immunity in the body against the rhinovirus infections. The building immunity by the vaccines resist the complications of infections.

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The companies developing therapeutics for the treatment of various infections due to rhinovirus, have shown positive clinical results in the various phases of drug development. For instance, in Pre-Clinical study, TVB-3567, showed positive results and minimized infections caused by rhinovirus, respiratory syntaxial virus, parainfluenza virus, severe adult respiratory syndrome virus, and hepatitis virus. The drug candidate reduced the replication of these viruses and helped in minimizing the number of inflammatory cells in the infected areas of the body. The drug candidate also prevented the emergence of drug resistance.

Some of the key players involved in the development of rhinovirus infection therapeutics in the late and mid stage include Romark L.C., Johnson & Johnson, Istari Oncology Inc., Merck & Co. Inc., and Vaxart Inc.

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Wiskott-Aldrich Syndrome Therapeutics Pipeline Analysis 2018

Wiskott-Aldrich syndrome is a hereditary immunodeficiency disorder characterized by abnormal functioning of immune system and decreased ability to form blood clots. The abnormality in the platelets leads to easy bruising effects in case of prolonged bleeding. 

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The white blood cells become non-functional and cause other immunological disorders in Wiskott-Aldrich syndrome. It has been discovered that this disease is caused by the mutation in WAS gene (Xp11.4-p11.21) that instruct to make Wiskott-Aldrich syndrome protein. 

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Some of the symptoms observed in the patients are thrombocytopenia, hematologic abnormalities, eczema, and malignancies. Genethon Inc. is in the process of developing autologous CD34 positive cells transduced with a lentiviral vector containing human WAS gene as a gene therapy for the treatment of Wiskott-Aldrich syndrome. Further, the University of Pittsburgh and Orchard Therapeutics Limited are also involved in the pipeline for Wiskott-Aldrich syndrome.

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Pleural Effusion Therapeutics Pipeline Analysis

Pleural effusion is the fluid build-up in the pleural space and is categorized into two types which includes exudate and transudate.

Transudate is usually composed of ultrafiltrates of plasma due to heart failure or cirrhosis; while, exudate is caused by inflammatory conditions. The major causes of pleural effusion are kidney failure, infection, congestive heart failure, malignancy, pulmonary embolism, cirrhosis, hypoalbuminemia and trauma.

The common symptoms associated with the pleural effusion are chest pain, difficulty in breathing, painful breathing, cough, fever and loss of appetite. The standard treatments available for pleural effusion are thoracentesis, surgery, antibiotics and diuretics.

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Lung Therapeutics Inc. is in the process of developing LTI-01 as a single chain urokinase plasminogen activator for the treatment of safe clearance of fibrinous scar tissue in patients with loculated pleural effusion. Genelux Corporation is another key player involved in the development of drugs for the management of pleural effusion.

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Opioid-Induced Bowel Dysfunction Therapeutics Pipeline Analysis 2018

Opioid-induced bowel dysfunction occurs due to excessive consumption of opioids to manage pain. Opioid is generally use in the clinical management of pain which affects gastrointestinal tract and causes several types of side-effects.

Opioid induced constipation is the most common side-effect occur due to excessive usage of opioids. People using opioid generally suffer from delayed gastric emptying, dyspepsia, nausea and vomiting.

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The opioids act on μ, δ, and κ-opioid receptors and perform function with respect to the type of receptors. The μ and δ opioid receptors are targeted for analgesic function. The κ-opioid receptor targets to analgesic, hallucinogenic, anti-depressants, and anti-anxiety functions. 

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Some of the major companies involved in the development of therapeutic agents for the treatment of opioid-induced bowel dysfunction includes Synergy Pharmaceuticals Inc., and Theravance Biopharma Inc.

Theravance Biopharma Inc. is involved in developing TD-1211, a μ-opioid receptor antagonist, for the treatment of opioid-induced bowel syndrome. Moreover, Synergy Pharmaceuticals Inc. is currently involved in development of SP-333, a guanylate cyclase C agonist, for the management of this medical condition.

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Tuberous Sclerosis Therapeutics Clinical Trial Results

Tuberous sclerosis, also known as tuberous sclerosis complex, is a genetic disorder characterized by the growth of numerous noncancerous (benign) tumors in many parts of the body.

It can occur in the brain, skin, kidneys, and other organs, in some cases leading to significant health problems. The signs and symptoms of the disease vary from person to person. Virtually all affected people have skin abnormalities, including patches of unusually light-coloured skin, areas of raised and thickened skin, and growths under the nails. It can also cause facial angiofibromas, tumors on the face beginning in childhood.

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Some affected children have the characteristic features of autism, a developmental disorder that affects communication and social interaction.

The drug candidates of tuberous sclerosis disease pipeline include, but not limited to, cannabidiol, and TAK-935. Novartis AG, GW Pharmaceuticals plc and Takeda Pharmaceutical Company Limited are some of the major companies having drugs in the tuberous sclerosis therapeutics pipeline.